ZA200602231B - Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer - Google Patents

Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer Download PDF

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Publication number
ZA200602231B
ZA200602231B ZA200602231A ZA200602231A ZA200602231B ZA 200602231 B ZA200602231 B ZA 200602231B ZA 200602231 A ZA200602231 A ZA 200602231A ZA 200602231 A ZA200602231 A ZA 200602231A ZA 200602231 B ZA200602231 B ZA 200602231B
Authority
ZA
South Africa
Prior art keywords
compound
formula
alkyl
ome
culture
Prior art date
Application number
ZA200602231A
Other languages
English (en)
Inventor
Hoffmann Holger
Haag-Richter Sabine
Kurz Michael
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of ZA200602231B publication Critical patent/ZA200602231B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA200602231A 2003-10-24 2006-03-16 Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer ZA200602231B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10349669A DE10349669B3 (de) 2003-10-24 2003-10-24 Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ZA200602231B true ZA200602231B (en) 2007-06-27

Family

ID=34484998

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200602231A ZA200602231B (en) 2003-10-24 2006-03-16 Bengamide derivatives, method for the production thereof and use thereof for the treatment of cancer

Country Status (29)

Country Link
EP (2) EP1873146B1 (fr)
JP (1) JP4769190B2 (fr)
KR (1) KR20060120044A (fr)
CN (2) CN100398520C (fr)
AR (1) AR046553A1 (fr)
AT (2) ATE477244T1 (fr)
AU (1) AU2004287561B2 (fr)
BR (1) BRPI0415529A (fr)
CA (1) CA2543003A1 (fr)
CL (1) CL2009000674A1 (fr)
CY (1) CY1110458T1 (fr)
DE (3) DE10349669B3 (fr)
DK (1) DK1680405T3 (fr)
ES (1) ES2320894T3 (fr)
HR (1) HRP20090187T1 (fr)
IL (1) IL174524A (fr)
MA (1) MA28213A1 (fr)
ME (1) MEP33108A (fr)
MX (1) MXPA06004084A (fr)
NO (1) NO20062149L (fr)
NZ (1) NZ546744A (fr)
PL (1) PL1680405T3 (fr)
PT (1) PT1680405E (fr)
RS (1) RS20060263A (fr)
RU (1) RU2357956C2 (fr)
SI (1) SI1680405T1 (fr)
UY (1) UY28574A1 (fr)
WO (1) WO2005044803A1 (fr)
ZA (1) ZA200602231B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2878528B1 (fr) 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
FR2878525B1 (fr) * 2004-11-29 2007-02-23 Aventis Pharma Sa Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation
FR2901556A1 (fr) 2006-05-24 2007-11-30 Sanofi Aventis Sa Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation
FR2901554B1 (fr) 2006-05-24 2011-04-01 Sanofi Aventis 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation
FR2901555A1 (fr) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240366B1 (fr) * 1986-04-04 1994-01-26 Sankyo Company Limited Dérivés de perhydrothiazépine et perhydroazépine, leur préparation et leur utilisation thérapeutique
CO5140099A1 (es) * 1998-11-17 2002-03-22 Novartis Ag Ciertas caprolactamas sustituidas, composiciones farmaceuticas que las contienen, y su uso en el tratamiento de tumores
JP2003532711A (ja) * 2000-05-11 2003-11-05 ノバルティス アクチエンゲゼルシャフト 置換カプロラクタム炭酸エステルおよびカプロラクタムエーテル、およびそれらの抗腫瘍薬としての使用
JP2004262793A (ja) * 2003-02-28 2004-09-24 Noyaku Bio Technology Kaihatsu Gijutsu Kenkyu Kumiai 化合物ｎ−９０１１、その製造法及び用途
CN1856486A (zh) * 2003-07-25 2006-11-01 诺瓦提斯公司 取代的内酰胺和它们作为抗癌剂的用途

Also Published As

Publication number Publication date
HRP20090187T1 (en) 2009-05-31
IL174524A0 (en) 2006-08-01
JP4769190B2 (ja) 2011-09-07
DE502004011536D1 (de) 2010-09-23
CN1871217A (zh) 2006-11-29
CN100398520C (zh) 2008-07-02
NO20062149L (no) 2006-07-11
NZ546744A (en) 2009-03-31
KR20060120044A (ko) 2006-11-24
EP1873146B1 (fr) 2010-08-11
BRPI0415529A (pt) 2006-12-26
UY28574A1 (es) 2005-05-31
ATE477244T1 (de) 2010-08-15
ES2320894T3 (es) 2009-05-29
EP1680405A1 (fr) 2006-07-19
CL2009000674A1 (es) 2009-08-07
WO2005044803A1 (fr) 2005-05-19
ATE420074T1 (de) 2009-01-15
JP2007509084A (ja) 2007-04-12
CY1110458T1 (el) 2015-04-29
RS20060263A (sr) 2008-09-29
MXPA06004084A (es) 2006-06-27
DE10349669B3 (de) 2005-05-25
AU2004287561B2 (en) 2011-06-02
PL1680405T3 (pl) 2009-06-30
RU2357956C2 (ru) 2009-06-10
EP1873146A2 (fr) 2008-01-02
EP1873146A3 (fr) 2008-05-21
CA2543003A1 (fr) 2005-05-19
RU2006117769A (ru) 2007-11-27
AU2004287561A1 (en) 2005-05-19
EP1680405B1 (fr) 2009-01-07
SI1680405T1 (sl) 2009-06-30
MEP33108A (en) 2010-10-10
MA28213A1 (fr) 2006-10-02
IL174524A (en) 2012-08-30
DE502004008837D1 (de) 2009-02-26
HK1098131A1 (zh) 2007-07-13
CN101294173A (zh) 2008-10-29
AR046553A1 (es) 2005-12-14
PT1680405E (pt) 2009-03-31
DK1680405T3 (da) 2009-05-04

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