ZA806528B - 6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals - Google Patents

6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals

Info

Publication number: ZA806528B
Authority: ZA; South Africa
Prior art keywords: derivatives; hydrogen; pharmaceuticals; processes; production
Prior art date: 1979-10-23

Application number

ZA00806528A

Other languages

English (en)

Inventor

Akkerman Antony Marie

Antony Marie Akkerman

Bakel Hermanus Carolus Cat Van

Hermanus Carolus Cathari Bakel

Smit Roelof Christiaan Klaas

Roelof Christiaan Klaas Smit

Welle Hendricus Berna Antonius

Hendricus Bernardus Anto Welle

Marko Magda

Magda Marko

Original Assignee

Acf Chemiefarma Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-23

Filing date

1980-10-23

Publication date

1982-06-30

1980-10-23 Application filed by Acf Chemiefarma Nv filed Critical Acf Chemiefarma Nv

1982-06-30 Publication of ZA806528B publication Critical patent/ZA806528B/xx

Links

NSLKFRGZLUIUKO-QWRGUYRKSA-N 6,7-benzomorphan Chemical class C1C2=CC=CC=C2[C@H]2CCN[C@@H]1C2 NSLKFRGZLUIUKO-QWRGUYRKSA-N 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000005452 alkenyloxyalkyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
125000006213 aryl hydroxyalkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001592 luteinising effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA00806528A 1979-10-23 1980-10-23 6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals ZA806528B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL7907800A NL7907800A (nl)	1979-10-23	1979-10-23	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.

Publications (1)

Publication Number	Publication Date
ZA806528B true ZA806528B (en)	1982-06-30

Family

ID=19834064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00806528A ZA806528B (en)	1979-10-23	1980-10-23	6,7-benzomorphan derivatives,processes for their production,pharmaceutical compositions containing said derivatives and their use as pharmaceuticals

Country Status (17)

Country	Link
US (2)	US4406904A (da)
EP (1)	EP0028717B1 (da)
JP (1)	JPS5686164A (da)
AT (1)	ATE8990T1 (da)
AU (1)	AU539310B2 (da)
CA (1)	CA1155840A (da)
DE (1)	DE3068961D1 (da)
DK (1)	DK435380A (da)
ES (1)	ES496167A0 (da)
FI (1)	FI67373C (da)
IE (1)	IE50667B1 (da)
IL (1)	IL61324A (da)
MY (1)	MY8700184A (da)
NL (1)	NL7907800A (da)
NZ (1)	NZ195329A (da)
PT (1)	PT71949B (da)
ZA (1)	ZA806528B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4579950A (en) *	1982-08-20	1986-04-01	Hoechst-Roussel Pharmaceuticals Inc.	Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine] compounds
JPH01102077A (ja) *	1987-09-24	1989-04-19	Hoechst Roussel Pharmaceut Inc	２，６‐メタノピロロ‐３‐ベンズアゾジン類
DE4121821A1 (de) *	1991-07-02	1993-01-14	Boehringer Ingelheim Kg	Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de) *	1995-08-03	1997-02-06	Boehringer Ingelheim Kg	Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
WO1999020223A2 (en) *	1997-10-20	1999-04-29	Novo Nordisk A/S	Luteinising hormone antagonists useful for treatment of estrogen deficiencies, or as a contraceptive
US6136980A (en) *	1998-05-01	2000-10-24	Boehringer Ingelheim Kg	Method of preparing norbenzomorphane as an intermediate in the preparation of pharmaceutically useful benzomorphane derivatives, in particular (-)-(1R,5S,2"R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzo morphane
JP2003509478A (ja)	1999-09-21	2003-03-11	エモリー・ユニバーシティ	血小板関連障害を処置する方法および組成物
US6495694B2 (en) *	2000-06-16	2002-12-17	Boehringer Ingelheim Pharma Kg	Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
WO2013167963A1 (en)	2012-05-11	2013-11-14	Purdue Pharma L.P.	Benzomorphan compounds as opioid receptors modulators
US10138207B2 (en)	2012-11-09	2018-11-27	Purdue Pharma, L.P.	Benzomorphan analogs and the use thereof
EP2951160B1 (en) *	2013-01-31	2019-04-24	Purdue Pharma LP	Benzomorphan analogs and the use thereof
CA2948144A1 (en)	2014-05-06	2015-11-12	Purdue Pharma L.P.	Benzomorphan analogs and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1050227A (da)	1963-11-07
US4087532A (en)	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1513961A (en) *	1975-02-25	1978-06-14	Acf Chemiefarma Nv	6,7-benzomorphans method for their preparation and intermediates
DE2716687A1 (de)	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
US4202897A (en) *	1977-07-25	1980-05-13	Sandoz, Inc.	Prolactin secretion inhibitors
IT8049377A0 (it)	1979-08-03	1980-07-30	Sandoz Ag	Medicamento a base di composti triciclici per inibire la secrezione dell'ormone luteinizzante(caso 1005224)

