WO2016108332A1 - Stimulateur actif à haute fréquence pulsatoire biologiquement implanté pour cathéter afin de stimuler le nerf rachidien épidural transsacral - Google Patents

Stimulateur actif à haute fréquence pulsatoire biologiquement implanté pour cathéter afin de stimuler le nerf rachidien épidural transsacral Download PDF

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Publication number
WO2016108332A1
WO2016108332A1 PCT/KR2015/001113 KR2015001113W WO2016108332A1 WO 2016108332 A1 WO2016108332 A1 WO 2016108332A1 KR 2015001113 W KR2015001113 W KR 2015001113W WO 2016108332 A1 WO2016108332 A1 WO 2016108332A1
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Prior art keywords
high frequency
pulsatile
pulsatile high
frequency signal
information
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Ceased
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PCT/KR2015/001113
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English (en)
Korean (ko)
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안상호
이상학
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Research Cooperation Foundation of Yeungnam University
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Research Cooperation Foundation of Yeungnam University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36175—Pulse width or duty cycle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36189—Control systems using modulation techniques
    • A61N1/36196—Frequency modulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data

Definitions

  • the present invention relates to a pulsatile radiofrequency stimulator for catheter (hereinafter referred to as an in vitro pulsatile radiofrequency stimulator for active catheter) for active biograft cervical epidural spinal nerve stimulation, in particular pulsatile radiofrequency signal generation information and body determined according to the symptoms of the patient Generates the driving power for the operation of the implanted active catheter outside the body and provides it wirelessly, and receives the pulsatile high frequency signal generation information and the driving power through the antenna implanted in the spinal region of the human body, and the pulsatile high frequency in the implanted active catheter.
  • an extracorporeal pulsatile high frequency stimulator for an active catheter that generates a signal and causes electrical stimulation to the spinal nerve through the electrode.
  • Pulsatile radiofrequency has been used for the treatment of various chronic pain syndromes. Compared with persistent high frequency, there is almost no nerve damage, and it has recently emerged as a neuromodulator. It can also be seen as a tool to avoid steroid injections in elderly patients with chronic pain disorders, which can cause various complications due to repeated injections. Tricuspid neuralgia, failure syndrome after spinal surgery, complex site pain syndrome For the treatment of postherpetic neuralgia, peripheral nerve pulsatile radiofrequency therapy of spinal nerve, face and trunk and limbs is expanding. Recently, intraarticular pulsatile radiofrequency has been reported to reduce chronic joint pain. Intra-articular pulsatile radiofrequency is expected to act on intra-articular tissues rather than directly on nerve tissues to act as an anti-inflammatory and immune cell regulator.
  • Micropulmonary cells known to be important for the development of neuropathic pain in the dorsal horn, when pulsatile radiofrequency ablation is performed on the dorsal root ganglion of animals with neuropathic pain, It has been found that the activity of microglia), astrocytes, and substance P (substance P) are reduced. Peripheral nerves and joint pain, such as the central nervous system spinal cord and the pain perception of the brain becomes sensitive and central sensitization occurs, the central sensitization is involved in the activation of microglia. Central sensitization causes the pain in the local area to gradually expand, spreading the pain over a wide area, causing pain or spontaneous pain even with minor irritation and not responding well to any treatment.
  • pulsatile radiofrequency therapy that reduces the activity of microglia is required.
  • the pulsatile high frequency treatment of nerves over the entire length of the spine is required because it does not respond well to single-time pulsatile radiotherapy for local nerves.
  • the epidural spinal nerve pulsatile pulsatile high frequency treatment the effect of reducing pain or nerve abnormality does not last long, so the pulsation that can continuously control the pain or nerve abnormality of the patient by inserting a living implantable catheter A high frequency stimulation device is necessary.
  • the pulsatile stimulation of the high frequency of 500,000 Hz which is more effective than the low frequency stimulation, enables the implantation of a living implantable cervical dura that can be stimulated over the entire spinal field for the treatment of central sensitized chronic fullness pain or for the control of nerve abnormalities.
  • a pulsatile radiofrequency device for external spinal nerve stimulation There is a need for a pulsatile radiofrequency device for external spinal nerve stimulation.
  • the present invention generates and provides pulsatile high frequency signal information determined in accordance with a symptom of a patient and driving power for electric stimulation in vitro, and transmits pulsatile high frequency signal information through an antenna implanted into the sacral region of the human body. And it is an object to provide an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter to receive the drive power to generate a pulsatile high frequency signal in the body to be electrical stimulation through the electrode.
