WO2024262012A1 - Kit pour bloc de gaz de dioxyde de carbone - Google Patents

Kit pour bloc de gaz de dioxyde de carbone Download PDF

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Publication number
WO2024262012A1
WO2024262012A1 PCT/JP2023/023346 JP2023023346W WO2024262012A1 WO 2024262012 A1 WO2024262012 A1 WO 2024262012A1 JP 2023023346 W JP2023023346 W JP 2023023346W WO 2024262012 A1 WO2024262012 A1 WO 2024262012A1
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WIPO (PCT)
Prior art keywords
carbon dioxide
sheet
water
acid
dioxide gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/JP2023/023346
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English (en)
Japanese (ja)
Inventor
光正 谷
克己 小林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amply Co Ltd
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Amply Co Ltd
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Filing date
Publication date
Application filed by Amply Co Ltd filed Critical Amply Co Ltd
Priority to JP2023559051A priority Critical patent/JP7461691B1/ja
Priority to PCT/JP2023/023346 priority patent/WO2024262012A1/fr
Priority to CN202380095132.4A priority patent/CN120882401A/zh
Priority to KR1020257030071A priority patent/KR20250145081A/ko
Publication of WO2024262012A1 publication Critical patent/WO2024262012A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms

Definitions

  • the present invention relates to a kit for a carbon dioxide gas pack that generates carbon dioxide gas.
  • Carbon dioxide gas is known to promote blood circulation in the skin, subcutaneous tissue, and muscles and activate metabolism when absorbed transdermally (transmucosally). For this reason, topical agents that generate carbon dioxide gas (hereafter referred to as "carbon dioxide gas packs”) have been attracting attention in recent years in the fields of beauty and medicine. Such carbon dioxide gas packs are designed to generate carbon dioxide gas, and are applied to the skin when used. When applied to the skin, carbon dioxide gas is generated in the carbon dioxide gas pack, and the generated carbon dioxide gas is released through the contact surface with the skin and is absorbed transdermally.
  • a carbon dioxide gas pack is required to generate carbon dioxide gas continuously so that it can be absorbed through the skin, and the generated carbon dioxide gas must be able to move to the outer surface of the pack. For this reason, carbon dioxide gas packs generally use viscous substances that exhibit fluidity. However, carbon dioxide gas packs that are viscous substances that exhibit fluidity have the problem that they can drip inside the pack, and they also require the effort of wiping and washing after use.
  • Patent Document 1 discloses a composition for preparing an external carbon dioxide agent (hereinafter also referred to as the "carbon dioxide gas pack of Patent Document 1") that consists of a substance that is hydrolyzed to generate an acid, a carbonate, a thickener, water, a gelling agent that gels with calcium ions, and a poorly water-soluble (water-insoluble) calcium salt.
  • an external carbon dioxide agent hereinafter also referred to as the "carbon dioxide gas pack of Patent Document 1”
  • calcium ions generated from the poorly water-soluble calcium salt are allowed to act on the gelling agent to gel the carbon dioxide gas pack.
  • a poorly water-soluble calcium salt is used as a source of calcium ions to act on the gelling agent, slowing down the gelling reaction rate.
  • Poorly water-soluble calcium salts have lower solubility in water compared to readily water-soluble calcium salts, and generate calcium ions by reacting with acid, which can slow down the gelling reaction rate.
  • the carbon dioxide pack of Patent Document 1 achieves both gelation and allowing carbon dioxide to reach the skin.
  • the carbon dioxide pack in Patent Document 1 is kept in a fluid, viscous state until it gels, allowing the generated carbon dioxide to move to the surface that comes into contact with the skin.
  • the carbon dioxide generated inside the pack diffuses in all directions, it is released not only from the surface that comes into contact with the skin, but also from external surfaces other than the surface that comes into contact with the skin.
  • the carbon dioxide pack in Patent Document 1 also has the problem of being unable to efficiently allow the generated carbon dioxide to reach the skin.
  • the present invention was made to solve the above-mentioned problems, and aims to provide a kit for a carbon dioxide gas pack that is less likely to drip and allows the generated carbon dioxide gas to reach the skin efficiently.
  • the gist of the present invention is as follows.
