WO2011123776A3 - Procédé de détection du sang occulte - Google Patents

Procédé de détection du sang occulte Download PDF

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Publication number
WO2011123776A3
WO2011123776A3 PCT/US2011/030934 US2011030934W WO2011123776A3 WO 2011123776 A3 WO2011123776 A3 WO 2011123776A3 US 2011030934 W US2011030934 W US 2011030934W WO 2011123776 A3 WO2011123776 A3 WO 2011123776A3
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WO
WIPO (PCT)
Prior art keywords
occult blood
chemifluorescent
chemiluminescent
specimen
testing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/US2011/030934
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English (en)
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WO2011123776A2 (fr
Inventor
B. Eugene Guthery
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Individual
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Individual
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Application filed by Individual filed Critical Individual
Publication of WO2011123776A2 publication Critical patent/WO2011123776A2/fr
Publication of WO2011123776A3 publication Critical patent/WO2011123776A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/725—Haemoglobin using peroxidative activity

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un nouveau procédé de détection du sang occulte dans les selles, l'urine, les sucs gastriques et les expectorations. Ledit procédé représente un progrès dans le domaine de la recherche du sang occulte, en particulier sous une forme « d'autotest » simple à utiliser par les non-spécialistes. Le procédé peut être appliqué à un échantillon préalablement déposé dans une zone d'essai, par exemple une cuvette de toilettes, sans qu'il soit nécessaire de manipuler l'échantillon. Le procédé consiste à appliquer un agent oxydant, contenant de préférence un chélateur de métaux, à l'échantillon souhaité, puis à appliquer un composé chimiluminescent ou chimifluorescent. Il faut ensuite éliminer la lumière ambiante pour permettre de détecter la lueur chimiluminescente ou chimifluorescente à l'œil nu. Les composés chimiluminescents ou chimifluorescents de l'invention sont choisis parmi le luminol de sodium ou de potassium purifié et l'hydrazide de benzo(ghi)pérylène-(acide 1,2-dicarboxylique) de sodium ou de potassium purifié, à un pH supérieur à 9,0. L'utilisation de ces sels de sodium ou de potassium d'hydrazides génère, en présence de sang occulte, une chimiluminescence dont l'intensité est visible à l'œil nu, sans matériel de détection.
PCT/US2011/030934 2010-04-01 2011-04-01 Procédé de détection du sang occulte Ceased WO2011123776A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32003810P 2010-04-01 2010-04-01
US61/320,038 2010-04-01

Publications (2)

Publication Number Publication Date
WO2011123776A2 WO2011123776A2 (fr) 2011-10-06
WO2011123776A3 true WO2011123776A3 (fr) 2012-02-09

Family

ID=44712855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/030934 Ceased WO2011123776A2 (fr) 2010-04-01 2011-04-01 Procédé de détection du sang occulte

Country Status (1)

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WO (1) WO2011123776A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102077288B1 (ko) * 2011-11-30 2020-02-14 에릭 비. 휠든 사람의 대소변에서 혈액을 원격 감지하는 장치 및 방법
US8802442B2 (en) * 2011-11-30 2014-08-12 Eric B. Wheeldon Apparatus and method for the remote sensing of blood in human feces and urine
CN114624216A (zh) * 2014-12-10 2022-06-14 丰能医药科技（上海）有限责任公司 一种检测排泄物隐血的装置
CA3231903A1 (fr) 2015-02-25 2016-09-01 Outsense Diagnostics Ltd. Analyse de substance corporelle
CN107923907B (zh) * 2015-08-28 2020-05-29 荣研化学株式会社 免疫学的测定用试剂组合物及其用途
US11111218B2 (en) * 2016-02-16 2021-09-07 Metriopharm Ag Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione
US11203575B2 (en) * 2016-02-16 2021-12-21 Metriopharm Ag Methhod for producing a crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione
WO2018042431A1 (fr) 2016-08-30 2018-03-08 Outsense Diagnostics Ltd. Analyse d'émission corporelle
CN112858269A (zh) * 2020-12-25 2021-05-28 广东绿康医疗器械有限公司 鼻咽粘膜细胞游离血红素的检测试剂制备方法及使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578358A (en) * 1983-05-03 1986-03-25 Warner-Lambert Company Collection of specimens and detection of occult blood therein
US4725553A (en) * 1983-09-29 1988-02-16 Helena Laboratories Corporation Test composition for detecting occult blood
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US5840584A (en) * 1995-06-07 1998-11-24 Waldenburg; Ottfried Blood in feces test device
US20070037296A1 (en) * 2005-08-12 2007-02-15 Leslie Goulden Combined chemical and immunochemical fecal occult blood test

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578358A (en) * 1983-05-03 1986-03-25 Warner-Lambert Company Collection of specimens and detection of occult blood therein
US4725553A (en) * 1983-09-29 1988-02-16 Helena Laboratories Corporation Test composition for detecting occult blood
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US5840584A (en) * 1995-06-07 1998-11-24 Waldenburg; Ottfried Blood in feces test device
US20070037296A1 (en) * 2005-08-12 2007-02-15 Leslie Goulden Combined chemical and immunochemical fecal occult blood test

Also Published As

Publication number Publication date
WO2011123776A2 (fr) 2011-10-06

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