BRPI0911048A2 - formulações líquidas tamponadas de gdf-5 - Google Patents

formulações líquidas tamponadas de gdf-5

Info

Publication number
BRPI0911048A2
BRPI0911048A2 BRPI0911048A BRPI0911048A BRPI0911048A2 BR PI0911048 A2 BRPI0911048 A2 BR PI0911048A2 BR PI0911048 A BRPI0911048 A BR PI0911048A BR PI0911048 A BRPI0911048 A BR PI0911048A BR PI0911048 A2 BRPI0911048 A2 BR PI0911048A2
Authority
BR
Brazil
Prior art keywords
gdf
liquid formulations
buffered liquid
buffered
formulations
Prior art date
Application number
BRPI0911048A
Other languages
English (en)
Inventor
Dongling Su
Julius Lopez
Original Assignee
Atrm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atrm Llc filed Critical Atrm Llc
Publication of BRPI0911048A2 publication Critical patent/BRPI0911048A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0911048A 2008-04-14 2009-04-08 formulações líquidas tamponadas de gdf-5 BRPI0911048A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4451808P 2008-04-14 2008-04-14
PCT/US2009/039925 WO2009129101A1 (en) 2008-04-14 2009-04-08 Liquid buffered gdf-5 formulations

Publications (1)

Publication Number Publication Date
BRPI0911048A2 true BRPI0911048A2 (pt) 2015-12-29

Family

ID=40886732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911048A BRPI0911048A2 (pt) 2008-04-14 2009-04-08 formulações líquidas tamponadas de gdf-5

Country Status (8)

Country Link
US (1) US7947649B2 (pt)
EP (1) EP2276458A1 (pt)
JP (1) JP5599778B2 (pt)
CN (1) CN102026619A (pt)
AU (1) AU2009236459B2 (pt)
BR (1) BRPI0911048A2 (pt)
CA (1) CA2720845A1 (pt)
WO (1) WO2009129101A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007234612B2 (en) * 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
AU2008255016B2 (en) * 2007-05-15 2013-05-09 Stryker Corporation Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にgdf−5を含むタンパク質製剤
WO2011109415A2 (en) * 2010-03-02 2011-09-09 Amgen Inc. Reducing viscosity of pharmaceutical formulations
ES2757591T3 (es) 2010-03-31 2020-04-29 Stabilitech Biopharma Ltd Estabilización de partículas virales
WO2011121301A1 (en) 2010-03-31 2011-10-06 Stabilitech Ltd Excipients for stabilising viral particles, polypeptides or biological material
EP2598660B1 (en) 2010-07-26 2017-03-15 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US20130122066A1 (en) * 2010-07-30 2013-05-16 Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
FR2994390B1 (fr) 2012-08-10 2014-08-15 Adocia Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
US20150150983A1 (en) * 2013-12-02 2015-06-04 Depuy Mitek, Llc Intra-articular Formulations and Methods for Treatment of Osteoarthritis
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CN106662512A (zh) * 2014-06-10 2017-05-10 生物马特里卡公司 在环境温度下稳定血液样品中的非变性多肽、核酸和外来体
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
US11357857B2 (en) 2014-06-20 2022-06-14 Comera Life Sciences, Inc. Excipient compounds for protein processing
US10478498B2 (en) 2014-06-20 2019-11-19 Reform Biologics, Llc Excipient compounds for biopolymer formulations
WO2015196091A1 (en) 2014-06-20 2015-12-23 Reform Biologics, Llc Viscosity-reducing excipient compounds for protein formulations
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
US20200289621A1 (en) * 2017-09-22 2020-09-17 Asahi Kasei Pharma Corporation Teriparatide-containing liquid pharmaceutical composition having excellent stability
US11324806B2 (en) * 2018-10-19 2022-05-10 Warsaw Orthopedic, Inc. Sustained delivery of a growth differentiation factor
CN116478268B (zh) * 2023-05-17 2025-04-25 重庆医科大学附属第三医院(捷尔医院) Bmp2蛋白保护液、bmp2蛋白制剂及其制备方法
CN119055588B (zh) * 2024-11-06 2025-02-18 黑龙江中桂制药有限公司 一种左卡尼汀液体制剂及制备方法

