ZA776497B - 4a-aryl-octahydro-1h-2-pyridines - Google Patents

4a-aryl-octahydro-1h-2-pyridines

Info

Publication number
ZA776497B
ZA776497B ZA00776497A ZA776497A ZA776497B ZA 776497 B ZA776497 B ZA 776497B ZA 00776497 A ZA00776497 A ZA 00776497A ZA 776497 A ZA776497 A ZA 776497A ZA 776497 B ZA776497 B ZA 776497B
Authority
ZA
South Africa
Prior art keywords
octahydro
pyridines
aryl
Prior art date
Application number
ZA00776497A
Other languages
English (en)
Inventor
D Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA776497B publication Critical patent/ZA776497B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
ZA00776497A 1976-11-02 1977-11-01 4a-aryl-octahydro-1h-2-pyridines ZA776497B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
ZA776497B true ZA776497B (en) 1979-06-27

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00776497A ZA776497B (en) 1976-11-02 1977-11-01 4a-aryl-octahydro-1h-2-pyridines

Country Status (26)

Country Link
JP (1) JPS5356669A (cs)
AR (1) AR223454A1 (cs)
AT (1) ATA782177A (cs)
AU (1) AU513679B2 (cs)
BE (1) BE860314A (cs)
CA (1) CA1100136A (cs)
CS (1) CS211380B2 (cs)
DD (1) DD133795A5 (cs)
DE (1) DE2748466A1 (cs)
DK (1) DK485277A (cs)
ES (3) ES463783A1 (cs)
FR (1) FR2369267A1 (cs)
GB (1) GB1590155A (cs)
GR (1) GR70053B (cs)
HU (1) HU176231B (cs)
IE (1) IE45901B1 (cs)
IL (1) IL53236A0 (cs)
NL (1) NL7712053A (cs)
NZ (1) NZ185539A (cs)
PH (1) PH12590A (cs)
PL (3) PL108466B1 (cs)
PT (1) PT67194B (cs)
RO (3) RO72900A (cs)
SE (3) SE7712218L (cs)
SU (3) SU812174A3 (cs)
ZA (1) ZA776497B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT68934A (en) * 1977-12-27 1979-01-01 Lilly Co Eli Process for preparing 4a-aryl-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
US8598164B2 (en) 2010-05-06 2013-12-03 Vertex Pharmaceuticals Incorporated Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
KR101923367B1 (ko) 2011-02-02 2018-12-04 버텍스 파마슈티칼스 인코포레이티드 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
WO2012112743A1 (en) 2011-02-18 2012-08-23 Vertex Pharmaceuticals Incorporated Chroman - spirocyclic piperidine amides as modulators of ion channels
US8828996B2 (en) 2011-03-14 2014-09-09 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
PL109690B1 (en) 1980-06-30
RO72900A (ro) 1981-11-04
SE7712218L (sv) 1978-05-03
AR223454A1 (es) 1981-08-31
DD133795A5 (de) 1979-01-24
PT67194B (en) 1979-03-23
PH12590A (en) 1979-06-27
SE8103107L (sv) 1981-05-18
GR70053B (cs) 1982-07-26
CA1100136A (en) 1981-04-28
GB1590155A (en) 1981-05-28
PL108466B1 (en) 1980-04-30
JPS5356669A (en) 1978-05-23
FR2369267B1 (cs) 1980-05-16
IE45901B1 (en) 1982-12-29
SU913941A3 (en) 1982-03-15
ES463784A1 (es) 1978-06-16
NL7712053A (nl) 1978-05-05
ES472276A1 (es) 1979-10-01
SE8103106L (sv) 1981-05-18
ES463783A1 (es) 1979-07-16
PL201885A1 (pl) 1978-12-04
SU845777A3 (ru) 1981-07-07
SU812174A3 (ru) 1981-03-07
PT67194A (en) 1977-11-01
AU513679B2 (en) 1980-12-18
HU176231B (en) 1981-01-28
RO78300A (ro) 1982-04-12
IE45901L (en) 1978-05-02
CS211380B2 (en) 1982-02-26
DK485277A (da) 1978-05-03
IL53236A0 (en) 1977-12-30
PL108610B1 (en) 1980-04-30
ATA782177A (de) 1981-10-15
DE2748466A1 (de) 1978-05-03
FR2369267A1 (fr) 1978-05-26
AU3023577A (en) 1979-05-10
BE860314A (fr) 1978-04-28
NZ185539A (en) 1979-12-11
RO77935A (ro) 1981-12-25

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