ZA835963B - Molecular cloning and characterization of a gene sequence coding for human relaxin - Google Patents

Molecular cloning and characterization of a gene sequence coding for human relaxin

Info

Publication number: ZA835963B
Authority: ZA; South Africa
Prior art keywords: characterization; molecular cloning; human relaxin; gene sequence; sequence coding
Prior art date: 1982-08-12

Application number

ZA835963A

Other languages

English (en)

Inventor

Peter John Hudson

John Shine

Hugh David Niall

Geoffrey William Tregear

Original Assignee

Florey Howard Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-12

Filing date

1983-08-12

Publication date

1984-04-25

1983-08-12 Application filed by Florey Howard Inst filed Critical Florey Howard Inst

1984-04-25 Publication of ZA835963B publication Critical patent/ZA835963B/xx

Links

BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title abstract 2
238000012512 characterization method Methods 0.000 title 1
238000010369 molecular cloning Methods 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

ZA835963A 1982-08-12 1983-08-12 Molecular cloning and characterization of a gene sequence coding for human relaxin ZA835963B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPF535282		1982-08-12

Publications (1)

Publication Number	Publication Date
ZA835963B true ZA835963B (en)	1984-04-25

Family

ID=3769689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA835963A ZA835963B (en)	1982-08-12	1983-08-12	Molecular cloning and characterization of a gene sequence coding for human relaxin

Country Status (14)

Country	Link
US (1)	US4871670A (fr)
EP (2)	EP0101309B1 (fr)
JP (3)	JP2537477B2 (fr)
KR (1)	KR930003515B1 (fr)
AT (1)	ATE78042T1 (fr)
CA (1)	CA1340542C (fr)
DE (1)	DE3382117D1 (fr)
DK (2)	DK171827B1 (fr)
ES (5)	ES8603579A1 (fr)
HU (1)	HU197350B (fr)
IE (1)	IE58682B1 (fr)
IL (1)	IL69469A (fr)
NZ (1)	NZ205241A (fr)
ZA (1)	ZA835963B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320953A (en) *	1982-08-12	1994-06-14	Howard Florey Institute Of Experimental Physiology And Medicine	Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
WO1989007945A1 (fr) *	1988-02-26	1989-09-08	Genentech, Inc.	Formulation de relaxine humaine
CA2051375C (fr) *	1989-05-04	2000-09-12	Dennis J. Henner	Procede et compositions pour l'isolement de la relaxine humaine
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
CA2165781C (fr) *	1993-06-21	2007-02-13	Tim Breece	Methode de preparation de relaxine
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
AU2002256359A1 (en) *	2001-04-24	2002-11-05	Epigenesis Pharmaceuticals, Inc.	Antisense and anti-inflammatory based compositions to treat respiratory disorders
CA2456753A1 (fr) *	2001-08-17	2003-02-27	The Board Of Trustees Of The Leland Stanford Junior University	Recepteurs de la relaxine chez les mammiferes
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
WO2005115435A2 (fr) *	2004-04-30	2005-12-08	Bas Medical, Inc.	Methodes et compositions de lutte contre les maladies de la croissance foetale par modulation de la relaxine
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US8389475B2 (en)	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
PE20140160A1 (es)	2010-08-17	2014-02-08	Ambrx Inc	Polipeptidos de relaxina modificados y sus usos
EP2652491B1 (fr)	2010-12-15	2017-11-29	Baxalta GmbH	Collection d'eluat avec gradient de conductivite
EP2630964A1 (fr)	2012-02-22	2013-08-28	Immundiagnostik AG	Procédé et médicament pour traiter des patients souffrant de prédiabète et diabètes de type 2
WO2015073727A1 (fr)	2013-11-13	2015-05-21	Aequus Biopharma, Inc.	Glycoprotéines modifiées et leurs utilisations
EP2946788A1 (fr)	2014-05-23	2015-11-25	Immundiagnostik AG	Procédé et composition pour le traitement de l'insuffisance cardiaque avec la fraction d'éjection préservée
CN115837014A (zh)	2016-05-18	2023-03-24	摩登纳特斯有限公司	编码松弛素的多核苷酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

