ZA200603038B - Method for producing gamma-carboxylated proteins - Google Patents

Method for producing gamma-carboxylated proteins

Info

Publication number
ZA200603038B
ZA200603038B ZA200603038A ZA200603038A ZA200603038B ZA 200603038 B ZA200603038 B ZA 200603038B ZA 200603038 A ZA200603038 A ZA 200603038A ZA 200603038 A ZA200603038 A ZA 200603038A ZA 200603038 B ZA200603038 B ZA 200603038B
Authority
ZA
South Africa
Prior art keywords
producing gamma
carboxylated proteins
carboxylated
proteins
gamma
Prior art date
Application number
ZA200603038A
Other languages
English (en)
Inventor
Fenge Christel
Loevgren Ann
Thelin Anders
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29559260&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200603038(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200603038B publication Critical patent/ZA200603038B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA200603038A 2003-10-14 2006-04-13 Method for producing gamma-carboxylated proteins ZA200603038B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0324044.7A GB0324044D0 (en) 2003-10-14 2003-10-14 Protein

Publications (1)

Publication Number Publication Date
ZA200603038B true ZA200603038B (en) 2007-09-26

Family

ID=29559260

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200603038A ZA200603038B (en) 2003-10-14 2006-04-13 Method for producing gamma-carboxylated proteins

Country Status (28)

Country Link
US (2) US7842477B2 (de)
EP (2) EP2292748B1 (de)
JP (1) JP4658946B2 (de)
KR (1) KR101201020B1 (de)
CN (2) CN1867669B (de)
AR (1) AR046180A1 (de)
AT (1) ATE491789T1 (de)
AU (2) AU2004281350B2 (de)
BR (1) BRPI0415277A (de)
CA (1) CA2541764C (de)
CO (1) CO5690657A2 (de)
DE (1) DE602004030603D1 (de)
DK (1) DK1678297T3 (de)
ES (2) ES2357603T3 (de)
GB (1) GB0324044D0 (de)
IL (2) IL174633A (de)
IS (1) IS8447A (de)
MX (1) MXPA06004060A (de)
MY (1) MY141859A (de)
NO (1) NO339740B1 (de)
NZ (2) NZ578306A (de)
PL (1) PL1678297T3 (de)
PT (1) PT1678297E (de)
RU (2) RU2372401C2 (de)
TW (1) TWI355419B (de)
UY (1) UY28558A1 (de)
WO (1) WO2005038019A1 (de)
ZA (1) ZA200603038B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380985B1 (de) * 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Vitamin-K-Epoxid-Reduktase exprimierende Zellen und deren Verwendung
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
NZ561925A (en) 2005-04-13 2010-04-30 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
US20090137001A1 (en) * 2005-09-30 2009-05-28 Tatsufumi Onchi Process for preparing recombinant human thrombin with culture cell
US7745484B2 (en) 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
EP1969127B8 (de) * 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Verfahren zur herstellung biologisch wirksamer vitamin-k-abhängiger proteine mit rekombinanten verfahren
JP2009528843A (ja) * 2006-03-06 2009-08-13 ヒューマジーン・インコーポレイテッド 組換えヒトトロンビンおよびフィブリノゲンの調製法
AU2008245524A1 (en) * 2007-04-26 2008-11-06 Cnj Holdings, Inc. Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
CA2812888A1 (en) * 2010-10-06 2012-04-12 Medimmune Limited Factor ii and fibrinogen for treatment of haemostatic disorders
EP2655607A4 (de) 2010-12-21 2014-05-14 Univ North Carolina Verfahren und zusammensetzungen zur herstellung aktiver vitamin-k-abhängiger proteine
CN103814137A (zh) * 2011-09-06 2014-05-21 米迪缪尼有限公司 处理凝血因子的方法
RU2500816C1 (ru) * 2012-07-19 2013-12-10 Общество с ограниченной ответственностью "Международный биотехнологический центр "Генериум" ("МБЦ "Генериум") РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК рАК380, КОДИРУЮЩАЯ ПОЛИПЕПТИД РЕКОМБИНАНТНОГО ФАКТОРА IХ СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА, ЛИНИЯ КЛЕТОК Cricetulus griseus CHO 1E6 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ФАКТОРА IХ СВЕРТЫВАЕМОСТИ КРОВИ ЧЕЛОВЕКА И СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА, ОБЛАДАЮЩЕГО АКТИВНОСТЬЮ РЕКОМБИНАНТНОГО ФАКТОРА IХ
JP5830486B2 (ja) 2013-03-29 2015-12-09 シスメックス株式会社 組換えバキュロウイルスおよびその利用
ES2758505T3 (es) * 2013-12-20 2020-05-05 Novartis Ag Células eucariotas novedosas y métodos para expresar de forma recombinante un producto de interés
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

