ZA200501457B - Subsituted heterocyclylpyrimidines - Google Patents

Subsituted heterocyclylpyrimidines Download PDF

Info

Publication number: ZA200501457B
Authority: ZA; South Africa
Prior art keywords: case; cyano; carbon atoms; fluorine; alkyl
Prior art date: 2002-08-23

Application number

ZA200501457A

Other languages

English (en)

Inventor

Rudiger Fischer

Bernd Alig

Thomas Bretschneider

Fritz Maurer

Christoph Erdelen

Jorg Konze

Peter Losel

Yukiyoshi Watanabe

Original Assignee

Bayer Cropscience Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-23

Filing date

2005-02-18

Publication date

2006-04-26

2005-02-18 Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag

2006-04-26 Publication of ZA200501457B publication Critical patent/ZA200501457B/en

Links

-1 cyano, carboxyl Chemical group 0.000 claims description 366
125000004432 carbon atom Chemical group C* 0.000 claims description 54
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical group [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 46
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 38
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 37
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 35
229910052736 halogen Inorganic materials 0.000 claims description 30
150000002367 halogens Chemical class 0.000 claims description 30
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 29
150000001875 compounds Chemical class 0.000 claims description 29
229910052731 fluorine Chemical group 0.000 claims description 28
239000011737 fluorine Chemical group 0.000 claims description 28
239000000460 chlorine Substances 0.000 claims description 26
125000000217 alkyl group Chemical group 0.000 claims description 25
229910052801 chlorine Inorganic materials 0.000 claims description 25
125000001544 thienyl group Chemical group 0.000 claims description 25
125000002541 furyl group Chemical group 0.000 claims description 23
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 21
229910052794 bromium Inorganic materials 0.000 claims description 21
125000000304 alkynyl group Chemical group 0.000 claims description 20
125000000392 cycloalkenyl group Chemical group 0.000 claims description 20
125000000753 cycloalkyl group Chemical group 0.000 claims description 20
229910052739 hydrogen Inorganic materials 0.000 claims description 20
239000001257 hydrogen Substances 0.000 claims description 20
125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 claims description 19
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
125000002496 methyl group Chemical class [H]C([H])([H])* 0.000 claims description 18
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 17
125000001424 substituent group Chemical group 0.000 claims description 17
125000001449 isopropyl group Chemical class [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 16
125000004123 n-propyl group Chemical class [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 16
125000000959 isobutyl group Chemical class [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 15
125000004108 n-butyl group Chemical class [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 15
125000002914 sec-butyl group Chemical class [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 15
125000000999 tert-butyl group Chemical class [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 15
125000004093 cyano group Chemical group *C#N 0.000 claims description 13
125000002950 monocyclic group Chemical group 0.000 claims description 13
229920006395 saturated elastomer Polymers 0.000 claims description 13
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 12
125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 12
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
125000003342 alkenyl group Chemical group 0.000 claims description 11
125000003545 alkoxy group Chemical group 0.000 claims description 11
125000003302 alkenyloxy group Chemical group 0.000 claims description 10
125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims description 10
125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 10
125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 10
125000003282 alkyl amino group Chemical group 0.000 claims description 10
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 10
125000004644 alkyl sulfinyl group Chemical group 0.000 claims description 10
125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 10
125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 10
125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims description 10
125000004414 alkyl thio group Chemical group 0.000 claims description 10
125000005133 alkynyloxy group Chemical group 0.000 claims description 10
125000005225 alkynyloxycarbonyl group Chemical group 0.000 claims description 10
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 10
125000004663 dialkyl amino group Chemical group 0.000 claims description 10
125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 10
125000004472 dialkylaminosulfonyl group Chemical group 0.000 claims description 10
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 9
125000006125 ethylsulfonyl group Chemical group 0.000 claims description 9
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 9
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims description 8
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 8
125000004369 butenyl group Chemical group C(=CCC)* 0.000 claims description 8
125000000480 butynyl group Chemical group [*]C#CC([H])([H])C([H])([H])[H] 0.000 claims description 8
229910052799 carbon Inorganic materials 0.000 claims description 8
125000004775 chlorodifluoromethyl group Chemical group FC(F)(Cl)* 0.000 claims description 8
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 8
125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims description 8
125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 8
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 8
125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 8
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 8
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 8
