ZA200406790B - Combinations comprising epothilone derivatives and alkylating agents - Google Patents

Combinations comprising epothilone derivatives and alkylating agents Download PDF

Info

Publication number: ZA200406790B
Authority: ZA; South Africa
Prior art keywords: combination according; combination; pharmaceutically acceptable; formula; medicament
Prior art date: 2002-03-08

Application number

ZA200406790A

Other languages

English (en)

Inventor

Judith R Anderson

John D Rothermel

Paul M Mcsheehy

Alan Boddy

Original Assignee

Novartis Ag

Univ Newcastle

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2004-08-26

Publication date

2006-05-31

2004-08-26 Application filed by Novartis Ag, Univ Newcastle filed Critical Novartis Ag

2006-05-31 Publication of ZA200406790B publication Critical patent/ZA200406790B/en

Links

150000003883 epothilone derivatives Chemical class 0.000 title claims description 15
229940100198 alkylating agent Drugs 0.000 title claims description 11
239000002168 alkylating agent Substances 0.000 title claims description 11
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150000001875 compounds Chemical class 0.000 claims description 26
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
201000010099 disease Diseases 0.000 claims description 21
230000002062 proliferating effect Effects 0.000 claims description 17
229960001842 estramustine Drugs 0.000 claims description 16
FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims description 16
229910052739 hydrogen Inorganic materials 0.000 claims description 15
239000001257 hydrogen Substances 0.000 claims description 15
239000004480 active ingredient Substances 0.000 claims description 14
150000003839 salts Chemical class 0.000 claims description 14
125000000217 alkyl group Chemical group 0.000 claims description 13
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
238000002360 preparation method Methods 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
239000003814 drug Substances 0.000 claims description 10
241001465754 Metazoa Species 0.000 claims description 9
239000008194 pharmaceutical composition Substances 0.000 claims description 9
239000003937 drug carrier Substances 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 5
229940045714 alkyl sulfonate alkylating agent Drugs 0.000 claims description 4
150000008052 alkyl sulfonates Chemical class 0.000 claims description 4
229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 claims description 4
150000001541 aziridines Chemical class 0.000 claims description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims description 3
CTRPRMNBTVRDFH-UHFFFAOYSA-N 2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical class CNC1=NC(N)=NC(N)=N1 CTRPRMNBTVRDFH-UHFFFAOYSA-N 0.000 claims description 3
NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims description 3
VFKZTMPDYBFSTM-KVTDHHQDSA-N Mitobronitol Chemical compound BrC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-KVTDHHQDSA-N 0.000 claims description 3
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TWVFRCAHAAGDNR-UHFFFAOYSA-N imidazo[4,5-e]tetrazin-6-one Chemical class N1=NN=NC2=NC(=O)N=C21 TWVFRCAHAAGDNR-UHFFFAOYSA-N 0.000 claims description 3
MQXVYODZCMMZEM-ZYUZMQFOSA-N mannomustine Chemical compound ClCCNC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CNCCCl MQXVYODZCMMZEM-ZYUZMQFOSA-N 0.000 claims description 3
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238000010998 test method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000003325 tomography Methods 0.000 description 1
IUCJMVBFZDHPDX-UHFFFAOYSA-N tretamine Chemical compound C1CN1C1=NC(N2CC2)=NC(N2CC2)=N1 IUCJMVBFZDHPDX-UHFFFAOYSA-N 0.000 description 1
229950001353 tretamine Drugs 0.000 description 1
229960000875 trofosfamide Drugs 0.000 description 1
UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
229960001055 uracil mustard Drugs 0.000 description 1
SPDZFJLQFWSJGA-UHFFFAOYSA-N uredepa Chemical compound C1CN1P(=O)(NC(=O)OCC)N1CC1 SPDZFJLQFWSJGA-UHFFFAOYSA-N 0.000 description 1
229950006929 uredepa Drugs 0.000 description 1
201000005112 urinary bladder cancer Diseases 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Silicon Polymers (AREA)

ZA200406790A 2002-03-08 2004-08-26 Combinations comprising epothilone derivatives and alkylating agents ZA200406790B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36273802P	2002-03-08	2002-03-08

