WO2013105802A3 - 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법 - Google Patents

자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법 Download PDF

Info

Publication number
WO2013105802A3
WO2013105802A3 PCT/KR2013/000221 KR2013000221W WO2013105802A3 WO 2013105802 A3 WO2013105802 A3 WO 2013105802A3 KR 2013000221 W KR2013000221 W KR 2013000221W WO 2013105802 A3 WO2013105802 A3 WO 2013105802A3
Authority
WO
WIPO (PCT)
Prior art keywords
corynebacterium
lysine
microorganisms
producing
xylose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2013/000221
Other languages
English (en)
French (fr)
Other versions
WO2013105802A2 (ko
Inventor
나소연
허란
김창겸
이광호
문준옥
이경한
성진석
김형준
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201380013346.9A priority Critical patent/CN104245921B/zh
Priority to ES13736186.1T priority patent/ES2654809T3/es
Priority to US14/371,653 priority patent/US9200300B2/en
Priority to JP2014552129A priority patent/JP5945336B2/ja
Priority to RU2014130234/10A priority patent/RU2584593C2/ru
Priority to PL13736186T priority patent/PL2803722T3/pl
Priority to EP13736186.1A priority patent/EP2803722B1/en
Priority to DK13736186.1T priority patent/DK2803722T3/en
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Priority to BR112014017088-6A priority patent/BR112014017088B1/pt
Publication of WO2013105802A2 publication Critical patent/WO2013105802A2/ko
Publication of WO2013105802A3 publication Critical patent/WO2013105802A3/ko
Anticipated expiration legal-status Critical
Priority to US14/923,825 priority patent/US9399784B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01017—Xylulokinase (2.7.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01005—Xylose isomerase (5.3.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 Ｌ-라이신의 생산방법에 관한 것으로, 구체적으로 본 발명은 자일로즈 합성효소인 자일로즈 이소머라제 및 자일룰로키나제를 코딩하는 유전자가 도입되어 상기 효소를 발현하도록 변이된 코리네박테리움 속 미생물 및 상기 변이된 코리네박테리움 속 미생물을 자일로즈를 탄소원으로 사용하여 배양하고, 상기 배양물로부터 L-라이신을 회수하는 단계를 포함하는 L-라이신의 생산방법에 관한 것이다.
PCT/KR2013/000221 2012-01-10 2013-01-10 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법 Ceased WO2013105802A2 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP13736186.1A EP2803722B1 (en) 2012-01-10 2013-01-10 Microorganisms of corynebacterium which can utilize xylose and method for producing l-lysine using same
US14/371,653 US9200300B2 (en) 2012-01-10 2013-01-10 Microorganisms of Corynebacterium which can utilize xylose and method for producing L-lysine using same
JP2014552129A JP5945336B2 (ja) 2012-01-10 2013-01-10 キシロース利用能が付与されたコリネバクテリウム属微生物、及びそれを用いたｌ−リジンの生産方法
RU2014130234/10A RU2584593C2 (ru) 2012-01-10 2013-01-10 МИКРООРГАНИЗМЫ Corynebacterium, СПОСОБНЫЕ УТИЛИЗИРОВАТЬ КСИЛОЗУ, И СПОСОБ ПОЛУЧЕНИЯ L-ЛИЗИНА С ПРИМЕНЕНИЕМ ТАКИХ МИКРООРГАНИЗМОВ
PL13736186T PL2803722T3 (pl) 2012-01-10 2013-01-10 Mikroorganizmy maczugowców, które mogą wykorzystywać ksylozę i sposób wytwarzania L-lizyny z ich wykorzystaniem
CN201380013346.9A CN104245921B (zh) 2012-01-10 2013-01-10 可利用木糖的棒状杆菌微生物和利用其产生l-赖氨酸的方法
ES13736186.1T ES2654809T3 (es) 2012-01-10 2013-01-10 Microorganismos de Corynebacterium que pueden utilizar xilosa y procedimiento de producción de L-lisina utilizando los mismos
DK13736186.1T DK2803722T3 (en) 2012-01-10 2013-01-10 Corynebacterium microorganisms capable of utilizing xylose, and method for producing L-lysine using the same
BR112014017088-6A BR112014017088B1 (pt) 2012-01-10 2013-01-10 Microrganismos de corynebacterium que podem utilizar xilose e método para a produção de l-lisina utilizando os mesmos
US14/923,825 US9399784B2 (en) 2012-01-10 2015-10-27 Microorganisms of Corynebacterium which can utilize xylose and method for producing L-lysine using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2012-0003133 2012-01-10
KR20120003133 2012-01-10