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 8
125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 claims description 8
125000006263 dimethyl aminosulfonyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])S(*)(=O)=O 0.000 claims description 8
125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 claims description 8
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 8
125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 8
125000001501 propionyl group Chemical class O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims description 8
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 claims description 8
125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 claims description 8
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 8
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 7
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 7
125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 claims description 7
125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 7
229910052740 iodine Inorganic materials 0.000 claims description 7
239000011630 iodine Substances 0.000 claims description 7
238000000034 method Methods 0.000 claims description 7
125000002757 morpholinyl group Chemical group 0.000 claims description 7
125000003226 pyrazolyl group Chemical group 0.000 claims description 7
125000002098 pyridazinyl group Chemical group 0.000 claims description 7
125000000168 pyrrolyl group Chemical group 0.000 claims description 7
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 7
125000000335 thiazolyl group Chemical group 0.000 claims description 7
125000001425 triazolyl group Chemical group 0.000 claims description 7
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 6
241000607479 Yersinia pestis Species 0.000 claims description 6
125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 6
125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims description 6
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 6
125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 6
125000001715 oxadiazolyl group Chemical group 0.000 claims description 6
125000002971 oxazolyl group Chemical group 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 6
239000001301 oxygen Substances 0.000 claims description 6
125000004430 oxygen atom Chemical group O* 0.000 claims description 6
125000003386 piperidinyl group Chemical group 0.000 claims description 6
125000003373 pyrazinyl group Chemical group 0.000 claims description 6
125000004076 pyridyl group Chemical group 0.000 claims description 6
125000000714 pyrimidinyl group Chemical group 0.000 claims description 6
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 6
125000001422 pyrrolinyl group Chemical group 0.000 claims description 6
229910052717 sulfur Inorganic materials 0.000 claims description 6
125000004434 sulfur atom Chemical group 0.000 claims description 6
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 6
125000003831 tetrazolyl group Chemical group 0.000 claims description 6
125000001113 thiadiazolyl group Chemical group 0.000 claims description 6
125000000464 thioxo group Chemical group S=* 0.000 claims description 6
125000000623 heterocyclic group Chemical group 0.000 claims description 5
125000000842 isoxazolyl group Chemical group 0.000 claims description 5
125000002755 pyrazolinyl group Chemical group 0.000 claims description 5
125000004450 alkenylene group Chemical group 0.000 claims description 4
125000002947 alkylene group Chemical group 0.000 claims description 4
125000005605 benzo group Chemical group 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 4
125000001153 fluoro group Chemical group F* 0.000 claims description 4
125000002883 imidazolyl group Chemical group 0.000 claims description 4
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
239000000575 pesticide Substances 0.000 claims description 4
JAFVVKTZAUYJSF-UHFFFAOYSA-N N#CO[S+](C#N)F Chemical compound N#CO[S+](C#N)F JAFVVKTZAUYJSF-UHFFFAOYSA-N 0.000 claims description 2
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 2
239000004606 Fillers/Extenders Substances 0.000 claims 1
TURAMGVWNUTQKH-UHFFFAOYSA-N propa-1,2-dien-1-one Chemical class C=C=C=O TURAMGVWNUTQKH-UHFFFAOYSA-N 0.000 claims 1
239000004094 surface-active agent Substances 0.000 claims 1
150000003230 pyrimidines Chemical class 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
239000007858 starting material Substances 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
241000244206 Nematoda Species 0.000 description 2
WSIDFIREQDHYPW-UHFFFAOYSA-N 4-bromo-1,1-difluorobut-1-ene Chemical compound FC(F)=CCCBr WSIDFIREQDHYPW-UHFFFAOYSA-N 0.000 description 1
KJPRQQYQQGMSKD-UHFFFAOYSA-N 4-chloro-6-methyl-2-(3,4,4-trifluorobut-3-enylsulfanyl)pyrimidine Chemical compound CC1=CC(Cl)=NC(SCCC(F)=C(F)F)=N1 KJPRQQYQQGMSKD-UHFFFAOYSA-N 0.000 description 1
UPVNBRCSYKXAJY-UHFFFAOYSA-N 6-pyridin-2-yl-1h-pyrimidine-2-thione Chemical compound N1C(=S)N=CC=C1C1=CC=CC=N1 UPVNBRCSYKXAJY-UHFFFAOYSA-N 0.000 description 1
241000239223 Arachnida Species 0.000 description 1
241000238631 Hexapoda Species 0.000 description 1
150000001204 N-oxides Chemical class 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
125000002619 bicyclic group Chemical group 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
125000000956 methoxy group Chemical class [H]C([H])([H])O* 0.000 description 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
239000011707 mineral Substances 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
239000002243 precursor Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA200501457A 2002-08-23 2005-02-18 Subsituted heterocyclylpyrimidines ZA200501457B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10238725A DE10238725A1 (de)	2002-08-23	2002-08-23	Substituierte Heterocyclypyrimidine

Publications (1)

Publication Number	Publication Date
ZA200501457B true ZA200501457B (en)	2006-04-26

Family

ID=31197289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501457A ZA200501457B (en)	2002-08-23	2005-02-18	Subsituted heterocyclylpyrimidines

Country Status (18)

