ZA814845B - Substituted pyrimidin-2-ones, the salts thereof, process for their preparation, pharmaceutical compositions containing them and a method therefor - Google Patents

Substituted pyrimidin-2-ones, the salts thereof, process for their preparation, pharmaceutical compositions containing them and a method therefor

Info

Publication number: ZA814845B
Authority: ZA; South Africa
Prior art keywords: group; compounds; salts; pharmaceutical compositions; compositions containing
Prior art date: 1980-07-15

Application number

ZA814845A

Other languages

English (en)

Inventor

G Phillipps

C Williamson

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-15

Filing date

1981-07-15

Publication date

1983-02-23

1981-07-15 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1983-02-23 Publication of ZA814845B publication Critical patent/ZA814845B/xx

Links

238000000034 method Methods 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
230000002159 abnormal effect Effects 0.000 abstract 3
125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
230000022131 cell cycle Effects 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
229940127089 cytotoxic agent Drugs 0.000 abstract 1
239000002254 cytotoxic agent Substances 0.000 abstract 1
238000010511 deprotection reaction Methods 0.000 abstract 1
238000003683 electrophilic halogenation reaction Methods 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000031864 metaphase Effects 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

ZA814845A 1980-07-15 1981-07-15 Substituted pyrimidin-2-ones, the salts thereof, process for their preparation, pharmaceutical compositions containing them and a method therefor ZA814845B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8023063		1980-07-15

Publications (1)

Publication Number	Publication Date
ZA814845B true ZA814845B (en)	1983-02-23

Family

ID=10514771

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA814845A ZA814845B (en)	1980-07-15	1981-07-15	Substituted pyrimidin-2-ones, the salts thereof, process for their preparation, pharmaceutical compositions containing them and a method therefor

Country Status (12)

Country	Link
US (1)	US4636509A (de)
EP (1)	EP0044704B1 (de)
JP (1)	JPS5740471A (de)
AT (1)	ATE19627T1 (de)
AU (1)	AU7300381A (de)
CA (1)	CA1160226A (de)
DE (1)	DE3174554D1 (de)
DK (1)	DK315281A (de)
ES (2)	ES8301473A1 (de)
NO (1)	NO812431L (de)
NZ (1)	NZ197714A (de)
ZA (1)	ZA814845B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0087326B1 (de) *	1982-02-24	1987-05-13	Nycomed As	Substituierte Pyrimidin-2-one und deren Salze
GB2135992B (en) *	1983-01-11	1986-09-24	Nyegaard & Co As	Substituted pyrimidines and processes for their preparation
GB8420610D0 (en) *	1984-08-14	1984-09-19	Glaxo Group Ltd	Chemical compounds
US4820711A (en) *	1987-05-15	1989-04-11	Pearlman Dale L	Method for treating actinic keratosis with cytotoxic agents
US4853388A (en) *	1987-05-15	1989-08-01	Pearlman Dale L	Method for treating psoriasis with cytotoxic agents
US4849426A (en) *	1987-05-15	1989-07-18	Pearlman Dale L	Method for treating actinic keratosis with cytotoxic agents
US4855466A (en) *	1987-12-28	1989-08-08	E. R. Squibb & Sons, Inc.	Purinyl cyclobutanes
KR100477070B1 (ko) *	1994-03-25	2006-04-21	이소테크니카 인코포레이티드	중수소화작용에의한의약품의효능강화법
US6334997B1 (en) *	1994-03-25	2002-01-01	Isotechnika, Inc.	Method of using deuterated calcium channel blockers
MXPA06014131A (es) *	2004-06-04	2007-03-07	Astellas Pharma Inc	Derivado de propano-1,3-diona o su sal.
SI1864976T1 (sl) *	2005-03-31	2012-12-31	Astellas Pharma Inc.	Propan-1,3-dionski derivat ali njegova sol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1561290A (en) *	1975-10-16	1980-02-20	Nyegaard & Co As	Pyrimid - 2 - ones
ES498337A0 (es) *	1980-01-07	1982-06-01	Nyegaard & Co As	Un procedimiento para la preparacion de 5-halo-pirimidin-2- onas
GB2080301B (en) *	1980-07-15	1984-04-18	Glaxo Group Ltd	Substituted pyrimidin-2-ones the salts thereof processes for their preparation and pharmaceutical compositions containing them
GB2080300B (en) *	1980-07-15	1984-04-26	Glaxo Group Ltd	Substituted pyrimidin-2-ones the salts thereof processes for their preparation and pharmaceutical compositions containing them