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/371,653 A-371-Of-International US9200300B2 (en) 2012-01-10 2013-01-10 Microorganisms of Corynebacterium which can utilize xylose and method for producing L-lysine using same
US14/923,825 Continuation US9399784B2 (en) 2012-01-10 2015-10-27 Microorganisms of Corynebacterium which can utilize xylose and method for producing L-lysine using same

Publications (2)

Publication Number Publication Date
WO2013105802A2 WO2013105802A2 (ko) 2013-07-18
WO2013105802A3 true WO2013105802A3 (ko) 2013-09-19

Family

ID=48782024

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/000221 Ceased WO2013105802A2 (ko) 2012-01-10 2013-01-10 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법

Country Status (12)

Country Link
US (2) US9200300B2 (ko)
EP (1) EP2803722B1 (ko)
JP (1) JP5945336B2 (ko)
KR (2) KR20130082124A (ko)
CN (2) CN104245921B (ko)
BR (1) BR112014017088B1 (ko)
DK (1) DK2803722T3 (ko)
ES (1) ES2654809T3 (ko)
MY (1) MY164858A (ko)
PL (1) PL2803722T3 (ko)
RU (1) RU2584593C2 (ko)
WO (1) WO2013105802A2 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6519476B2 (ja) 2013-10-23 2019-05-29 味の素株式会社 目的物質の製造法
KR101755767B1 (ko) * 2014-09-05 2017-07-10 씨제이제일제당 (주) L-라이신 생산능이 향상된 미생물 및 이를 이용한 l-라이신 생산방법
KR101694850B1 (ko) * 2014-10-08 2017-01-10 씨제이제일제당 주식회사 L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법
KR101793328B1 (ko) * 2015-07-03 2017-11-03 씨제이제일제당 (주) Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법
CN122256151A (zh) 2015-07-13 2026-06-23 玛拉可再生能源公司 增强木糖的微藻代谢
CN105567567A (zh) * 2016-02-03 2016-05-11 程雪娇 一种甘蔗渣培养基及其制备方法
DK3533875T5 (da) 2016-09-01 2024-09-02 Ningxia Eppen Biotech Co Ltd Corynebacterium til fremstilling af l-lysin ved fermentering
KR101915433B1 (ko) * 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법
CN110551648B (zh) * 2018-05-30 2022-03-15 天津大学 发酵木糖生产琥珀酸的谷氨酸棒杆菌及用途
KR102112240B1 (ko) * 2018-09-28 2020-05-18 씨제이제일제당 주식회사 알파-글루코시다제의 활성이 강화된 l-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산 생산 방법
JP7362895B2 (ja) * 2019-12-23 2023-10-17 シージェイ チェルジェダン コーポレイション シトクロムｃの活性が強化されたｌ－アミノ酸生産微生物およびこれを用いたｌ－アミノ酸の生産方法
CN112877269B (zh) 2020-01-15 2021-12-24 中国科学院天津工业生物技术研究所 生产赖氨酸的微生物以及赖氨酸的生产方法
CN112458108A (zh) * 2020-11-24 2021-03-09 华东理工大学 一种在谷氨酸棒状杆菌中利用木糖生成谷氨酸的合成路径的构建方法
KR102277031B1 (ko) * 2021-01-29 2021-07-13 씨제이제일제당 (주) 신규한 타입 ii 시트레이트 신타아제 변이체 및 이를 이용한 l-라이신 생산 방법
KR20220156323A (ko) * 2021-05-18 2022-11-25 씨제이제일제당 (주) Agl 단백질의 활성이 강화된, 아미노산을 생산하는 미생물 및 이를 이용한 아미노산 생산 방법
CN115896152B (zh) * 2021-09-30 2026-01-09 上海凯赛生物技术股份有限公司 一种谷氨酸棒状杆菌及其应用
WO2024206168A1 (en) * 2023-03-24 2024-10-03 Natáur Llc Bioproduction of sulfur-containing compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216804A1 (en) * 2003-09-11 2006-09-28 Karhumaa Kaisa J Construction of new xylose utilizing saccharomyces cerevisiae strain