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2931802A (en) * 1958-04-30 1960-04-05 Eastman Kodak Co Mixed esters of glucose and sucrose
US4120810A (en) * 1974-10-07 1978-10-17 Palmer David A Paint remover with improved safety characteristics
JPH0779694B2 (ja) 1985-07-09 1995-08-30 カドラント バイオリソ−シズ リミテツド 蛋白質および同類品の保護
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US4892319A (en) * 1988-07-20 1990-01-09 Johnson Ii Theodore D Word game
US5202311A (en) * 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
USRE38385E1 (en) * 1989-02-16 2004-01-13 Nektar Therapeutics Storage of materials
DK0429570T3 (da) 1989-03-28 1998-04-27 Genetics Inst Osteoinducerende præparater
WO1991018098A1 (en) 1990-05-16 1991-11-28 Genetics Institute, Inc. Bone and cartilage inductive proteins
CA2085134C (en) 1990-06-15 2003-03-18 Carnegie Institution Of Washington Gdf-1
US5231169A (en) * 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
DK0625989T3 (da) 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
US6171584B1 (en) * 1992-02-12 2001-01-09 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Method of treatment with growth/differentiation factors of the TGF-β family
CA2147598A1 (en) 1992-11-03 1994-05-11 Stryker Corporation Op-3-induced morphogenesis
US5808007A (en) 1993-01-12 1998-09-15 The Johns Hopkins University School Of Medicine Growth differentiation factor-3
EP0690871A4 (en) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med GROWTH DIFFERENTIATION FACTOR-5
CA2153653C (en) 1993-01-12 2010-12-07 Se-Jin Lee Growth differentiation factor-9
AU685784B2 (en) * 1993-02-23 1998-01-29 Genentech Inc. Excipient stabilization of polypeptides treated with organic solvents
DK0690873T3 (da) 1993-03-19 2003-09-29 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-8
JPH09501305A (ja) 1993-05-12 1997-02-10 ジェネティックス・インスティテュート・インコーポレイテッド Bmp−10組成物
WO1994026892A1 (en) 1993-05-12 1994-11-24 Genetics Institute, Inc. Bmp-11 compositions
WO1995001801A1 (en) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
IL110589A0 (en) 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6764994B1 (en) * 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6204047B1 (en) 1993-10-08 2001-03-20 The Johns Hopkins University School Of Medicine Growth differentiation factor-10
DE4334646C1 (de) 1993-10-12 1994-09-29 Quinting Friedhelm Durchsichtige Analog-Zeituhr
AU689184B2 (en) * 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US5516645A (en) * 1994-04-25 1996-05-14 Johnson & Johnson Clinical Diagnostics, Inc. Immunoassay analytical elements containing vanadium IV(V+4)ions
IL114397A0 (en) 1994-07-01 1995-10-31 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF-beta-family
EP1574577A3 (en) 1994-07-08 2006-06-14 The Johns Hopkins University School Of Medicine Growth differentiation factor-11
AU1120295A (en) 1994-11-07 1996-05-31 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Cartilage-derived morphogenetic proteins
US6165981A (en) 1995-03-07 2000-12-26 Dade Behring Inc. Stabilizing solutions for proteins and peptides
WO1996033215A1 (en) 1995-04-19 1996-10-24 Hoechst Pharmaceuticals & Chemicals K.K. Novel protein and process for producing the same
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
EP1364656B1 (en) * 1995-06-05 2013-11-20 Genetics Institute, LLC Use of bone morphogenetic proteins for healing and repair of connective tissue attachment
US5968542A (en) * 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
US5747058A (en) * 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US7833543B2 (en) 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
EP0747343B1 (en) * 1995-06-09 1999-05-06 Nippon Shokubai Co., Ltd. Polycarboxylic monomer, polymer of the same, and detergent composition containing the polymer
US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US5770700A (en) * 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
ATE508733T1 (de) * 1996-03-04 2011-05-15 Penn State Res Found Materialien und verfahren zur steigerung der zellulären internalisierung
EP0894004B2 (en) * 1996-03-22 2007-02-21 Curis, Inc. Method for enhancing functional recovery of motor coordination, speech or sensory perception after central nervous system ischemia or trauma
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US20040132653A1 (en) * 1997-01-30 2004-07-08 Biopharm Gmbh Lyophilized composition of bone morphogenetic factor human MP52
JP4388602B2 (ja) * 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6991790B1 (en) * 1997-06-13 2006-01-31 Genentech, Inc. Antibody formulation