  • the active extracorporeal pulsatile high frequency stimulation apparatus generates pulsatile high frequency signal information to generate and transmit pulsatile high frequency signal information and driving power, respectively, in response to a request for generating pulsatile high frequency signals according to a patient's condition, and transmits the generated pulsatile high frequency signal information.
  • Controller is implanted in the body of the patient, receives the driving power and uses the driving power for generating the pulsatile high frequency signal, receives the pulsatile high frequency signal generation information, and converts the pulsatile high frequency signal for spinal nerve stimulation into electrical stimulation at the corresponding site. It may include an active biograft catheter to be applied.
  • the apparatus for generating pulsatile high frequency signal information provides a pulsatile high frequency signal generating menu item so as to generate different pulsatile high frequency signals according to a patient's condition, and pulsatile high frequency generating menu item by the pulsatile high frequency signal generating menu item
  • the control unit for outputting the pulsatile high frequency generation control signal in response to the pulsatile high frequency signal generation information and outputting the power generation control signal to the power supply based on the pulsatile high frequency generation control signal in response to the input unit for outputting the signal generation information.
  • a pulsatile high frequency signal information generator for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and a data wireless transmitter for converting the pulsatile high frequency signal information into a radio type signal and transmitting the same through a antenna.
  • an active biotransplant catheter includes a voltage / current detector for detecting and feeding back a voltage and a current of an output terminal, and a voltage and current of the output terminal are fed back from the voltage / current detector, and a power generation control signal of the controller is provided. It may be composed of a power transmission control unit for outputting the driving power based on the feedback current and voltage, and the power generation control signal received from the input, and a wireless power transmitter for transmitting the driving power in a wireless manner.
  • two pulsatile high frequency signal information generators are placed in a synchronous mode for stimulating synchronization of two active biograft catheters to insert two active biograft catheters into the body to stimulate a desired spinal cord nerve segment. Can service.
  • the electrode in the implantable device is composed of a single electrode or a plurality of electrodes, so that the user can adjust the electrical stimulation point from the outside.
  • the input unit may serve to select a duration and treatment time of the frequency when selecting a frequency required for the treatment of pain or nerve abnormality.
  • a control unit provides a plurality of patient state information through an input unit and one of the patient state information is selected, the corresponding treatment frequency, duration, treatment time, synchronization mode, and internal electrode
  • An interface screen for providing a service for selecting a location may be provided.
  • the apparatus further includes a storage unit which stores the duration and treatment time information linked to the plurality of patient status information and the plurality of patient status information, and the controller inputs the information stored in the storage unit. Can be provided through wealth.
  • the input unit may be provided in the form of a touch screen.
  • the apparatus for generating pulsatile high frequency signal information may further include a wireless communication unit which receives a pulsatile high frequency generation request signal input according to a patient state transmitted from an external device and outputs it to a controller.
  • the wireless communication unit may be one of a Bluetooth communication module, a WIFI module, and a Zigbee communication module.
  • the present invention generates and provides a pulsatile high frequency signal information generation control signal and electric power for driving the stimulation determined in accordance with the symptoms of the patient in vitro, and through the antenna implanted in the lumbar region of the human body pulsatile high frequency signal generation information and driving power
  • a pulsatile high frequency signal information generation control signal and electric power for driving the stimulation determined in accordance with the symptoms of the patient in vitro, and through the antenna implanted in the lumbar region of the human body pulsatile high frequency signal generation information and driving power
  • the present invention by generating and transmitting the pulsatile radio frequency signal information required for treatment in vitro non-invasive, it is possible to eliminate unnecessary pain generated every time a high-frequency needle is inserted into the patient, according to the symptoms of the patient It is effective in controlling pain or nerve abnormalities.
  • FIG. 1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • 1 is a block diagram illustrating the configuration of an extracorporeal pulsatile high frequency stimulation apparatus for an active catheter according to the present invention.
  • 2 to 8 is a view for explaining the results of treatment through the extracorporeal pulsatile high frequency stimulation apparatus to which the present invention is applied.
  • the active extracorporeal pulsatile high frequency stimulation apparatus includes a pulsatile high frequency signal information generation control device 200 and an active biotransplantable catheter 300.
