WO2020170031A3 - Méthode de traitement de la rosacée - Google Patents

Méthode de traitement de la rosacée Download PDF

Info

Publication number
WO2020170031A3
WO2020170031A3 PCT/IB2020/000120 IB2020000120W WO2020170031A3 WO 2020170031 A3 WO2020170031 A3 WO 2020170031A3 IB 2020000120 W IB2020000120 W IB 2020000120W WO 2020170031 A3 WO2020170031 A3 WO 2020170031A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
treatment
weeks
regimen
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2020/000120
Other languages
English (en)
Other versions
WO2020170031A2 (fr
Inventor
Ofra Levy-Hacham
Ori NOV
Vered Ram
Ofer Toledano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sol Gel Technologies Ltd
Original Assignee
Sol Gel Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sol Gel Technologies Ltd filed Critical Sol Gel Technologies Ltd
Priority to CA3130437A priority Critical patent/CA3130437A1/fr
Publication of WO2020170031A2 publication Critical patent/WO2020170031A2/fr
Publication of WO2020170031A3 publication Critical patent/WO2020170031A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/327—Peroxy compounds, e.g. hydroperoxides, peroxides, peroxyacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un régime pour le traitement thérapeutique de la rosacée, consistant à appliquer topiquement sur la peau d'un sujet une composition pharmaceutique. La composition pharmaceutique comprend d'environ 1 % en poids/poids à environ 10 % en poids/poids de peroxyde de benzoyle en tant que principe actif, et un véhicule ou excipient pharmaceutiquement acceptable, le peroxyde de benzoyle étant le seul principe actif dans la composition pharmaceutique. La composition pharmaceutique est appliquée une fois par jour pendant une période d'environ 2 semaines, d'environ 4 semaines, d'environ 8 semaines et d'environ 12 semaines. Le régime de traitement atteint un taux de réussite d'au moins environ 6 %, le taux de réussite étant défini en tant que pourcentage d'augmentation du nombre de sujets parvenant à une peau nette ou presque nette sur l'échelle d'évaluation globale de participants (IGA) après traitement avec la composition pharmaceutique. Le régime de traitement permet également de parvenir à une réduction remarquablement plus importante du nombre de lésions inflammatoires par rapport au traitement avec le véhicule seul.
PCT/IB2020/000120 2019-02-19 2020-02-19 Méthode de traitement de la rosacée Ceased WO2020170031A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3130437A CA3130437A1 (fr) 2019-02-19 2020-02-19 Methode de traitement de la rosacee

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US201962807368P 2019-02-19 2019-02-19
US201962807356P 2019-02-19 2019-02-19
US62/807,368 2019-02-19
US62/807,356 2019-02-19
US201962871283P 2019-07-08 2019-07-08
US201962871286P 2019-07-08 2019-07-08
US62/871,283 2019-07-08
US62/871,286 2019-07-08
US201962925258P 2019-10-24 2019-10-24
US62/925,258 2019-10-24
US202062960384P 2020-01-13 2020-01-13
US62/960,384 2020-01-13
US202062972310P 2020-02-10 2020-02-10
US62/972,310 2020-02-10
US202062972896P 2020-02-11 2020-02-11
US62/972,896 2020-02-11
US202062977974P 2020-02-18 2020-02-18
US202062977952P 2020-02-18 2020-02-18
US62/977,974 2020-02-18
US62/977,952 2020-02-18

Publications (2)

Publication Number Publication Date
WO2020170031A2 WO2020170031A2 (fr) 2020-08-27
WO2020170031A3 true WO2020170031A3 (fr) 2020-10-22