1979
- 1979-10-23 NL NL7907800A patent/NL7907800A/nl not_active Application Discontinuation
1980
- 1980-10-13 EP EP80106213A patent/EP0028717B1/en not_active Expired
- 1980-10-13 AT AT80106213T patent/ATE8990T1/de active
- 1980-10-13 DE DE8080106213T patent/DE3068961D1/de not_active Expired
- 1980-10-14 DK DK435380A patent/DK435380A/da not_active Application Discontinuation
- 1980-10-14 FI FI803237A patent/FI67373C/fi not_active IP Right Cessation
- 1980-10-21 AU AU63540/80A patent/AU539310B2/en not_active Ceased
- 1980-10-21 IL IL61324A patent/IL61324A/xx unknown
- 1980-10-21 CA CA000362879A patent/CA1155840A/en not_active Expired
- 1980-10-21 NZ NZ195329A patent/NZ195329A/en unknown
- 1980-10-22 PT PT71949A patent/PT71949B/pt unknown
- 1980-10-22 JP JP14887180A patent/JPS5686164A/ja active Pending
- 1980-10-22 ES ES496167A patent/ES496167A0/es active Granted
- 1980-10-22 IE IE2188/80A patent/IE50667B1/en unknown
- 1980-10-23 ZA ZA00806528A patent/ZA806528B/xx unknown
1981
- 1981-07-13 US US06/283,084 patent/US4406904A/en not_active Expired - Fee Related
- 1981-07-13 US US06/282,799 patent/US4425353A/en not_active Expired - Fee Related
1987
- 1987-12-30 MY MY184/87A patent/MY8700184A/xx unknown

Also Published As

Publication number	Publication date
NL7907800A (nl)	1981-04-27
DE3068961D1 (en)	1984-09-20
IE802188L (en)	1981-04-23
JPS5686164A (en)	1981-07-13
DK435380A (da)	1981-04-24
CA1155840A (en)	1983-10-25
EP0028717A1 (en)	1981-05-20
NZ195329A (en)	1984-05-31
FI67373C (fi)	1985-03-11
PT71949B (en)	1981-12-17
FI67373B (fi)	1984-11-30
US4425353A (en)	1984-01-10
AU6354080A (en)	1981-04-30
IE50667B1 (en)	1986-06-11
PT71949A (en)	1981-08-19
ES8106894A1 (es)	1981-09-16
MY8700184A (en)	1987-12-31
EP0028717B1 (en)	1984-08-15
IL61324A (en)	1985-03-31
ATE8990T1 (de)	1984-09-15
ES496167A0 (es)	1981-09-16
IL61324A0 (en)	1980-12-31
FI803237L (fi)	1981-04-24
AU539310B2 (en)	1984-09-20
US4406904A (en)	1983-09-27

Publication	Publication Date	Title
DE3065304D1 (en)	1983-11-17	Morpholine derivatives, pharmaceutical compositions containing them and processes for their preparation
DE3068961D1 (en)	1984-09-20	6,7-benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
DE69230163D1 (de)	1999-11-25	Thiazolylbenzofuranderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
AU529663B2 (en)	1983-06-16	Piperidine alkyl ethers of coumarin and quinoline
CA2011346A1 (en)	1990-09-03	2-(1-piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same
GB1014053A (en)	1965-12-22	7-hydroxy-coumarin derivatives and process for their production
IL77452A0 (en)	1986-08-31	Derivatives of arylcyclobutylalkylamines,their preparation and pharmaceutical compositions containing them
GB9215844D0 (en)	1992-09-09	Novel compounds
PH20421A (en)	1987-01-05	Derivatives of piperidinedione for protecting the myocardium presenting an anti-arrythmic activity and pharmaceutical compositions containing them
JPS5665869A (en)	1981-06-03	Novel 22hydroxyalkyll3455trihydroxyypiperidine compound* its manufacture and drug
ES482472A1 (es)	1980-04-01	Procedimiento para la preparacion de isoquinoleinas.
ATE8144T1 (de)	1984-07-15	Indolobenzoxazine, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen.
GR3031820T3 (en)	2000-02-29	4-amino-n --(4-methyl-4-piperidinyl)-2-methoxybenzamides.
ES8107214A1 (es)	1981-08-16	Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol
ES458481A1 (es)	1978-04-01	Un procedimiento de preparacion de nuevos derivados de ben- zodiazepina.
ES8501382A1 (es)	1984-11-16	Procedimiento para la preparacion de derivados de acido fenilacetico.
DE3063450D1 (en)	1983-07-07	Theophylline derivatives, process for their preparation and medicaments containing these compounds
NZ217276A (en)	1988-10-28	Bicyclic heterocyclic compounds and pharmaceutical compositions
ES8307734A1 (es)	1983-08-01	"procedimiento de producir derivados amidicos".
FI851456L (fi)	1985-10-12	Foerfarande foer framstaellning av 1-cyklohexyl-3,4-dihydroisokinolinderivat.
ES8200112A1 (es)	1981-10-16	Un procedimiento para la preparacion de un derivado del aci do clavulanico.