YU110690A - Acylated derivatives of etopozide - Google Patents

Acylated derivatives of etopozide

Info

Publication number
YU110690A
YU110690A YU01106/90A YU110690A YU110690A YU 110690 A YU110690 A YU 110690A YU 01106/90 A YU01106/90 A YU 01106/90A YU 110690 A YU110690 A YU 110690A YU 110690 A YU110690 A YU 110690A
Authority
YU
Yugoslavia
Prior art keywords
etopozide
acylated derivatives
acylated
derivatives
Prior art date
Application number
YU01106/90A
Other languages
English (en)
Inventor
T Ohnuma
R Obata
H Kamei
T Naito
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of YU110690A publication Critical patent/YU110690A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
YU01106/90A 1989-06-07 1990-06-06 Acylated derivatives of etopozide YU110690A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/362,555 US5036055A (en) 1989-06-07 1989-06-07 Acylated derivatives of etoposide

Publications (1)

Publication Number Publication Date
YU110690A true YU110690A (en) 1992-05-28

Family

ID=23426565

Family Applications (1)

Application Number Title Priority Date Filing Date
YU01106/90A YU110690A (en) 1989-06-07 1990-06-06 Acylated derivatives of etopozide

Country Status (17)

Country Link
US (1) US5036055A (pt)
EP (1) EP0401800A3 (pt)
JP (1) JPH0324097A (pt)
KR (1) KR910000778A (pt)
CN (1) CN1024197C (pt)
AU (1) AU637104B2 (pt)
CA (1) CA2018067A1 (pt)
CZ (1) CZ283890A3 (pt)
DD (1) DD294947A5 (pt)
FI (1) FI902767A7 (pt)
HU (1) HU206221B (pt)
IL (1) IL94606A0 (pt)
NO (1) NO173239C (pt)
NZ (1) NZ233900A (pt)
PT (1) PT94281A (pt)
YU (1) YU110690A (pt)
ZA (1) ZA904366B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) * 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
TW260671B (pt) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
ES2191733T3 (es) * 1995-12-04 2003-09-16 Nippon Kayaku Kk Procedimiento para producir etoposido.
JP4698775B2 (ja) * 1997-06-02 2011-06-08 ブリストル−マイヤーズ スクイブ カンパニー エトポシドの製造方法
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US8240508B2 (en) 2008-12-29 2012-08-14 Gojo Industries, Inc. Low cost radio frequency identification (RFID) dispensing systems
WO2014107803A1 (en) * 2013-01-14 2014-07-17 Advanomics Corporation Gem-difluorinated c-glycoside compounds as anti-cancer agents

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6613143A (pt) * 1965-09-21 1967-03-22
CH507934A (de) * 1965-12-14 1971-05-31 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
FR1518706A (fr) * 1965-12-14 1968-03-29 Sandoz Sa Glucosides dérivant de composés apparentés à la podophyllotoxine et leur préparation
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
JPS58219196A (ja) * 1982-06-15 1983-12-20 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの製造法
JPS58225096A (ja) * 1982-06-25 1983-12-27 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPS61134396A (ja) * 1984-12-06 1986-06-21 Nippon Kayaku Co Ltd エトポシドの新規製造法
JPS61227590A (ja) * 1985-04-02 1986-10-09 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフイロトキシン誘導体
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
JPS63150293A (ja) * 1986-12-12 1988-06-22 Nippon Kayaku Co Ltd エトポシド水溶性誘導体
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4868291A (en) * 1987-08-20 1989-09-19 Bristol-Myers Company 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use
US4888419A (en) * 1987-08-31 1989-12-19 Bristol-Myers Company 3'-demethoxyepipodophyllotoxin glucoside derivatives
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives

Also Published As

Publication number Publication date
AU637104B2 (en) 1993-05-20
KR910000778A (ko) 1991-01-30
NO173239C (no) 1993-11-17
NO902495L (no) 1990-12-10
HU206221B (en) 1992-09-28
DD294947A5 (de) 1991-10-17
NO173239B (no) 1993-08-09
AU5682890A (en) 1990-12-13
CA2018067A1 (en) 1990-12-07
FI902767A0 (fi) 1990-06-04
ZA904366B (en) 1991-05-29
US5036055A (en) 1991-07-30
NZ233900A (en) 1992-02-25
CN1047869A (zh) 1990-12-19
PT94281A (pt) 1991-02-08
CN1024197C (zh) 1994-04-13
EP0401800A3 (en) 1991-04-10
HU903517D0 (en) 1990-10-28
EP0401800A2 (en) 1990-12-12
NO902495D0 (no) 1990-06-06
CZ283890A3 (en) 1995-02-15
JPH0324097A (ja) 1991-02-01
FI902767A7 (fi) 1990-12-08
HUT54174A (en) 1991-01-28
IL94606A0 (en) 1991-04-15

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