Family

ID=72041117

Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/IB2020/000121 Ceased WO2020170032A2 (fr) 2019-02-19 2020-02-19 Méthode de traitement de la rosacée chez des patients âgés de 65 ans et plus
PCT/IB2020/000126 Ceased WO2020170035A2 (fr) 2019-02-19 2020-02-19 Procédé de traitement de la rosacée comprenant des résultats rapportés au patient de celui-ci
PCT/IB2020/000123 Ceased WO2020170033A2 (fr) 2019-02-19 2020-02-19 Méthode de traitement de symptômes d'érythème modéré à sévère chez des patients atteints de rosacée
PCT/US2020/018906 Ceased WO2020172333A1 (fr) 2019-02-19 2020-02-19 Procédé de traitement thérapeutique de la rosacée
PCT/IB2020/000119 Ceased WO2020170030A2 (fr) 2019-02-19 2020-02-19 Procédé permettant de fournir un début d'action précoce dans le traitement de la rosacée
PCT/IB2020/000125 Ceased WO2020170034A1 (fr) 2019-02-19 2020-02-19 Procédé de traitement à long terme de la rosacée
PCT/IB2020/000118 Ceased WO2020170029A2 (fr) 2019-02-19 2020-02-19 Procédé de traitement de première intention de la rosacée
PCT/IB2020/000120 Ceased WO2020170031A2 (fr) 2019-02-19 2020-02-19 Méthode de traitement de la rosacée

Family Applications Before (7)

Application Number Title Priority Date Filing Date
PCT/IB2020/000121 Ceased WO2020170032A2 (fr) 2019-02-19 2020-02-19 Méthode de traitement de la rosacée chez des patients âgés de 65 ans et plus
PCT/IB2020/000126 Ceased WO2020170035A2 (fr) 2019-02-19 2020-02-19 Procédé de traitement de la rosacée comprenant des résultats rapportés au patient de celui-ci
PCT/IB2020/000123 Ceased WO2020170033A2 (fr) 2019-02-19 2020-02-19 Méthode de traitement de symptômes d'érythème modéré à sévère chez des patients atteints de rosacée
PCT/US2020/018906 Ceased WO2020172333A1 (fr) 2019-02-19 2020-02-19 Procédé de traitement thérapeutique de la rosacée
PCT/IB2020/000119 Ceased WO2020170030A2 (fr) 2019-02-19 2020-02-19 Procédé permettant de fournir un début d'action précoce dans le traitement de la rosacée
PCT/IB2020/000125 Ceased WO2020170034A1 (fr) 2019-02-19 2020-02-19 Procédé de traitement à long terme de la rosacée
PCT/IB2020/000118 Ceased WO2020170029A2 (fr) 2019-02-19 2020-02-19 Procédé de traitement de première intention de la rosacée

Country Status (3)

Country Link
US (15) US20200261395A1 (fr)
CA (4) CA3130437A1 (fr)
WO (8) WO2020170032A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200261395A1 (en) * 2019-02-19 2020-08-20 Sol-Gel Technologies Ltd. Method for treatment of rosacea
US12491163B2 (en) * 2020-05-22 2025-12-09 Mayne Pharma Llc Stabilized microcapsules, method of their preparation and uses thereof
WO2023021493A1 (fr) * 2021-08-20 2023-02-23 Sol-Gel Technologies Ltd. Méthode de traitement de la rosacée chez des patients âgés de 35-64 ans

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110262506A1 (en) * 2009-01-05 2011-10-27 Sol-Gel Technologies Ltd. Topical compositions containing coated active agents
US20130095185A1 (en) * 2011-06-29 2013-04-18 Medicis Pharamaceutical Corporation Stabilized topical formulations containing core-shell microcapsules
US20140147396A1 (en) * 2012-11-27 2014-05-29 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
WO2014083557A1 (fr) * 2012-11-27 2014-06-05 Sol-Gel Technologies Ltd. Compositions pour le traitement de l'acné rosacée

