CU23210A3 - NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS - Google Patents

NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS

Info

Publication number
CU23210A3
CU23210A3 CU20020079A CU20020079A CU23210A3 CU 23210 A3 CU23210 A3 CU 23210A3 CU 20020079 A CU20020079 A CU 20020079A CU 20020079 A CU20020079 A CU 20020079A CU 23210 A3 CU23210 A3 CU 23210A3
Authority
CU
Cuba
Prior art keywords
useful
treatment
arritmies
oxabispidine
cardiac
Prior art date
Application number
CU20020079A
Other languages
English (en)
Inventor
Michael Wilstermann
Colin Thomson
Peder Svensson
Gert Stranlud
Fritiof Ponten
John Pavey
Kurt-Jurgen Hoffman
Magnus Bjorsne
Annika Bjore
David Clading-Boel
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CU23210A3 publication Critical patent/CU23210A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se proporcionan compuestos de formula I en donde R1, R2,R3, R4, R41 A R46, A, B y G tienn los significados proporcionados en la descripcion, los cuales son Utiles en la profilaxis y el tratamiento de arritmias , de manera particular , en arritmias auriculars y ventriculares.
CU20020079A 1999-10-18 2002-04-16 NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS CU23210A3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903759A SE9903759D0 (sv) 1999-10-18 1999-10-18 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
CU23210A3 true CU23210A3 (es) 2007-06-20

Family

ID=20417401

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20020079A CU23210A3 (es) 1999-10-18 2002-04-16 NUEVOS COMPUESTOS DE OXABISPIDINE uTIL EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS

Country Status (41)

Country Link
US (6) US6559143B1 (es)
EP (2) EP1235831B1 (es)
JP (3) JP3973906B2 (es)
KR (1) KR100796142B1 (es)
CN (2) CN100379743C (es)
AP (1) AP1536A (es)
AR (2) AR026064A1 (es)
AT (1) ATE292134T1 (es)
AU (1) AU769513B2 (es)
BG (1) BG65785B1 (es)
BR (1) BR0014804A (es)
CA (1) CA2386910A1 (es)
CO (1) CO5271655A1 (es)
CU (1) CU23210A3 (es)
CZ (1) CZ20021328A3 (es)
DE (1) DE60019158T2 (es)
DK (1) DK1235831T3 (es)
EA (1) EA005319B1 (es)
EE (1) EE04854B1 (es)
ES (1) ES2239047T3 (es)
HK (1) HK1049003B (es)
HR (1) HRP20020336B1 (es)
HU (1) HUP0204085A3 (es)
IL (5) IL149108A0 (es)
IS (2) IS2224B (es)
MX (1) MXPA02003848A (es)
MY (1) MY130661A (es)
NO (1) NO327977B1 (es)
NZ (2) NZ518156A (es)
OA (1) OA12067A (es)
PL (1) PL354970A1 (es)
PT (1) PT1235831E (es)
RS (1) RS50760B (es)
SE (1) SE9903759D0 (es)
SI (1) SI1235831T1 (es)
SK (1) SK286723B6 (es)
TR (1) TR200201059T2 (es)
TW (1) TWI283680B (es)
UA (1) UA75052C2 (es)
WO (1) WO2001028992A2 (es)
ZA (1) ZA200202575B (es)

Families Citing this family (30)

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TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
TWI259836B (en) * 2001-04-12 2006-08-11 Astrazeneca Ab Modified release formulation suitable for antiarrhythmic compounds
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101329D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab Pharmaceutical formulation
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New process
BR0214225A (pt) * 2001-11-22 2004-09-21 Astrazeneca Ab Processos para a preparação e para a formação de um composto, e, composto
SE0201374D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Pharmaceutical combination
SE0201373D0 (sv) * 2002-05-06 2002-05-06 Astrazeneca Ab Combination therapy
SE0201662D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
JP2008543750A (ja) * 2005-06-13 2008-12-04 アストラゼネカ アクチボラグ 心不整脈の処置用の新規オキサビスピジン化合物
AR054391A1 (es) * 2005-06-20 2007-06-20 Astrazeneca Ab Procedimiento para la preparacion de 3,7- dihidroxi-1,5-diazaciclooctanos
CA2610093A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab Process for the preparation of sulfonic acid salts of oxabispidines
US20100222335A1 (en) * 2005-06-20 2010-09-02 Astrazeneca Ab Process For The Preparation Of N,N'-Disubstituted Oxabispidines
WO2006137772A1 (en) * 2005-06-20 2006-12-28 Astrazeneca Ab New physical form of n,n´- disubstituted oxabispidines
CN1330636C (zh) * 2005-09-26 2007-08-08 鲁南制药集团股份有限公司 盐酸替罗非班中间体的合成方法
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
GB2495308B (en) * 2011-10-05 2014-09-10 John Royce Method and apparatus for cleaning a filter
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10231970B2 (en) 2014-09-30 2019-03-19 NV Heterocycles Methods of producing heteropolycycles via bis-epoxidation
JP7800143B2 (ja) * 2022-01-07 2026-01-16 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物
JP2023101256A (ja) * 2022-01-07 2023-07-20 三菱ケミカル株式会社 エポキシ樹脂組成物及び硬化物