1983
- 1983-08-11 EP EP83304662A patent/EP0101309B1/fr not_active Expired - Lifetime
- 1983-08-11 DK DK366483A patent/DK171827B1/da not_active IP Right Cessation
- 1983-08-11 ES ES524885A patent/ES8603579A1/es not_active Expired
- 1983-08-11 DE DE8383304662T patent/DE3382117D1/de not_active Expired - Lifetime
- 1983-08-11 IL IL69469A patent/IL69469A/xx not_active IP Right Cessation
- 1983-08-11 AT AT88104503T patent/ATE78042T1/de not_active IP Right Cessation
- 1983-08-11 EP EP88104503A patent/EP0287820B1/fr not_active Expired - Lifetime
- 1983-08-12 JP JP58146766A patent/JP2537477B2/ja not_active Expired - Lifetime
- 1983-08-12 IE IE190983A patent/IE58682B1/en not_active IP Right Cessation
- 1983-08-12 ZA ZA835963A patent/ZA835963B/xx unknown
- 1983-08-12 KR KR1019830003783A patent/KR930003515B1/ko not_active Expired - Lifetime
- 1983-08-12 HU HU832842A patent/HU197350B/hu unknown
- 1983-08-12 CA CA000434438A patent/CA1340542C/fr not_active Expired - Fee Related
- 1983-08-12 NZ NZ205241A patent/NZ205241A/xx unknown
1985
- 1985-03-01 ES ES540886A patent/ES8802160A1/es not_active Expired
1986
- 1986-01-16 ES ES550943A patent/ES8802394A1/es not_active Expired
- 1986-05-12 US US06/863,819 patent/US4871670A/en not_active Expired - Lifetime
1987
- 1987-04-15 ES ES557506A patent/ES8801671A1/es not_active Expired
- 1987-04-15 ES ES557505A patent/ES8801676A1/es not_active Expired
1992
- 1992-12-28 DK DK156592A patent/DK171683B1/da not_active IP Right Cessation
1993
- 1993-03-19 JP JP5060138A patent/JP2670001B2/ja not_active Expired - Lifetime
1995
- 1995-01-05 JP JP7000236A patent/JP2892596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0287820B1 (fr)	1992-07-08
HU197350B (en)	1989-03-28
NZ205241A (en)	1991-01-29
EP0101309B1 (fr)	1991-01-16
DK366483A (da)	1984-02-13
CA1340542C (fr)	1999-05-18
DK171683B1 (da)	1997-03-10
JP2892596B2 (ja)	1999-05-17
IL69469A (en)	1991-06-10
IL69469A0 (en)	1983-11-30
JPH07215998A (ja)	1995-08-15
ES524885A0 (es)	1985-12-16
EP0101309A2 (fr)	1984-02-22
JP2537477B2 (ja)	1996-09-25
JP2670001B2 (ja)	1997-10-29
ES557505A0 (es)	1988-02-16
DK171827B1 (da)	1997-06-23
EP0101309A3 (en)	1984-12-27
ES8801676A1 (es)	1988-02-16
ATE78042T1 (de)	1992-07-15
ES540886A0 (es)	1988-04-01
ES8603579A1 (es)	1985-12-16
JPS5985292A (ja)	1984-05-17
EP0287820A1 (fr)	1988-10-26
US4871670A (en)	1989-10-03
KR930003515B1 (ko)	1993-05-01
ES557506A0 (es)	1988-02-16
DE3382117D1 (de)	1991-02-21
KR840005739A (ko)	1984-11-16
ES8802160A1 (es)	1988-04-01
ES8801671A1 (es)	1988-02-16
IE831909L (en)	1984-02-12
IE58682B1 (en)	1993-11-03
DK366483D0 (da)	1983-08-11
ES8802394A1 (es)	1988-05-16
JPH0690780A (ja)	1994-04-05
ES550943A0 (es)	1988-05-16
DK156592D0 (da)	1992-12-28
DK156592A (da)	1992-12-28

Publication	Publication Date	Title
IL69469A0 (en)	1983-11-30	Molecular cloning and characterization of a gene sequence coding for human relaxin
EP0112149A3 (en)	1985-05-22	Molecular cloning and characterization of a further gene sequence coding for human relaxin
GB9823897D0 (en)	1998-12-30	Immunotherapeutic methods and molecules
DK0477971T3 (da)	1998-09-21	Humant CNP gen og precursorprotein
IL95223A (en)	1992-08-18	Dna sequence for production of serine protease inhibitors
NZ216316A (en)	1991-11-26	Hepta and octapeptides with thymic humoral activity
ZA899247B (en)	1990-09-26	Anticoagulant peptides
DE3380495D1 (en)	1989-10-05	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
EP0367641A3 (en)	1990-08-29	Lymphokines, dna sequences encoding these lymphokines and pharmaceutical compositions containing these lymphokines
ATE112290T1 (de)	1994-10-15	Peptiden von retinblastoma gen produkten und antikoerper dagegen.
EP0723016A3 (fr)	1997-08-20	Facteur d'activation des leukocytes
EP0288325A3 (en)	1989-04-26	Dna encoding isopenicillin n-synthetase from a.nidulans, its use and vectors encoding it.
ATE75255T1 (de)	1992-05-15	Peptid und dafuer kodierendes gen.
ES8700691A1 (es)	1986-10-16	Un metodo para sintetizar por adn recombinante un inhibidor de serin-proteasa con una unica cadena polipeptidica