ZA832400B - Stabilization of unstable drugs or food supplements - Google Patents

Stabilization of unstable drugs or food supplements

Info

Publication number: ZA832400B
Authority: ZA; South Africa
Prior art keywords: stabilization; food supplements; drugs; unstable drugs; hydroxide
Prior art date: 1982-04-05

Application number

ZA832400A

Other languages

English (en)

Inventor

Richard J Yarwood

Howard C Maxfield

Anthony J Phillips

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-05

Filing date

1983-04-05

Publication date

1984-11-28

1983-04-05 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

1984-11-28 Publication of ZA832400B publication Critical patent/ZA832400B/xx

Links

229940079593 drug Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 3
235000015872 dietary supplement Nutrition 0.000 title abstract 2
230000006641 stabilisation Effects 0.000 title abstract 2
238000011105 stabilization Methods 0.000 title abstract 2
-1 e.g. Substances 0.000 abstract 2
239000005660 Abamectin Substances 0.000 abstract 1
HMSYAPGFKGSXAJ-PAHGNTJYSA-N Mocimycin Chemical compound C(/[C@H]1O[C@H]([C@H]([C@H]1O)O)[C@H](C)[C@H](OC)C(/C)=C/C=C/CNC(=O)[C@@H](CC)[C@]1(O)[C@@H]([C@H](O)C(C)(C)[C@H](\C=C\C=C/C)O1)O)=C\C=C\C=C(/C)C(=O)C1=C(O)NC=CC1=O HMSYAPGFKGSXAJ-PAHGNTJYSA-N 0.000 abstract 1
229920000615 alginic acid Polymers 0.000 abstract 1
239000000783 alginic acid Substances 0.000 abstract 1
229960001126 alginic acid Drugs 0.000 abstract 1
235000010443 alginic acid Nutrition 0.000 abstract 1
150000004781 alginic acids Chemical class 0.000 abstract 1
ASOJLQIBBYOFDE-HCHBIZCOSA-N chembl2106443 Chemical compound C(/[C@H]1O[C@H]([C@H]([C@H]1O)O)[C@H](C)[C@H](OC)C(/C)=C/C=C/CNC(=O)[C@@H](CC)[C@]1(O)[C@@H]([C@H](O[C@H]2[C@@H]([C@H](OC)[C@H](O[C@H]3[C@@H]([C@H](O)[C@@H](OC)[C@H](C)O3)OC)[C@@H](C)O2)O)C(C)(C)[C@H](\C=C\C=C\C)O1)O)=C\C=C\C=C(/C)C(=O)C1=C(O)C=CN(C)C1=O ASOJLQIBBYOFDE-HCHBIZCOSA-N 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
229950003445 efrotomycin Drugs 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000003349 gelling agent Substances 0.000 abstract 1
239000008187 granular material Substances 0.000 abstract 1
238000005469 granulation Methods 0.000 abstract 1
230000003179 granulation Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
150000002680 magnesium Chemical class 0.000 abstract 1
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 abstract 1
229910001862 magnesium hydroxide Inorganic materials 0.000 abstract 1
239000000347 magnesium hydroxide Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 abstract 1
ZLBGSRMUSVULIE-GSMJGMFJSA-N milbemycin A3 Chemical class O1[C@H](C)[C@@H](C)CC[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 ZLBGSRMUSVULIE-GSMJGMFJSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229950008095 mocimycin Drugs 0.000 abstract 1
HMSYAPGFKGSXAJ-KNHRXMRASA-N mocimycin Natural products C([C@H]1O[C@H]([C@H]([C@H]1O)O)[C@H](C)[C@H](OC)C(C)=CC=CCNC(=O)[C@@H](CC)[C@]1(O)[C@@H]([C@H](O)C(C)(C)[C@H](C=CC=CC)O1)O)=CC=CC=C(C)C(=O)C1=C(O)NC=CC1=O HMSYAPGFKGSXAJ-KNHRXMRASA-N 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
150000004804 polysaccharides Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Animal Husbandry (AREA)
Zoology (AREA)
Food Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Fodder In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA832400A 1982-04-05 1983-04-05 Stabilization of unstable drugs or food supplements ZA832400B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US36541882A	1982-04-05	1982-04-05

Publications (1)

Publication Number	Publication Date
ZA832400B true ZA832400B (en)	1984-11-28

Family

ID=23438838

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA832400A ZA832400B (en)	1982-04-05	1983-04-05	Stabilization of unstable drugs or food supplements

Country Status (16)

