YU50002A - Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju - Google Patents

Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju

Info

Publication number
YU50002A
YU50002A YU50002A YUP50002A YU50002A YU 50002 A YU50002 A YU 50002A YU 50002 A YU50002 A YU 50002A YU P50002 A YUP50002 A YU P50002A YU 50002 A YU50002 A YU 50002A
Authority
YU
Yugoslavia
Prior art keywords
compounds
production
methods
medicaments containing
substituted piperidines
Prior art date
Application number
YU50002A
Other languages
English (en)
Inventor
Klaus Rudolf
Wolfgang Eberlein
Alexander Dreyer
Stephan Georg Muller
Henri Doods
Eckhart Bauer
Rudolf Hurnaus
Original Assignee
Boehringer Ingelheim Pharma Gmbh. & Co.Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh. & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh. & Co.Kg.
Publication of YU50002A publication Critical patent/YU50002A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Addiction (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovaj se pronalazak odnosi na supstituisane piperidine, opšte formule (I), u kojoj su A1, A2, R, R1 i R2 definisani kao u zahtevu (1), na njihove tautomere, njihove dijastereomere, njihove enantiomere, njihove smeše i njihove soli, naročito njihove fiziološki podnošljive soli sa neorganskim ili organskim kiselinama ili bazama, koji ispoljavaju dragocena farmakološka svojstva, naročito CGRP-antagonistička svojstva, na lekove koji sadrže ova jedinjenja, na njihovu primenu i postupke za njihovo pripremanje.[The invention relates to substituted piperdines of general formula (I) in which A1, A2, R, R1 and R2 are defined as in Claim No. 1, to their tautomers, diastereomers, enantiomers, mixtures, and to their salts, in particular, their physiologically compatible salts with inorganic or organic acids or bases, which comprise valuable pharmacological properties, in particular, CGRP-antagonistic properties. The invention also relates to medicaments containing these compounds, to their use and to methods for the production thereof.
YU50002A 1999-12-30 2000-12-22 Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju YU50002A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19963868A DE19963868A1 (de) 1999-12-30 1999-12-30 Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
YU50002A true YU50002A (sh) 2005-11-28

Family

ID=7935059

Family Applications (1)

Application Number Title Priority Date Filing Date
YU50002A YU50002A (sh) 1999-12-30 2000-12-22 Supstituisani piperidini, lekovi koji sadrže ova jedinjenja i postupci za njihovu proizvodnju

Country Status (28)