Publications (1)

Publication Number	Publication Date
ZA200406790B true ZA200406790B (en)	2006-05-31

Family

ID=27805222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200406790A ZA200406790B (en)	2002-03-08	2004-08-26	Combinations comprising epothilone derivatives and alkylating agents

Country Status (22)

Country	Link
EP (1)	EP1485090B1 (da)
JP (1)	JP2005522461A (da)
KR (1)	KR20040101274A (da)
CN (2)	CN1939299A (da)
AT (1)	ATE375157T1 (da)
AU (1)	AU2003223958B2 (da)
BR (1)	BR0308258A (da)
CA (1)	CA2478223C (da)
CY (1)	CY1107126T1 (da)
DE (1)	DE60316775T2 (da)
DK (1)	DK1485090T3 (da)
ES (1)	ES2295575T3 (da)
HU (1)	HUP0500092A2 (da)
IL (3)	IL163774A0 (da)
MX (1)	MXPA04008707A (da)
NO (1)	NO20044208L (da)
NZ (1)	NZ535081A (da)
PL (1)	PL371098A1 (da)
PT (1)	PT1485090E (da)
RU (1)	RU2341260C2 (da)
WO (1)	WO2003075899A2 (da)
ZA (1)	ZA200406790B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999001124A1 (en)	1996-12-03	1999-01-14	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
ES2587381T3 (es)	2007-04-25	2016-10-24	Cyclacel Limited	Uso de sapacitabina para tratar una enfermedad proliferativa
AU2011255647A1 (en)	2010-05-18	2012-11-15	Cerulean Pharma Inc.	Compositions and methods for treatment of autoimmune and other diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6515016B2 (en) *	1996-12-02	2003-02-04	Angiotech Pharmaceuticals, Inc.	Composition and methods of paclitaxel for treating psoriasis
PT975638E (pt) *	1997-02-25	2002-12-31	Biotechnolog Forschung Mbh Gbf	Epothilons modificados nas cadeias laterais
US6320045B1 (en) *	1997-12-04	2001-11-20	Bristol-Myers Squibb Company	Process for the reduction of oxiranyl epothilones to olefinic epothilones
EP1051490A2 (en) *	1998-01-30	2000-11-15	Cold Spring Harbor Laboratory	Modulation of cell proliferation, methods and reagents
BR0008379A (pt) *	1999-02-22	2002-09-24	Biotechnolog Forschung Gmbh	Epotilonas modificadas em c-21
UA75365C2 (en) *	2000-08-16	2006-04-17	Bristol Myers Squibb Co	Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon

2003
- 2003-03-07 EP EP03720323A patent/EP1485090B1/en not_active Expired - Lifetime
- 2003-03-07 CN CNA2006100879160A patent/CN1939299A/zh active Pending
- 2003-03-07 MX MXPA04008707A patent/MXPA04008707A/es active IP Right Grant
- 2003-03-07 IL IL16377403A patent/IL163774A0/xx unknown
- 2003-03-07 KR KR10-2004-7014013A patent/KR20040101274A/ko not_active Ceased
- 2003-03-07 NZ NZ535081A patent/NZ535081A/en not_active IP Right Cessation
- 2003-03-07 BR BR0308258-0A patent/BR0308258A/pt not_active IP Right Cessation
- 2003-03-07 DE DE60316775T patent/DE60316775T2/de not_active Expired - Lifetime
- 2003-03-07 AU AU2003223958A patent/AU2003223958B2/en not_active Ceased
- 2003-03-07 PL PL03371098A patent/PL371098A1/xx not_active Application Discontinuation
- 2003-03-07 HU HU0500092A patent/HUP0500092A2/hu unknown
- 2003-03-07 CA CA2478223A patent/CA2478223C/en not_active Expired - Fee Related
- 2003-03-07 CN CNB038055309A patent/CN100402029C/zh not_active Expired - Fee Related
- 2003-03-07 PT PT03720323T patent/PT1485090E/pt unknown
- 2003-03-07 DK DK03720323T patent/DK1485090T3/da active
- 2003-03-07 ES ES03720323T patent/ES2295575T3/es not_active Expired - Lifetime
- 2003-03-07 RU RU2004130283/15A patent/RU2341260C2/ru not_active IP Right Cessation
- 2003-03-07 JP JP2003574174A patent/JP2005522461A/ja not_active Withdrawn
- 2003-03-07 AT AT03720323T patent/ATE375157T1/de active
- 2003-03-07 WO PCT/EP2003/002364 patent/WO2003075899A2/en not_active Ceased
2004
- 2004-08-26 IL IL163774A patent/IL163774A/en not_active IP Right Cessation
- 2004-08-26 ZA ZA200406790A patent/ZA200406790B/en unknown
- 2004-10-04 NO NO20044208A patent/NO20044208L/no not_active Application Discontinuation
2008
- 2008-01-03 CY CY20081100012T patent/CY1107126T1/el unknown
- 2008-01-17 IL IL188859A patent/IL188859A0/en unknown