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY113040A (en) * 1994-02-24 2001-11-30 Ajinomoto Kk Novel gene derived from coryneform bacteria and use thereof
KR0159812B1 (ko) 1995-12-20 1998-11-16 손경식 코리네박테리움 글루타미컴 씨에이치 77 및 이 균주를 이용한 l-라이신의 제조 방법
KR100397322B1 (ko) 2000-12-30 2003-09-06 씨제이 주식회사 엘-라이신의 제조방법
US8003367B2 (en) 2004-03-16 2011-08-23 Ajinomoto Co., Inc. Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
RU2283346C1 (ru) * 2005-03-14 2006-09-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот методом ферментации с использованием бактерий, обладающих повышенной экспрессией генов утилизации ксилозы
KR100620092B1 (ko) 2004-12-16 2006-09-08 씨제이 주식회사 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법
RU2304615C2 (ru) * 2005-10-12 2007-08-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Способ получения l-аминокислот с использованием бактерий, принадлежащих к роду escherichia
US9109242B2 (en) 2006-09-15 2015-08-18 Cj Cheiljedang Corporation Corynebacteria having enhanced L-lysine productivity and a method of producing L-lysine using the same
KR100838035B1 (ko) * 2006-12-29 2008-06-12 씨제이제일제당 (주) Ｌ-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용한 ｌ-라이신 생산 방법
CN102037120B (zh) * 2008-03-27 2013-09-11 纳幕尔杜邦公司 具有改善的木糖利用率的发酵单胞菌属
KR101126041B1 (ko) 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 ｌ-라이신 생산방법
US8685703B2 (en) * 2008-06-17 2014-04-01 Research Institute Of Innovative Technology For The Earth Coryneform bacterium transformant having improved D-xylose-utilizing ability
KR101083136B1 (ko) * 2009-02-13 2011-11-11 씨제이제일제당 (주) Ｌ-아미노산 생산용 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216804A1 (en) * 2003-09-11 2006-09-28 Karhumaa Kaisa J Construction of new xylose utilizing saccharomyces cerevisiae strain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOMBACH, B. ET AL.: "Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of L-lysine production strains.", APPL. MICROBIOL. BIOTECHNOL., vol. 86, 24 March 2010 (2010-03-24), pages 1313 - 1322, XP019800020 *
BUSCHKE, N. ET AL.: "Metabolic engineering of Corynebacterium glutamicum for production of 1, 5-diaminopentane from hemicellulose.", BIOTECHNOL. J., vol. 6, no. 3, 7 February 2011 (2011-02-07), pages 306 - 317, XP055157287 *
SASAKI, M. ET AL.: "Simultaneous utilization of D-cellobiose, D-glucose, and D-xylose by recombinant Corynebacterium glutamicum under oxygen-deprived conditions.", APPL. MICROBIOL. BIOTECHNOL., vol. 81, 23 September 2008 (2008-09-23), pages 691 - 699, XP019654190 *