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040171561A1 (en) 2002-09-03 2004-09-02 Popp Karl F. Topical formulations for treatment of rosacea
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
FR2886850B1 (fr) 2005-06-10 2007-10-05 Galderma Sa Composition a base d'une avermectine et de peroxyde de benzoyle notamment pour le traitement de la rosacee
EP2431089A1 (fr) * 2005-08-02 2012-03-21 Sol-Gel Technologies Ltd. Revêtement d'oxyde métallique d'ingrédients insolubles dans l'eau
WO2007092312A2 (fr) 2006-02-03 2007-08-16 Stiefel Laboratories, Inc. Compositions pour traitement cutane topique
US8920821B2 (en) 2006-04-14 2014-12-30 Perrigo Israel Pharmaceuticals Ltd. Pharmaceutical compositions comprising silica microspheres
US10278917B2 (en) 2006-04-14 2019-05-07 Perrigo Israel Pharmaceuticals Ltd. Pharmaceutical compositions comprising silica microspheres
WO2008057411A1 (fr) 2006-11-02 2008-05-15 Stiefel Laboratories, Inc. Trousses comprenant des tampons de peroxyde de benzoyle et une autre composition de traitement de l'acné, et préparations et méthodes d'utilisation associées
FR2909000B1 (fr) 2006-11-28 2009-02-06 Galderma Res & Dev S N C Snc Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations.
JP2010517996A (ja) 2007-02-01 2010-05-27 ソル − ゲル テクノロジーズ リミテッド 過酸化物及びレチノイドを含む局所適用用組成物
AU2008211554B2 (en) 2007-02-01 2013-12-19 Sol-Gel Technologies Ltd. Method for preparing particles comprising metal oxide coating and particles with metal oxide coating
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
CA2723029C (fr) * 2008-06-05 2016-07-19 Dow Pharmaceutical Sciences, Inc. Formulations pharmaceutiques topiques contenant une faible concentration de peroxyde de benzoyle en suspension dans de l'eau et un solvant organique miscible avec l'eau
US20140121188A1 (en) 2009-10-02 2014-05-01 Foamix Ltd. Compositions for the improved treatment of acne and related disorders
JP5784619B2 (ja) 2009-10-21 2015-09-24 ドウ ファーマシューティカル サイエンシーズ、インク． 過酸化ベンゾイルを含む粉末を湿潤させるための方法
BR112012012023A2 (pt) 2009-12-31 2016-05-17 Sol Gel Technologies Ltd processo para preparar microcápsulas, microcápsulas, composição, método para tratar uma condição superficial em um indivíduo, e, uso das microcápsulas
US11071878B2 (en) 2009-12-31 2021-07-27 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
US10653899B2 (en) 2009-12-31 2020-05-19 Sol-Gel Technologies Ltd. Core stabilized microcapsules, method of their preparation and uses thereof
WO2011101868A2 (fr) * 2010-02-18 2011-08-25 Helios Pharmaceuticals Private Limited Préparations pharmaceutiquement stables contenant de la clindamycine et du peroxyde de benzoyle, et méthode associée
US20120064135A1 (en) 2010-09-15 2012-03-15 Norac Pharma Benzoyl Peroxide Composition, Methods for Making Same, and Pharmaceutical or Cosmetic Formulations Comprising Same, and Uses Thereof
DE202011100767U1 (de) 2011-05-17 2011-12-19 Walter Dubiel Benzoylperoxid 5% Gel als Mittel zur Anwendung gegen Rosazea
US20200261395A1 (en) * 2019-02-19 2020-08-20 Sol-Gel Technologies Ltd. Method for treatment of rosacea
US12491163B2 (en) * 2020-05-22 2025-12-09 Mayne Pharma Llc Stabilized microcapsules, method of their preparation and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110262506A1 (en) * 2009-01-05 2011-10-27 Sol-Gel Technologies Ltd. Topical compositions containing coated active agents
US20130095185A1 (en) * 2011-06-29 2013-04-18 Medicis Pharamaceutical Corporation Stabilized topical formulations containing core-shell microcapsules
US20140147396A1 (en) * 2012-11-27 2014-05-29 Sol-Gel Technologies Ltd. Compositions for the treatment of rosacea
WO2014083557A1 (fr) * 2012-11-27 2014-06-05 Sol-Gel Technologies Ltd. Compositions pour le traitement de l'acné rosacée

