ZA745355B - Improved dimeric indole akaloid purification process - Google Patents
Improved dimeric indole akaloid purification processInfo
- Publication number
- ZA745355B ZA745355B ZA00745355A ZA745355A ZA745355B ZA 745355 B ZA745355 B ZA 745355B ZA 00745355 A ZA00745355 A ZA 00745355A ZA 745355 A ZA745355 A ZA 745355A ZA 745355 B ZA745355 B ZA 745355B
- Authority
- ZA
- South Africa
- Prior art keywords
- akaloid
- improved
- purification process
- dimeric indole
- dimeric
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/409,225 US3932417A (en) | 1973-10-24 | 1973-10-24 | Dimeric indole alkaloid purification process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA745355B true ZA745355B (en) | 1976-03-31 |
Family
ID=23619578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00745355A ZA745355B (en) | 1973-10-24 | 1974-08-20 | Improved dimeric indole akaloid purification process |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3932417A (da) |
| JP (1) | JPS5649919B2 (da) |
| AR (1) | AR200542A1 (da) |
| AT (1) | AT342215B (da) |
| BE (1) | BE819663A (da) |
| BG (1) | BG40316A3 (da) |
| CA (1) | CA1030963A (da) |
| CH (1) | CH606022A5 (da) |
| CS (1) | CS177884B2 (da) |
| DD (1) | DD115675A5 (da) |
| DE (1) | DE2442245A1 (da) |
| DK (1) | DK138541B (da) |
| ES (1) | ES431340A1 (da) |
| FR (1) | FR2249090B1 (da) |
| GB (1) | GB1479512A (da) |
| HU (1) | HU170134B (da) |
| IE (1) | IE39669B1 (da) |
| IL (1) | IL45553A (da) |
| NL (1) | NL184110C (da) |
| PH (1) | PH10811A (da) |
| PL (1) | PL95570B1 (da) |
| SE (1) | SE418185B (da) |
| SU (2) | SU884573A3 (da) |
| YU (1) | YU36610B (da) |
| ZA (1) | ZA745355B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178084B (en) * | 1977-05-31 | 1982-03-28 | Richter Gedeon Vegyeszet | New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue |
| US4749787A (en) * | 1986-10-23 | 1988-06-07 | Harbor Branch Oceanographic Institution, Inc. | Process of isolating vinblastine from the plant catharanthis roseus |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| CN100336817C (zh) * | 2005-07-12 | 2007-09-12 | 东北林业大学 | 一种连续中压柱层析制备高纯度硫酸长春碱的方法 |
| CN115124505B (zh) * | 2022-08-01 | 2023-07-18 | 云南中烟工业有限责任公司 | 一种吲哚生物碱类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
| US3205220A (en) * | 1961-10-26 | 1965-09-07 | Lilly Co Eli | Leurosidine and leurocristine and their production |
| US3225030A (en) * | 1965-02-15 | 1965-12-21 | Lilly Co Eli | Method of preparing leurosine and vincaleukoblastine |
| US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
| DE2124023C3 (de) * | 1970-05-27 | 1980-07-10 | Richter Gedeon Vegyeszeti Gyar R.T., Budapest | Verfahren zur selektiven Gewinnung von Vinblastin, Vinleurosin und Vincristin oder von deren Sulfaten |
| BE793336A (fr) * | 1972-12-05 | 1973-04-16 | Richter Gedeon Vegyeszet | Procede pour augmenter le rendement en vincristine lors de l'isolement de la vincristine de parties de la plante vinca rosea l. |
-
1973
- 1973-10-24 US US05/409,225 patent/US3932417A/en not_active Expired - Lifetime
-
1974
- 1974-08-19 IE IE1723/74A patent/IE39669B1/xx unknown
- 1974-08-20 ZA ZA00745355A patent/ZA745355B/xx unknown
- 1974-08-23 PH PH16202A patent/PH10811A/en unknown
- 1974-08-27 IL IL45553A patent/IL45553A/xx unknown
- 1974-08-29 CA CA208,126A patent/CA1030963A/en not_active Expired
- 1974-09-04 DE DE2442245A patent/DE2442245A1/de not_active Withdrawn
- 1974-09-06 FR FR7430292A patent/FR2249090B1/fr not_active Expired
- 1974-09-06 YU YU2405/74A patent/YU36610B/xx unknown
- 1974-09-09 BE BE1006167A patent/BE819663A/xx not_active IP Right Cessation
- 1974-09-12 CH CH1243174A patent/CH606022A5/xx not_active IP Right Cessation
- 1974-09-12 DD DD181067A patent/DD115675A5/xx unknown
- 1974-09-19 AR AR255655A patent/AR200542A1/es active
- 1974-09-24 SU SU742062709A patent/SU884573A3/ru active
- 1974-10-02 BG BG027829A patent/BG40316A3/xx unknown
- 1974-10-18 NL NLAANVRAGE7413724,A patent/NL184110C/xx not_active IP Right Cessation
- 1974-10-22 PL PL1974175028A patent/PL95570B1/pl unknown
- 1974-10-23 SE SE7413357A patent/SE418185B/xx not_active IP Right Cessation
- 1974-10-23 DK DK555374AA patent/DK138541B/da not_active IP Right Cessation
- 1974-10-23 GB GB45910/74A patent/GB1479512A/en not_active Expired
- 1974-10-24 HU HUEI569A patent/HU170134B/hu unknown
- 1974-10-24 AT AT856974A patent/AT342215B/de not_active IP Right Cessation
- 1974-10-24 JP JP12329574A patent/JPS5649919B2/ja not_active Expired
- 1974-10-24 CS CS7285A patent/CS177884B2/cs unknown
- 1974-10-24 ES ES431340A patent/ES431340A1/es not_active Expired
-
1979
- 1979-10-19 SU SU792833053A patent/SU1207396A3/ru active
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