Also Published As

Publication number Publication date
ES2654809T3 (es) 2018-02-15
US9399784B2 (en) 2016-07-26
KR20150046778A (ko) 2015-04-30
JP5945336B2 (ja) 2016-07-05
CN104245921A (zh) 2014-12-24
RU2014130234A (ru) 2016-02-27
CN104245921B (zh) 2018-09-14
WO2013105802A2 (ko) 2013-07-18
CN108467848A (zh) 2018-08-31
RU2584593C2 (ru) 2016-05-20
US20140377816A1 (en) 2014-12-25
DK2803722T3 (en) 2018-01-08
US20160040200A1 (en) 2016-02-11
EP2803722B1 (en) 2017-09-27
EP2803722A2 (en) 2014-11-19
BR112014017088A2 (ko) 2017-06-13
MY164858A (en) 2018-01-30
KR20130082124A (ko) 2013-07-18
KR101592140B1 (ko) 2016-02-22
EP2803722A4 (en) 2015-07-22
BR112014017088B1 (pt) 2022-04-19
US9200300B2 (en) 2015-12-01
PL2803722T3 (pl) 2018-03-30
JP2015503359A (ja) 2015-02-02

Similar Documents

Publication Publication Date Title
MY164858A (en) Microorganisms of corynebacterium which can utilize xylose and method for producing l-lysine using same
MY173771A (en) A method for producing a target substance by fermentation
EP4026901A3 (en) Method for screening alpha-amylases
AU2012353654A8 (en) Modified microorganisms and methods of making butadiene using same
PH12014500588A1 (en) Microorganisms and methods for producing alkenes
WO2012173659A3 (en) Lignocellulosic hydrolysates as feedstocks for isobutanol fermentation
WO2013027999A3 (ko) 열 안정성이 향상된 사이코스 에피머화 효소 변이체 및 이를 이용한 사이코스의 연속적 생산
MY172307A (en) Production of muconic acid from genetically engineered microorganisms
MX2013012904A (es) Microorganismos geneticamente modificados que metabolizan xilosa.
EA201492057A1 (ru) Ферментация и способ с псевдодвижущимся слоем
MY175283A (en) Mutant microorganisms having high ability to produce putrescine and method for producing putrescine using the same
MY172288A (en) Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
UA108468C2 (en) Microorganism that expresses xylose isomerase
WO2013015663A3 (ko) 태양광 및 수소를 이용한 이산화탄소의 환원 방법 및 이를 위한 장치
MY181203A (en) Microorganism of corynebacterium sp. having enhanced l-lysine producibility and method for producing l-lysine using same
MY182946A (en) Production of organic acids by fermentation at low ph
WO2011036213A3 (en) Fermentation process for producing glycolic acid
WO2012141542A3 (ko) 미생물 발효를 통해 제조된 생성물을 흡착제를 이용하여 분리 정제하는 장치 및 방법
WO2012169819A3 (ko) 2-하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법
WO2011155799A3 (ko) 탄화수소 생성능을 가지는 변이 미생물 및 이를 이용한 탄화수소의 제조방법
WO2013006681A3 (en) Bioreactors circulation apparatus, system and method
WO2012177983A3 (en) Microorganisms for producing ethylene glycol and methods related thereto
WO2014049382A3 (en) Ethylenediamine fermentative production by a recombinant microorganism
WO2012124941A3 (ko) ２-하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트를 생산하는 능력을 가지는 재조합 미생물 및 이를 이용한 ２-하이드록시부티레이트를 모노머로 함유하고 있는 폴리하이드록시알카노에이트의 제조방법
WO2014041011A3 (en) Method for the production of primary amines

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13736186

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2014552129

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 14371653

Country of ref document: US

REEP Request for entry into the european phase

Ref document number: 2013736186

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2013736186

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2014130234

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112014017088

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112014017088

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20140710

ENP Entry into the national phase

Ref document number: 112014017088

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20140710