ZA846504B - Polyoxypropylene-polyoxyethylene block polymer based adjuvants - Google Patents

Polyoxypropylene-polyoxyethylene block polymer based adjuvants

Info

Publication number: ZA846504B
Authority: ZA; South Africa
Prior art keywords: amount; volume; polyoxypropylene; block polymer; polyoxyethylene block
Prior art date: 1983-08-22

Application number

ZA846504A

Other languages

English (en)

Inventor

Anthony Clifford Allison

Noelene Elva Byars

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-22

Filing date

1984-08-21

Publication date

1986-03-26

1984-08-21 Application filed by Syntex Inc filed Critical Syntex Inc

1986-03-26 Publication of ZA846504B publication Critical patent/ZA846504B/xx

Links

229920003171 Poly (ethylene oxide) Polymers 0.000 title abstract 2
239000002671 adjuvant Substances 0.000 title abstract 2
229920000642 polymer Polymers 0.000 title abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 abstract 1
102000002068 Glycopeptides Human genes 0.000 abstract 1
108010015899 Glycopeptides Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
239000000427 antigen Substances 0.000 abstract 1
102000036639 antigens Human genes 0.000 abstract 1
108091007433 antigens Proteins 0.000 abstract 1
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 abstract 1
230000002434 immunopotentiative effect Effects 0.000 abstract 1
230000003308 immunostimulating effect Effects 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/5555—Muramyl dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
- Y10S516/02—Organic and inorganic agents containing, except water
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Mycology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Microbiology (AREA)
Dispersion Chemistry (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Polyethers (AREA)
Lubricants (AREA)

ZA846504A 1983-08-22 1984-08-21 Polyoxypropylene-polyoxyethylene block polymer based adjuvants ZA846504B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/525,190 US4606918A (en)	1983-08-22	1983-08-22	Polyoxypropylene-polyoxyethylene block polymer based adjuvants

Publications (1)

Publication Number	Publication Date
ZA846504B true ZA846504B (en)	1986-03-26

Family

ID=24092296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA846504A ZA846504B (en)	1983-08-22	1984-08-21	Polyoxypropylene-polyoxyethylene block polymer based adjuvants

Country Status (14)

Country	Link
US (1)	US4606918A (fr)
EP (1)	EP0135376B1 (fr)
JP (2)	JPH0617314B2 (fr)
AT (1)	ATE58062T1 (fr)
AU (1)	AU578907B2 (fr)
CA (1)	CA1236017A (fr)
DE (1)	DE3483553D1 (fr)
DK (1)	DK167173B1 (fr)
HK (1)	HK82392A (fr)
IE (1)	IE58035B1 (fr)
IL (1)	IL72740A (fr)
NZ (1)	NZ209293A (fr)
PH (1)	PH21112A (fr)
ZA (1)	ZA846504B (fr)

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FR2368282A1 (fr) *	1976-10-22	1978-05-19	Anvar	Adjuvant immunologique constitue par le p-amino-phenyl de n-acetyl-muramyl-l-alanyl-d-isoglutamine
FR2428050A1 (fr) *	1978-06-05	1980-01-04	Anvar	Oligomeres de composes du type muramyl-peptide et medicaments les contenant
JPS5543030A (en) *	1978-09-21	1980-03-26	Dai Ichi Seiyaku Co Ltd	Prophylactic and remedy for microbial infection disease
FR2449697A1 (fr) *	1979-02-20	1980-09-19	Anvar	Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) *	1979-02-21	1980-08-28	Takeda Chem Ind Ltd	Glucosamine derivative and its preparation
CA1185237A (fr) *	1979-02-28	1985-04-09	Yuichi Yamamura	Derives de 6 desoxyglucosamine-peptide; preparation et utilisation
US4384974A (en) *	1979-07-27	1983-05-24	Revlon, Inc.	Stable water-in-oil emulsions
FI803077A7 (fi) *	1979-10-12	1981-04-13	Ciba Geigy Ag	Foerfarande foer framstaellning av myramylpeptider
US4409209A (en) *	1979-10-12	1983-10-11	Ciba-Geigy Corporation	Novel phosphorylmuramyl peptides and processes for the manufacture thereof
US4406889A (en) *	1980-02-15	1983-09-27	Ciba-Geigy Corporation	Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
GR78246B (fr) *	1981-01-23	1984-09-26	Ciba Geigy Ag
US4397870A (en) *	1982-07-27	1983-08-09	The University Of Pennsylvania	Process for prolonging retention of emulsion particles in the bloodstream
US4606918A (en) *	1983-08-22	1986-08-19	Syntex (U.S.A.) Inc.	Polyoxypropylene-polyoxyethylene block polymer based adjuvants