  • a kit for a carbon dioxide gas pack comprising a viscous composition (A), a carbon dioxide supplement (B), and a sheet (C), wherein the viscous composition (A) comprises a carbonate, a thickener, water, a gelling agent that gels with calcium ions, and a poorly water-soluble calcium salt, the carbon dioxide supplement (B) comprises at least one of an acid and a substance that is hydrolyzed to produce an acid, and the sheet (C) has a readily water-soluble calcium salt attached thereto.
  • the sheet (C) is a fiber sheet made of fibers.
  • the sheet (C) according to [5] which is a fiber sheet composed of fibers.
  • the sheet (C) according to [5] or [6], wherein the amount of the water-soluble calcium salt attached is 1.0 to 100 g/ m2 .
  • the present invention provides a kit for a carbon dioxide gas pack that is less likely to drip and allows the generated carbon dioxide gas to efficiently reach the skin.
  • This embodiment is a kit for a carbon dioxide gas pack that includes a viscous composition (A), a carbon dioxide supplement (B), and a sheet (C).
  • a viscous composition (A), a carbon dioxide supplement (B), and a sheet (C) First, of the viscous composition (A), the carbon dioxide supplement (B), and the sheet (C), the viscous composition (A) will be described.
  • the viscous composition (A) is a composition that contains at least a carbonate, a thickener, water, a gelling agent that gels with calcium ions, and a poorly water-soluble calcium salt.
  • the carbonate contained in the viscous composition (A) is a source of carbon dioxide gas and generates carbon dioxide (carbon dioxide gas) by reacting with an acid.
  • the carbonate may be any carbonate that generates carbon dioxide by reacting with an acid, and examples of the carbonate include ammonium carbonate, ammonium bicarbonate, potassium carbonate, potassium bicarbonate, potassium sesquicarbonate, sodium carbonate, sodium bicarbonate, sodium sesquicarbonate, lithium carbonate, lithium bicarbonate, lithium sesquicarbonate, cesium carbonate, cesium bicarbonate, cesium sesquicarbonate, magnesium carbonate, magnesium bicarbonate, calcium bicarbonate, calcium carbonate, magnesium hydroxide carbonate, and barium carbonate. One or more of these may be used.
  • the carbonate is a water-soluble carbonate such as sodium bicarbonate or sodium carbonate.
  • the carbonate content is not particularly limited, but may be, for example, 0.1 to 10 mass% and preferably 0.1 to 5 mass% relative to 100 mass% of the viscous composition (A).
  • the carbonate content mentioned above refers to the total amount of the carbonates contained.
  • the carbonates mentioned above also include poorly water-soluble calcium salts such as calcium carbonate.
  • poorly water-soluble calcium salts such as calcium carbonate.
  • the inclusion of the substance can be regarded as the viscous composition (A) containing both the carbonate and the poorly water-soluble calcium salt.
  • the viscous composition (A) may further contain a carbonate different from the substance, or may further contain a poorly water-soluble calcium salt different from the substance.
  • the thickener contained in the viscous composition (A) is not particularly limited, and one or more selected from natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances can be used.
  • the thickener may be acidic, neutral, or alkaline, but from the viewpoint of timely generation of carbon dioxide gas, it is preferable that the thickener is neutral or alkaline.
  • neutral or alkaline thickeners examples include the following:
  • natural polymers include plant-based polymers such as gum arabic, carrageenin, galactan, agar, quince seed, guar gum, tragacanth, mannan, locust bean gum, wheat starch, rice starch, tara gum, corn starch, and potato starch; microbial polymers such as curdlan, xanthan gum, succinoglucan, dextran, and pullulan; and protein-based polymers such as albumin, casein, collagen, gelatin, and fibroin; and one or more of these may be used.
  • plant-based polymers such as gum arabic, carrageenin, galactan, agar, quince seed, guar gum, tragacanth, mannan, locust bean gum, wheat starch, rice starch, tara gum, corn starch, and potato starch
  • microbial polymers such as curdlan, xanthan gum, succinoglucan, dextran, and pullulan
  • protein-based polymers such as albumin, casein
  • semi-synthetic polymers include cellulose-based polymers such as ethyl cellulose, carboxymethyl cellulose and its salts, carboxymethyl ethyl cellulose and its salts, carboxymethyl starch and its salts, croscarmellose and its salts, crystalline cellulose, cellulose acetate, cellulose acetate phthalate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, hydroxypropyl methyl cellulose phthalate, methyl cellulose, and methyl hydroxypropyl cellulose; starch-based polymers such as pregelatinized starch, partially pregelatinized starch, carboxymethyl starch, dextrin, and methyl starch; alginic acid-based polymers such as sodium alginate, potassium alginate, ammonium alginate, and propylene glycol alginate; and other polysaccharide-based polymers such as sodium chondroit
  • Examples of synthetic polymers include sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinylpyrrolidone, methacrylic acid-ethyl acrylate copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate-trimethylammonium ethyl methacrylate chloride copolymer, and dimethylaminoethyl methacrylate-methyl methacrylate copolymer, and one or more of these may be used.
