ZA854832B - Potent thymopentin analogs - Google Patents

Potent thymopentin analogs

Info

Publication number: ZA854832B
Authority: ZA; South Africa
Prior art keywords: potent; thymopentin; analogs; thymopentin analogs; splenin
Prior art date: 1984-06-27

Application number

ZA854832A

Other languages

English (en)

Inventor

Gideon Goldstein

George Heavner

Daniel Kroon

Tapan Audhya

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-27

Filing date

1985-06-26

Publication date

1987-02-25

1985-06-26 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1987-02-25 Publication of ZA854832B publication Critical patent/ZA854832B/xx

Links

230000003389 potentiating effect Effects 0.000 title abstract 2
PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical class NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 title abstract 2
101710195641 Splenin Proteins 0.000 abstract 1
102400000160 Thymopentin Human genes 0.000 abstract 1
101800001703 Thymopentin Proteins 0.000 abstract 1
102400000159 Thymopoietin Human genes 0.000 abstract 1
MLKWIQODPVLVLN-SHVFRELUSA-N ac1q1oa8 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(C)C)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C1=CC=C(O)C=C1 MLKWIQODPVLVLN-SHVFRELUSA-N 0.000 abstract 1
230000007812 deficiency Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000000987 immune system Anatomy 0.000 abstract 1
230000004957 immunoregulator effect Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000002992 thymic effect Effects 0.000 abstract 1
229960004517 thymopentin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/66—Thymopoietins
- C07K14/662—Thymopoietins at least 1 amino acid in D-form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Control Of Eletrric Generators (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Control Of Charge By Means Of Generators (AREA)
Control Of Combustion (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA854832A 1984-06-27 1985-06-26 Potent thymopentin analogs ZA854832B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/625,344 US4629723A (en)	1984-06-27	1984-06-27	Potent thymopentin analogs

Publications (1)

Publication Number	Publication Date
ZA854832B true ZA854832B (en)	1987-02-25

Family

ID=24505633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA854832A ZA854832B (en)	1984-06-27	1985-06-26	Potent thymopentin analogs

Country Status (14)

