YU37101A - Proces za pripremanje n,n'-bis(2,3- dihidroksipropil)-5-((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida - Google Patents

Proces za pripremanje n,n'-bis(2,3- dihidroksipropil)-5-((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida

Info

Publication number
YU37101A
YU37101A YU37101A YU37101A YU37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A YU 37101 A YU37101 A YU 37101A
Authority
YU
Yugoslavia
Prior art keywords
triiodo
hydroxyacetyl
dihydroxypropyl
methylamino
bis
Prior art date
Application number
YU37101A
Other languages
English (en)
Inventor
Laura Alessandroni
Patrizia Ambrosetti
Maria Argese
Renato Geremia
Enrico Moretti
Vittorio Valle
Giorgio Ripa
Marcella Murru
Original Assignee
Bracco International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International B.V. filed Critical Bracco International B.V.
Publication of YU37101A publication Critical patent/YU37101A/sh
Publication of RS50038B publication Critical patent/RS50038B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polyamides (AREA)

Abstract

Novi procesi pripremanja N,N'-bis[2,3-dihidroksipropil]-5-[(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida formule (I) opšte poznatog kao lomeprol, novog ne-jonskog kontrasnog agensa koji pokazuje vrlo dobru sigurnost i efektivnu kontrastnost.[A novel process for the preparation of N,N'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide of formula (I), commonly known as lomeprol, a novel non-ionic contrast agent which shows very good safety and contrast effectiveness.
YUP-371/01A 1998-11-27 1999-11-25 Postupak za pripremanje n,n'-bis(2,3-dihidroksipropil)-5- ((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida RS50038B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1998MI002574A IT1303797B1 (it) 1998-11-27 1998-11-27 Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.

Publications (2)

Publication Number Publication Date
YU37101A true YU37101A (sh) 2003-04-30
RS50038B RS50038B (sr) 2008-11-28

Family

ID=11381150

Country Status (24)

Country Link
US (1) US6420603B1 (sh)
EP (1) EP1133466B1 (sh)
JP (1) JP4439123B2 (sh)
KR (1) KR100630400B1 (sh)
CN (1) CN1163474C (sh)
AT (1) ATE247630T1 (sh)
AU (1) AU753601B2 (sh)
BR (1) BR9915608B1 (sh)
CA (1) CA2351717C (sh)
CZ (1) CZ296096B6 (sh)
DE (1) DE69910609T2 (sh)
EA (1) EA003253B1 (sh)
ES (1) ES2205949T3 (sh)
HK (1) HK1040988B (sh)
HR (1) HRP20010393B1 (sh)
HU (1) HU229092B1 (sh)
IL (1) IL143150A0 (sh)
IT (1) IT1303797B1 (sh)
ME (2) MEP8809A (sh)
NO (1) NO327037B1 (sh)
RS (1) RS50038B (sh)
SK (1) SK285050B6 (sh)
TR (1) TR200101439T2 (sh)
WO (1) WO2000032561A1 (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2093206A1 (en) * 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
US9157156B2 (en) * 2009-07-07 2015-10-13 Bracco Imaging S.P.A. Process for the preparation of a iodinating agent
EP2277846A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide
EP2394984A1 (en) * 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
KR101833334B1 (ko) * 2016-04-29 2018-02-28 (주)유케이케미팜 신규 중간체 화합물 및 이를 이용한 이오메프롤의 제조방법
KR102128423B1 (ko) 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
JP2024536065A (ja) 2021-09-24 2024-10-04 ブラッコ・イメージング・ソシエタ・ペル・アチオニ Ｎ，ｎ’－（２，３－ジヒドロキシプロピル）－５－ヒドロキシ－１，３－ベンゼンジカルボキサミドの電気化学的ヨウ素化
JP2025514326A (ja) 2022-04-29 2025-05-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ２，４，６－トリヨードフェノール誘導体の製造方法
WO2026017631A1 (en) 2024-07-17 2026-01-22 Bracco Imaging Spa Process for the purification of 3-amino-1,2-propanediol (isoserinol)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196363B (it) * 1984-12-10 1988-11-16 Bracco Ind Chimica Spa Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici
CA1327600C (en) 1987-05-22 1994-03-08 Ernest Felder Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process