Country	Link
US (1)	US20060106042A1 (fr)
EP (1)	EP1534701A1 (fr)
JP (1)	JP2006508059A (fr)
KR (1)	KR20050032586A (fr)
CN (1)	CN1688571A (fr)
AU (1)	AU2003271560A1 (fr)
BR (1)	BR0313751A (fr)
CA (1)	CA2496306A1 (fr)
CR (1)	CR7678A (fr)
DE (1)	DE10238725A1 (fr)
HR (1)	HRP20050270A2 (fr)
IL (1)	IL166740A0 (fr)
MX (1)	MXPA05001962A (fr)
NO (1)	NO20051500D0 (fr)
PL (1)	PL375550A1 (fr)
RU (1)	RU2005108352A (fr)
WO (1)	WO2004026858A1 (fr)
ZA (1)	ZA200501457B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5498392B2 (ja)	2007-11-30	2014-05-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｃｎｓ障害の治療のためのｐｄｅ９ａモジュレーターとしてのそれらの使用
UA105362C2 (en)	2008-04-02	2014-05-12	Бьорингер Ингельхайм Интернациональ Гмбх	1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
KR20110063447A (ko)	2008-09-08	2011-06-10	베링거 인겔하임 인터내셔날 게엠베하	피라졸로피리미딘 및 ｃｎｓ 장애의 치료를 위한 이들의 용도
AR075717A1 (es)	2009-03-04	2011-04-20	Basf Se	Compuestos de 3- aril quinazolin -4- ona para combatir plagas de invertebrados
PT2414363E (pt)	2009-03-31	2014-02-26	Boehringer Ingelheim Int	Derivados de 1-heterociclil-1,5-di-hidro-pirazolo[3,4- d]pirimidin-4-ona e sua utilização como moduladores de pde9a
KR101123178B1 (ko) *	2009-04-09	2012-06-13	(주)에스메디	2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
EP2603511B1 (fr)	2010-08-12	2017-03-15	Boehringer Ingelheim International GmbH	Dérivés 6-cycloalkyle-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one et leur utilisation en tant qu'inhibiteurs de pde9a
US8809345B2 (en)	2011-02-15	2014-08-19	Boehringer Ingelheim International Gmbh	6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
EP3363786A1 (fr) *	2017-02-15	2018-08-22	Merck Patent GmbH	Composés de dispositifs optiquement actifs
EP4626878A1 (fr)	2022-12-02	2025-10-08	Neumora Therapeutics, Inc.	Méthodes de traitement de troubles neurologiques

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Publication number	Priority date	Publication date	Assignee	Title
DE58904307D1 (de) *	1988-03-19	1993-06-17	Hoechst Ag	Verfahren zur herstellung von ungesaettigten halogenierten kohlenwasserstoffen.
GB9205484D0 (en) *	1991-03-28	1992-04-29	Ici Plc	Heterocyclic compounds
GB9219635D0 (en) *	1992-09-16	1992-10-28	Ici Plc	Heterocyclic compounds
DE69430667T2 (de) *	1993-08-05	2003-02-06	Syngenta Ltd., Haslemere	Verfahren zur herstellung von fluoralkenylthio heterozyclische derivate
IL112721A0 (en) *	1994-03-10	1995-05-26	Zeneca Ltd	Azole derivatives
GB9510459D0 (en) *	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
US6080772A (en) *	1995-06-07	2000-06-27	Sugen, Inc.	Thiazole compounds and methods of modulating signal transduction
DE19605585A1 (de) *	1996-02-15	1997-08-21	Bayer Ag	Verfahren zur Herstellung eines Gemisches aus Cyclohexylamin und Dicyclohexylamin
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
CA2271749A1 (fr) *	1996-11-26	1998-06-18	Christopher Richard Ayles Godfrey	Derives de 8-azabicyclo¬3.2.1.\|octane-, 8-azabicyclo¬3.2.1\|oct-6-ene-, 9-azabicyclo¬3.3.1\|nonane-, 9-aza-3-oxabicyclo¬3.3.1\|nonane- et 9-aza-3-thiabicyclo¬3.3.1\|nonane, leur preparation et leur utilisation comme insecticides

