ZA200604657B - A pharmaceutical composition comprising an active principle sulphobetaine - Google Patents

A pharmaceutical composition comprising an active principle sulphobetaine Download PDF

Info

Publication number: ZA200604657B
Authority: ZA; South Africa
Prior art keywords: pharmaceutical composition; ndsb; protein; csf; composition according
Prior art date: 2003-12-23

Application number

ZA200604657A

Other languages

English (en)

Inventor

Menart Viktor

Gaberc Porekar Vladka

Podobnik Barbara

Original Assignee

Lek Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-23

Filing date

2006-06-07

Publication date

2007-10-31

2006-06-07 Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals

2007-10-31 Publication of ZA200604657B publication Critical patent/ZA200604657B/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 85
IZWSFJTYBVKZNK-UHFFFAOYSA-O N-dodecyl-N,N-dimethyl-3-ammonio-1-propanesulfonic acid Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS(O)(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-O 0.000 title abstract description 6
239000003599 detergent Substances 0.000 claims abstract description 10
108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 71
102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 71
102000004169 proteins and genes Human genes 0.000 claims description 44
108090000623 proteins and genes Proteins 0.000 claims description 44
239000008186 active pharmaceutical agent Substances 0.000 claims description 18
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 16
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 16
239000000600 sorbitol Substances 0.000 claims description 16
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 15
239000000546 pharmaceutical excipient Substances 0.000 claims description 15
238000002360 preparation method Methods 0.000 claims description 15
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 12
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PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
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KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 8
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CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 6
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CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 6
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 5
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 5
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HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 5
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims description 5
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims description 4
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PAMIQIKDUOTOBW-UHFFFAOYSA-N N-methylcyclohexylamine Natural products CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 claims description 3
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA200604657A 2003-12-23 2006-06-07 A pharmaceutical composition comprising an active principle sulphobetaine ZA200604657B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SI200300318A SI21639A (sl)	2003-12-23	2003-12-23	Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine

Publications (1)

Publication Number	Publication Date
ZA200604657B true ZA200604657B (en)	2007-10-31

Family

ID=34709498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200604657A ZA200604657B (en)	2003-12-23	2006-06-07	A pharmaceutical composition comprising an active principle sulphobetaine

Country Status (14)

Country	Link
US (1)	US7906109B2 (de)
EP (1)	EP1729794B1 (de)
JP (1)	JP4971798B2 (de)
CN (1)	CN1897967B (de)
AT (1)	ATE400290T1 (de)
AU (1)	AU2004305421B2 (de)
BR (1)	BRPI0417265A (de)
CA (1)	CA2545632C (de)
DE (1)	DE602004014991D1 (de)
ES (1)	ES2308292T3 (de)
RU (1)	RU2380112C2 (de)
SI (2)	SI21639A (de)
WO (1)	WO2005060989A1 (de)
ZA (1)	ZA200604657B (de)

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CN101116670B (zh) *	2006-08-01	2010-11-10	广州和竺生物科技有限公司	可提供活性甲基或参与甲基转移的化合物作为制备治疗病毒性疾病的药的应用
AU2007234612B2 (en)	2006-12-14	2013-06-27	Johnson & Johnson Regenerative Therapeutics, Llc	Protein stabilization formulations
US7678764B2 (en)	2007-06-29	2010-03-16	Johnson & Johnson Regenerative Therapeutics, Llc	Protein formulations for use at elevated temperatures
JP5323832B2 (ja)	2007-08-07	2013-10-23	アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー	酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
BRPI0911048A2 (pt)	2008-04-14	2015-12-29	Atrm Llc	formulações líquidas tamponadas de gdf-5
RU2435589C2 (ru) *	2009-06-02	2011-12-10	Федеральное государственное учреждение "Государственный научный центр дерматовенерологии и косметологии" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "ГНЦДК Минздравсоцразвития России)	Состав консервирующей добавки к контрольным материалам, используемым при серодиагностике сифилиса
UY34105A (es)	2011-06-03	2012-07-31	Lg Life Sciences Ltd	Formulación líquida estable de etanercept
CN107233569B (zh)	2011-10-25	2021-08-31	普罗西纳生物科学有限公司	抗体制剂和方法
GB201315321D0 (en)	2013-08-28	2013-10-09	Koninklijke Nederlandse Akademie Van Wetenschappen	Transduction Buffer
WO2015079977A1 (ja) *	2013-11-26	2015-06-04	シャープ株式会社	抗体分離方法、抗体評価方法、医薬の評価方法、及び、抗体の２次元電気泳動用キット
GB201521101D0 (en)	2015-11-30	2016-01-13	Koninklijke Nederlandse Akademie Van Wetenschappen	Transduction buffer
CN112933039A (zh) *	2019-12-11	2021-06-11	深圳赛保尔生物药业有限公司	一种重组人促红细胞生成素液体制剂

