WO2014194245A3 - Inhibiteurs de cdk8 et leurs utilisations - Google Patents

Inhibiteurs de cdk8 et leurs utilisations Download PDF

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Publication number
WO2014194245A3
WO2014194245A3 PCT/US2014/040320 US2014040320W WO2014194245A3 WO 2014194245 A3 WO2014194245 A3 WO 2014194245A3 US 2014040320 W US2014040320 W US 2014040320W WO 2014194245 A3 WO2014194245 A3 WO 2014194245A3
Authority
WO
WIPO (PCT)
Prior art keywords
cdk8
disorders
compounds
kinases
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/040320
Other languages
English (en)
Other versions
WO2014194245A2 (fr
Inventor
Donna L. Romero
Divya Chaudhary
Shaughnessy Robinson
Craig E. Masse
Michael J. Morin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nimbus Iris Inc
Original Assignee
Nimbus Iris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nimbus Iris Inc filed Critical Nimbus Iris Inc
Publication of WO2014194245A2 publication Critical patent/WO2014194245A2/fr
Publication of WO2014194245A3 publication Critical patent/WO2014194245A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés consistant à utiliser les composés représentés par la formule (I); et des compositions associées pour l'inhibition de CDK8, et le traitement de troubles médiés par CDK8.
PCT/US2014/040320 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et leurs utilisations Ceased WO2014194245A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361829840P 2013-05-31 2013-05-31
US61/829,840 2013-05-31

Publications (2)

Publication Number Publication Date
WO2014194245A2 WO2014194245A2 (fr) 2014-12-04
WO2014194245A3 true WO2014194245A3 (fr) 2015-01-29

Family

ID=51989541

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2014/040320 Ceased WO2014194245A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et leurs utilisations
PCT/US2014/040243 Ceased WO2014194201A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et applications de ceux-ci

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2014/040243 Ceased WO2014194201A2 (fr) 2013-05-31 2014-05-30 Inhibiteurs de cdk8 et applications de ceux-ci

Country Status (1)

Country Link
WO (2) WO2014194245A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110114A1 (fr) * 2013-01-10 2014-07-17 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisations
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
EP3049086A4 (fr) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Inhibiteurs d'irak et leurs utilisation
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US20210322651A1 (en) * 2014-12-18 2021-10-21 Senex Biotechnology, Inc. Suppression of neointimal formation following vascular surgeru using cdk8 inhibitors
BR112018008931A8 (pt) * 2015-11-03 2019-02-26 Lu License Ab ?compostos para tratamento de distúrbios hipoproliferativos?
US11285144B2 (en) 2016-08-03 2022-03-29 The Broad Institute, Inc. Use of CDK8 inhibitors to treat diseases of inflammation and autoimmunity
JP7142846B2 (ja) 2017-01-30 2022-09-28 国立大学法人京都大学 新規化合物及び制御性ｔ細胞の製造方法
CN111163775B (zh) 2017-10-02 2023-07-11 勃林格殷格翰国际有限公司 作为cdk8/cdk19抑制剂的新型[1,6]萘啶化合物和衍生物
ES2974634T3 (es) 2018-12-21 2024-06-28 Celgene Corp Inhibidores de tienopiridinas de RIPK2
ES2991429T3 (es) 2019-02-01 2024-12-03 Univ South Carolina Compuestos de piridina bicíclicos para su uso en el tratamiento del cáncer
AU2020393896A1 (en) 2019-11-26 2022-06-23 Dana-Farber Cancer Institute, Inc. Potent and selective azaindole inhibitors of CDK8 and CDK19
EP4410965A4 (fr) 2021-09-27 2025-09-24 Univ Kyoto Procédé de production de lymphocyte t
KR20240130083A (ko) 2021-11-24 2024-08-28 레그셀 가부시키가이샤 T세포 관련 질환을 치료 또는 예방하기 위한 의약 조성물
TW202330911A (zh) 2021-11-24 2023-08-01 日商雷格細胞股份有限公司 人類誘導性控制性ｔ細胞及其製作方法
EP4497822A4 (fr) 2022-03-23 2026-03-18 Univ Kyoto Procédé de production de lymphocytes t régulateurs
CA3251059A1 (fr) 2022-05-02 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Compositions, systèmes et procédés de modulation d’un gène cible
CN120112629A (zh) 2022-09-26 2025-06-06 国立大学法人京都大学 T细胞产生方法
EP4596684A1 (fr) 2022-09-26 2025-08-06 Regcell Co., Ltd. Lymphocytes t régulateurs induits contenant un récepteur antigénique chimérique (car)
US20260232799A1 (en) 2023-02-08 2026-08-13 Regcell Co., Ltd. Pharmaceutical composition for treating or preventing pemphigus
CN121057812A (zh) 2023-03-29 2025-12-02 雷格细胞股份有限公司 人诱导性调节性t细胞及其制作方法以及用于治疗或预防t细胞相关疾病的药物组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323214B1 (en) * 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US20060235034A1 (en) * 2004-11-01 2006-10-19 Nouri Neamati Novel compounds for treatment of cancer and disorders associated with angiogenesis function
US20110282056A1 (en) * 2008-01-22 2011-11-17 Merck Patent Gmbh Protein kinase inhibitors and use thereof
US20120283238A1 (en) * 2011-01-10 2012-11-08 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323214B1 (en) * 1997-10-29 2001-11-27 Medco Research, Inc Allosteric adenosine receptor modulators
US20060235034A1 (en) * 2004-11-01 2006-10-19 Nouri Neamati Novel compounds for treatment of cancer and disorders associated with angiogenesis function
US20110282056A1 (en) * 2008-01-22 2011-11-17 Merck Patent Gmbh Protein kinase inhibitors and use thereof
US20120283238A1 (en) * 2011-01-10 2012-11-08 Nimbus Iris, Inc. Irak inhibitors and uses thereof
US20130231328A1 (en) * 2012-01-10 2013-09-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADEPU ET AL.: "Novel thieno[2,3-d]pyrimidines: their design, synthesis, crystal structure analysis and pharmacological evaluation.", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, no. 29, 2012, pages 5554 - 5569, XP055232212, Retrieved from the Internet <URL:http://www.researchgate.net/publication/227342543_Novel_thieno23-dpyrimidines_their_design_synthesis_crystal_structure_analysis_and_pharmacological_evaluation> [retrieved on 20141107], DOI: doi:10.1039/c2ob25420d *

Also Published As

Publication number Publication date
WO2014194245A2 (fr) 2014-12-04
WO2014194201A2 (fr) 2014-12-04

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