Also Published As

Publication number Publication date
KR100630400B1 (ko) 2006-10-02
IL143150A0 (en) 2002-04-21
ATE247630T1 (de) 2003-09-15
NO20012547D0 (no) 2001-05-23
EA003253B1 (ru) 2003-02-27
IT1303797B1 (it) 2001-02-23
NO327037B1 (no) 2009-04-06
DE69910609T2 (de) 2004-03-18
CA2351717A1 (en) 2000-06-08
RS50038B (sr) 2008-11-28
DE69910609D1 (de) 2003-09-25
TR200101439T2 (tr) 2001-10-22
HUP0104507A3 (en) 2004-07-28
ME00606B (me) 2011-12-20
US6420603B1 (en) 2002-07-16
HRP20010393B1 (en) 2004-04-30
AU1386200A (en) 2000-06-19
MEP8809A (en) 2011-12-20
HK1040988A1 (en) 2002-06-28
SK285050B6 (sk) 2006-05-04
HK1040988B (zh) 2005-04-29
BR9915608B1 (pt) 2010-11-16
CZ20011833A3 (cs) 2001-10-17
ITMI982574A1 (it) 2000-05-27
BR9915608A (pt) 2001-08-14
EP1133466A1 (en) 2001-09-19
JP2002531432A (ja) 2002-09-24
WO2000032561A1 (en) 2000-06-08
AU753601B2 (en) 2002-10-24
EP1133466B1 (en) 2003-08-20
CN1328539A (zh) 2001-12-26
SK7052001A3 (en) 2001-12-03
HRP20010393A2 (en) 2002-06-30
HU229092B1 (en) 2013-07-29
CZ296096B6 (cs) 2006-01-11
HUP0104507A2 (hu) 2002-04-29
ES2205949T3 (es) 2004-05-01
KR20010101053A (ko) 2001-11-14
NO20012547L (no) 2001-07-25
EA200100462A1 (ru) 2001-12-24
CA2351717C (en) 2010-10-05
JP4439123B2 (ja) 2010-03-24
CN1163474C (zh) 2004-08-25

Similar Documents

Publication Publication Date Title
YU37101A (sh) Proces za pripremanje n,n'-bis(2,3- dihidroksipropil)-5-((hidroksiacetil)metilamino)-2,4,6-trijodo-1,3- benzendikarboksamida
WO2001066564A3 (en) Gamma-secretase inhibitors
PL356402A1 (en) The combination of a serotonin reuptake inhibitor and a 5-ht2c
ZA200300712B (en) Pharmaceutical compositions for the treatment of mucositis, stomatitis and Behcet's syndrome.
NO975743D0 (no) Fremgangsmåte for å fremstille ioversol
PT1154986E (pt) Processo para a preparacao de iopamidol
EP1900802A3 (en) Toilet bar having a latent acidifier
EP0886634A4 (en) PROCESS FOR THE PREPARATION OF IOVERSOL
GB0112812D0 (en) Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
ATE257139T1 (de) Ein (1'r,2's,5'r)-3-l-menthoxypropan-1-ol, das eine kühlende empfindung erzeugt
BR9904075A (pt) Cetonas
GB9618056D0 (en) Process
IL135634A0 (en) 5-htif agonists
PL336848A1 (en) Yellow polymorphous variety of 5-amino-2,4,6-tri-iodine-n,n'-bis-(2,3-dihydroxypropyl) isophtalamide
EG22778A (en) Substituted n-benzoyl-n'-(tetrazolylphenyl)-ureas
MXPA04006085A (es) Compuestos de isocromano para el tratamiento de trastornos del sistema nervioso central.
MX9708624A (es) Composiciones bacteriostaticas y su uso en fluidos de metalisteria.
SI1133466T1 (en) A process for the preparation of n,n'-bis 2, 3-dihydroxypropyl) -5-((hydroxyacetyl) methylamino)-2, 4,6-triiodo-1, 3-benzenedi carboxamide
MX220674B (en) Process for hydrolysis of adiponitrile and prodn. of nylon 6,6 utilizing low catalyst levels
IL161642A0 (en) IMPROVED PURIFICATION OF 4,4'(5')-DI-t-BUTYLCYCLOHEXANO-18-CROWN-6
BG105549A (en) Use of n-substituted azabicycloalkane derivatives for treating diseases of the central nervous system
YAMAMOTO et al. Trends of Spring Technology Material Material
DE60022172D1 (de) Salz des (2r,3r,4r)3,4-dihydroxy-2-hydroxymethylpyrrolidins
ZA200308097B (en) Substituted sulfonamide compounds, process for their use as medicament for the treatment of CNS disorders, obesity and type II diabetes.
ITRM970700A1 (it) Medicinale per la cura delle patologie che provocano l'ostruzione respiratoria nasale e di altre patologie ad esse correlate, nonche' delle otiti medie secretive e della cefalea rinogena