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DE3364292D1 (en) *	1982-02-03	1986-08-07	Procter & Gamble	Oxygen-bleach-containing liquid detergent compositions
DE3880923T3 (de) *	1987-02-23	1997-12-18	Shiseido Co Ltd	Perkutaner absorptionspromotor und dermatologische zusammensetzung für externe anwendung.
NZ236819A (en) *	1990-02-03	1993-07-27	Max Planck Gesellschaft	Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
DE4242863A1 (de) *	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
US5550416A (en) *	1995-02-09	1996-08-27	Fanchang; We C.	Control mechanism of revolving speed of an electric tool
DE19549232C2 (de) *	1995-12-20	1998-05-20	Boehringer Mannheim Gmbh	Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern
EP0904345A4 (de) *	1996-01-12	1999-07-07	Procter & Gamble	Desinfizierende zusammensetzungen und verfahren zum desinfizieren von oberflächen
US6103683A (en)	1996-01-12	2000-08-15	The Procter & Gamble Co.	Disinfecting compositions and processes for disinfecting surfaces
CZ218798A3 (cs) *	1996-02-23	1999-07-14	The Procter & Gamble Company	Dezinfekční prostředky
SE9801288D0 (sv)	1998-04-14	1998-04-14	Astra Ab	Vaccine delivery system and metod of production
SI21273A (sl) *	2002-07-31	2004-02-29	LEK farmacevtska dru�ba d.d.	Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina

2003
- 2003-12-23 SI SI200300318A patent/SI21639A/sl not_active IP Right Cessation
2004
- 2004-12-22 BR BRPI0417265-5A patent/BRPI0417265A/pt not_active IP Right Cessation
- 2004-12-22 US US10/583,157 patent/US7906109B2/en not_active Expired - Fee Related
- 2004-12-22 AU AU2004305421A patent/AU2004305421B2/en not_active Ceased
- 2004-12-22 JP JP2006546933A patent/JP4971798B2/ja not_active Expired - Fee Related
- 2004-12-22 AT AT04809251T patent/ATE400290T1/de active
- 2004-12-22 CN CN200480038901.4A patent/CN1897967B/zh not_active Expired - Fee Related
- 2004-12-22 SI SI200430881T patent/SI1729794T1/sl unknown
- 2004-12-22 CA CA2545632A patent/CA2545632C/en not_active Expired - Fee Related
- 2004-12-22 WO PCT/SI2004/000043 patent/WO2005060989A1/en not_active Ceased
- 2004-12-22 EP EP04809251A patent/EP1729794B1/de not_active Expired - Lifetime
- 2004-12-22 DE DE602004014991T patent/DE602004014991D1/de not_active Expired - Lifetime
- 2004-12-22 ES ES04809251T patent/ES2308292T3/es not_active Expired - Lifetime
- 2004-12-22 RU RU2006126784/15A patent/RU2380112C2/ru not_active IP Right Cessation
2006
- 2006-06-07 ZA ZA200604657A patent/ZA200604657B/en unknown

Also Published As

Publication number	Publication date
ATE400290T1 (de)	2008-07-15
AU2004305421B2 (en)	2010-07-08
ES2308292T3 (es)	2008-12-01
RU2006126784A (ru)	2008-01-27
SI1729794T1 (sl)	2008-12-31
CN1897967A (zh)	2007-01-17
WO2005060989A1 (en)	2005-07-07
JP4971798B2 (ja)	2012-07-11
EP1729794A1 (de)	2006-12-13
JP2007516281A (ja)	2007-06-21
BRPI0417265A (pt)	2007-03-06
DE602004014991D1 (de)	2008-08-21
AU2004305421A1 (en)	2005-07-07
CN1897967B (zh)	2010-09-08
EP1729794B1 (de)	2008-07-09
US20070184019A1 (en)	2007-08-09
CA2545632A1 (en)	2005-07-07
RU2380112C2 (ru)	2010-01-27
SI21639A (sl)	2005-06-30
US7906109B2 (en)	2011-03-15
CA2545632C (en)	2014-10-14

Publication	Publication Date	Title
ES2326498T3 (es)	2009-10-13	Formulacion liquida de g-csf.
US8580246B2 (en)	2013-11-12	Surfactant-free stable pharmaceutical composition comprising granulocyte-colony stimulating factor
US20070244299A1 (en)	2007-10-18	Method of Stabilizing Proteins
CA2545632C (en)	2014-10-14	A pharmaceutical composition comprising an active principle and a non-detergent sulphobetaine
KR20070046791A (ko)	2007-05-03	안정성이 증가된 생체분자-함유 제형
KR20050099637A (ko)	2005-10-14	장기 안정화 제제
JP5349452B2 (ja)	2013-11-20	安定な水性ｇ‐ｃｓｆ製剤
MXPA06007308A (en)	2006-12-13	A pharmaceutical composition comprising an active principle and sulphobetaine
AU2011268944B2 (en)	2014-05-01	Long-term storage of non-glycosylated recombinant human G-CSF
JPH06247870A (ja)	1994-09-06	インターロイキン−６を含有する医薬製剤
KR101191536B1 (ko)	2012-10-15	안정화된 인터페론 액상 제제
KR20070030855A (ko)	2007-03-16	단백질을 안정화하는 방법
KR20180049887A (ko)	2018-05-14	페길레이션된 에리스로포이에틴을 포함하는 신규한 제제