US6936582B1 (en) * 1997-09-09 2005-08-30 Curis, Inc. Synergistic effects of OP/BMP morphogens and GDNF/NGF neurotrophic factors
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
JP4221078B2 (ja) * 1998-07-09 2009-02-12 株式会社林原生物化学研究所 トレハロース2含水結晶とその製造方法並びに用途
ES2253851T3 (es) * 1998-08-07 2006-06-01 Curis, Inc. Composicion farmaceutica estable de proteinas hedgehog y uso de la misma.
US6958149B2 (en) * 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) * 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6340369B1 (en) * 1999-08-13 2002-01-22 Bret A. Ferree Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix
US6969404B2 (en) * 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US6419702B1 (en) * 1999-08-13 2002-07-16 Bret A. Ferree Treating degenerative disc disease through transplantation of the nucleus pulposis
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6344058B1 (en) * 1999-08-13 2002-02-05 Bret A. Ferree Treating degenerative disc disease through transplantation of allograft disc and vertebral endplates
US6352557B1 (en) * 1999-08-13 2002-03-05 Bret A. Ferree Treating degenerative disc disease through transplantion of extracellular nucleus pulposus matrix and autograft nucleus pulposus cells
US6755863B2 (en) * 1999-10-08 2004-06-29 Bret A. Ferree Rotator cuff repair using engineered tissues
US6454804B1 (en) * 1999-10-08 2002-09-24 Bret A. Ferree Engineered tissue annulus fibrosis augmentation methods and apparatus
US6793677B2 (en) * 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
US7435260B2 (en) * 1999-08-13 2008-10-14 Ferree Bret A Use of morphogenetic proteins to treat human disc disease
US6648918B2 (en) 1999-08-13 2003-11-18 Bret A. Ferree Treating degenerative disc disease through the transplantation of dehydrated tissue
US6685695B2 (en) * 1999-08-13 2004-02-03 Bret A. Ferree Method and apparatus for providing nutrition to intervertebral disc tissue
US20030026788A1 (en) * 1999-10-08 2003-02-06 Ferree Bret A. Use of extracellular matrix tissue to preserve cultured cell phenotype
US6645247B2 (en) 1999-10-08 2003-11-11 Bret A. Ferree Supplementing engineered annulus tissues with autograft of allograft tendons
US6648920B2 (en) 1999-10-08 2003-11-18 Bret A. Ferree Natural and synthetic supplements to engineered annulus and disc tissues
US6648919B2 (en) 1999-10-14 2003-11-18 Bret A. Ferree Transplantation of engineered meniscus tissue to the intervertebral disc
ES2278648T3 (es) * 1999-12-06 2007-08-16 Warsaw Orthopedic, Inc. Dispositivo para tratar un disco intervertebral.
US6992065B2 (en) * 2000-04-19 2006-01-31 Genentech, Inc. Sustained release formulations
US20030185812A1 (en) * 2000-06-30 2003-10-02 Ferree Bret A. Method of treating dural leaks with platelet-rich plasma (PRP)
US20020032155A1 (en) * 2000-06-30 2002-03-14 Ferree Bret A. Method of treating disc herniation and disc degeneration with concentrated growth and differentiation factors
US6656492B2 (en) 2000-06-30 2003-12-02 Yamanouchi Pharmaceutical Co., Ltd. Quick disintegrating tablet in buccal cavity and manufacturing method thereof
US20020173770A1 (en) * 2001-05-16 2002-11-21 Flory Alan R. Adhesive delivery system
JP4460892B2 (ja) 2001-06-21 2010-05-12 ジェネンテック インコーポレイテッド 徐放性組成物
CN1738635A (zh) 2001-10-05 2006-02-22 印特缪恩股份有限公司 用多阶段干扰素传递曲线治疗肝炎病毒感染的方法
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
ES2247423T5 (es) * 2001-11-19 2015-12-30 Scil Technology Gmbh Método de producción de un dispositivo recubierto homogéneamente que tiene propiedades osteoinductoras y osteoconductoras
TWI265654B (en) * 2001-11-21 2006-11-01 Polyfuel Inc Catalyst agglomerates for membrane electrode assemblies
WO2003066120A1 (en) 2002-02-04 2003-08-14 Ferree Bret A Treating degenerative disc disease through transplantation of allograft disc
WO2003066585A2 (en) * 2002-02-08 2003-08-14 Alkermes Controlled Therapeutics, Inc. Polymer-based compositions for sustained release
US6780324B2 (en) * 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US20030192554A1 (en) * 2002-04-11 2003-10-16 Ferree Bret A. Methods and apparatus for adhering musculoskeletal tissues
US20040024471A1 (en) * 2002-06-27 2004-02-05 Ferree Bret A. Bone cell covered arthroplasty devices
US20040022771A1 (en) * 2002-07-30 2004-02-05 Ferree Bret A. Transfer of cells, tissue, and other substances to bone
US7744651B2 (en) * 2002-09-18 2010-06-29 Warsaw Orthopedic, Inc Compositions and methods for treating intervertebral discs with collagen-based materials
ES2265590T3 (es) 2002-10-25 2007-02-16 Intervet International Bv Composicion farmaceutica de liberacion prolongada.