Also Published As

Publication number	Publication date
NZ535081A (en)	2007-05-31
EP1485090A2 (en)	2004-12-15
HUP0500092A2 (hu)	2005-04-28
DE60316775D1 (de)	2007-11-22
EP1485090B1 (en)	2007-10-10
ATE375157T1 (de)	2007-10-15
IL163774A0 (en)	2005-12-18
BR0308258A (pt)	2005-01-04
AU2003223958B2 (en)	2007-04-19
JP2005522461A (ja)	2005-07-28
CN1939299A (zh)	2007-04-04
KR20040101274A (ko)	2004-12-02
IL163774A (en)	2010-12-30
AU2003223958A1 (en)	2003-09-22
CN100402029C (zh)	2008-07-16
CN1638767A (zh)	2005-07-13
ES2295575T3 (es)	2008-04-16
NO20044208D0 (no)	2004-10-04
NO20044208L (no)	2004-10-14
WO2003075899A2 (en)	2003-09-18
CA2478223C (en)	2012-05-15
HK1072723A1 (en)	2005-09-09
PL371098A1 (en)	2005-06-13
RU2341260C2 (ru)	2008-12-20
IL188859A0 (en)	2008-04-13
WO2003075899A3 (en)	2004-03-11
DE60316775T2 (de)	2008-04-30
MXPA04008707A (es)	2006-03-08
DK1485090T3 (da)	2008-02-04
PT1485090E (pt)	2008-01-14
CA2478223A1 (en)	2003-09-18
RU2004130283A (ru)	2005-08-10
CY1107126T1 (el)	2012-10-24

Publication	Publication Date	Title
US20090246172A1 (en)	2009-10-01	Compositions comprising epothilones and their use for the treatment of carcinoid syndrome
EP2670405B1 (en)	2015-09-02	Combinations comprising macitentan for the treatment of glioblastoma multiforme
RU2358730C2 (ru)	2009-06-20	Производное эпотилона для лечения гепатомы и других раковых заболеваний
TWI341728B (en)	2011-05-11	Combinations comprising epothilones and anti-metabolites
CA2478223C (en)	2012-05-15	Combinations comprising epothilone derivatives and alkylating agents
US20090233973A1 (en)	2009-09-17	Epothilone derivatives for the treatment of multiple myeloma
EP1854464A2 (en)	2007-11-14	Combinations comprising epothilone derivatives
AU2007201437A1 (en)	2007-04-19	Combinations comprising epothilone derivatives and alkylating agents
US7754716B2 (en)	2010-07-13	Combination comprising a vasculostatic compound and an alkylating agent for the treatment of a tumor
HK1072723B (en)	2008-03-28	Combinations comprising an epothilone derivatives and an imidazotetrazinone
US20030139430A1 (en)	2003-07-24	Use of organic compounds
AU2002366531B2 (en)	2007-02-22	Compositions comprising epothilones and their use for the treatment of carcinoid syndrome
ZA200404013B (en)	2005-08-29	Compositions comprising epothilones and their use for the treatment of carcinoid syndrome.
HK1069983B (en)	2007-01-19	Compositions comprising epothilones and their use for the treatment of the carcinoid syndrome