  • the pulsatile high frequency signal information generation and control apparatus 200 generates pulsatile high frequency signal information and driving power, respectively, in response to the pulsatile high frequency generation request signal input according to the patient state, and converts them into a wireless signal.
  • the pulsatile high frequency signal information generation control device 200 generates pulsatile high frequency signal information in response to a pulsatile high frequency signal generation request signal input according to a patient state, converts it into a wireless form, and transmits the pulsatile high frequency signal information generation unit 210; It is composed of a wireless power supply unit 220 for generating power based on the pulsatile high frequency signal information generated by the pulsatile high frequency signal information generating unit 210, and converts the generated power into a wireless form and transmits it.
  • the pulsatile high frequency signal information generating unit 210 provides the pulsatile high frequency signal generation menu item to generate different pulsatile high frequency signals according to the patient's condition, and the pulsatile high frequency signal generating information is generated by the pulsatile high frequency signal generating menu item, Outputs the pulsatile high frequency generation control signal in response to the input unit 211 and the pulsatile high frequency signal generation information of the input unit 211, and transmits the power generation control signal to the wireless power supply unit 220 based on the pulsatile high frequency generation control signal.
  • a control unit 212 for outputting, a pulsatile high frequency signal information generating unit 213 for generating pulsatile high frequency signal information in response to the pulsatile high frequency generation control signal, and converting a high frequency signal into a wireless signal and transmitting it through the antenna 214
  • the storage unit 216 stores time, synchronization mode, and internal electrode position information by linking, and receives a pulsatile high frequency generation request signal according to a patient state transmitted from an external device, and outputs it to the control unit 212. It consists of a communication unit 217.
  • the service may be configured to select a duration and treatment time of the frequency, an electrode position in the body, and whether to select a synchronization mode.
  • the input unit 211 is provided in the form of a touch screen. That is, when the input unit 211 forms the touch screen, the input unit 211 has the function of the output unit at the same time, and provides all menu items for generating a pulsatile high frequency signal for the treatment of pain or nerve abnormality control. Service to be able to select and input condition by selecting.
  • the output unit is provided separately, and based on the pulsatile high frequency signal selection and the selected pulsatile high frequency signal, the duration and treatment time can be selected by turning the knob switch.
  • the control unit 212 recognizes this and outputs the current value of the knob switch through the output unit, so that the doctor or therapist can check and select the values while viewing it.
  • the control unit 212 provides a plurality of patient state information through the input unit 211, and if one of the patient state information is selected, the service to select the corresponding treatment frequency, synchronization mode, duration, treatment time Interface screen to be provided.
  • the controller 212 reads the information stored in the storage 216 to be provided through the input unit 211.
  • the wireless communication unit 217 may employ any module having a communication function capable of receiving wireless data transmitted from an external device such as a Bluetooth communication module, a WIFI module, a Zigbee communication module, and the like.
  • the voltage / current detector 221 which the wireless power supply unit 220 detects and feeds back the voltage and current of the output terminal, receives the voltage and current of the output terminal from the voltage / current detector 221 and generates power of the controller 212.
  • the power transmission control unit 222 receives the control signal and outputs the driving power based on the fed back current and voltage and the power generation control signal, and the wireless power transmitter 223 transmitting the driving power in a wireless manner.
  • the active biograft catheter 300 is implanted in the patient's body and is provided as a driving power source for receiving pulsating high frequency signals and receiving data and converting the data radio signals into pulsating high frequency signals to generate electrical Allow the stimulus to be applied.
  • the active biograft type catheter 300 receives power of a wireless type and is supplied by a driving power supply for driving pulsatile high frequency signals and a driving power for driving pulsatile high frequency signals to generate pulsatile high frequency signal information. It consists of a pulsatile radio frequency signal generator 320 for receiving the therapeutic pulsatile radio frequency information transmitted from the control device 200 and converting it into a spinal nerve stimulus signal, and an electrode 330 for applying electrical stimulation to the corresponding site.
  • the pulsatile high frequency signal generator 320 receives the therapeutic pulsatile high frequency information transmitted from the pulsatile high frequency signal information generation control device 200 and outputs a pulsatile high frequency signal generating control unit 321 for outputting a control signal for generating a pulsatile high frequency signal. And a signal generator 322 for generating a pulsatile high frequency signal and outputting the pulsatile high frequency signal to the electrode 330 under the control of the pulsatile high frequency signal generation controller 321.