Also Published As

Publication number Publication date
US12295935B2 (en) 2025-05-13
US11877997B2 (en) 2024-01-23
US20210145790A1 (en) 2021-05-20
US11426378B2 (en) 2022-08-30
WO2020172333A1 (fr) 2020-08-27
CA3130439A1 (fr) 2020-08-27
US11541026B2 (en) 2023-01-03
US20200261399A1 (en) 2020-08-20
WO2020170030A2 (fr) 2020-08-27
WO2020170030A3 (fr) 2020-12-03
US20200261396A1 (en) 2020-08-20
WO2020170034A1 (fr) 2020-08-27
US20200261397A1 (en) 2020-08-20
WO2020170035A2 (fr) 2020-08-27
WO2020170035A3 (fr) 2020-09-24
US20230364050A1 (en) 2023-11-16
WO2020170029A2 (fr) 2020-08-27
WO2020170033A3 (fr) 2020-09-24
US11628155B2 (en) 2023-04-18
WO2020170029A3 (fr) 2020-09-24
WO2020170031A2 (fr) 2020-08-27
CA3130441A1 (fr) 2020-08-27
US20200261398A1 (en) 2020-08-20
US20210169841A1 (en) 2021-06-10
US20220362204A1 (en) 2022-11-17
US20230106220A1 (en) 2023-04-06
US20200261401A1 (en) 2020-08-20
US20200261400A1 (en) 2020-08-20
WO2020170033A8 (fr) 2022-06-02
CA3130362A1 (fr) 2020-08-27
US20200261395A1 (en) 2020-08-20
WO2020170033A2 (fr) 2020-08-27
US11865100B2 (en) 2024-01-09
US10933046B2 (en) 2021-03-02
US20200261402A1 (en) 2020-08-20
WO2020170032A3 (fr) 2020-12-03
US10945987B2 (en) 2021-03-16
WO2020170032A2 (fr) 2020-08-27
US20220133678A1 (en) 2022-05-05
CA3130437A1 (fr) 2020-08-27
US20230248687A1 (en) 2023-08-10
US11986456B2 (en) 2024-05-21

Similar Documents

Publication Publication Date Title
SA521421897B1 (ar) تركيبة تعتمد على جزء من نباتات طبية أو مستخلصاتها واستخداماتها ومنتجاتها
WO2020170031A3 (fr) Méthode de traitement de la rosacée
MX2010008802A (es) Formulacion liquida de la fsh.
EP4397375A3 (fr) Formulations d'isoxazoline parasiticide et procédés de traitement de blépharite
MX2021010058A (es) Formulaciones de rapamicina tópicas y su uso en el tratamiento de angiofibromas faciales y otros trastornos de la piel.
WO2021168483A3 (fr) Traitement d'infections à coronavirus humain à l'aide d'inhibiteurs de traitement de glycoprotéine alpha-glucosidase
EP4552650A3 (fr) Procédés et compositions pour le traitement de la peau
Weiss et al. Customized single-agent therapy management of severe inflammatory acne: a randomized, double-blind, parallel-group, controlled study of a new treatment--adapalene 0.3%-benzoyl peroxide 2.5% gel
EP4410295A3 (fr) Utilisation de vibegron pour traiter une vessie hyperactive
CR20250293A (es) Formulaciones de enzima hialuronidasa para la administración de alto volumen
MX2025009125A (es) Fito-composiciones
MX382949B (es) Formulaciones tópicas de detomidina.
CA3156680A1 (fr) Methodes et compositions pour le traitement du syndrome de rett
WO2023114369A3 (fr) Formulations topiques d'inhibiteurs de pi3k-delta
NO20062234L (no) Transdemisk,farmasoytisk spray-formulering omfattende en VP/UA kopolymer og en ikke-vandig vehikkel
WO2015100348A8 (fr) Réduction des chéloïdes au moyen d'allantoïne topique
CA2519789A1 (fr) Aplidine utilisee dans le traitement du myelome multiple
MX2010009578A (es) Metodos para incrementar el espesor epidermico de la piel mediante la administracion topica de un compuesto de vitamina d que contiene 19-nor.
GEAP202215586A (en) Therapy of high-risk human papillomavirus infections
ZA202306750B (en) Hydrogel composition and uses thereof in the prevention and/or treatment of skin damage caused by radiation
ZA202400915B (en) Pharmaceutical composition and use thereof
Gold Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and benzoyl peroxide (3.75%) aqueous gel in moderate and severe acne vulgaris subpopulations
MX2022016183A (es) Formulaciones topicas de (1s)-1-fenil-2-piridin-2-iletanamina.
WO2023019095A3 (fr) Polythérapie à base de momélotinib
WO2021092242A3 (fr) Inhibiteurs de ror gamma t et leurs utilisations topiques

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20759496

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 3130437

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20759496

Country of ref document: EP

Kind code of ref document: A2