ZA200902184B - Process for the preparation of trifluoroethoxytoluenes - Google Patents

Process for the preparation of trifluoroethoxytoluenes

Info

Publication number: ZA200902184B
Authority: ZA; South Africa
Prior art keywords: preparation; dibromotoluene; trifluoroethoxytoluenes; starting material; salts
Prior art date: 2006-11-06

Application number

ZA200902184A

Other languages

English (en)

Inventor

Reine Inese

Zandersons Armands

Original Assignee

Grindeks

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-06

Filing date

2009-04-16

Publication date

2010-03-31

2009-04-16 Application filed by Grindeks filed Critical Grindeks

2010-03-31 Publication of ZA200902184B publication Critical patent/ZA200902184B/xx

Links

238000000034 method Methods 0.000 title abstract 4
DEMDYEJUAMZMSJ-UHFFFAOYSA-N 2,2,2-trifluoroethoxymethylbenzene Chemical class FC(F)(F)COCC1=CC=CC=C1 DEMDYEJUAMZMSJ-UHFFFAOYSA-N 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
QKEZTJYRBHOKHH-UHFFFAOYSA-N 1,4-dibromo-2-methylbenzene Chemical compound CC1=CC(Br)=CC=C1Br QKEZTJYRBHOKHH-UHFFFAOYSA-N 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000007858 starting material Substances 0.000 abstract 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
DJBNUMBKLMJRSA-UHFFFAOYSA-N Flecainide Chemical compound FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(C(=O)NCC2NCCCC2)=C1 DJBNUMBKLMJRSA-UHFFFAOYSA-N 0.000 abstract 1
RHQDFWAXVIIEBN-UHFFFAOYSA-N Trifluoroethanol Chemical compound OCC(F)(F)F RHQDFWAXVIIEBN-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
229910052802 copper Inorganic materials 0.000 abstract 1
239000010949 copper Substances 0.000 abstract 1
229960003670 flecainide acetate Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/09—Preparation of ethers by dehydration of compounds containing hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/205—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
- C07C43/2055—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring containing more than one ether bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)

ZA200902184A 2006-11-06 2009-04-16 Process for the preparation of trifluoroethoxytoluenes ZA200902184B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06123547A EP1918280A1 (de)	2006-11-06	2006-11-06	Verfahren zur Herstellung von 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamid und dessen Salze

Publications (1)

Publication Number	Publication Date
ZA200902184B true ZA200902184B (en)	2010-03-31

Family

ID=37965028

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA200902184A ZA200902184B (en)	2006-11-06	2009-04-16	Process for the preparation of trifluoroethoxytoluenes
ZA200902183A ZA200902183B (en)	2006-11-06	2009-04-16	Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA200902183A ZA200902183B (en)	2006-11-06	2009-04-16	Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide and salts thereof

Country Status (14)

Country	Link
US (2)	US20100056794A1 (de)
EP (3)	EP1918280A1 (de)
JP (2)	JP2010508330A (de)
KR (2)	KR20090064456A (de)
CN (2)	CN101516817A (de)
AT (1)	ATE514670T1 (de)
AU (2)	AU2007316692A1 (de)
BR (2)	BRPI0714991A2 (de)
CA (2)	CA2660358A1 (de)
EA (2)	EA200900357A1 (de)
MX (2)	MX2009004648A (de)
PL (1)	PL2079674T3 (de)
WO (2)	WO2008055849A1 (de)
ZA (2)	ZA200902184B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102977003A (zh) *	2012-11-28	2013-03-20	郑州大明药物科技有限公司	醋酸氟卡胺的制备方法
CN111018694A (zh) *	2019-12-12	2020-04-17	贵州省欣紫鸿药用辅料有限公司	一种氟卡尼的生产方法
CN115368786B (zh) *	2022-08-15	2023-05-09	江阴市华昌不锈钢管有限公司	一种超级奥氏体耐高温、耐腐蚀不锈钢焊管的制备工艺
CN116120146B (zh) *	2022-08-18	2024-01-16	浙江省化工研究院有限公司	一种六氟丁二烯的生产方法和系统
CN117385378B (zh) *	2023-10-13	2024-09-24	厦门大学	一种缺电子芳香缩醛的电氧化制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3900481A (en) *	1974-04-01	1975-08-19	Riker Laboratories Inc	Derivatives of pyrrolidine and piperidine
US4617396A (en) *	1979-03-19	1986-10-14	Riker Laboratories, Inc.	Process for the preparation of derivatives of piperidine
IL120715A (en) *	1997-04-21	2000-07-16	Finetech Ltd	Process for the preparation of (2,2,2,-trifluoroethoxy)benzoic acids
DE10025700A1 (de) *	2000-05-26	2001-11-29	Merck Patent Gmbh	Verfahren zur Herstellung von trifluorethoxysubstituierten Benzoesäuren
US6458957B1 (en) *	2000-07-12	2002-10-01	Geneva Pharmaceuticals, Inc.	α,α-dibromo-α-chloro-acetophenones as synthons
ITMI20011772A1 (it) *	2001-08-10	2003-02-10	A M S A Anonima Materie Sint E	Processo per la preparazione della 2,5-bis-(2,2,2-trifluoroetossi)-n-(2-piperidilmetil)-benzamide(flecainide)
US7196197B2 (en) *	2003-09-17	2007-03-27	Apotex Pharmachem Inc.	Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof

2006
- 2006-11-06 EP EP06123547A patent/EP1918280A1/de not_active Withdrawn
2007
- 2007-11-02 EA EA200900357A patent/EA200900357A1/ru unknown
- 2007-11-02 CA CA002660358A patent/CA2660358A1/en not_active Abandoned
- 2007-11-02 BR BRPI0714991-3A patent/BRPI0714991A2/pt not_active Application Discontinuation
- 2007-11-02 AT AT07847103T patent/ATE514670T1/de not_active IP Right Cessation
- 2007-11-02 BR BRPI0714989-1A patent/BRPI0714989A2/pt not_active Application Discontinuation
- 2007-11-02 EA EA200900356A patent/EA200900356A1/ru unknown
- 2007-11-02 WO PCT/EP2007/061818 patent/WO2008055849A1/en not_active Ceased
- 2007-11-02 US US12/312,322 patent/US20100056794A1/en not_active Abandoned
- 2007-11-02 CN CNA2007800358109A patent/CN101516817A/zh active Pending
- 2007-11-02 US US12/312,323 patent/US20100063292A1/en not_active Abandoned
- 2007-11-02 AU AU2007316692A patent/AU2007316692A1/en not_active Abandoned
- 2007-11-02 AU AU2007316690A patent/AU2007316690A1/en not_active Abandoned
- 2007-11-02 KR KR1020097007916A patent/KR20090064456A/ko not_active Ceased
- 2007-11-02 WO PCT/EP2007/061820 patent/WO2008055851A1/en not_active Ceased
- 2007-11-02 EP EP07822153A patent/EP2079692A1/de not_active Withdrawn
- 2007-11-02 CN CNA2007800358537A patent/CN101516845A/zh active Pending
- 2007-11-02 CA CA002660364A patent/CA2660364A1/en not_active Abandoned
- 2007-11-02 JP JP2009535081A patent/JP2010508330A/ja active Pending
- 2007-11-02 MX MX2009004648A patent/MX2009004648A/es not_active Application Discontinuation
- 2007-11-02 PL PL07847103T patent/PL2079674T3/pl unknown
- 2007-11-02 JP JP2009535082A patent/JP2010508331A/ja active Pending
- 2007-11-02 EP EP07847103A patent/EP2079674B1/de active Active
- 2007-11-02 MX MX2009004647A patent/MX2009004647A/es not_active Application Discontinuation
- 2007-11-02 KR KR1020097007909A patent/KR20090055638A/ko not_active Ceased
2009
- 2009-04-16 ZA ZA200902184A patent/ZA200902184B/xx unknown
- 2009-04-16 ZA ZA200902183A patent/ZA200902183B/xx unknown

Also Published As

Publication number	Publication date
WO2008055851A8 (en)	2009-04-09
ATE514670T1 (de)	2011-07-15
BRPI0714989A2 (pt)	2013-07-30
KR20090064456A (ko)	2009-06-18
AU2007316692A1 (en)	2008-05-15
EA200900356A1 (ru)	2009-10-30
WO2008055851A1 (en)	2008-05-15
US20100063292A1 (en)	2010-03-11
CA2660358A1 (en)	2008-05-15
KR20090055638A (ko)	2009-06-02
MX2009004647A (es)	2009-05-20
EP2079674B1 (de)	2011-06-29
MX2009004648A (es)	2009-05-21
CN101516845A (zh)	2009-08-26
WO2008055849A1 (en)	2008-05-15
BRPI0714991A2 (pt)	2013-07-30
CA2660364A1 (en)	2008-05-15
EP2079692A1 (de)	2009-07-22
EP1918280A1 (de)	2008-05-07
JP2010508330A (ja)	2010-03-18
EP2079674A1 (de)	2009-07-22
PL2079674T3 (pl)	2011-11-30
US20100056794A1 (en)	2010-03-04
JP2010508331A (ja)	2010-03-18
CN101516817A (zh)	2009-08-26
ZA200902183B (en)	2010-07-28
EA200900357A1 (ru)	2009-10-30
AU2007316690A1 (en)	2008-05-15

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