ZA200201032B - Monomeric protein of the TG-β family. - Google Patents

Monomeric protein of the TG-β family.

Info

Publication number: ZA200201032B
Authority: ZA; South Africa
Prior art keywords: proteins; nucleic acids; monomeric; family; concerned
Prior art date: 1999-08-06

Application number

ZA200201032A

Other languages

English (en)

Inventor

Gertrud Hotten

Rolf Bechtold

Jens Pohl

Original Assignee

Hygene Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-06

Filing date

2002-02-06

Publication date

2002-12-24

2002-02-06 Application filed by Hygene Ag filed Critical Hygene Ag

2002-12-24 Publication of ZA200201032B publication Critical patent/ZA200201032B/xx

Links

102000004169 proteins and genes Human genes 0.000 title abstract 6
108090000623 proteins and genes Proteins 0.000 title abstract 6
235000018102 proteins Nutrition 0.000 abstract 5
102000039446 nucleic acids Human genes 0.000 abstract 3
108020004707 nucleic acids Proteins 0.000 abstract 3
150000007523 nucleic acids Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Transplantation (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

ZA200201032A 1999-08-06 2002-02-06 Monomeric protein of the TG-β family. ZA200201032B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99115613A EP1074620A1 (de)	1999-08-06	1999-08-06	Monomer Protein der TGF-beta Familie

Publications (1)

Publication Number	Publication Date
ZA200201032B true ZA200201032B (en)	2002-12-24

Family

ID=8238746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200201032A ZA200201032B (en)	1999-08-06	2002-02-06	Monomeric protein of the TG-β family.

Country Status (12)

Country	Link
US (2)	US6972321B1 (de)
EP (3)	EP1074620A1 (de)
JP (1)	JP2003506086A (de)
AT (1)	ATE299937T1 (de)
AU (1)	AU782481B2 (de)
CA (1)	CA2381219C (de)
DE (1)	DE60021388T2 (de)
DK (1)	DK1198570T3 (de)
ES (1)	ES2242630T3 (de)
NZ (1)	NZ517125A (de)
WO (1)	WO2001011041A1 (de)
ZA (1)	ZA200201032B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586388B2 (en)	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
US7811793B2 (en) *	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
CA2405680C (en) *	2000-04-20	2018-02-13	St. Vincent's Hospital Sydney Limited	Diagnostic assay and method of treatment involving macrophage inhibitory cytokine -1 (mic-1)
CA2441588A1 (en)	2001-03-23	2002-10-03	Biopharm Gesellschaft Zue Biotechnologischen Entwicklung Von Pharmaka Mbh	Use of cytokines of the tgf-.beta. superfamily for the treatment and diagnosis of skin related disorders
FI116827B (fi)	2001-08-24	2006-03-15	Univ Zuerich	Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
EG23432A (de)	2001-12-17	2005-07-25	New Zealand Dairy Board
JP2005533089A (ja) *	2002-07-09	2005-11-04	ストライカーコーポレイション	靱帯成長および修復のための組成物および方法
EP1462126A1 (de) *	2003-03-28	2004-09-29	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Verbesserte osteoinduktive Materialien
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
PT1948689E (pt) *	2005-11-18	2012-05-09	Bioph Biotech Entw Pharm Gmbh	Mutantes do fator de crescimento com atividade elevada
GB0604938D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0604966D0 (en) *	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
PL2027152T3 (pl)	2006-06-13	2012-04-30	Helix Biomedix Inc	Fragmenty peptydów do indukowania syntezy białek macierzy zewnątrzkomórkowej
EP1880731A1 (de)	2006-07-18	2008-01-23	BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH	Menschlicher Wachstums und Differenzierungsfaktor GDF-5
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
SI2121142T1 (sl) *	2007-01-25	2012-12-31	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Uporaba GDF-5 za izboljĹˇanje ali vzdrĹľevanje videza koĹľe
EP2300610A1 (de) *	2008-06-09	2011-03-30	Wyeth LLC	Neue bmp-12-verwandte proteine und herstellungsverfahren dafür
AU2011284657B2 (en)	2010-07-30	2013-11-14	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Drug delivery devices and growth factor formulations for accelerated wound healing
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
EP2537538A1 (de)	2011-06-22	2012-12-26	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	Bioresorbierbarer Wundverband
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints
CN114786707A (zh)	2019-12-18	2022-07-22	默克专利股份公司	Gdf-5突变体用于治疗疼痛和软骨破坏的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19525416A1 (de) *	1995-07-12	1997-01-16	Bioph Biotech Entw Pharm Gmbh	Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems
EP0690871A4 (de) *	1993-01-12	1999-10-20	Univ Johns Hopkins Med	Wachstums-differenzierungsfaktor-5
US5420243A (en) *	1993-01-26	1995-05-30	Celtrix Pharmaceuticals, Inc.	Biologically active TGF-β2 peptides
IL110589A0 (en) *	1993-08-10	1994-11-11	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF- beta family
EP0733109B9 (de) *	1993-12-07	2006-07-05	Genetics Institute, LLC	Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
IL114397A0 (en) *	1994-07-01	1995-10-31	Bioph Biotech Entw Pharm Gmbh	Growth/differentiation factor of the TGF-beta-family
JPH09295945A (ja) *	1996-04-30	1997-11-18	Hoechst Yakuhin Kogyo Kk	成熟型骨誘導因子の製造方法
JPH11335398A (ja) *	1998-05-22	1999-12-07	Hoechst Marion Roussel Kk	新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬

1999
- 1999-08-06 EP EP99115613A patent/EP1074620A1/de not_active Withdrawn
2000
- 2000-08-04 US US10/048,458 patent/US6972321B1/en not_active Expired - Lifetime
- 2000-08-04 WO PCT/EP2000/007600 patent/WO2001011041A1/en not_active Ceased
- 2000-08-04 DE DE60021388T patent/DE60021388T2/de not_active Expired - Lifetime
- 2000-08-04 ES ES00958383T patent/ES2242630T3/es not_active Expired - Lifetime
- 2000-08-04 DK DK00958383T patent/DK1198570T3/da active
- 2000-08-04 EP EP00958383A patent/EP1198570B1/de not_active Expired - Lifetime
- 2000-08-04 JP JP2001515827A patent/JP2003506086A/ja active Pending
- 2000-08-04 EP EP05013166A patent/EP1574578A1/de not_active Withdrawn
- 2000-08-04 NZ NZ517125A patent/NZ517125A/en not_active IP Right Cessation
- 2000-08-04 AU AU69927/00A patent/AU782481B2/en not_active Ceased
- 2000-08-04 CA CA002381219A patent/CA2381219C/en not_active Expired - Fee Related
- 2000-08-04 AT AT00958383T patent/ATE299937T1/de active
2002
- 2002-02-06 ZA ZA200201032A patent/ZA200201032B/xx unknown
2005
- 2005-07-28 US US11/191,072 patent/US7569227B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6972321B1 (en)	2005-12-06
AU782481B2 (en)	2005-08-04
DE60021388T2 (de)	2006-01-05
WO2001011041A1 (en)	2001-02-15
ATE299937T1 (de)	2005-08-15
EP1198570A1 (de)	2002-04-24
US7569227B2 (en)	2009-08-04
EP1074620A1 (de)	2001-02-07
DE60021388D1 (de)	2005-08-25
EP1574578A1 (de)	2005-09-14
CA2381219A1 (en)	2001-02-15
ES2242630T3 (es)	2005-11-16
US20050282255A1 (en)	2005-12-22
NZ517125A (en)	2003-08-29
DK1198570T3 (da)	2005-10-31
JP2003506086A (ja)	2003-02-18
AU6992700A (en)	2001-03-05
EP1198570B1 (de)	2005-07-20
CA2381219C (en)	2008-11-18

Publication	Publication Date	Title
DE60021388D1 (de)	2005-08-25	Monomeres protein der tgf-beta familie
BRPI0512286A (pt)	2008-03-18	proteìnas quiméricas inibidoras da angiogênese e o uso
ATE114169T1 (de)	1994-12-15	Morphogenetisches knochenprotein.
DK0625989T3 (da)	2000-06-26	DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
NO20050998L (no)	1995-10-02	DNA som koder for et biologisk aktivt fragment av baktericid/premeabilitetsokende protein fremgangsmate for fremstilling av dette, samt farmasoytisk preparat inneholdende dette
DE69433690D1 (de)	2004-05-13	Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
WO2003059934A3 (en)	2004-02-26	Albumin fusion proteins
CY1113684T1 (el)	2016-06-22	Anti-mikρobiaka πεπτιδια που περιλαμβανουν μια αργινινη (arginine)- kai/ή λυσινη (lysine)- που περιεχουν υποκινητη
EA200400815A1 (ru)	2004-12-30	Контролируемый синтез зипразидона и его композиции
EA200901129A1 (ru)	2010-04-30	Нуклеиновые кислоты и полипептиды нового рецептора
BR0214350A (pt)	2005-05-10	Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso
FI934812A0 (fi)	1993-10-29	Stabiliserade entzymer
WO2003020932A1 (en)	2003-03-13	Novel secretory proteins and dna thereof
BRPI0411363A (pt)	2006-07-25	seqüências de ácidos nucléicos codificando e composições compreendendo peptìdeo sinal ige e/ou il-15 e processos para uso das mesmas
IL124831A0 (en)	1999-01-26	Ob protein derivatives having prolonged half-life
ATE258598T1 (de)	2004-02-15	Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
ATE463580T1 (de)	2010-04-15	Verfahren zur herstellung von rekombinantem protein und fusionsprotein
DE69504808D1 (de)	1998-10-22	Corticotropin freisetzende rezeptoren des faktor 2
WO2001021807A8 (en)	2001-10-11	Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof
WO2004043403A3 (en)	2005-12-15	Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
IL162568A0 (en)	2005-11-20	fluorescent protein from aequorea coerulscens and uses thereof
DK1279677T3 (da)	2007-05-07	GD3-mimetiske peptider
WO2005042717A3 (en)	2007-08-16	Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
DE69812597D1 (de)	2003-04-30	Peptide zur Inhibition von HPV E7 Proteinen
ES2059801T3 (es)	1994-11-16	Nuevas linfoquinas, secuencias de adn que codifican para estas linfoquinas, y composiciones farmaceuticas conteniendo estas linfoquinas.