  • inorganic substances neutral or alkaline thickeners
  • examples of inorganic substances include hydrated silicon dioxide, colloidal alumina, bentonite, and laponite, and one or more of these can be used.
  • acidic thickeners examples include the following:
  • Examples of natural polymers include alginic acid, pectin, and hyaluronic acid
  • examples of semi-synthetic polymers include carboxyvinyl polymers
  • examples of inorganic substances include light anhydrous silicic acid, and these can be used alone or in combination of two or more kinds.
  • the content of the thickener is not particularly limited, but may be, for example, 0.5 to 20% by mass, and preferably 1.0 to 10% by mass, relative to 100% by mass of the viscous composition (A).
  • the content of the thickener mentioned above refers to the total content of the thickeners contained.
  • the above-mentioned thickeners also include gelling agents such as sodium alginate that gel with calcium ions.
  • gelling agents such as sodium alginate that gel with calcium ions.
  • the inclusion of such substances can be considered to mean that the viscous composition (A) contains both a thickener and a gelling agent that gels with calcium ions.
  • the viscous composition (A) may further contain a thickener different from the substance in question, or may further contain a gelling agent that gels with calcium ions different from the substance in question.
  • the water contained in the viscous composition (A) is not particularly limited, and natural water, tap water, distilled water, purified water, etc. can be used.
  • the water content is not particularly limited, but can be, for example, 40 to 95% by mass relative to 100% by mass of the viscous composition (A).
  • the gelling agent contained in the viscous composition (A) that gels due to calcium ions may be any substance that gels due to the action of calcium ions, and is not particularly limited. Examples include sodium alginate, carrageenan, tara gum, and locust bean gum, and one or more of these may be used. Of the gelling agents described above, the gelling agent that gels due to calcium ions is preferably sodium alginate.
  • a gel refers to a structure in which molecules are linked together by cross-linking or the like to form a three-dimensional network structure, the inside of which is filled with a solvent such as water.
  • the content of the gelling agent that gels with calcium ions is not particularly limited, but can be, for example, 0.5 to 10 mass% relative to 100 mass% of the viscous composition (A), and is preferably 1.0 to 5.0 mass%.
  • the content of the gelling agent mentioned above means the total content of the gelling agents contained.
  • the poorly water-soluble calcium salt contained in the viscous composition (A) is a calcium salt having a solubility in water at 25°C and pH 7.0 of less than 3.7 g/100 ml.
  • Examples of poorly water-soluble calcium salts contained in the viscous composition (A) include calcium carbonate, calcium sulfate, calcium alginate, calcium pyrophosphate, calcium monophosphate, calcium diphosphate, calcium silicate, calcium gluconate, and calcium benzoate, and one or more of these can be used.
  • calcium carbonate is preferable.
  • the content of the poorly water-soluble calcium salt is not particularly limited, but may be, for example, 0.1 to 5 mass% relative to 100 mass% of the viscous composition (A), and is preferably 0.3 to 3.0 mass%.
  • the content of the poorly water-soluble calcium salts mentioned above means the total content of the poorly water-soluble calcium salts contained.
  • the viscous composition (A) may be composed of only the carbonate, thickener, water, gelling agent that gels with calcium ions, and poorly water-soluble calcium salt as described above, but may also contain other components in addition to these components.
  • other components include components contained in known topical agents and cosmetics, and specific examples include fragrances, colorants, surfactants, oils, moisturizing agents, alcohols, preservatives, antioxidants, pH adjusters, dispersants, sequestering agents, coloring inhibitors, ultraviolet absorbing and scattering agents, vitamins, amino acids, arbutin, kojic acid, nutrients, anti-inflammatory agents, vasodilators, hormones, astringents, antihistamines, bactericides, sebum suppressants, keratin peeling and dissolving agents, antiseborrheic agents, and antipruritic agents, and one or more of these may be contained.
