ZA747820B - Isoquinoline derivatives and processes for their preparation - Google Patents

Isoquinoline derivatives and processes for their preparation

Info

Publication number
ZA747820B
ZA747820B ZA00747820A ZA747820A ZA747820B ZA 747820 B ZA747820 B ZA 747820B ZA 00747820 A ZA00747820 A ZA 00747820A ZA 747820 A ZA747820 A ZA 747820A ZA 747820 B ZA747820 B ZA 747820B
Authority
ZA
South Africa
Prior art keywords
processes
preparation
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
ZA00747820A
Other languages
English (en)
Inventor
K Becker
H Schliep
W Mehrhof
R Pohlke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA747820B publication Critical patent/ZA747820B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA00747820A 1973-12-10 1974-12-09 Isoquinoline derivatives and processes for their preparation ZA747820B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2361390A DE2361390A1 (de) 1973-12-10 1973-12-10 Isochinolinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ZA747820B true ZA747820B (en) 1975-12-31

Family

ID=5900348

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00747820A ZA747820B (en) 1973-12-10 1974-12-09 Isoquinoline derivatives and processes for their preparation

Country Status (18)

Country Link
US (1) US3985881A (fr)
JP (1) JPS5088077A (fr)
AT (1) AT351026B (fr)
BE (1) BE823027A (fr)
CA (1) CA1053675A (fr)
CH (1) CH605776A5 (fr)
CS (1) CS188933B2 (fr)
DD (1) DD115666A5 (fr)
DE (1) DE2361390A1 (fr)
DK (1) DK137007C (fr)
ES (1) ES432716A1 (fr)
FR (1) FR2253522B1 (fr)
GB (1) GB1447611A (fr)
HU (1) HU171483B (fr)
IL (1) IL46160A0 (fr)
NL (1) NL7416050A (fr)
SE (1) SE7415247L (fr)
ZA (1) ZA747820B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504250A1 (de) * 1975-02-01 1976-08-05 Merck Patent Gmbh Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) * 1978-10-18 1980-11-04 Miles Laboratories, Inc. Isoquinoline propionamides exhibiting analgesic properties
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
DE3713743A1 (de) * 1987-04-24 1988-11-17 Boehringer Ingelheim Kg Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2061972T3 (es) * 1988-02-19 1994-12-16 Smithkline Beecham Farma 1,2,3,4-tetrahidroisoquinoleinas, procedimiento para su preparacion y su uso como agonistas kapa-receptores.
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
GB0225884D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US8993555B2 (en) * 2012-12-21 2015-03-31 Epizyme, Inc. PRMT5 inhibitors and uses thereof
CA2996813C (fr) * 2015-09-01 2023-09-26 Merck Patent Gmbh Procede de production de praziquantel et de ses precurseurs
US20180305334A1 (en) * 2015-10-14 2018-10-25 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
SG11202002032SA (en) 2017-09-22 2020-04-29 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
CA3076476A1 (fr) 2017-10-18 2019-04-25 Jubilant Epipad LLC Composes imidazo-pyridine a utiliser en tant qu'inhibiteurs de pad
BR112020008851A2 (pt) 2017-11-06 2020-10-20 Jubilant Prodel LLC composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
PL3704120T3 (pl) 2017-11-24 2024-09-16 Jubilant Episcribe Llc Związki heterocykliczne jako inhibitory prmt5
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612503A (en) * 1949-04-19 1952-09-30 Smith Kline French Lab Basic ether-substituted isoquinolines
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3483206A (en) * 1967-12-15 1969-12-09 Ciba Geigy Corp N-isoquinolylalkanoyl-n-arylamines
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils

Also Published As

Publication number Publication date
SE7415247L (fr) 1975-06-11
DE2361390A1 (de) 1975-06-19
ATA981974A (de) 1978-12-15
DD115666A5 (fr) 1975-10-12
ES432716A1 (es) 1977-03-01
FR2253522A1 (fr) 1975-07-04
GB1447611A (en) 1976-08-25
CH605776A5 (fr) 1978-10-13
FR2253522B1 (fr) 1978-06-30
PL93405B1 (fr) 1977-05-30
DK639674A (fr) 1975-08-11
AU7625774A (en) 1976-06-10
HU171483B (hu) 1978-01-28
US3985881A (en) 1976-10-12
DK137007C (da) 1978-06-05
CS188933B2 (en) 1979-03-30
NL7416050A (nl) 1975-06-12
BE823027A (fr) 1975-06-06
AT351026B (de) 1979-07-10
DK137007B (da) 1978-01-02
IL46160A0 (en) 1975-02-10
JPS5088077A (fr) 1975-07-15
CA1053675A (fr) 1979-05-01

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