ZA200400066B - Calcium phosphate delivery vehicles for osteoinductive proteins - Google Patents

Calcium phosphate delivery vehicles for osteoinductive proteins Download PDF

Info

Publication number: ZA200400066B
Authority: ZA; South Africa
Prior art keywords: phosphate; bmp; composition; bone; calcium
Prior art date: 2001-06-08

Application number

ZA200400066A

Other languages

English (en)

Inventor

Li Rebecca Hung-Mei

Seeherman Howard Joel

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-08

Filing date

2004-01-06

Publication date

2007-04-25

2004-01-06 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-04-25 Publication of ZA200400066B publication Critical patent/ZA200400066B/en

Links

239000001506 calcium phosphate Substances 0.000 title claims description 110
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims description 109
235000011010 calcium phosphates Nutrition 0.000 title claims description 102
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XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 19
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230000014759 maintenance of location Effects 0.000 description 1
239000011738 major mineral Substances 0.000 description 1
235000011963 major mineral Nutrition 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
QLNWXBAGRTUKKI-UHFFFAOYSA-N metacetamol Chemical compound CC(=O)NC1=CC=CC(O)=C1 QLNWXBAGRTUKKI-UHFFFAOYSA-N 0.000 description 1
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229920001223 polyethylene glycol Polymers 0.000 description 1
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
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- A—HUMAN NECESSITIES
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Materials Engineering (AREA)
Inorganic Chemistry (AREA)
Rheumatology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Materials For Medical Uses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Prostheses (AREA)
Dental Prosthetics (AREA)

ZA200400066A 2001-06-08 2004-01-06 Calcium phosphate delivery vehicles for osteoinductive proteins ZA200400066B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US29681801P	2001-06-08	2001-06-08

Publications (1)

Publication Number	Publication Date
ZA200400066B true ZA200400066B (en)	2007-04-25

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ID=23143697

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Application Number	Title	Priority Date	Filing Date
ZA200400066A ZA200400066B (en)	2001-06-08	2004-01-06	Calcium phosphate delivery vehicles for osteoinductive proteins

Country Status (18)

Country	Link
US (3)	US7413753B2 (fr)
EP (2)	EP1404346B1 (fr)
JP (5)	JP4414218B2 (fr)
KR (3)	KR20040019300A (fr)
CN (2)	CN101239182B (fr)
AR (1)	AR034347A1 (fr)
AU (1)	AU2002314928B2 (fr)
BR (1)	BRPI0210282B8 (fr)
CA (2)	CA2449713C (fr)
HU (1)	HU230046B1 (fr)
IL (3)	IL159136A0 (fr)
MX (1)	MXPA03011236A (fr)
NO (1)	NO333548B1 (fr)
NZ (1)	NZ530435A (fr)
PL (1)	PL216040B1 (fr)
TW (1)	TWI267378B (fr)
WO (1)	WO2002100331A2 (fr)
ZA (1)	ZA200400066B (fr)

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Also Published As

Publication number	Publication date
US7622139B2 (en)	2009-11-24
NO333548B1 (no)	2013-07-08
EP2260860A1 (fr)	2010-12-15
CA2852202A1 (fr)	2002-12-19
MXPA03011236A (es)	2004-03-24
WO2002100331A3 (fr)	2003-03-20
JP2016084361A (ja)	2016-05-19
EP1404346B1 (fr)	2016-03-23
BRPI0210282B8 (pt)	2021-05-25
WO2002100331A2 (fr)	2002-12-19
US20100074876A1 (en)	2010-03-25
US8003133B2 (en)	2011-08-23
CN101239182B (zh)	2011-06-22
US20020187104A1 (en)	2002-12-12
HUP0401357A2 (hu)	2004-10-28
CN1541100A (zh)	2004-10-27
KR20100086079A (ko)	2010-07-29
HK1062530A1 (zh)	2004-11-12
IL159136A0 (en)	2004-05-12
US7413753B2 (en)	2008-08-19
TWI267378B (en)	2006-12-01
PL367224A1 (en)	2005-02-21
JP5091188B2 (ja)	2012-12-05
KR101105908B1 (ko)	2012-01-17
JP2013226469A (ja)	2013-11-07
CA2449713A1 (fr)	2002-12-19
PL216040B1 (pl)	2014-02-28
US20080096797A1 (en)	2008-04-24
BR0210282A (pt)	2004-07-20
JP4414218B2 (ja)	2010-02-10
IL230994A0 (en)	2014-03-31
JP2009172425A (ja)	2009-08-06
EP1404346A2 (fr)	2004-04-07
KR100980164B1 (ko)	2010-09-03
KR20080075563A (ko)	2008-08-18
EP1404346A4 (fr)	2006-02-08
CA2449713C (fr)	2014-07-29
CN101239182A (zh)	2008-08-13
AR034347A1 (es)	2004-02-18
HUP0401357A3 (en)	2009-11-30
HK1123502A1 (en)	2009-06-19
IL159136A (en)	2014-03-31
AU2002314928B2 (en)	2007-05-17
JP2004535232A (ja)	2004-11-25
NO20035383D0 (no)	2003-12-03
JP2010207653A (ja)	2010-09-24
BRPI0210282B1 (pt)	2015-08-11
EP2260860B1 (fr)	2016-03-23
NZ530435A (en)	2005-08-26
HU230046B1 (hu)	2015-06-29
CN100379424C (zh)	2008-04-09
KR20040019300A (ko)	2004-03-05

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EP1404346B1 (fr)	2016-03-23	Vecteurs d'apport de phosphate de calcium pour proteines osteoinductrices
AU2002314928A1 (en)	2003-05-15	Calcium phosphate delivery vehicles for osteoinductive proteins
US6331312B1 (en)	2001-12-18	Bioresorbable ceramic composites
JP2007533376A (ja)	2007-11-22	遅延凝固リン酸カルシウムペースト
EP2200537B1 (fr)	2015-11-11	Administration avec du phosphate de calcium de facteurs de croissance et de différenciation à un os fragilisé
AU2007203555B2 (en)	2009-01-08	Calcium Phosphate Delivery Vehicles for Osteoinductive Proteins
HK1062530B (en)	2016-11-25	Calcium phosphate delivery vehicles for osteoinductive proteins
HK1123502B (en)	2012-05-04	Calcium phosphate delivery vehicles for osteoinductive proteins
Dickenhorst	2010	Preparation and characterization of DCPD-forming calcium phosphate cements and of cement-protein drug microparticle composites for bone tissue engineering