  • the viscous composition (A) is a viscous material having a higher viscosity than water, and more specifically, a viscous material (sol substance) that exhibits fluidity.
  • the viscosity of the viscous composition (A) is not particularly limited, but can be, for example, 20,000 to 1,100,000 mPa ⁇ s, and preferably 50,000 to 1,100,000 mPa ⁇ s.
  • the viscosity refers to the viscosity measured using a Brookfield viscometer at 25°C, a rotation speed of 0.5 rpm, and spindle number LV4.
  • the pH of the viscous composition (A) is preferably weakly alkaline to weakly acidic (e.g., 4 to 9) from the viewpoint of application to the skin, and is preferably weakly alkaline to neutral (e.g., 7 to 9) from the viewpoint of timely generation of carbon dioxide gas.
  • the viscous composition (A) can be produced by appropriately mixing a carbonate, a thickener, water, a gelling agent that gels with calcium ions, and a poorly water-soluble calcium salt, and other components that are included as necessary.
  • the carbon dioxide auxiliary agent (B) is an agent that, when mixed with the viscous composition (A), promotes a reaction that generates carbon dioxide gas in the viscous composition (A), and contains at least one of an acid and a substance that is hydrolyzed to generate an acid.
  • the acid that can be contained in the carbon dioxide adjuvant (B) may be either an organic acid or an inorganic acid, and one or more of these may be used.
  • the acid may be in the form of a salt.
  • organic acids include straight-chain fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, and valeric acid; dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, and terephthalic acid; acidic amino acids such as glutamic acid and aspartic acid; and oxyacids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, ⁇ -oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, and gluconic acid. One or more of these can be used.
  • dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fuma
  • inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acid hexametaphosphate, potassium acid hexametaphosphate, sodium acid pyrophosphate, potassium acid pyrophosphate, and sulfamic acid, and one or more of these can be used.
  • the substance that can be contained in the carbon dioxide supplement (B) and that generates an acid upon hydrolysis may be any substance that generates an acid upon contact with water, and is not particularly limited. Examples include lactones and cyclic dimers of organic acids, and one or more of these can be used.
  • the substance that generates an acid upon hydrolysis is preferably a lactone and/or a cyclic dimer of an organic acid in a crystalline state, and is preferably at least one selected from the group consisting of glucono-delta-lactone, pantolactone, D,L- or L-lactide (3,6-dimethyl-1,4-dioxane-2,5-dione), and D,L- or L-glycolide.
  • the content of the acid in the carbon dioxide supplement (B) and the content of the substance that generates an acid upon hydrolysis can be appropriately set in consideration of the amount of carbon dioxide gas generated and the time until gelation. From the viewpoint of percutaneous absorption of a larger amount of carbon dioxide gas, the content is preferably 1 to 100 times (1 to 100 times by mass) the amount of carbonate contained in the viscous composition (A), more preferably 1 to 50 times (1 to 50 times by mass), and even more preferably 1 to 10 times (1 to 10 times by mass).
  • the content of the acid in the carbon dioxide supplement (B) is preferably 1 to 500 times (1 to 500 times by mass) the amount of poorly water-soluble calcium salt contained in the viscous composition (A), more preferably 5 to 400 times (5 to 400 times by mass), and even more preferably 8 to 20 times (8 to 20 times by mass).
  • the above-mentioned content refers to the total content of both an acid and a substance that is hydrolyzed to produce an acid when the carbon dioxide supplement (B) contains both an acid and a substance that is hydrolyzed to produce an acid, and refers to the content of only one of them when the carbon dioxide supplement (B) contains only an acid or a substance that is hydrolyzed to produce an acid.
  • the carbon dioxide adjuvant (B) may be composed only of the above-mentioned acids or substances that generate acids upon hydrolysis, but may also contain other ingredients in addition to these ingredients.
  • other ingredients include ingredients contained in known topical agents and cosmetics, such as fragrances, colorants, surfactants, oils, moisturizers, alcohols, preservatives, antioxidants, pH adjusters, dispersants, sequestering agents, color inhibitors, UV absorbing and scattering agents, excipients, binders, stabilizers, disintegrants, lubricants, dispersion media, vitamins, amino acids, arbutin, kojic acid, nutrients, anti-inflammatory agents, vasodilators, hormones, astringents, antihistamines, bactericides, sebum suppressants, keratin peeling and dissolving agents, antiseborrheic agents, and antipruritic agents, and one or more of these may be contained.