Country	Link
US (2)	US4629723A (de)
EP (1)	EP0166612B1 (de)
JP (1)	JPH0689029B2 (de)
KR (1)	KR920006563B1 (de)
AT (1)	ATE81135T1 (de)
AU (1)	AU592309B2 (de)
CA (1)	CA1269499A (de)
DE (1)	DE3586697T2 (de)
DK (1)	DK171238B1 (de)
FI (1)	FI92325C (de)
IL (1)	IL75637A (de)
NO (1)	NO167924C (de)
NZ (1)	NZ212461A (de)
ZA (1)	ZA854832B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU602483B2 (en) *	1985-01-18	1990-10-18	Immunetech Pharmaceuticals	Immunoregulatory peptides
DE3619633A1 (de) *	1986-06-11	1987-12-17	Hoechst Ag	Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
HUT46044A (en) *	1986-11-21	1988-09-28	Richter Gedeon Vegyeszet	Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same
IT1216908B (it) *	1987-03-19	1990-03-14	Eniricerche Spa	Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
US5656601A (en) *	1987-06-19	1997-08-12	Berlin-Chemie Ag	Acylated splenopentins, methods for their synthesis and their use
HU199878B (en) *	1987-06-19	1990-03-28	Berlin Chemie Veb	Process for producing acylated splenopentynes and pharmaceutical compositions comprising such compounds as active ingredient
JPH01125328A (ja) *	1987-07-30	1989-05-17	Centro Natl De Biopreparados	髄膜炎菌ワクチン
WO1989009229A1 (en) *	1988-03-31	1989-10-05	Immunobiology Research Institute, Inc.	Treatment of hiv viremic patients with thymopentin
NZ229004A (en) *	1988-05-19	1993-09-27	Immunobiology Res Inst Inc	Tetrapeptides having t cell helper acitivity
US4943477A (en) *	1988-09-27	1990-07-24	Mitsubishi Rayon Co., Ltd.	Conductive sheet having electromagnetic interference shielding function
WO1990003180A1 (en) *	1988-09-30	1990-04-05	Immunobiology Research Institute, Inc.	Peptides having t cell suppressor activity
US5218089A (en) *	1988-12-23	1993-06-08	Sclavo S.P.A.	Retro-inverso analogues of thymopentin and the method for their synthesis
IT1227908B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche
US5036050A (en) *	1989-01-12	1991-07-30	Immunobiology Research Institute, Inc.	Compositions containing thymopentin for topical treatment of skin disorders
WO1992013546A1 (en) *	1991-02-04	1992-08-20	George Washington University	Mb-40 peptide that enhances the production of interleukin-1 and modulates age-associated immune response
US5492894A (en) *	1991-03-21	1996-02-20	The Procter & Gamble Company	Compositions for treating wrinkles comprising a peptide
US5215964A (en) *	1991-06-03	1993-06-01	Immunobiology Research Institute, Inc.	Peptides useful in regulating the immune and nervous systems
WO1994025482A1 (en) *	1993-04-23	1994-11-10	Evans Herbert J	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5952465A (en) *	1993-04-23	1999-09-14	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US6258550B1 (en)	1993-04-23	2001-07-10	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) *	1993-04-23	1999-07-27	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5965698A (en) *	1993-04-23	1999-10-12	Virginia Commonwealth University	Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US5639729A (en) *	1993-08-26	1997-06-17	Immunobiology Research Institute, Inc.	Tripeptides useful in immune and CNS therapy
US6084066A (en) *	1993-10-29	2000-07-04	Virginia Commonwealth University	Polypetides that include conformation-constraining groups which flank a protein-protein interaction site
FR2741076B1 (fr)	1995-11-15	1998-01-30	Rech De Pathologie Appliquee S	Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
CN101168560B (zh) *	2006-10-23	2012-09-05	江苏正大天晴药业股份有限公司	N-取代肽酰胺，其药物组合物与用途
CN116712571B (zh) *	2021-12-16	2024-01-30	江西中医药大学	一种新型环肽在制备肿瘤诊断和或治疗试剂中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4077949A (en) *	1973-12-28	1978-03-07	Sloan-Kettering Institute For Cancer Research	Polypeptide hormones of the thymus
US4002740A (en) *	1975-08-21	1977-01-11	Gideon Goldstein	Tridecapeptide compositions and methods
US4190646A (en) *	1975-11-11	1980-02-26	Sloan-Kettering Institute For Cancer Research	Polypeptide compositions and methods
SE446867B (sv) *	1977-11-15	1986-10-13	Sloan Kettering Inst Cancer	Sett att framstella en polypeptid med formaga att inducera differentiering av t-lymfocyter men inte av komplementreceptor (cr?72+) b-lymfocyter
US4261886A (en) *	1980-03-13	1981-04-14	Ortho Pharmaceutical Corporation	Peptides having thymopoietin-like activity
CA1157466A (en) *	1979-04-12	1983-11-22	Gideon Goldstein	Peptides having thymopoietin-like activity
ZA802170B (en) *	1979-04-12	1981-11-25	Ortho Pharma Corp	Peptides having thymopoietin-like activity
DE2938420A1 (de) *	1979-09-22	1981-04-09	Hoechst Ag, 6000 Frankfurt	Neue peptide und verfahren zu ihrer herstellung
US4309340A (en) *	1980-03-31	1982-01-05	American Home Products Corporation	Polypeptide compositions
US4361673A (en) *	1980-09-19	1982-11-30	American Home Products Corporation	Polypeptide compositions
US4305852A (en) *	1980-10-20	1981-12-15	American Home Products Corporation	Polypeptide compositions
US4505853A (en) *	1983-11-18	1985-03-19	Ortho Pharmaceutical Corporation	Enzyme-resistant immunomodulatory peptides
DE3421614A1 (de) *	1984-06-09	1985-12-12	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von pentapeptiden mit wirkung auf das immunsystem und zwischenprodukte dieses verfahrens