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US3196154A (en) 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
JPS5772977A (en) * 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
FI67320C (fi) * 1983-05-09 1985-03-11 Partek Ab Foerfarande och glidgjutanordning foer gjutning av betongstycken
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FR2664270B1 (fr) * 1990-07-09 1994-04-08 Norsolor Sa Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
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SE9704709D0 (sv) * 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
CZ20013608A3 (cs) 1999-04-09 2002-05-15 Astrazeneca Ab Adamantanové deriváty
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
SE9904765D0 (sv) * 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas

Also Published As

Publication number Publication date
HUP0204085A3 (en) 2006-01-30
AR039226A2 (es) 2005-02-09
US6559143B1 (en) 2003-05-06
NO20021811L (no) 2002-06-06
JP2003512352A (ja) 2003-04-02
HRP20020336A2 (en) 2004-02-29
EE200200203A (et) 2003-06-16
ATE292134T1 (de) 2005-04-15
IL149108A0 (en) 2002-11-10
DE60019158T2 (de) 2006-02-02
US7164017B2 (en) 2007-01-16
CN100379743C (zh) 2008-04-09
CO5271655A1 (es) 2003-04-30
IS6346A (is) 2002-04-17
EP1559717A3 (en) 2009-04-29
YU29402A (sh) 2004-12-31
NO20021811D0 (no) 2002-04-17
CN101265262A (zh) 2008-09-17
IS8586A (is) 2006-12-27
US7351821B2 (en) 2008-04-01
JP3973906B2 (ja) 2007-09-12
EP1235831B1 (en) 2005-03-30
SE9903759D0 (sv) 1999-10-18
US7772229B2 (en) 2010-08-10
SI1235831T1 (es) 2005-08-31
US20030153564A1 (en) 2003-08-14
MY130661A (en) 2007-07-31
HRP20020336B1 (en) 2006-02-28
BR0014804A (pt) 2002-06-11
WO2001028992A3 (en) 2001-09-13
EP1235831A2 (en) 2002-09-04
AP1536A (en) 2006-01-09
BG65785B1 (bg) 2009-11-30
EA005319B1 (ru) 2005-02-24
AU1069101A (en) 2001-04-30
IL149108A (en) 2009-12-24
US20090326221A1 (en) 2009-12-31
BG106588A (en) 2003-01-31
AR026064A1 (es) 2002-12-26
PT1235831E (pt) 2005-06-30
HK1049003B (en) 2005-09-09
SK5062002A3 (en) 2002-11-06
US20060166979A1 (en) 2006-07-27
SK286723B6 (sk) 2009-04-06
CZ20021328A3 (cs) 2002-09-11
US20060166980A1 (en) 2006-07-27
MXPA02003848A (es) 2002-10-23
US20070117799A1 (en) 2007-05-24
KR20020038956A (ko) 2002-05-24
IS2224B (is) 2007-04-15
CN1399639A (zh) 2003-02-26
TWI283680B (en) 2007-07-11
JP2007204486A (ja) 2007-08-16
NZ531260A (en) 2005-08-26
HUP0204085A2 (hu) 2003-04-28
IL183852A0 (en) 2009-02-11
ES2239047T3 (es) 2005-09-16
KR100796142B1 (ko) 2008-01-21
HK1049003A1 (en) 2003-04-25
DE60019158D1 (de) 2005-05-04
TR200201059T2 (tr) 2002-09-23
CA2386910A1 (en) 2001-04-26
EA200200390A1 (ru) 2002-10-31
DK1235831T3 (da) 2005-06-27
ZA200202575B (en) 2003-09-23
UA75052C2 (en) 2006-03-15
NZ518156A (en) 2004-05-28
IL183854A0 (en) 2009-02-11
AP2002002471A0 (en) 2002-06-30
EP1559717A2 (en) 2005-08-03
JP2006342182A (ja) 2006-12-21
IL183853A0 (en) 2009-02-11
NO327977B1 (no) 2009-11-02
OA12067A (en) 2006-05-04
RS50760B (sr) 2010-08-31
EE04854B1 (et) 2007-06-15
AU769513B2 (en) 2004-01-29
PL354970A1 (en) 2004-03-22
WO2001028992A2 (en) 2001-04-26

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Legal Events

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