  • the form of the carbon dioxide adjuvant (B) is not particularly limited and may be either liquid or solid, but is preferably solid, and more preferably particulate such as granules, fine grains, or powder.
  • the carbon dioxide supplement (B) can be produced by appropriately mixing the above-mentioned acid or a substance that generates an acid when hydrolyzed with the above-mentioned other components that are contained as necessary.
  • the carbon dioxide supplement (B) can be made into a granular form using a granulation method (compression molding method, extrusion granulation method, rolling granulation method, spray granulation method, stirring granulation method, etc.) that is normally used in the manufacture of pharmaceuticals.
  • a granulation method compression molding method, extrusion granulation method, rolling granulation method, spray granulation method, stirring granulation method, etc.
  • the particle size is not particularly limited, but can be, for example, 1 to 1000 ⁇ m, and preferably 5 to 600 ⁇ m.
  • the particle size refers to the particle size determined by sieving through a sieve.
  • the sheet (C) is a sheet that is placed over the mixture of carbon dioxide supplement (B) and viscous composition (A) (hereinafter also referred to as “mixture (A)(B)”) applied to the skin so as to come into contact with the mixture, and has at least a water-soluble calcium salt attached thereto.
  • the water-soluble calcium salt attached to the sheet (C) is a calcium salt having a solubility of 3.7 g/100 ml or more in water at pH 7.0 at 25°C.
  • water-soluble calcium salts include calcium chloride, calcium chlorate, calcium perchlorate, calcium permanganate, calcium formate, calcium glycerophosphate, calcium glutamate, calcium acetate, calcium salicylate, calcium hypochlorite, calcium bromide, calcium bromate, calcium nitrate, calcium lactate, calcium pantothenate, calcium propionate, and calcium phosphorylated oligosaccharides, and one or more of these may be used.
  • the readily water-soluble calcium salt is preferably a calcium salt having a solubility of 10.0 g/100 ml or more in water having a pH of 7.0 at 20°C among the readily water-soluble calcium salts mentioned above, more preferably a calcium salt having a solubility of 30.0 g/100 ml or more in water having a pH of 7.0 at 20°C, even more preferably a calcium salt having a solubility of 50.0 g/100 ml or more in water having a pH of 7.0 at 20°C, and particularly preferably calcium chloride.
  • the amount of the water-soluble calcium salt to be attached is not particularly limited, but from the viewpoint of allowing the generated carbon dioxide gas to reach the skin more efficiently, it is preferably 1.0 to 100 g/m 2 , more preferably 1.5 to 80.0 g/m 2 , and even more preferably 2.3 to 55.8 g/m 2.
  • the amount of the water-soluble calcium salt to be attached (g/m 2 ) is the mass of water-soluble calcium per unit area of the sheet, and is calculated by dividing the mass (g) of the water-soluble calcium salt attached to the sheet by the area (m 2 ) of the sheet.
  • the area of the sheet means the projected area from the thickness direction of the sheet (the area of the upper or lower surface of the sheet), and is an area that does not take into account fine gaps and pores formed between the raw materials (e.g., fibers) constituting the sheet.
  • the area of the holes (openings) is not taken into account in the area of the sheet (not included in the area of the sheet).
  • the sheet (C) has the above-mentioned water-soluble calcium salt attached thereto
  • other components besides the water-soluble calcium salt may be attached thereto.
  • examples of such other components include ascorbyl glucoside, 3-O-ethyl ascorbic acid, arbutin, sodium hyaluronate, hydrolyzed hyaluronic acid, sodium hydrolyzed hyaluronate, sodium acetylated hyaluronate, sodium carboxymethyl hyaluronate, hydrolyzed alkyl (C12-13) glyceryl hyaluronate, hydrolyzed collagen, niacinamide, and dipotassium glycyrrhizinate, and one or more of these may be used.
  • the sheet (C) may be made of any material to which a water-soluble calcium salt can be attached, such as a film, a porous material, a foam, a nonwoven fabric, a woven fabric, or paper.