1983
- 1983-08-22 US US06/525,190 patent/US4606918A/en not_active Expired - Lifetime
1984
- 1984-08-20 PH PH31121A patent/PH21112A/en unknown
- 1984-08-21 NZ NZ209293A patent/NZ209293A/xx unknown
- 1984-08-21 EP EP84305687A patent/EP0135376B1/fr not_active Expired - Lifetime
- 1984-08-21 IL IL72740A patent/IL72740A/xx not_active IP Right Cessation
- 1984-08-21 DK DK400684A patent/DK167173B1/da not_active IP Right Cessation
- 1984-08-21 ZA ZA846504A patent/ZA846504B/xx unknown
- 1984-08-21 DE DE8484305687T patent/DE3483553D1/de not_active Expired - Lifetime
- 1984-08-21 JP JP59174861A patent/JPH0617314B2/ja not_active Expired - Lifetime
- 1984-08-21 AU AU32251/84A patent/AU578907B2/en not_active Expired
- 1984-08-21 AT AT84305687T patent/ATE58062T1/de not_active IP Right Cessation
- 1984-08-21 IE IE214884A patent/IE58035B1/en not_active IP Right Cessation
- 1984-08-21 CA CA000461465A patent/CA1236017A/fr not_active Expired
1992
- 1992-10-22 HK HK823/92A patent/HK82392A/en not_active IP Right Cessation
1993
- 1993-08-17 JP JP5203231A patent/JP2557603B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE58062T1 (de)	1990-11-15
JPH0665097A (ja)	1994-03-08
US4606918A (en)	1986-08-19
DK400684A (da)	1985-02-23
CA1236017A (fr)	1988-05-03
EP0135376A2 (fr)	1985-03-27
JPS60105630A (ja)	1985-06-11
IE58035B1 (en)	1993-06-16
IL72740A (en)	1988-02-29
AU578907B2 (en)	1988-11-10
NZ209293A (en)	1988-10-28
HK82392A (en)	1992-10-30
AU3225184A (en)	1985-02-28
DK167173B1 (da)	1993-09-13
DK400684D0 (da)	1984-08-21
EP0135376B1 (fr)	1990-11-07
JPH0617314B2 (ja)	1994-03-09
JP2557603B2 (ja)	1996-11-27
IL72740A0 (en)	1984-11-30
IE842148L (en)	1985-02-22
EP0135376A3 (en)	1986-12-30
DE3483553D1 (de)	1990-12-13
PH21112A (en)	1987-07-16

Publication	Publication Date	Title
PH21112A (en)	1987-07-16	Polyoxypropylene-polyoxyethylene block polymer based adjuvants
DK1140165T3 (da)	2009-02-16	Fordbedrede adjuvanssammensætninger baseret på saponin og dermed tilhörende metoder
HU900653D0 (en)	1990-04-28	Process for preparing vaccines containing tocholes as adjuvants
SE8903777D0 (sv)	1989-11-10	Liposome/doxorubicin, komposition och foerfarande
GB2303855B (en)	1998-10-28	Helicobacter pylori antigenic protein preparation and immunoassays
ATE116993T1 (de)	1995-01-15	Saponin-hilfsmittel.
NL940017I1 (nl)	1994-10-17	Vaccin-preparaat
ES2092306T3 (es)	1996-11-16	Adyuvante para vacunas.
OA09800A (en)	1994-04-15	Vaccine compositions containing liposomes.
GB2189143B (en)	1990-07-25	Immunological adjuvants for polysaccharide vaccines
DE3473825D1 (en)	1988-10-13	Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained
ATE149091T1 (de)	1997-03-15	Einen tetra-polyol enthaltendes impfstoff- adjuvans
ES444983A1 (es)	1977-08-16	Procedimiento de preparacion de emulsiones estables de agua en aceite.
GB1546027A (en)	1979-05-16	Stabilised thymosin fraction and a method for the preparation of same
Thevenson et al.	1990	Epidemiological study of bovine leptospirosis in New-Caledonia.
EP0249502A3 (fr)	1989-03-15	Facteur immunosuppresseur soluble et cellules suppressives
Chappel et al.	1993	LEPTOSPIRES OF SEROVAR BRATISLAVA AS A POSSIBLE PATHOGEN IN AUSTRALIAN PIGS
Jongh-Leuvenink et al.	1986	Characterization of antibodies against lipopolysaccharide of R and S strains of E. coli and Salmonella by ELISA and immunoblotting.
IT8235971V0 (it)	1982-07-30	Dispositivo di aspirazione per uso rianimatorio, integrabile in particolare all'attrezzatura per immersione subacquea
RO100102B1 (ro)	1990-10-30	Vaccin pentru imunoprofilaxia specifica a hipodermozei si procedeu de preparare a acestuia
IT8005092U1 (it)	1982-06-18	Dispositivo per la formazione di neve finta per uso scenico o simili