Country Link
US (1) US6949541B2 (sh)
EP (1) EP1252153A1 (sh)
JP (1) JP2003519222A (sh)
KR (1) KR100736063B1 (sh)
CN (1) CN1203069C (sh)
AR (1) AR027113A1 (sh)
AU (1) AU783275B2 (sh)
BG (1) BG106848A (sh)
BR (1) BR0017063A (sh)
CA (1) CA2395541C (sh)
CZ (1) CZ20022628A3 (sh)
DE (1) DE19963868A1 (sh)
EA (1) EA005600B1 (sh)
EE (1) EE200200369A (sh)
HR (1) HRP20020560A2 (sh)
HU (1) HUP0300002A3 (sh)
IL (2) IL150377A0 (sh)
MX (1) MXPA02006509A (sh)
NO (1) NO323700B1 (sh)
NZ (1) NZ519939A (sh)
PL (1) PL356400A1 (sh)
SK (1) SK9412002A3 (sh)
TW (1) TWI255267B (sh)
UA (1) UA75346C2 (sh)
UY (1) UY26513A1 (sh)
WO (1) WO2001049676A1 (sh)
YU (1) YU50002A (sh)
ZA (1) ZA200205181B (sh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211770A1 (de) * 2002-03-14 2003-10-02 Boehringer Ingelheim Pharma Neue substituierte Piperidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US7842808B2 (en) * 2002-06-05 2010-11-30 Bristol-Myers Squibb Company Anti-migraine spirocycles
RS52552B (sr) * 2002-06-05 2013-04-30 Bristol-Myers Squibb Company Antagonisti, peptidnog receptora koji je u vezi sa kalcitoninskim genom
US7220862B2 (en) * 2002-06-05 2007-05-22 Bristol-Myers Squibb Company Calcitonin gene related peptide receptor antagonists
ATE466860T1 (de) * 2003-04-15 2010-05-15 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
CA2529227A1 (en) * 2003-06-26 2005-01-06 Merck & Co., Inc. Benzodiazepine cgrp receptor antagonists
EP1641423B1 (en) * 2003-06-26 2010-03-17 Merck Sharp & Dohme Corp. Benzodiazepine cgrp receptor antagonists
TW200524601A (en) * 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
RS20060382A (sr) 2003-12-05 2008-09-29 Bristol-Myers Squibb Company, Antagonisti receptora za peptid povezan sa genom za kalcitonin
EP1695961A4 (en) * 2003-12-17 2007-10-24 Takeda Pharmaceutical UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE
CN101124217A (zh) * 2004-01-29 2008-02-13 默克公司 Cgrp受体拮抗剂
US20050192230A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim International Gambh Process for preparing 1- [N²-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine
DE102004006893A1 (de) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 1[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazin
TW200533398A (en) 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
CN101014345A (zh) * 2004-09-09 2007-08-08 默克公司 三环酰苯胺螺环内酰胺cgrp受体拮抗剂
US7750010B2 (en) * 2004-09-13 2010-07-06 Merck Sharp & Dohme Corp. Tricyclic anilide spirohydantion CGRP receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) * 2004-12-03 2008-11-11 Bristol-Myers Squibb Company Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
EP1770091A1 (de) * 2005-09-29 2007-04-04 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
WO2006103701A1 (en) * 2005-04-01 2006-10-05 Pankaj Kehr Reusable metal blade handle
US7834007B2 (en) 2005-08-25 2010-11-16 Bristol-Myers Squibb Company CGRP antagonists
US8168592B2 (en) * 2005-10-21 2012-05-01 Amgen Inc. CGRP peptide antagonists and conjugates
AR127170A1 (es) * 2021-09-30 2023-12-27 Crinetics Pharmaceuticals Inc Antagonistas del receptor de la hormona paratiroidea (pth) y sus usos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5011390A (sh) * 1973-05-30 1975-02-05
WO1996035713A1 (en) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
DE19636623A1 (de) 1996-09-10 1998-03-12 Thomae Gmbh Dr K Abgewandelte Aminosäuren, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
SK285631B6 (sk) 1996-09-10 2007-05-03 Dr. Karl Thomae Gmbh Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie
WO2000018764A1 (en) 1998-09-30 2000-04-06 Merck Sharp & Dohme Limited Benzimidazolinyl piperidines as cgrp ligands
DE10250080A1 (de) * 2002-10-25 2004-05-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
DE19963868A1 (de) 2001-07-12
IL150377A (en) 2007-06-17
NO20023161D0 (no) 2002-06-28
NZ519939A (en) 2006-08-31
US20030212057A1 (en) 2003-11-13
NO323700B1 (no) 2007-06-25
TWI255267B (en) 2006-05-21
CZ20022628A3 (cs) 2002-10-16
ZA200205181B (en) 2003-09-30
US6949541B2 (en) 2005-09-27
NO20023161L (no) 2002-06-28
HUP0300002A3 (en) 2006-01-30
EE200200369A (et) 2003-10-15
HK1054026A1 (en) 2003-11-14
MXPA02006509A (es) 2002-11-29
KR100736063B1 (ko) 2007-07-06
UA75346C2 (en) 2006-04-17
AR027113A1 (es) 2003-03-12
CA2395541A1 (en) 2001-07-12
JP2003519222A (ja) 2003-06-17
SK9412002A3 (en) 2002-11-06
PL356400A1 (en) 2004-06-28
HUP0300002A2 (en) 2003-05-28
AU3537901A (en) 2001-07-16
EP1252153A1 (de) 2002-10-30
IL150377A0 (en) 2002-12-01
WO2001049676A1 (de) 2001-07-12
KR20020073493A (ko) 2002-09-26
EA200200651A1 (ru) 2002-12-26
HRP20020560A2 (en) 2005-04-30
UY26513A1 (es) 2001-07-31
CA2395541C (en) 2008-09-23
CN1203069C (zh) 2005-05-25
AU783275B2 (en) 2005-10-06
BG106848A (bg) 2002-12-29
CN1414960A (zh) 2003-04-30
BR0017063A (pt) 2002-10-22
EA005600B1 (ru) 2005-04-28

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