  • Examples of materials for the film, porous body, or foam include polyolefin resins (polyethylene, polypropylene, etc.), acrylic resins (polymethyl methacrylate, etc.), polyester resins (polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, etc.), polyvinyl alcohol, ethylene-vinyl alcohol copolymers, polyvinyl chloride, polyvinylidene chloride, polystyrene, polyurethane resins, polyacrylonitrile, fluorine resins, styrene-isoprene-styrene block copolymers, styrene-butadiene-styrene block copolymers, styrene-ethylene-propylene-styrene block copolymers, styrene-butadiene rubber, ethylene-vinyl acetate copolymers, polyamides, polysulfones, polyesters
  • Materials for the nonwoven fabric, woven fabric, and paper include, for example, rayon, polyamide, polyester resins such as polyethylene and polyethylene terephthalate, polyolefin resins such as polypropylene, polyester ether, polyurethane resins, acrylic resins, polyvinyl alcohol, polystyrene resins, cotton, hemp, etc., and one or more of these can be used.
  • the sheet (C) is preferably a fiber sheet composed of fibers such as nonwoven fabric, woven fabric, and paper.
  • the sheet (C) is a fiber sheet
  • the water contained in the mixture (A) and (B) is likely to move into the fine gaps between the fibers constituting the sheet (C) due to capillary action.
  • calcium ions are likely to be generated from the water-soluble calcium salt attached to the sheet (C), and the outer surface of the mixture (A) and (B) in contact with the sheet (C) can be gelled more quickly.
  • the basis weight of the fiber sheet is not particularly limited, but can be exemplified as 10 to 120 g/m 2 .
  • the shape of the sheet (C) is not particularly limited, and can be set appropriately depending on the area to which the mixtures (A) and (B) are to be applied.
  • the sheet (C) may have holes (openings) so as not to cover the eyes, nose, etc., or may have cuts so that it can be deformed to fit the shape of the bent part.
  • the sheet (C) can be manufactured by adhering (fixing) a water-soluble calcium salt to a sheet substrate.
  • the method for adhering the water-soluble calcium salt is not particularly limited, and any conventionally known method can be used.
  • a method can be exemplified in which a solution in which a water-soluble calcium salt is dissolved or dispersed is applied to the sheet substrate, and this is then dried.
  • the solution in which the water-soluble calcium salt is dissolved or dispersed is not particularly limited, and examples of such a solution include water and alcohol.
  • the carbon dioxide gas pack kit of this embodiment may be composed of only the viscous composition (A), carbon dioxide supplement (B), and sheet (C) described above, but may also include other items.
  • the carbon dioxide gas pack kit of this embodiment may include, in addition to the viscous composition (A), carbon dioxide supplement (B), and sheet (C), a spatula for mixing the viscous composition (A) and the carbon dioxide supplement (B).
  • the method of using the carbon dioxide gas pack kit of this embodiment includes at least three steps: a mixing step, an application step, and a coating step.
  • the mixing step is a step of mixing the viscous composition (A) and the carbon dioxide supplement (B).
  • an external agent that generates carbon dioxide gas carbon dioxide gas pack
  • the viscous composition (A) and the carbon dioxide supplement (B) can be mixed in such a way that the acids contained in the carbon dioxide supplement (B) and the substances that generate acids when hydrolyzed are not unevenly distributed in the viscous composition (A) (so that they are uniform), and there is no particular mixing method.
  • the carbon dioxide auxiliary agent (B) contains an acid
  • the acid contained in the carbon dioxide auxiliary agent (B) reacts with the carbonate contained in the viscous composition (A) to generate carbon dioxide gas.
  • the acid contained in the carbon dioxide auxiliary agent (B) also reacts with the poorly water-soluble calcium salt contained in the viscous composition (A) to generate calcium ions.
  • the generated calcium ions react with the gelling agent contained in the viscous composition (A) to proceed with the gelling reaction.
  • the carbon dioxide auxiliary (B) contains a substance that generates an acid upon hydrolysis
  • the substance in the carbon dioxide auxiliary (B) that generates an acid upon hydrolysis reacts with the water contained in the viscous composition (A) to generate an acid.
  • the generated acid then reacts with the carbonate contained in the viscous composition (A) to generate carbon dioxide gas.
  • the generated acid also reacts with the poorly water-soluble calcium salt contained in the viscous composition (A) to generate calcium ions.
  • the generated calcium ions react with the gelling agent contained in the viscous composition (A) to proceed with the gelling reaction.
  • the application step is a step of applying a mixture of the viscous composition (A) and the carbon dioxide adjuvant (B) (i.e., mixture (A)(B)) to the skin.
