YU37101A - Proces za pripremanje n,n'-bis(2,3- dihidroksipropil)-5-((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida - Google Patents

Proces za pripremanje n,n'-bis(2,3- dihidroksipropil)-5-((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida

Info

Publication number
YU37101A
YU37101A YU37101A YU37101A YU37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A
Authority
YU
Yugoslavia
Prior art keywords
triiodo
hydroxyacetyl
dihydroxypropyl
methylamino
bis
Prior art date
Application number
YU37101A
Other languages
English (en)
Inventor
Laura Alessandroni
Patrizia Ambrosetti
Maria Argese
Renato Geremia
Enrico Moretti
Vittorio Valle
Giorgio Ripa
Marcella Murru
Original Assignee
Bracco International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International B.V. filed Critical Bracco International B.V.
Publication of YU37101A publication Critical patent/YU37101A/sh
Publication of RS50038B publication Critical patent/RS50038B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyamides (AREA)

Abstract

Novi procesi pripremanja N,N'-bis[2,3-dihidroksipropil]-5-[(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida formule (I) opšte poznatog kao lomeprol, novog ne-jonskog kontrasnog agensa koji pokazuje vrlo dobru sigurnost i efektivnu kontrastnost.[A novel process for the preparation of N,N'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel non-ionic contrast agent which shows very good safety and contrast effectiveness.
YUP-371/01A 1998-11-27 1999-11-25 Postupak za pripremanje n,n'-bis(2,3-dihidroksipropil)-5- ((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida RS50038B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002574A IT1303797B1 (it) 1998-11-27 1998-11-27 Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.

Publications (2)

Publication Number Publication Date
YU37101A true YU37101A (sh) 2003-04-30
RS50038B RS50038B (sr) 2008-11-28

Family

ID=11381150

Country Status (24)

Country Link
US (1) US6420603B1 (sh)
EP (1) EP1133466B1 (sh)
JP (1) JP4439123B2 (sh)
KR (1) KR100630400B1 (sh)
CN (1) CN1163474C (sh)
AT (1) ATE247630T1 (sh)
AU (1) AU753601B2 (sh)
BR (1) BR9915608B1 (sh)
CA (1) CA2351717C (sh)
CZ (1) CZ296096B6 (sh)
DE (1) DE69910609T2 (sh)
EA (1) EA003253B1 (sh)
ES (1) ES2205949T3 (sh)
HK (1) HK1040988B (sh)
HR (1) HRP20010393B1 (sh)
HU (1) HU229092B1 (sh)
IL (1) IL143150A0 (sh)
IT (1) IT1303797B1 (sh)
ME (2) ME00606B (sh)
NO (1) NO327037B1 (sh)
RS (1) RS50038B (sh)
SK (1) SK285050B6 (sh)
TR (1) TR200101439T2 (sh)
WO (1) WO2000032561A1 (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2093206A1 (en) * 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
BR112012001103B1 (pt) * 2009-07-07 2021-05-11 Bracco Imaging Spa processo para a preparação de um agente de iodação
EP2277846A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide
EP2394984A1 (en) * 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
KR101833334B1 (ko) * 2016-04-29 2018-02-28 (주)유케이케미팜 신규 중간체 화합물 및 이를 이용한 이오메프롤의 제조방법
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
WO2023046815A1 (en) 2021-09-24 2023-03-30 Bracco Imaging Spa Electrochemical iodination of n,n'-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide
US12269790B1 (en) 2022-04-29 2025-04-08 Bracco Imaging S.P.A. Process for the preparation of 2,4,6-triiodophenol derivatives
WO2026017631A1 (en) 2024-07-17 2026-01-22 Bracco Imaging Spa Process for the purification of 3-amino-1,2-propanediol (isoserinol)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196363B (it) * 1984-12-10 1988-11-16 Bracco Ind Chimica Spa Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici
EP0365541B1 (en) * 1987-05-22 1992-08-12 BRACCO S.p.A. Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives

Also Published As

Publication number Publication date
HK1040988A1 (en) 2002-06-28
RS50038B (sr) 2008-11-28
NO327037B1 (no) 2009-04-06
EP1133466A1 (en) 2001-09-19
EA003253B1 (ru) 2003-02-27
EP1133466B1 (en) 2003-08-20
DE69910609T2 (de) 2004-03-18
HU229092B1 (en) 2013-07-29
TR200101439T2 (tr) 2001-10-22
BR9915608B1 (pt) 2010-11-16
JP4439123B2 (ja) 2010-03-24
ITMI982574A1 (it) 2000-05-27
NO20012547D0 (no) 2001-05-23
CZ20011833A3 (cs) 2001-10-17
US6420603B1 (en) 2002-07-16
KR100630400B1 (ko) 2006-10-02
IL143150A0 (en) 2002-04-21
SK7052001A3 (en) 2001-12-03
WO2000032561A1 (en) 2000-06-08
HRP20010393A2 (en) 2002-06-30
CN1328539A (zh) 2001-12-26
HUP0104507A3 (en) 2004-07-28
AU1386200A (en) 2000-06-19
AU753601B2 (en) 2002-10-24
KR20010101053A (ko) 2001-11-14
ME00606B (me) 2011-12-20
HUP0104507A2 (hu) 2002-04-29
BR9915608A (pt) 2001-08-14
EA200100462A1 (ru) 2001-12-24
MEP8809A (en) 2011-12-20
CZ296096B6 (cs) 2006-01-11
CA2351717C (en) 2010-10-05
HRP20010393B1 (en) 2004-04-30
IT1303797B1 (it) 2001-02-23
JP2002531432A (ja) 2002-09-24
CN1163474C (zh) 2004-08-25
CA2351717A1 (en) 2000-06-08
SK285050B6 (sk) 2006-05-04
HK1040988B (zh) 2005-04-29
DE69910609D1 (de) 2003-09-25
ES2205949T3 (es) 2004-05-01
ATE247630T1 (de) 2003-09-15
NO20012547L (no) 2001-07-25

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