  • the doctor or therapist lays down the patient on the treatment bed, and then, through the input unit 211 of the pulsatile high frequency signal information generation unit 210 constituting the pulsatile high frequency signal information generation control device 200, to treat the pain of the patient.
  • the input unit 211 of the pulsatile high frequency signal information generation unit 210 constituting the pulsatile high frequency signal information generation control device 200 to treat the pain of the patient.
  • the active biograft catheter 300 is implanted in the sacral region between the spine and the lumbar spine through the procedure, and the signal generator 322 is connected to the electrode 330 and the signal generator 322. Pulsating high frequency signal generation control unit 321 is connected.
  • the input unit 211 is the pulsatile high frequency to the control unit 212.
  • the control unit 212 outputs the pulsatile high frequency generation control signal to the pulsatile high frequency information radio signal generator 213 based on the pulsatile high frequency signal generation information, the pulsatile high frequency information radio signal generator 213 Allow wirelessly generating pulsatile high frequency signal information.
  • the generated signal is input to the data wireless transmitter 215, converted into a wireless signal, and then transmitted to the active biograft catheter 300 implanted in the patient's body through the antenna 214.
  • the controller 212 generates a power generation control signal based on the pulsating high frequency generation control signal and outputs it to the power supply unit 220. Then, the power supply unit 220 generates driving power for generating a pulsatile high frequency signal in response to the power generation control signal, and transmits the generated power to the active biograft catheter 300 through the wireless power transmitter 223 and the antenna 224. .
  • the active biograft catheter 300 receives the driving power through the driving power receiving antenna 311 of the power supply unit 310 and stores the driving power in the power storage unit 312.
  • the driving power stored in the power storage unit 312 is supplied to the pulsatile high frequency signal generation controller 321 of the pulsatile high frequency signal generator 320 so that the pulsatile high frequency signal generation controller 321 receives the radio signal.
  • the signal generator 322 receives a radio signal through the 323, the signal generator 322 generates a pulsatile high frequency signal and supplies it to the electrode 330 of the internal electrode position specified by the medical staff, the electrode 330 is applied to the pulsatile high frequency signal patient Electrical stimulation is applied to the affected area in the body to relieve pain or to control nerve abnormalities.
  • the pulsatile high frequency signal information generation control device 200 of the present invention includes a wireless communication unit 217 made of a Bluetooth module, so that the doctor or therapist generates pulsatile high frequency signal information using a terminal in which the Bluetooth module is embedded. Remote control of the operating state of the control device 200, or to perform a plurality of setting actions for generating the patient state information and the pulsatile high frequency signal remotely.
  • Figure 2 implants the active catheter of the present invention for patients complaining urethral pain during urination, and initially "600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done” conditions through the in vitro pulsatile high frequency stimulator (Fig. 2 (a Pulmonary radiofrequency signals were applied to the electrodes inserted into the sacral region between the spine and the vertebrae of the patient for 3 to 4 days. After one month of treatment, the pulsatile high frequency signal was passed through the in vitro pulsatile high frequency stimulator to have a "Pulsed RF 600sec 55V, 5Hz / 5ms, 300 ⁇ , 200mA done" condition (see FIG. 2 (b)). When applied to the electrical stimulation is made to the area to treat the pain, the pain was improved.
  • Figure 3 is a patient complaining of fever in the pain and back around the anus, MRI (see Fig. 3 (a)) and a picture of the present invention (see Fig. 3 (b)), the pain when sitting in a hard place
  • the patient is appealing.
  • the patient who was treated by breaking the tailbone after falling only 3m from the patient the patient was implanted with the active catheter of the present invention, and the pulsed RF 600sec 55V, 5Hz / 5ms, 360 ⁇ , 150mA
  • the heat sensitivity of the back is improved by 30% or more.
  • the pain in the tailbone was improved by 40-50% after 5 days more pain after treatment using pulsatile radiofrequency signals. After one month of treatment using these pulsatile radiofrequency signals, the pain in the tailbone was 70% better than in the first place.
  • Figure 4 shows that the whole arm is missing, we complain of pain at night, it is hard to fall asleep, pain in the left arm and left hand, lose weight, hard to stretch fingers, limp walking in limp because there is no strength in the left leg (Atrophic lateral sclerosis)
  • the patient is implanted with the active catheter of the present invention, and the pulsatile high frequency signal having the condition "Pulsed RF 600sec 55V, 5Hz / 5ms, 182ohm, 304mA done" through an in vitro pulsatile radiofrequency stimulator is applied to the site.
