WO2019093631A3 - 통증 억제 물질 스크리닝 방법 - Google Patents

통증 억제 물질 스크리닝 방법 Download PDF

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Publication number
WO2019093631A3
WO2019093631A3 PCT/KR2018/009735 KR2018009735W WO2019093631A3 WO 2019093631 A3 WO2019093631 A3 WO 2019093631A3 KR 2018009735 W KR2018009735 W KR 2018009735W WO 2019093631 A3 WO2019093631 A3 WO 2019093631A3
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WO
WIPO (PCT)
Prior art keywords
test sample
pain
substance
site
microdialysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/009735
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English (en)
French (fr)
Other versions
WO2019093631A2 (ko
Inventor
김형건
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Neurovis Co
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Neurovis Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180098078A external-priority patent/KR102176745B1/ko
Application filed by Neurovis Co filed Critical Neurovis Co
Priority to US16/763,194 priority Critical patent/US20210069351A1/en
Publication of WO2019093631A2 publication Critical patent/WO2019093631A2/ko
Publication of WO2019093631A3 publication Critical patent/WO2019093631A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/0077—Cerebrospinal fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

본 발명은, (a) 신경병증 통증 동물모델의 척수(spinal cord)의 배각(dorasl horn) L1 부위에 미세투석 탐침(microdialysis probe)을 삽입하고; (b) 미세투석(microdialysis)에 의해 L1 부위로부터 1차 시료를 수집하고; (c) 상기 동물모델에 통증 억제 후보물질을 체내 투여하고; (d) 통증 억제 후보 물질 투입 후 미세투석에 의해 L1 부위로부터 2차 시료를 수집하고; (e) 상기 1차 시료 및 상기 2차 시료에서 각각 통증 지표 물질의 농도를 측정하고; 그리고 (f) 상기 1차 시료와 2차 시료의 통증 지표물질의 농도를 비교하는; 단계를 포함하는 통증 억제 물질 스크리닝 방법에 대한 것이다.
PCT/KR2018/009735 2017-11-13 2018-08-23 통증 억제 물질 스크리닝 방법 Ceased WO2019093631A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/763,194 US20210069351A1 (en) 2017-11-13 2018-08-23 Method for screening pain inhibiting substance

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170150658 2017-11-13
KR10-2017-0150658 2017-11-13
KR1020180098078A KR102176745B1 (ko) 2017-11-13 2018-08-22 통증 억제 물질 스크리닝 방법
KR10-2018-0098078 2018-08-22

Publications (2)

Publication Number Publication Date
WO2019093631A2 WO2019093631A2 (ko) 2019-05-16
WO2019093631A3 true WO2019093631A3 (ko) 2019-07-18

Family

ID=66437822

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/009735 Ceased WO2019093631A2 (ko) 2017-11-13 2018-08-23 통증 억제 물질 스크리닝 방법

Country Status (1)

Country Link
WO (1) WO2019093631A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114705710B (zh) * 2022-03-11 2025-06-27 湘潭大学 一种用于筛选痛经模型小鼠生物标志物的肝脏代谢组学方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110030059A (ko) * 2009-09-17 2011-03-23 고려대학교 산학협력단 새로운 ｔｒｐａ１ 활성 억제제 및 이의 용도
KR101626058B1 (ko) * 2014-12-12 2016-05-31 서울대학교 산학협력단 신경병증성 통증 치료제의 스크리닝 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110030059A (ko) * 2009-09-17 2011-03-23 고려대학교 산학협력단 새로운 ｔｒｐａ１ 활성 억제제 및 이의 용도
KR101626058B1 (ko) * 2014-12-12 2016-05-31 서울대학교 산학협력단 신경병증성 통증 치료제의 스크리닝 방법

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PARK, H. R. ET AL.: "Assessment of gaba and glutamate level by spinel dorsal horn microdialysis in rats with neuropathic pain", 69TH ANNUAL MEETING OF THE KOREAN SOCIETY OF PHARMACOLOGY, 7 November 2017 (2017-11-07), pages 104 *
SIDES, C. R. ET AL.: "Microdialysis sampling techniques applied to studies of the foreign body reaction", EUR. J. PHARM. SCI., vol. 57, 2014, pages 74 - 86, XP028648893 *
WALKER, J. M ET AL.: "Pain modulation by release of the endogenous cannabinoid anandamide", PROC. NATL. ACAD. SCI. USA., vol. 96, no. 21, 1999, pages 12198 - 12203, XP055625078 *

Also Published As

Publication number Publication date
WO2019093631A2 (ko) 2019-05-16

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