ZA766986B - Antibiotics and process for preparing same - Google Patents

Antibiotics and process for preparing same

Info

Publication number
ZA766986B
ZA766986B ZA00766986A ZA766986A ZA766986B ZA 766986 B ZA766986 B ZA 766986B ZA 00766986 A ZA00766986 A ZA 00766986A ZA 766986 A ZA766986 A ZA 766986A ZA 766986 B ZA766986 B ZA 766986B
Authority
ZA
South Africa
Prior art keywords
antibiotics
preparing same
preparing
same
Prior art date
Application number
ZA00766986A
Other languages
English (en)
Inventor
J Kahan
F Kahan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA766986B publication Critical patent/ZA766986B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA00766986A 1975-11-24 1976-11-23 Antibiotics and process for preparing same ZA766986B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24

Publications (1)

Publication Number Publication Date
ZA766986B true ZA766986B (en) 1978-06-28

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00766986A ZA766986B (en) 1975-11-24 1976-11-23 Antibiotics and process for preparing same

Country Status (16)

Country Link
JP (1) JPS5265295A (fr)
AR (1) AR224224A1 (fr)
AU (1) AU510252B2 (fr)
BE (1) BE848349A (fr)
CH (1) CH625803A5 (fr)
DE (1) DE2652678A1 (fr)
DK (1) DK497476A (fr)
ES (1) ES453508A1 (fr)
FR (1) FR2351979A1 (fr)
GB (1) GB1561108A (fr)
GR (1) GR61407B (fr)
HU (1) HU175266B (fr)
NL (1) NL7612932A (fr)
PT (1) PT65845B (fr)
SE (1) SE7612295L (fr)
ZA (1) ZA766986B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7800958A (nl) * 1977-02-11 1978-08-15 Merck & Co Inc Antibioticum desacetyl-dihydro 890 a9, werkwijze ter bereiding daarvan en farmaceutisch preparaat dat dit antibioticum bevat.
SE7800978L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
ATE4224T1 (de) * 1979-08-28 1983-08-15 Merck & Co. Inc. Verfahren zur reinigung von thienamycin.
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Also Published As

Publication number Publication date
JPS5265295A (en) 1977-05-30
AU510252B2 (en) 1980-06-19
ES453508A1 (es) 1978-03-01
CH625803A5 (en) 1981-10-15
SE7612295L (sv) 1977-05-25
BE848349A (fr) 1977-05-16
FR2351979B1 (fr) 1982-08-13
HU175266B (hu) 1980-06-28
GB1561108A (en) 1980-02-13
AR224224A1 (es) 1981-11-13
DK497476A (da) 1977-05-25
AU1964576A (en) 1978-05-25
DE2652678A1 (de) 1977-06-02
PT65845A (en) 1976-12-01
NL7612932A (nl) 1977-05-26
PT65845B (en) 1978-10-10
FR2351979A1 (fr) 1977-12-16
GR61407B (en) 1978-11-11

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