WO2018226902A3 - Modèle de vaisseau sanguin - Google Patents

Modèle de vaisseau sanguin Download PDF

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Publication number
WO2018226902A3
WO2018226902A3 PCT/US2018/036364 US2018036364W WO2018226902A3 WO 2018226902 A3 WO2018226902 A3 WO 2018226902A3 US 2018036364 W US2018036364 W US 2018036364W WO 2018226902 A3 WO2018226902 A3 WO 2018226902A3
Authority
WO
WIPO (PCT)
Prior art keywords
holes
blood vessel
vessel model
microchannels
opposing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2018/036364
Other languages
English (en)
Other versions
WO2018226902A2 (fr
Inventor
Koju Ito
Chihaya Kakinuma
Daichi HIKIMOTO
Shinji MIMA
Takafumi SUEHIRO
Craig M. Neville
Cathryn A. Sundback
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
General Hospital Corp
Original Assignee
Fujifilm Corp
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/618,151 external-priority patent/US20180356399A1/en
Application filed by Fujifilm Corp, General Hospital Corp filed Critical Fujifilm Corp
Priority to KR1020197036088A priority Critical patent/KR102345370B1/ko
Priority to EP18813126.2A priority patent/EP3635395A4/fr
Priority to JP2019565825A priority patent/JP6869379B2/ja
Priority to CN201880037657.1A priority patent/CN111263697B/zh
Priority to CA3066616A priority patent/CA3066616C/fr
Publication of WO2018226902A2 publication Critical patent/WO2018226902A2/fr
Priority to US16/705,216 priority patent/US12504425B2/en
Anticipated expiration legal-status Critical
Publication of WO2018226902A3 publication Critical patent/WO2018226902A3/fr
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N15/0806—Details, e.g. sample holders, mounting samples for testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1347—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Vascular Medicine (AREA)
  • Fluid Mechanics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne un modèle de vaisseau sanguin comprenant : une paire d'éléments canaux, mutuellement opposés, chacun comprenant une face opposée dans laquelle est formé un microcanal respectif ; et une membrane poreuse qui comprend plusieurs orifices traversants pénétrant dans une direction d'épaisseur, qui est disposée entre les faces opposées de la paire d'éléments canaux, et qui sépare les microcanaux, la membrane poreuse étant dotée d'une couche de cellules endothéliales vasculaires de manière à recouvrir une face faisant face à l'un des microcanaux, un diamètre d'ouverture moyen des orifices traversants étant de 1 µm à 20 µm, et un rapport de couverture d'ouverture des orifices traversants étant de 30 % à 70 %.
PCT/US2018/036364 2017-06-09 2018-06-07 Modèle de vaisseau sanguin Ceased WO2018226902A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1020197036088A KR102345370B1 (ko) 2017-06-09 2018-06-07 혈관 모델
EP18813126.2A EP3635395A4 (fr) 2017-06-09 2018-06-07 Modèle de vaisseau sanguin
JP2019565825A JP6869379B2 (ja) 2017-06-09 2018-06-07 血管モデル
CN201880037657.1A CN111263697B (zh) 2017-06-09 2018-06-07 血管模型
CA3066616A CA3066616C (fr) 2017-06-09 2018-06-07 Modele de vaisseau sanguin
US16/705,216 US12504425B2 (en) 2017-06-09 2019-12-05 Blood vessel model

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15/618,151 US20180356399A1 (en) 2017-06-09 2017-06-09 Blood vessel model
US15/618,151 2017-06-09
US201862640589P 2018-03-09 2018-03-09
US62/640,589 2018-03-09

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US15/618,151 Continuation US20180356399A1 (en) 2017-06-09 2017-06-09 Blood vessel model

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/705,216 Continuation US12504425B2 (en) 2017-06-09 2019-12-05 Blood vessel model

Publications (2)

Publication Number Publication Date
WO2018226902A2 WO2018226902A2 (fr) 2018-12-13
WO2018226902A3 true WO2018226902A3 (fr) 2020-03-26

Family

ID=64566007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/036364 Ceased WO2018226902A2 (fr) 2017-06-09 2018-06-07 Modèle de vaisseau sanguin

Country Status (6)

Country Link
EP (1) EP3635395A4 (fr)
JP (1) JP6869379B2 (fr)
KR (1) KR102345370B1 (fr)
CN (1) CN111263697B (fr)
CA (1) CA3066616C (fr)
WO (1) WO2018226902A2 (fr)

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Publication number Priority date Publication date Assignee Title
US20180356398A1 (en) * 2017-06-09 2018-12-13 Fujifilm Corporation Living tissue model device, vascular wall model, vascular wall model device and method of evaluating test substance
US20180356399A1 (en) 2017-06-09 2018-12-13 Fujifilm Corporation Blood vessel model
JP7628074B2 (ja) * 2019-03-28 2025-02-07 富士フイルム株式会社 測定装置、測定装置の作動プログラム及び測定方法
JP2021024089A (ja) * 2019-07-31 2021-02-22 株式会社リコー 立体造形モデル及びその製造方法、並びにハイドロゲル造形物用コーティング剤
JP7865197B2 (ja) * 2020-06-25 2026-05-26 東洋製罐グループホールディングス株式会社 生体組織形成装置、及び生体組織の形成方法
JP7842545B2 (ja) * 2021-09-27 2026-04-08 東洋製罐グループホールディングス株式会社 マイクロ流体デバイス、及びマイクロ流体デバイスの使用方法
CN114149923B (zh) * 2021-11-19 2024-03-08 大连理工大学 内皮细胞-平滑肌细胞共培养的单流道微芯片模型的构建方法
EP4289934B1 (fr) * 2022-06-09 2025-12-31 Finnadvance Oy Structure de membrane de culture cellulaire, ses procédés de production, plaque de culture cellulaire, appareil de culture cellulaire comprenant la structure de membrane de culture cellulaire et procédés de culture cellulaire à l'aide de l'appareil de culture cellulaire

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JP5815643B2 (ja) * 2008-07-16 2015-11-17 チルドレンズ メディカル センター コーポレーション マイクロチャネルを有する臓器模倣装置ならびにその使用および製造方法

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JP5815643B2 (ja) * 2008-07-16 2015-11-17 チルドレンズ メディカル センター コーポレーション マイクロチャネルを有する臓器模倣装置ならびにその使用および製造方法
US8679336B2 (en) * 2008-11-14 2014-03-25 Fuji Xerox Co., Ltd. Microchannel device, separation apparatus, and separation method

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Also Published As

Publication number Publication date
CA3066616C (fr) 2022-06-21
KR102345370B1 (ko) 2021-12-31
JP6869379B2 (ja) 2021-05-12
EP3635395A2 (fr) 2020-04-15
WO2018226902A2 (fr) 2018-12-13
CN111263697B (zh) 2022-04-08
KR20200005742A (ko) 2020-01-16
CN111263697A (zh) 2020-06-09
JP2020521974A (ja) 2020-07-27
CA3066616A1 (fr) 2018-12-13
EP3635395A4 (fr) 2020-07-29

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