ZA844640B - Hydroxy substituted peptide compounds - Google Patents

Hydroxy substituted peptide compounds

Info

Publication number: ZA844640B
Authority: ZA; South Africa
Prior art keywords: hydroxy substituted; peptide compounds; substituted peptide; useful; compounds
Prior art date: 1983-07-21

Application number

ZA844640A

Other languages

English (en)

Inventor

Eric Michael Gordon

Jollie Duaine Godfrey Jr

Sesha Iyer Natarajan

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-21

Filing date

1984-06-19

Publication date

1985-02-27

1984-06-19 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1985-02-27 Publication of ZA844640B publication Critical patent/ZA844640B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
230000000694 effects Effects 0.000 abstract 2
230000005764 inhibitory process Effects 0.000 abstract 2
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
102000003729 Neprilysin Human genes 0.000 abstract 1
108090000028 Neprilysin Proteins 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

ZA844640A 1983-07-21 1984-06-19 Hydroxy substituted peptide compounds ZA844640B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/515,729 US4514391A (en)	1983-07-21	1983-07-21	Hydroxy substituted peptide compounds

Publications (1)

Publication Number	Publication Date
ZA844640B true ZA844640B (en)	1985-02-27

Family

ID=24052507

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA844640A ZA844640B (en)	1983-07-21	1984-06-19	Hydroxy substituted peptide compounds

Country Status (8)

