ZA826660B - Substituted pyrimid-2-ones,the salts thereof,processes for their preparation and pharmaceutical compositions containing them - Google Patents

Substituted pyrimid-2-ones,the salts thereof,processes for their preparation and pharmaceutical compositions containing them

Info

Publication number: ZA826660B
Authority: ZA; South Africa
Prior art keywords: group; salts; ones; processes; preparation
Prior art date: 1981-09-11

Application number

ZA826660A

Other languages

English (en)

Inventor

Tore Benneche

Mikkel Josef Gacek

Kjell Undheim

Original Assignee

Nyegaard & Co As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-09-11

Filing date

1982-09-10

Publication date

1983-08-31

1982-09-10 Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As

1983-08-31 Publication of ZA826660B publication Critical patent/ZA826660B/xx

Links

150000003839 salts Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000001931 aliphatic group Chemical group 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
KUAWDIFZEBBSPW-UHFFFAOYSA-N 5-(trifluoromethyl)-1h-pyrimidin-2-one Chemical compound OC1=NC=C(C(F)(F)F)C=N1 KUAWDIFZEBBSPW-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000002015 acyclic group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
-1 hydroxy, mercapto Chemical class 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Saccharide Compounds (AREA)

ZA826660A 1981-09-11 1982-09-10 Substituted pyrimid-2-ones,the salts thereof,processes for their preparation and pharmaceutical compositions containing them ZA826660B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8127505		1981-09-11

Publications (1)

Publication Number	Publication Date
ZA826660B true ZA826660B (en)	1983-08-31

Family

ID=10524445

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA826660A ZA826660B (en)	1981-09-11	1982-09-10	Substituted pyrimid-2-ones,the salts thereof,processes for their preparation and pharmaceutical compositions containing them

Country Status (11)

Country	Link
US (1)	US4478839A (de)
EP (1)	EP0074820B1 (de)
JP (1)	JPS5857368A (de)
AT (1)	ATE21693T1 (de)
AU (1)	AU8818882A (de)
DE (1)	DE3272892D1 (de)
DK (1)	DK404982A (de)
ES (1)	ES8308860A1 (de)
NO (1)	NO823075L (de)
NZ (1)	NZ201883A (de)
ZA (1)	ZA826660B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0087326B1 (de) *	1982-02-24	1987-05-13	Nycomed As	Substituierte Pyrimidin-2-one und deren Salze
JPH0613535B2 (ja) *	1984-09-10	1994-02-23	株式会社三和化学研究所	新規な有機珪素化合物、その製法並びに該化合物を有効成分とする抗腫瘍剤
US4675321A (en) *	1986-02-07	1987-06-23	Merck & Co., Inc.	Substituted pyrimidines useful as calcium channel blockers
JP2873340B2 (ja) *	1988-04-29	1999-03-24	武田薬品工業株式会社	抗生物質ｔａｎ―１０５７，その製造法および用途
US8679231B2 (en)	2011-01-19	2014-03-25	Advanced Technology Materials, Inc.	PVDF pyrolyzate adsorbent and gas storage and dispensing system utilizing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1561290A (en) *	1975-10-16	1980-02-20	Nyegaard & Co As	Pyrimid - 2 - ones
US4052400A (en) *	1976-10-29	1977-10-04	Morton-Norwich Products, Inc.	Hypertensive 1-substituted 2(1h)-pyrimidones

1982
- 1982-09-10 AT AT82304780T patent/ATE21693T1/de active
- 1982-09-10 DK DK404982A patent/DK404982A/da not_active Application Discontinuation
- 1982-09-10 NO NO823075A patent/NO823075L/no unknown
- 1982-09-10 NZ NZ201883A patent/NZ201883A/en unknown
- 1982-09-10 ES ES515640A patent/ES8308860A1/es not_active Expired
- 1982-09-10 US US06/416,670 patent/US4478839A/en not_active Expired - Fee Related
- 1982-09-10 DE DE8282304780T patent/DE3272892D1/de not_active Expired
- 1982-09-10 ZA ZA826660A patent/ZA826660B/xx unknown
- 1982-09-10 JP JP57156882A patent/JPS5857368A/ja active Pending
- 1982-09-10 AU AU88188/82A patent/AU8818882A/en not_active Abandoned
- 1982-09-10 EP EP82304780A patent/EP0074820B1/de not_active Expired

Also Published As

Publication number	Publication date
DK404982A (da)	1983-03-12
ES515640A0 (es)	1983-10-01
ATE21693T1 (de)	1986-09-15
ES8308860A1 (es)	1983-10-01
US4478839A (en)	1984-10-23
JPS5857368A (ja)	1983-04-05
AU8818882A (en)	1983-03-17
EP0074820B1 (de)	1986-08-27
EP0074820A1 (de)	1983-03-23
NZ201883A (en)	1985-11-08
DE3272892D1 (en)	1986-10-02
NO823075L (no)	1983-03-14

Publication	Publication Date	Title
DE3173080D1 (en)	1986-01-16	Pyrimidine-2-sulphides and their s-oxides for use in medicine, pharmaceutical compositions containing them, processes for their preparation and such compounds when novel per se
ATE9793T1 (de)	1984-10-15	5-oxo- und 5-thioxoproline, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DK114783A (da)	1983-09-11	Hidtil ukendte forbindelser, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK159148C (da)	1991-02-11	Analogifremgangsmaade til fremstilling af tranexamsyrederivater
IL69292A0 (en)	1983-11-30	Muramyl peptides,their manufacture and pharmaceutical compositions containing them
ZA818934B (en)	1983-09-28	Trisubstituted pyrimido pyrimidines,processes for their preparation,and pharmaceutical compositions thereof
DE3170937D1 (en)	1985-07-18	2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
ES453161A1 (es)	1977-11-01	Un procedimiento de preparacion de espiro (1,3-dioxolan-4,3)quinuclidinas.
DE3272892D1 (en)	1986-10-02	Substituted pyrimid-2-ones, the salts thereof, processes for their preparation and pharmaceutical compositions containing them
ATE20588T1 (de)	1986-07-15	Heterozyklische verbindungen geeignet als pestizide und verfahren zu ihrer herstellung.
ES8801637A1 (es)	1988-02-16	Un procedimiento para la preparacion de benzimidazoles.
ES483247A1 (es)	1980-04-16	Procedimiento para la obtencion de nuevos diazacicloalquenostiosustituidos
ATE25523T1 (de)	1987-03-15	Bicyclische phenolether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel.
ATE19879T1 (de)	1986-06-15	Furyloxazolylessigsaeure-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ES481603A1 (es)	1980-06-16	Un procedimiento para la preparacion de un derivado de la hidantoina.
ES8104242A1 (es)	1981-04-16	Un procedimiento para la preparacion de nuevos derivados de hidantoina.
ES8201986A1 (es)	1982-01-16	Un procedimiento para la preparacion de derivados de 1,2,4- triazolidin-3,5-diona