1981
- 1981-07-14 CA CA000381712A patent/CA1160226A/en not_active Expired
- 1981-07-14 NZ NZ197714A patent/NZ197714A/en unknown
- 1981-07-15 ZA ZA814845A patent/ZA814845B/xx unknown
- 1981-07-15 JP JP56110634A patent/JPS5740471A/ja active Pending
- 1981-07-15 DK DK315281A patent/DK315281A/da not_active Application Discontinuation
- 1981-07-15 AT AT81303254T patent/ATE19627T1/de not_active IP Right Cessation
- 1981-07-15 EP EP81303254A patent/EP0044704B1/de not_active Expired
- 1981-07-15 ES ES503984A patent/ES8301473A1/es not_active Expired
- 1981-07-15 DE DE8181303254T patent/DE3174554D1/de not_active Expired
- 1981-07-15 AU AU73003/81A patent/AU7300381A/en not_active Abandoned
- 1981-07-15 NO NO812431A patent/NO812431L/no unknown
1982
- 1982-06-16 ES ES513177A patent/ES8307758A1/es not_active Expired
1983
- 1983-05-27 US US06/498,723 patent/US4636509A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0044704B1 (de)	1986-05-07
ES503984A0 (es)	1982-12-01
EP0044704A1 (de)	1982-01-27
ES8301473A1 (es)	1982-12-01
NO812431L (no)	1982-01-18
JPS5740471A (en)	1982-03-06
CA1160226A (en)	1984-01-10
DE3174554D1 (en)	1986-06-12
AU7300381A (en)	1982-01-21
ES513177A0 (es)	1983-07-01
US4636509A (en)	1987-01-13
NZ197714A (en)	1984-11-09
DK315281A (da)	1982-01-16
ES8307758A1 (es)	1983-07-01
ATE19627T1 (de)	1986-05-15

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DE122009000040I2 (de)	2011-01-13	Naphthalin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen.
DK92781A (da)	1981-08-30	Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
DE3174554D1 (en)	1986-06-12	Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, and pharmaceutical compositions containing them
HUT45230A (en)	1988-06-28	Process for producing new phenoxy-acetic acid derivatives and pharmaceuticals comprising such compounds
ES2000456A6 (es)	1988-03-01	Procedimiento para preparar deirvados de acido eicosatriinoico-5,8,11 y utilizacion de estos en composiciones farmaceuticas y cosmeticas.
AU558261B2 (en)	1987-01-22	Dialkylaminoalkyoxybenzylalcohol derivatives
ZA8164B (en)	1982-03-31	5-halo-pyrimid-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
PT76614A (de)	1983-05-01	Thiomethylpyridin-derivate verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3167186D1 (en)	1984-12-20	Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
ATE95180T1 (de)	1993-10-15	Berbanderivate und ihre herstellung und pharmazeutische zubereitung.
ATE28632T1 (de)	1987-08-15	Piperidin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES474694A1 (es)	1979-03-16	Un procedimiento de preparacion de nuevos derivados de las 5h-benzociclohepten-7-amina
ATE36154T1 (de)	1988-08-15	4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES8206435A1 (es)	1982-08-16	Procedimiento para la obtencion de un nuevo compuesto deri- vado del acido p-clorofenoxiacetico
JPH04128220A (ja)	1992-04-28	抗ヘルペスウイルス剤