EP1462126A1 (en) * 2003-03-28 2004-09-29 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Improved Osteoinductive Materials
MXPA05010555A (es) * 2003-04-04 2006-03-09 Genentech Inc Formulaciones de proteina y anticuerpo de alta concentracion.
DE10333835A1 (de) * 2003-07-24 2005-03-10 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung
US7375077B2 (en) * 2003-09-19 2008-05-20 The Board Of Trustees Of The University Of Illinois In vivo synthesis of connective tissues
US7879102B2 (en) * 2003-09-30 2011-02-01 Depuy Acromed, Inc. Method for treatment of defects in the intervertebral disc
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
SI21639A (sl) 2003-12-23 2005-06-30 LEK farmacevtska dru�ba d.d. Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine
KR20070010046A (ko) 2004-04-06 2007-01-19 제넨테크, 인크. Dr5 항체 및 그의 용도
US20070269477A1 (en) 2004-05-05 2007-11-22 Igo Stephen R Heart Treatment Method
CA2567405A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
EP1604693A1 (en) 2004-06-09 2005-12-14 Scil Technology GmbH In situ forming scaffold, its manufacturing and use
FR2871457B1 (fr) 2004-06-10 2006-08-11 Giat Ind Sa Composition pyrotechnique ayant une tenue mecanique amelioree
US8105983B2 (en) * 2005-03-29 2012-01-31 The Regents Of The University Of California High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins
BRPI0611901A2 (pt) 2005-06-14 2012-08-28 Amgen, Inc composição, liofilizado, kit, e, processo para preparar uma composição
US20060287676A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use
US20060286289A1 (en) 2005-06-15 2006-12-21 Rita Prajapati Method of intraoperative coating therapeutic agents onto sutures
US20060286171A1 (en) 2005-06-17 2006-12-21 Tianhong Zhou Bone morphogenetic protein formulations
US7648764B2 (en) * 2005-06-30 2010-01-19 Uchicago Argonne, Llc Two-piece container seal and method of manufacture
AU2006295340B2 (en) * 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
US8932633B2 (en) 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
US8249724B2 (en) * 2005-08-31 2012-08-21 Cochlear Limited Elongate implantable carrier member having an embedded stiffener
CN101365499A (zh) * 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
BRPI0620316A2 (pt) * 2005-12-21 2011-11-08 Wyeth Corp formulações de proteìnas com viscosidades reduzida e seus usos
US20070178159A1 (en) * 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
EP1880731A1 (en) 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Human growth and differentiation factor GDF-5
WO2008042408A2 (en) * 2006-10-03 2008-04-10 Wyeth Lyophilization methods and apparatuses
WO2008045498A1 (en) 2006-10-12 2008-04-17 Ethicon, Inc. Kidney-derived cells and methods of use in tissue repair and regeneration
EP1915986A1 (en) 2006-10-23 2008-04-30 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Lipid growth factor formulations
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US8048857B2 (en) 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
GB2446652A (en) 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
GB2446653A (en) 2007-02-16 2008-08-20 Inion Ltd Osteogenic compounds
US20080234727A1 (en) * 2007-03-22 2008-09-25 Venkat Garigapati Novel Carriers For Coating Growth Factors Onto Sutures
AU2008255016B2 (en) * 2007-05-15 2013-05-09 Stryker Corporation Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof
US7883664B2 (en) * 2007-06-27 2011-02-08 University Of North Carolina At Charlotte Microwave drying process for vitrification of biologics
WO2009006301A2 (en) 2007-06-29 2009-01-08 Battelle Memorial Institute Protein stabilization
US7678764B2 (en) * 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
DE602008004351D1 (de) * 2007-06-29 2011-02-17 Atrm Llc Flüssige proteinformulierungen mit gdf-5 zur verwendung bei erhöhten temperaturen
EP2019117A1 (en) 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimized purification process of recombinant growth factor protein
FR2919188B1 (fr) 2007-07-27 2010-02-26 Proteins & Peptides Man Complexes entre un polymere amphiphile et une proteine osteogenique appartenant a la famille des bmps
GB2451451A (en) 2007-07-30 2009-02-04 Inion Ltd Osteogenic compounds
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にgdf−5を含むタンパク質製剤
US8420081B2 (en) 2007-11-30 2013-04-16 Abbvie, Inc. Antibody formulations and methods of making same
CN102026621A (zh) 2008-05-15 2011-04-20 巴克斯特国际公司 稳定的药物制剂
CA2729972C (en) * 2008-08-05 2018-11-20 Wyeth Llc Lyophilization above collapse