  • the method of applying the mixture (A)(B) is not particularly limited, but from the viewpoint of making it easier for the generated carbon dioxide gas to be absorbed percutaneously, it is preferable to apply the mixture (A)(B) so that the thickness of the mixture (A)(B) applied to the skin is 0.2 mm to 50.0 mm. Note that if the mixture (A)(B) gels, it becomes difficult for the carbon dioxide gas to be absorbed percutaneously, so it is preferable that the application step is performed immediately after the completion of the mixing step.
  • mixture (A) and (B) are applied to the skin, and some of the carbon dioxide gas generated in mixture (A) and (B) is released from the contact surface with the skin. As a result, the carbon dioxide gas can be absorbed transdermally.
  • the covering step is a step in which the sheet (C) is placed over the mixture (A)(B) on the skin so that the sheet (C) comes into contact with the mixture (A)(B) applied to the skin.
  • the sheet (C) is placed over the mixture (A)(B) on the skin, it is sufficient that the area where the water-soluble calcium salt adheres comes into contact with the mixture (A)(B); it is not necessary for all surfaces of the sheet (C) to come into contact with the mixture (A)(B).
  • the mixture (A) (B) applied to the skin is brought into contact with the sheet (C), and the water-soluble calcium salt attached to the sheet (C) is dissolved by the water contained in the mixture (A) (B), generating calcium ions.
  • the calcium ions react with the gelling agent (a gelling agent that gels with calcium ions) contained in the mixture (A) (B), promoting the gelling reaction occurring in the mixture (A) (B).
  • the covering step is performed immediately after the application step is completed.
  • sheet (C) that is covered with mixture (A)(B) may be peeled off from mixture (A)(B).
  • the carbon dioxide gas pack kit of this embodiment can be used by a method including the mixing step, application step, and coating step described above, but in addition to these steps, it may also include a leaving step of leaving the mixture (A)(B) from which carbon dioxide gas has been generated on the skin for a predetermined period of time in order to increase the amount of carbon dioxide gas absorbed percutaneously, and a removal step of removing the gelled mixture (A)(B) from the skin after the entire mixture (A)(B) has gelled.
  • the carbon dioxide gas pack kit of this embodiment described above can cause a first gelation of the mixture (A) (B) applied to the skin, which gels the contact surface with the sheet (C) (and the surrounding area), followed by a second gelation of other areas. Therefore, with the carbon dioxide gas pack kit of this embodiment, the carbon dioxide gas pack (i.e., the mixture (A) (B)) is less likely to drip, and the carbon dioxide gas generated in the carbon dioxide gas pack (i.e., the mixture (A) (B)) can efficiently reach the skin.
  • Viscos composition (A) The components shown in Table 1 below were prepared and mixed to obtain a viscous composition a. This was used as viscous composition (A).
  • Gluconodeltalactone (particle size of 10 to 500 ⁇ m) was prepared as the carbon dioxide supplement b.
  • the carbon dioxide supplement b was used as the carbon dioxide supplement (B) in an amount 9 times the amount of the calcium carbonate contained in the viscous composition (A).
  • Examples and Comparative Examples The viscous composition (A), the carbon dioxide adjuvant (B), and the sheet (C) were combined as shown in Table 4 below to obtain carbon dioxide gas pack kits of Examples 1 to 10 and Comparative Example 1.
  • Table 4 below a indicates the viscous composition a
  • b indicates the carbon dioxide adjuvant b
  • c1 to c10 indicate the nonwoven fabric sheets c1 to c10, respectively.
  • the viscous composition (A) and the carbon dioxide adjuvant (B) were mixed for 30 seconds after the carbon dioxide adjuvant (B) was added to the viscous composition (A).
  • the mixtures (A) and (B) were applied to areas of the skin of the same area that had been marked in advance. The thickness of the mixtures (A) and (B) applied to the skin was approximately 5 mm.
  • the covering sheet (C) was peeled off from the mixture (A) (B) 3 minutes after the mixture (A) (B) was applied to the skin.
  • the outer surface (the side not in contact with the skin) of the mixture (A) (B) was touched with a finger. If the mixture (A) (B) was still attached to the finger even after the finger was removed, it was judged as not gelling (rating: ⁇ ), and if the mixture (A) (B) did not adhere to the finger, it was judged as gelling (rating: ⁇ ). Furthermore, among the mixtures (A) (B) that did not adhere to the finger, if the gelled part had a thickness of 0.5 mm or more, it was rated as ⁇ . The results are shown in Table 5.