2002
- 2002-08-23 DE DE10238725A patent/DE10238725A1/de not_active Withdrawn
2003
- 2003-08-11 KR KR1020057001913A patent/KR20050032586A/ko not_active Withdrawn
- 2003-08-11 CN CNA038246082A patent/CN1688571A/zh active Pending
- 2003-08-11 MX MXPA05001962A patent/MXPA05001962A/es not_active Application Discontinuation
- 2003-08-11 AU AU2003271560A patent/AU2003271560A1/en not_active Abandoned
- 2003-08-11 RU RU2005108352/04A patent/RU2005108352A/ru not_active Application Discontinuation
- 2003-08-11 US US10/524,438 patent/US20060106042A1/en not_active Abandoned
- 2003-08-11 BR BR0313751-1A patent/BR0313751A/pt not_active Application Discontinuation
- 2003-08-11 EP EP03753355A patent/EP1534701A1/fr not_active Withdrawn
- 2003-08-11 CA CA002496306A patent/CA2496306A1/fr not_active Abandoned
- 2003-08-11 HR HR20050270A patent/HRP20050270A2/xx not_active Application Discontinuation
- 2003-08-11 PL PL03375550A patent/PL375550A1/xx not_active Application Discontinuation
- 2003-08-11 JP JP2004536934A patent/JP2006508059A/ja active Pending
- 2003-08-11 WO PCT/EP2003/008881 patent/WO2004026858A1/fr not_active Ceased
2005
- 2005-02-08 IL IL16674005A patent/IL166740A0/xx unknown
- 2005-02-09 CR CR7678A patent/CR7678A/es not_active Application Discontinuation
- 2005-02-18 ZA ZA200501457A patent/ZA200501457B/en unknown
- 2005-03-21 NO NO20051500A patent/NO20051500D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2006508059A (ja)	2006-03-09
NO20051500L (no)	2005-03-21
NO20051500D0 (no)	2005-03-21
BR0313751A (pt)	2005-06-21
AU2003271560A1 (en)	2004-04-08
WO2004026858A1 (fr)	2004-04-01
DE10238725A1 (de)	2004-03-04
EP1534701A1 (fr)	2005-06-01
CR7678A (es)	2005-09-02
US20060106042A1 (en)	2006-05-18
CA2496306A1 (fr)	2004-04-01
KR20050032586A (ko)	2005-04-07
IL166740A0 (en)	2006-01-15
CN1688571A (zh)	2005-10-26
HRP20050270A2 (hr)	2006-07-31
RU2005108352A (ru)	2005-08-27
MXPA05001962A (es)	2005-04-28
PL375550A1 (en)	2005-11-28

Publication	Publication Date	Title
JP3290178B2 (ja)	2002-06-10	スルホンアミド除草剤
AU592839B2 (en)	1990-01-25	Pyri (mi) dyl-oxy- and -thio-benzoic acid derivatives
EP1544202A1 (fr)	2005-06-22	Nouveaux herbicides, leur utilisation, nouveaux derives de thienopyrimidine, leurs intermediaires, et methode de production desdits composes
EP0364797A2 (fr)	1990-04-25	Hétérocycles N-aryl-azotés, leur procédé de préparation et leur utilisation comme herbicides
ZA200501457B (en)	2006-04-26	Subsituted heterocyclylpyrimidines
WO1999005125A1 (fr)	1999-02-04	N-aryle-n-thioxocarbonyle-sulfonamides substitues s'utilisant comme herbicides
JPH10158246A (ja)	1998-06-16	新規除草剤
EP1070055A1 (fr)	2001-01-24	Pyridazinones de phenyle substituees
CA2368459A1 (fr)	2000-10-05	Benzoylpyrazoles substitues en tant qu'herbicides
JP2002530277A (ja)	2002-09-17	イソチアゾールカルボン酸誘導体
US6559102B1 (en)	2003-05-06	Substituted 3-aryl-pyrazoles
JPH08502736A (ja)	1996-03-26	除草性ピコリンアミド誘導体
WO2000043375A2 (fr)	2000-07-27	Composes heterocycliques d'aryle substitues
CA2256508A1 (fr)	1997-12-11	3-cyanoaryl-pyrazoles et leur utilisation comme herbicides
JP4674676B2 (ja)	2011-04-20	２−置換アミノピリミジノン誘導体、それらの製造方法並びにそれらを有効成分とする殺虫、殺ダニ剤
CA2070717A1 (fr)	1992-12-08	Derives de substitution d'imidazolinylpyrimidines
AU770424B2 (en)	2004-02-19	Substituted 2-aryl-1,2,4-triazine-3,5-di(thi)one
JPH03190863A (ja)	1991-08-20	ピラゾリン―５―オン誘導体
MXPA03003426A (es)	2005-01-25	Fenil-uracilos sustituidos.
CA2262606A1 (fr)	1998-02-19	1-(3-pyrazolyl)-pyrazoles substitues a action herbicide et produits intermediaires pour leur fabrication
DE19615259A1 (de)	1997-10-23	3-Cyanoaryl-pyrazole
JPH0390067A (ja)	1991-04-16	置換されたアリールスルホニルアミノグアニジノアジン
KR20040015809A (ko)	2004-02-19	살진균제로서의 티아졸로[4,5-ｂ]피리딘
JP2004137270A (ja)	2004-05-13	新規除草剤、その使用方法、新規置換チエノピリミジン誘導体及びその中間体並びにそれらの製造方法
KR20020011989A (ko)	2002-02-09	치환된 제초성 페닐우라실