Country	Link
US (1)	US4514391A (de)
EP (1)	EP0132304B1 (de)
JP (1)	JPS6049000A (de)
AT (1)	ATE43848T1 (de)
AU (1)	AU563644B2 (de)
CA (1)	CA1258948A (de)
DE (1)	DE3478606D1 (de)
ZA (1)	ZA844640B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4766110A (en) *	1981-08-21	1988-08-23	Ryan James W	Novel complex amido and imido derivatives of carboxyalkyl peptides
AU1643283A (en) *	1982-07-19	1984-01-26	E.R. Squibb & Sons, Inc.	Substituted peptides
US4604402A (en) *	1984-03-30	1986-08-05	E. R. Squibb & Sons, Inc.	Hydroxy substituted ureido amino and imino acids
US4500518A (en) *	1984-04-19	1985-02-19	E. R. Squibb & Sons, Inc.	Amino thiol dipeptides
JPS61502818A (ja) *	1984-07-30	1986-12-04	シェリング・コ−ポレ−ション	シス、エンド−オクタヒドロシクロペンタ〔ｂ〕ピロ−ル−２−カルボキシレ−トの新規製造方法
US4749698A (en) *	1985-07-08	1988-06-07	Rorer Pharmaceutical Corporation	Antihypertensive derivatives
US4616088A (en) *	1984-10-29	1986-10-07	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitor
US4629724A (en) *	1984-12-03	1986-12-16	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitors
US4665193A (en) *	1984-12-14	1987-05-12	E. R. Squibb & Sons, Inc.	Amino acid ester renin inhibitors
FR2578544A1 (en) *	1985-03-11	1986-09-12	Usv Pharma Corp	Antihypertension spirocyclic compounds
US4749781A (en) *	1985-11-12	1988-06-07	E. R. Squibb & Sons, Inc.	Aminocarbonyl renin inhibitors
US4757050A (en) *	1985-12-23	1988-07-12	E. R. Squibb Sons, Inc.	Ureido renin inhibitors
ZA87563B (en) *	1986-02-03	1987-09-30	Squibb & Sons Inc	N-heterocyclic alcohol renin inhibitors
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
DE69009476T2 (de) *	1989-06-30	1994-12-22	Massachusetts Inst Technology	Hemmung des reaktionswegs für die n-ende-regel in lebenden zellen.
US5614522A (en) *	1990-11-19	1997-03-25	G.D. Searle & Co.	Retroviral protease inhibitors
US5583238A (en) *	1990-11-19	1996-12-10	G. D. Searle & Co.	Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5482947A (en) *	1990-11-19	1996-01-09	Talley; John J.	Retroviral protease inhibitors
US5475013A (en) *	1990-11-19	1995-12-12	Monsanto Company	Retroviral protease inhibitors
US5475027A (en) *	1990-11-19	1995-12-12	G.D. Searle & Co.	Retroviral protease inhibitors
US5648511A (en) *	1990-11-19	1997-07-15	G.D. Searle & Co.	Method for making intermediates useful in the synthesis of retroviral protease inhibitors
US5510487A (en) *	1990-11-19	1996-04-23	G.D. Searle & Co.	Retroviral protease inhibitors
EP1148050A1 (de) *	1992-05-21	2001-10-24	Monsanto Company	Retrovirale Proteaseinhibitoren
ES2123065T3 (es) *	1992-08-25	1999-01-01	Searle & Co	Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
DE69311810T2 (de) *	1992-08-25	1997-11-27	Monsanto Co	N-(alkanoylamino-2-hydroxypropyl)-sulfonamide verwendbar als retrovirale proteaseninhibitoren
US7141609B2 (en) *	1992-08-25	2006-11-28	G.D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5760076A (en) *	1992-08-25	1998-06-02	G.D Searle & Co.	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6022994A (en) *	1992-08-25	2000-02-08	G. D. Searle &. Co.	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5968942A (en)	1992-08-25	1999-10-19	G. D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
RU2146668C1 (ru) *	1992-08-25	2000-03-20	Джи Ди Сирл энд Компани	Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз
US6046190A (en) *	1992-08-25	2000-04-04	G.D. Searle & Co.	Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
US6743929B1 (en) *	1992-08-25	2004-06-01	G. D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5830897A (en) *	1992-08-27	1998-11-03	G. D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
EP0885880A3 (de) *	1992-10-30	1999-10-06	G.D. Searle & Co.	Sulfonylalkanoylaminohydroxyethylaminosulfamidsäuren verwendbar als retrovirale Proteasehemmer
US5578606A (en)	1992-10-30	1996-11-26	G. D. Searle & Co.	α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US5756498A (en) *	1992-10-30	1998-05-26	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US6337398B1 (en) *	1992-10-30	2002-01-08	G.D. Searle & Co.	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
ATE211462T1 (de)	1992-10-30	2002-01-15	Searle & Co	N-substituierte hydroxyethylaminosulfamidsäure- derivate verwendbar als inhibitoren retroviraler proteasen
US5514801A (en) *	1992-12-29	1996-05-07	Monsanto Company	Cyclic sulfone containing retroviral protease inhibitors
US5750648A (en) *	1993-08-20	1998-05-12	G.D. Searle & Co.	Retroviral protease inhibitors and combinations thereof
US5602119A (en) *	1993-10-29	1997-02-11	Vazquez; Michael L.	Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
US6133444A (en) *	1993-12-22	2000-10-17	Perseptive Biosystems, Inc.	Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
CA2210889C (en)	1995-01-20	2007-08-28	G.D. Searle & Co.	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5831117A (en) *	1995-01-20	1998-11-03	G. D. Searle & Co.	Method of preparing retroviral protease inhibitor intermediates
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6140505A (en)	1995-03-10	2000-10-31	G. D. Searle & Co.	Synthesis of benzo fused heterocyclic sulfonyl chlorides
US7339078B2 (en) *	1995-03-10	2008-03-04	G.D. Searle Llc	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) *	1995-03-10	2002-06-18	G. D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en)	1995-03-10	2005-03-01	G. D. Searle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5985870A (en) *	1995-03-10	1999-11-16	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (de)	1995-03-10	2002-03-20	G.D. Searle & Co.	Verbindungen der Struktur bis-Aminosäure-Hydroxyethylamino-Sulfonamid als Inhibitoren der retroviralen Protease
BR9607625A (pt)	1995-03-10	1999-06-15	Searle & Co	Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6169085B1 (en)	1995-03-10	2001-01-02	G. D. Searle & Company	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6667307B2 (en)	1997-12-19	2003-12-23	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en) *	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1095022A1 (de)	1998-07-08	2001-05-02	G.D. Searle & Co.	Inhibitoren von retoviraler protease
AU2321900A (en)	1999-01-28	2000-08-18	Ajinomoto Co., Inc.	Process for the preparation of alpha-aminoketones
WO2000053172A1 (en) *	1999-03-08	2000-09-14	Smithkline Beecham Corporation	Ccr-3 receptor antagonists
US20050064076A1 (en) *	2003-09-22	2005-03-24	Fmc Technologies, Inc.	Method of measuring volatile components of foods
UA96283C2 (uk)	2005-12-23	2011-10-25	Зіланд Фарма А/С	Модифіковані міметики лізину
EP2074087A2 (de)	2006-12-21	2009-07-01	Wyeth	Synthese von pyrrolidinverbindungen
CN110709096B (zh)	2017-05-05	2023-10-31	泽兰德制药公司	细胞间隙连接通讯调节剂及其在糖尿病性眼病治疗中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4105776A (en) *	1976-06-21	1978-08-08	E. R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4199512A (en) *	1976-05-10	1980-04-22	E. R. Squibb & Sons, Inc.	Compounds for alleviating hypertension
US4192878A (en) *	1976-12-03	1980-03-11	E. R. Squibb & Sons, Inc.	Derivatives of thiazolidinecarboxylic acids and related acids
US4129566A (en) *	1978-02-15	1978-12-12	E. R. Squibb & Sons, Inc.	Derivatives of dehydrocyclicimino acids
JPS5834474B2 (ja) *	1977-06-29	1983-07-27	ウェルファイド株式会社	チアゾリジン誘導体の製造法
US4154935A (en) *	1978-02-21	1979-05-15	E. R. Squibb & Sons, Inc.	Halogen substituted mercaptoacylamino acids
JPS584711B2 (ja) *	1978-08-02	1983-01-27	参天製薬株式会社	ピロリジン誘導体
US4316906A (en) *	1978-08-11	1982-02-23	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of substituted prolines
JPS5572169A (en) *	1978-11-27	1980-05-30	Tanabe Seiyaku Co Ltd	Isoquinoline derivative and its preparation
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4311697A (en) *	1978-12-22	1982-01-19	E. R. Squibb & Sons, Inc.	Derivatives of mercaptoacyl prolines and pipecolic acids
US4217359A (en) *	1979-01-15	1980-08-12	E. R. Squibb & Sons, Inc.	Carbamate derivatives of mercaptoacyl hydroxy prolines
GB2048863B (en) *	1979-05-16	1983-06-15	Morton Norwich Products Inc	Tetrahydroisoquinoline-3-carboxylic acids
US4234489A (en) *	1979-06-25	1980-11-18	E. R. Squibb & Sons, Inc.	Pyroglutamic acid derivatives and analogs
US4296113A (en) *	1980-01-14	1981-10-20	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of keto substituted proline and pipecolic acid
US4296033A (en) *	1980-07-23	1981-10-20	E. R. Squibb & Sons, Inc.	4-Azido-1-mercaptoacyl proline
US4316905A (en) *	1980-07-01	1982-02-23	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of various 4-substituted prolines
IE51409B1 (en) *	1980-07-24	1986-12-24	Ici Ltd	Amide derivatives
LU88621I2 (fr) *	1980-10-23	1995-09-01	Schering Corp	Sandopril
US4470973A (en) *	1982-07-19	1984-09-11	E. R. Squibb & Sons, Inc.	Substituted peptide compounds

