WO2014194245A3 - Inhibiteurs de cdk8 et leurs utilisations - Google Patents

Inhibiteurs de cdk8 et leurs utilisations Download PDF

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Publication number
WO2014194245A3
WO2014194245A3 PCT/US2014/040320 US2014040320W WO2014194245A3 WO 2014194245 A3 WO2014194245 A3 WO 2014194245A3 US 2014040320 W US2014040320 W US 2014040320W WO 2014194245 A3 WO2014194245 A3 WO 2014194245A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdk8
disorders
compounds
kinases
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/040320
Other languages
English (en)
Other versions
WO2014194245A2 (fr
Inventor
Donna L. Romero
Divya Chaudhary
Shaughnessy Robinson
Craig E. Masse
Michael J. Morin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nimbus Iris Inc
Original Assignee
Nimbus Iris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nimbus Iris Inc filed Critical Nimbus Iris Inc
Publication of WO2014194245A2 publication Critical patent/WO2014194245A2/fr
Publication of WO2014194245A3 publication Critical patent/WO2014194245A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés consistant à utiliser les composés représentés par la formule (I); et des compositions associées pour l'inhibition de CDK8, et le traitement de troubles médiés par CDK8.
PCT/US2014/040320 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et leurs utilisations Ceased WO2014194245A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361829840P 2013-05-31 2013-05-31
US61/829,840 2013-05-31

Publications (2)

Publication Number Publication Date
WO2014194245A2 WO2014194245A2 (fr) 2014-12-04
WO2014194245A3 true WO2014194245A3 (fr) 2015-01-29

Family

ID=51989541

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2014/040320 Ceased WO2014194245A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et leurs utilisations
PCT/US2014/040243 Ceased WO2014194201A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et applications de ceux-ci

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2014/040243 Ceased WO2014194201A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et applications de ceux-ci

Country Status (1)

Country Link
WO (2) WO2014194245A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016505012A (ja) * 2013-01-10 2016-02-18 ニンバス アイリス， インコーポレイテッド Ｉｒａｋ阻害剤およびその使用
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
BR112016006319A2 (pt) 2013-09-27 2017-08-01 Nimbus Iris Inc inibidores de irak e usos dos mesmos
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US20210322651A1 (en) * 2014-12-18 2021-10-21 Senex Biotechnology, Inc. Suppression of neointimal formation following vascular surgeru using cdk8 inhibitors
MX390651B (es) * 2015-11-03 2025-03-21 Apriligen Inc Compuestos para el tratamiento de trastornos hipoproliferativos
US11285144B2 (en) 2016-08-03 2022-03-29 The Broad Institute, Inc. Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity
US11578067B2 (en) 2017-01-30 2023-02-14 Kyoto University Compound, and method for producing regulatory T cells
EP3691642B1 (fr) 2017-10-02 2024-03-06 Boehringer Ingelheim International GmbH Composés et dérivés de [1,6]naphthyridine comme inhibiteurs cdk8/cdk19
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
CA3128377A1 (fr) 2019-02-01 2020-08-06 University Of South Carolina Compositions de pyridine bicyclique et procedes pour leur utilisation pour la therapie du cancer
US12410194B2 (en) 2019-11-26 2025-09-09 Dana-Farber Cancer Institute, Inc. Potent and selective azaindole inhibitors of CDK8 and CDK19
US20240400993A1 (en) 2021-09-27 2024-12-05 Kyoto University Method for producing t cell
CN118591619A (zh) 2021-11-24 2024-09-03 雷格细胞股份有限公司 人诱导性调节性t细胞及其制作方法
US20250352578A1 (en) 2021-11-24 2025-11-20 Regcell Co., Ltd. Pharmaceutical composition for treating or preventing t cell-related disorders
US20250230411A1 (en) 2022-03-23 2025-07-17 Kyoto University Method for producing regulatory t cells
EP4596684A1 (fr) 2022-09-26 2025-08-06 Regcell Co., Ltd. Lymphocytes t régulateurs induits contenant un récepteur antigénique chimérique (car)
JPWO2024071010A1 (fr) 2022-09-26 2024-04-04
EP4663195A1 (fr) 2023-02-08 2025-12-17 Regcell Co., Ltd. Composition pharmaceutique pour le traitement ou la prévention du pemphigus
WO2024204553A1 (fr) 2023-03-29 2024-10-03 レグセル株式会社 Lymphocytes t régulateurs inductibles humains et leur procédé de production, et composition pharmaceutique pour le traitement ou la prévention d'une maladie liée aux lymphocytes t

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323214B1 (en) * 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US20060235034A1 (en) * 2004-11-01 2006-10-19 Nouri Neamati Novel compounds for treatment of cancer and disorders associated with angiogenesis function
US20110282056A1 (en) * 2008-01-22 2011-11-17 Merck Patent Gmbh Protein kinase inhibitors and use thereof
US20120283238A1 (en) * 2011-01-10 2012-11-08 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323214B1 (en) * 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US20060235034A1 (en) * 2004-11-01 2006-10-19 Nouri Neamati Novel compounds for treatment of cancer and disorders associated with angiogenesis function
US20110282056A1 (en) * 2008-01-22 2011-11-17 Merck Patent Gmbh Protein kinase inhibitors and use thereof
US20120283238A1 (en) * 2011-01-10 2012-11-08 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADEPU ET AL.: "Novel thieno[2,3-d]pyrimidines: their design, synthesis, crystal structure analysis and pharmacological evaluation.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, no. 29, 2012, pages 5554 - 5569, XP055232212, Retrieved from the Internet <URL:http://www.researchgate.net/publication/227342543_Novel_thieno23-dpyrimidines_their_design_synthesis_crystal_structure_analysis_and_pharmacological_evaluation> [retrieved on 20141107], DOI: doi:10.1039/c2ob25420d *

Also Published As

Publication number Publication date
WO2014194245A2 (fr) 2014-12-04
WO2014194201A2 (fr) 2014-12-04

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