  • the electrical stimulation treatment the pain was eliminated and relaxed, the left arm pain improved from 70% to 85%, 0.5kg of dumbbell exercise was possible, Biceps increased, and no longer lost weight. It is possible to grab paper with the left hand, reduce the dim feeling when walking, and improve to walk 4 ⁇ 5km at a time.
  • 5 to 7 is a patient in a state of hospitalization for continuous rehabilitation treatment with neuropathic pain
  • the active catheter of the present invention to the patient complains of pain such as popping of the hands and feet and the pain of hot feeling such as the back lit
  • a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 °C, 320 ⁇ " condition (see Fig. 5 (a)) through an in vitro pulsatile high frequency stimulator
  • the hand and foot and back pain after treatment fell the day after the procedure, after which there was a slight fluctuation, but appeared to be lower than before the procedure.
  • Fig. 5 (a) a pulsatile high frequency signal having a primary "Pulsed RF mode: 600sec, 55V, 5Hz / 20ms, 42 °C, 320 ⁇ " condition
  • Figure 8 implants the active catheter of the present invention to a patient who complains of sloppy and soles of stepping on gravel, and performs treatment to give electrical stimulation to the corresponding site by using an pulsatile radiofrequency signal through an in vitro pulsatile radiofrequency stimulator. After this treatment, it was possible to reduce the gritty pain of the patients' feet by 50%, and there was a feeling of stepping on the gravel of the two feet, but the pain was smaller than before.

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Abstract

La présente invention concerne un stimulateur actif in vitro à haute fréquence pulsatoire permettant une stimulation électrique par l'intermédiaire d'une électrode de stimulation en générant et en fournissant, in vitro, un signal pour commander la génération d'informations de signal à haute fréquence pulsatoire déterminées selon les symptômes d'un patient et une puissance d'entraînement pour stimulation électrique, en recevant des informations de signal à haute fréquence pulsatoire et de la puissance d'entraînement par l'intermédiaire d'une antenne implantée sur le site vertébral coccygeal du corps humain, et en générant un signal à haute fréquence pulsatoire in vivo, la présente invention comprenant : un dispositif pour commander la génération d'informations de signal à haute fréquence pulsatoire, le dispositif répondant à un signal de demande de génération à haute fréquence pulsatoire qui est donné en fonction de l'état d'un patient, la génération d'un signal à haute fréquence pulsatoire et une puissance d'entraînement respectivement, en convertissant ces derniers en signaux sans fil, puis en transmettant ces derniers; et un cathéter actif de type biologiquement implanté en étant implanté à l'intérieur du corps du patient, en réceptionnant la puissance d'entraînement et en utilisant ce dernier en tant que source de puissance d'entraînement pour générer un signal à haute fréquence pulsatoire, la réception d'un signal à haute fréquence et en convertissant ce dernier en un signal à haute fréquence pulsatoire, et en permettant à un stimulus électrique de s'appliquer à un site correspondant. Une électrode du cathéter actif de type biologiquement implanté est configuré de manière à être une ou une pluralité d'électrodes; l'emplacement d'une électrode de stimulation peut être sélectionné sur la base d'informations d'emplacement d'électrode in vivo réglées sur un dispositif externe; et un mode de synchronisation peut servir à une synchronisation de stimulus de deux cathéters actifs de type biologiquement implantés pour l'insertion de deux cathéters actifs de type biologiquement implantés in vivo et la stimulation d'un intervalle souhaité d'un nerf rachidien. En tant que telle, la présente invention a l'effet de ne pas permettre uniquement le soulagement de la douleur ou une anomalie neurologique d'un patient, mais également d'améliorer le traitement de la douleur ou le traitement de neuromodulation pour une anomalie neurologique.
PCT/KR2015/001113 2014-12-31 2015-02-03 Stimulateur actif à haute fréquence pulsatoire biologiquement implanté pour cathéter afin de stimuler le nerf rachidien épidural transsacral Ceased WO2016108332A1 (fr)

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KR10-2014-0194941 2014-12-31
KR1020140194941A KR101653889B1 (ko) 2014-12-31 2014-12-31 능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치

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KR102160212B1 (ko) * 2018-07-19 2020-09-25 주식회사 에이치엘메디텍 척수신경 자극을 위한 카테터용 박동성 고주파 신호 발생장치
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