1983
- 1983-07-21 US US06/515,729 patent/US4514391A/en not_active Expired - Fee Related
1984
- 1984-06-14 CA CA000456639A patent/CA1258948A/en not_active Expired
- 1984-06-19 ZA ZA844640A patent/ZA844640B/xx unknown
- 1984-06-21 AU AU29705/84A patent/AU563644B2/en not_active Ceased
- 1984-06-22 DE DE8484304227T patent/DE3478606D1/de not_active Expired
- 1984-06-22 AT AT84304227T patent/ATE43848T1/de not_active IP Right Cessation
- 1984-06-22 EP EP84304227A patent/EP0132304B1/de not_active Expired
- 1984-07-21 JP JP59151967A patent/JPS6049000A/ja active Pending

Also Published As

Publication number	Publication date
ATE43848T1 (de)	1989-06-15
US4514391A (en)	1985-04-30
AU563644B2 (en)	1987-07-16
AU2970584A (en)	1985-01-24
EP0132304B1 (de)	1989-06-07
EP0132304A2 (de)	1985-01-30
JPS6049000A (ja)	1985-03-16
EP0132304A3 (en)	1987-04-22
CA1258948A (en)	1989-08-29
DE3478606D1 (en)	1989-07-13

Publication	Publication Date	Title
DE3478606D1 (en)	1989-07-13	Hydroxy substituted peptide compounds
EP0099785A3 (en)	1984-09-05	Amino and substituted amino phosphinylalkanoyl compounds
DE3569368D1 (en)	1989-05-18	Angiotensin converting enzyme inhibitors and their production and use as pharmaceuticals
ES8801930A1 (es)	1988-03-16	Procedimiento para la preparacion de dipeptidos de n,n'-dialquilguanidino
JPS5718611A (en)	1982-01-30	Angiotensin converting enzyme inhibitor
GR80966B (en)	1985-03-15	Synthesis of fibrinolytic agents by yeast
DE3163812D1 (en)	1984-07-05	Angiotensin converting enzyme inhibitors
JPS5589230A (en)	1980-07-05	Angiotensin conversion enzyme inhibitor
ZA852199B (en)	1985-11-27	Amino thiol dipeptides
ZA853379B (en)	1985-12-24	Substituted 1-oxa-dethiachphalosporins as anti-inflammatory and antidegenerative agents
SE8304031D0 (sv)	1983-07-18	Substituerade peptidforeningar
ZA84670B (en)	1985-09-25	Thiorphan analogs as enkephalinase and angiotensin converting enzyme inhibitors
GB8526344D0 (en)	1985-11-27	Supervising functioning of i c engine
JPS5753447A (en)	1982-03-30	Tripeptide inhibitor to angiotensin converting enzyme
DE3161915D1 (en)	1984-02-23	Angiotensin converting enzyme inhibitors
GB8402124D0 (en)	1984-02-29	Prevention of corrosion of threaded fastenings
AU7409487A (en)	1987-12-17	Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors
SU1220180A1 (ru)	1996-04-10	Установка для массообмена
CA1270350C (en)	1990-06-12	AMINO THIO DIPEPTIDES
GB8528099D0 (en)	1985-12-18	Water spray suppression
ZA851426B (en)	1986-10-29	17 beta-n-monosubstituted carbamoyl-4-aza-5 alpha-androst-1-en-3-ones as 5 alpha reductase inhibitors
SU1051981A1 (ru)	1996-05-27	Способ защиты от коррозии ледоколов и судов ледового плавания
ZA843828B (en)	1984-12-24	Angiotensin-converting enzyme inhibitors
AU3334184A (en)	1985-03-28	Compounds being angiotensin converting enzyme inhibitors
ZA836068B (en)	1985-02-27	Angiotensin-converting enzyme inhibitors