Also Published As

Publication number Publication date
WO2009129101A1 (en) 2009-10-22
US7947649B2 (en) 2011-05-24
CA2720845A1 (en) 2009-10-22
JP2011516608A (ja) 2011-05-26
CN102026619A (zh) 2011-04-20
EP2276458A1 (en) 2011-01-26
AU2009236459A1 (en) 2009-10-22
JP5599778B2 (ja) 2014-10-01
US20090259023A1 (en) 2009-10-15
AU2009236459B2 (en) 2013-07-25

Similar Documents

Publication Publication Date Title
BRPI0911048A2 (pt) formulações líquidas tamponadas de gdf-5
BRPI0910515A2 (pt) composição líquida
BRPI0921298A2 (pt) dispositivo de exibição
BRPI0822306A2 (pt) Dispositivo de exibição
BRPI0818324A2 (pt) formulações líquidas de lh
BRPI0909644A2 (pt) dispositivo de foto-epilação
PT3072906T (pt) Formulação de anticorpos
EP2248011A4 (en) ROUTE REWARD INCREASE
BRPI0912271A2 (pt) co-autoria estruturada
BRPI0909375A2 (pt) Moduladores de receptores de quimiocinas
DK2114143T3 (da) Flydende sulfonylurea-herbicidformuleringer
DK2200752T3 (da) Doseringsindretning
BRPI0913252A2 (pt) dispositivo de display
EP2504020A4 (en) Daptomycin FORMULATIONS
EP2383711A4 (en) DRIVER ASSISTANCE DEVICE
BRPI0906734A2 (pt) Dispositivo de virola
BRPI0915210A2 (pt) dispositivo de exibição
DK2323933T3 (da) Stableenhed
DK2342060T3 (da) Doseringsindretning
BRPI0923891A2 (pt) dispositivo de dosagem
BRPI0918475A2 (pt) dispositivo de display
DE112009002275A5 (de) Anzeigevorrichtung
ATE520307T1 (de) Stabilisierte malathion-mikrokapselformulierungen
BRPI0915364A2 (pt) dispositivo de visualização
PT2376075E (pt) Formulações nasais de metoclopramida

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]