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US4599308A (en) * 1981-10-06 1986-07-08 Hamer Dean H Protein from SV40 recombinants
EP0173552B1 (de) 1984-08-24 1991-10-09 The Upjohn Company Rekombinante DNA-Verbindungen und Expression von Polypeptiden wie tPA
ZA862768B (en) * 1985-04-17 1986-12-30 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
WO1988003926A1 (en) 1986-11-17 1988-06-02 New England Medical Center Enhancing gamma-carboxylation of recombinant vitamin k-dependent proteins
US6224864B1 (en) 1986-12-03 2001-05-01 Pharmacia & Upjohn Company Antibiotic 10381A, and process for the preparation of anitbiotics 10381B
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CA2452768C (en) 2001-07-06 2011-06-07 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for preparing human thrombin by genetic engineering technique
ES2407134T3 (es) 2001-07-10 2013-06-11 The Chemo-Sero-Therapeutic Research Institute Composiciones hemostáticas farmacéuticamente estables
EP2380985B1 (de) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Vitamin-K-Epoxid-Reduktase exprimierende Zellen und deren Verwendung
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
ATE466074T1 (de) 2003-10-14 2010-05-15 Baxter Int Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
EP1676911B1 (de) 2003-10-24 2010-04-21 Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute Neue rekombinante tierzellen mit hoher proteinproduktion, verfahren zur konstruktion davon sowie verfahren zur massenproduktion von protein unter verwendung davon
JP2008523837A (ja) 2004-12-21 2008-07-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ガンマ―カルボキシル化に欠陥のある宿主系におけるガンマ―カルボキシル化ポリペプチドの発現
NZ561925A (en) 2005-04-13 2010-04-30 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
EP1963506B1 (de) 2005-12-02 2010-10-27 Wake Forest University Health Sciences Zusammensetzungen und verfahren zur erhöhung der produktion rekombinanter gamma-carboxylierter proteine
EP1969127B8 (de) 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Verfahren zur herstellung biologisch wirksamer vitamin-k-abhängiger proteine mit rekombinanten verfahren
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin

Also Published As

Publication number Publication date
IL226313A0 (en) 2013-06-27
CA2541764A1 (en) 2005-04-28
MXPA06004060A (es) 2006-06-28
CN1867669B (zh) 2011-10-19
NZ546584A (en) 2009-08-28
ATE491789T1 (de) 2011-01-15
PL1678297T3 (pl) 2011-11-30
JP2007508820A (ja) 2007-04-12
TWI355419B (en) 2012-01-01
US7842477B2 (en) 2010-11-30
JP4658946B2 (ja) 2011-03-23
US20110092429A1 (en) 2011-04-21
HK1155475A1 (en) 2012-05-18
EP2292748A1 (de) 2011-03-09
ES2357603T3 (es) 2011-04-28
IL174633A0 (en) 2006-08-20
MY141859A (en) 2010-07-16
US8697440B2 (en) 2014-04-15
AU2004281350A1 (en) 2005-04-28
GB0324044D0 (en) 2003-11-19
AR046180A1 (es) 2005-11-30
KR101201020B1 (ko) 2012-11-14
RU2006110147A (ru) 2007-11-20
RU2009123931A (ru) 2010-12-27
US20050164367A1 (en) 2005-07-28
NZ578306A (en) 2011-02-25
EP1678297B1 (de) 2010-12-15
CN102443548A (zh) 2012-05-09
CN1867669A (zh) 2006-11-22
DE602004030603D1 (de) 2011-01-27
CO5690657A2 (es) 2006-10-31
ES2532470T3 (es) 2015-03-27
BRPI0415277A (pt) 2006-12-19
EP2292748B1 (de) 2014-12-17
DK1678297T3 (da) 2011-03-14
KR20060123152A (ko) 2006-12-01
TW200523365A (en) 2005-07-16
CA2541764C (en) 2015-03-31
AU2004281350B2 (en) 2008-05-15
RU2372401C2 (ru) 2009-11-10
NO20061470L (no) 2006-05-12
IS8447A (is) 2006-05-10
IL174633A (en) 2013-06-27
WO2005038019A1 (en) 2005-04-28
EP1678297A1 (de) 2006-07-12
NO339740B1 (no) 2017-01-30
UY28558A1 (es) 2005-05-31
PT1678297E (pt) 2011-03-15
AU2008205445A1 (en) 2008-09-04
CN102443548B (zh) 2014-03-12

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