  • the carbon dioxide gas pack kits of Examples 1 to 10 make the carbon dioxide gas packs (i.e., mixtures (A) and (B)) less likely to drip, and allow the carbon dioxide gas generated in the carbon dioxide gas packs (i.e., mixtures (A) and (B)) to efficiently reach the skin.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

[Problème] La présente invention aborde le problème de la fourniture d'un kit pour un bloc de gaz de dioxyde de carbone qui ne provoque pratiquement aucun égouttement de liquide et est capable de faire en sorte qu'un gaz généré de dioxyde de carbone à atteindre la peau. [Solution] La solution selon l'invention porte sur un kit pour un bloc de gaz de dioxyde de carbone qui comprend une composition visqueuse (A), un agent auxiliaire de dioxyde de carbone (B) et une feuille (C), le kit étant caractérisé en ce que : la composition visqueuse (A) comprend un carbonate, un épaississant, de l'eau, un agent gélifiant pouvant être gélifié par des ions calcium, et un sel de calcium faiblement soluble dans l'eau ; l'agent auxiliaire de dioxyde de carbone (B) comprend un acide et/ou une substance pouvant être hydrolysée pour générer un acide ; et un sel de calcium facilement soluble dans l'eau est fixé à la feuille (C).
PCT/JP2023/023346 2023-06-23 2023-06-23 Kit pour bloc de gaz de dioxyde de carbone Ceased WO2024262012A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2023559051A JP7461691B1 (ja) 2023-06-23 2023-06-23 炭酸ガスパック用キット
PCT/JP2023/023346 WO2024262012A1 (fr) 2023-06-23 2023-06-23 Kit pour bloc de gaz de dioxyde de carbone
CN202380095132.4A CN120882401A (zh) 2023-06-23 2023-06-23 二氧化碳气袋用套件
KR1020257030071A KR20250145081A (ko) 2023-06-23 2023-06-23 탄산 가스 팩용 키트

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2023/023346 WO2024262012A1 (fr) 2023-06-23 2023-06-23 Kit pour bloc de gaz de dioxyde de carbone

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WO2024262012A1 true WO2024262012A1 (fr) 2024-12-26

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KR (1) KR20250145081A (fr)
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057228A1 (fr) * 2001-12-28 2003-07-17 Neochemir Inc. Compositions a base de dioxyde de carbone pour usage externe et procede de fabrication
WO2006080398A1 (fr) * 2005-01-28 2006-08-03 Neochemir Inc. Composition pour preparer une preparation de dioxyde de carbone a usage externe
JP2016020309A (ja) * 2014-07-11 2016-02-04 株式会社アイビーティジェイ 二酸化炭素外用剤調製用組成物、その製造方法及び評価方法、並びに二酸化炭素外用剤
JP2017226604A (ja) * 2016-06-20 2017-12-28 株式会社バスクリン シート状パックキット

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Publication number Priority date Publication date Assignee Title
JPH06321733A (ja) * 1993-05-07 1994-11-22 Noevir Co Ltd シート状パック剤及びその製造方法
CA2318345C (fr) * 1997-12-24 2011-06-07 Shaklee Corporation Composition hautement efficace pour proteger la peau contre les effets nuisibles du rayonnement ultraviolet
JP5564130B1 (ja) * 2013-03-18 2014-07-30 株式会社みやびコスメティックス 発泡型皮膚外用剤
JP2015107928A (ja) * 2013-12-04 2015-06-11 株式会社タイキ 炭酸発生シート
JP2023091312A (ja) * 2021-12-20 2023-06-30 ロレアル レチノイドを含む安定組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003057228A1 (fr) * 2001-12-28 2003-07-17 Neochemir Inc. Compositions a base de dioxyde de carbone pour usage externe et procede de fabrication
WO2006080398A1 (fr) * 2005-01-28 2006-08-03 Neochemir Inc. Composition pour preparer une preparation de dioxyde de carbone a usage externe
JP2016020309A (ja) * 2014-07-11 2016-02-04 株式会社アイビーティジェイ 二酸化炭素外用剤調製用組成物、その製造方法及び評価方法、並びに二酸化炭素外用剤
JP2017226604A (ja) * 2016-06-20 2017-12-28 株式会社バスクリン シート状パックキット

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JPWO2024262012A1 (fr) 2024-12-26
CN120882401A (zh) 2025-10-31

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