Country	Link
EP (1)	EP0091767B1 (mo)
JP (1)	JPS58190357A (mo)
KR (1)	KR910000743B1 (mo)
AT (1)	ATE50492T1 (mo)
AU (1)	AU555304B2 (mo)
CA (1)	CA1213217A (mo)
DE (1)	DE3381235D1 (mo)
DK (1)	DK163343C (mo)
ES (1)	ES521194A0 (mo)
GR (1)	GR78150B (mo)
HK (1)	HK25091A (mo)
IE (1)	IE56276B1 (mo)
IL (1)	IL68282A0 (mo)
NZ (1)	NZ203684A (mo)
PT (1)	PT76448B (mo)
ZA (1)	ZA832400B (mo)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2575008B2 (ja) *	1986-03-31	1997-01-22	日本農薬株式会社	動物用医薬品組成物
US5152995A (en) *	1986-12-18	1992-10-06	Syntex (U.S.A.) Inc.	Stable antibiotic ester feed compositions
IE59883B1 (en) *	1986-12-18	1994-04-20	Syntex Inc	Stable antibiotic ester feed compositions
SI8710674B (sl) *	1987-04-14	1998-06-30	Pliva	Postopek za pripravo 10,11,12,13-tetrahidro derivatov tilozina
JPH02124894A (ja) *	1988-11-01	1990-05-14	Sanwa Kagaku Kenkyusho Co Ltd	フィチン酸安定化組成物
JPH06511237A (ja) *	1991-07-24	1994-12-15	コ、トーマス　サイ　イーング	治療用組成物およびその製造方法
MX9308001A (es) *	1992-12-21	1994-08-31	Lilly Co Eli	Premezcla para piensos de animales que contiene tilosina y procedimiento para su obtencion.
GB9306106D0 (en) *	1993-03-24	1993-05-12	Norbrook Lab Ltd	Sustained release veterinary composition
FI980902A7 (fi) *	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaanin stabiileja koostumuksia
FI980901A7 (fi)	1998-04-23	1999-10-24	Orion Yhtymae Oyj	Levosimendaania säädellysti vapauttavia oraalisia koostumuksia
DE10056345A1 (de)	2000-11-14	2002-05-29	Rettenmaier & Soehne Gmbh & Co	Futtermittel
GB0230034D0 (en) *	2002-12-23	2003-01-29	Biochemie Gmbh	Organic compounds
US7671034B2 (en) *	2003-12-19	2010-03-02	Merial Limited	Stabilized formulation of ivermectin feed premix with an extended shelf life

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3150042A (en) *	1963-03-15	1964-09-22	Upjohn Co	Treating coccidiosis with lincomycin
US3627885A (en) *	1968-07-18	1971-12-14	Rit Rech Ind Therapeut	Stabilized antibiotic compositions for animal feeding
JPS4856577A (mo) *	1971-11-22	1973-08-08
US4042685A (en) *	1974-05-15	1977-08-16	Walton John Smith	Milk of magnesia
US4048268A (en) *	1975-02-19	1977-09-13	Eli Lilly And Company	Stabilization method
US4087556A (en) *	1976-12-22	1978-05-02	Chemische Industrie Randstad, N.V.	Folic acid animal feed materials and processes
JPS58175449A (ja) *	1982-04-02	1983-10-14	Nippon Soda Co Ltd	反すう動物用飼料添加組成物

1983
- 1983-03-24 NZ NZ203684A patent/NZ203684A/en unknown
- 1983-03-24 PT PT76448A patent/PT76448B/pt not_active IP Right Cessation
- 1983-03-24 AU AU12764/83A patent/AU555304B2/en not_active Ceased
- 1983-03-30 DK DK146283A patent/DK163343C/da not_active IP Right Cessation
- 1983-03-30 ES ES521194A patent/ES521194A0/es active Granted
- 1983-03-30 CA CA000424955A patent/CA1213217A/en not_active Expired
- 1983-03-31 IE IE737/83A patent/IE56276B1/en not_active IP Right Cessation
- 1983-04-01 IL IL68282A patent/IL68282A0/xx not_active IP Right Cessation
- 1983-04-04 KR KR1019830001398A patent/KR910000743B1/ko not_active Expired
- 1983-04-04 GR GR70975A patent/GR78150B/el unknown
- 1983-04-05 AT AT83301890T patent/ATE50492T1/de not_active IP Right Cessation
- 1983-04-05 ZA ZA832400A patent/ZA832400B/xx unknown
- 1983-04-05 EP EP83301890A patent/EP0091767B1/en not_active Expired - Lifetime
- 1983-04-05 JP JP58058831A patent/JPS58190357A/ja active Granted
- 1983-04-05 DE DE8383301890T patent/DE3381235D1/de not_active Expired - Lifetime
1991
- 1991-04-04 HK HK250/91A patent/HK25091A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK163343B (da)	1992-02-24
NZ203684A (en)	1986-06-11
KR910000743B1 (ko)	1991-02-06
AU1276483A (en)	1983-10-13
HK25091A (en)	1991-04-12
ES8501231A1 (es)	1984-12-01
DK163343C (da)	1992-07-20
IE830737L (en)	1983-10-05
IE56276B1 (en)	1991-06-05
EP0091767A2 (en)	1983-10-19
ATE50492T1 (de)	1990-03-15
GR78150B (mo)	1984-09-26
EP0091767A3 (en)	1986-01-15
IL68282A0 (en)	1983-07-31
KR840004347A (ko)	1984-10-15
DE3381235D1 (de)	1990-04-05
ES521194A0 (es)	1984-12-01
DK146283A (da)	1983-10-06
PT76448B (en)	1986-03-20
CA1213217A (en)	1986-10-28
JPS58190357A (ja)	1983-11-07
AU555304B2 (en)	1986-09-18
EP0091767B1 (en)	1990-02-28
DK146283D0 (da)	1983-03-30
JPH0427816B2 (mo)	1992-05-12
PT76448A (en)	1983-04-01

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