1984
- 1984-06-27 US US06/625,344 patent/US4629723A/en not_active Ceased
1985
- 1985-06-18 NZ NZ212461A patent/NZ212461A/xx unknown
- 1985-06-26 EP EP85304559A patent/EP0166612B1/de not_active Expired - Lifetime
- 1985-06-26 DE DE8585304559T patent/DE3586697T2/de not_active Expired - Lifetime
- 1985-06-26 NO NO852567A patent/NO167924C/no unknown
- 1985-06-26 AU AU44215/85A patent/AU592309B2/en not_active Expired
- 1985-06-26 ZA ZA854832A patent/ZA854832B/xx unknown
- 1985-06-26 CA CA000485260A patent/CA1269499A/en not_active Expired - Lifetime
- 1985-06-26 DK DK289285A patent/DK171238B1/da not_active IP Right Cessation
- 1985-06-26 FI FI852522A patent/FI92325C/fi not_active IP Right Cessation
- 1985-06-26 KR KR1019850004553A patent/KR920006563B1/ko not_active Expired
- 1985-06-26 AT AT85304559T patent/ATE81135T1/de not_active IP Right Cessation
- 1985-06-26 IL IL75637A patent/IL75637A/xx not_active IP Right Cessation
- 1985-06-27 JP JP60141464A patent/JPH0689029B2/ja not_active Expired - Lifetime
1990
- 1990-04-25 US US07/514,184 patent/USRE34165E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU592309B2 (en)	1990-01-11
DE3586697T2 (de)	1993-02-11
NZ212461A (en)	1988-10-28
US4629723A (en)	1986-12-16
JPS6118799A (ja)	1986-01-27
EP0166612B1 (de)	1992-09-30
KR860000314A (ko)	1986-01-28
IL75637A (en)	1990-02-09
DE3586697D1 (en)	1992-11-05
FI852522L (fi)	1985-12-28
FI92325C (fi)	1994-10-25
NO852567L (no)	1985-12-30
USRE34165E (en)	1993-01-19
KR920006563B1 (ko)	1992-08-08
EP0166612A3 (en)	1987-08-05
NO167924B (no)	1991-09-16
EP0166612A2 (de)	1986-01-02
CA1269499A (en)	1990-05-22
FI92325B (fi)	1994-07-15
DK289285D0 (da)	1985-06-26
JPH0689029B2 (ja)	1994-11-09
AU4421585A (en)	1986-01-02
DK289285A (da)	1985-12-28
FI852522A0 (fi)	1985-06-26
DK171238B1 (da)	1996-08-05
NO167924C (no)	1991-12-27
IL75637A0 (en)	1985-10-31
ATE81135T1 (de)	1992-10-15

Publication	Publication Date	Title
EP0166612A3 (en)	1987-08-05	Potent thymopentin analogs
EP0165033A3 (de)	1988-04-27	Verbindungen von Thymopentin-Type mit konformationäler Beschränkung
ES8607732A1 (es)	1986-06-01	Procedimiento para producir un preparado implantable de un peptido regulador, uno de sus analogos o una de sus sales fisiologicamente compatibles.
MY103189A (en)	1993-05-29	Nor-statine and nor-cyclostatine polypeptides
MY102046A (en)	1992-03-31	Compartmentalized transdermal delivery system.
EG18454A (en)	1994-10-30	Enzymatic membrane method for the synthesis and separation of peptides.
AU566133B2 (en)	1987-10-08	New polypeptide from thymus glands
MY128260A (en)	2007-01-31	Cyclopentane-and-pentene-b-amino acids
AU3539484A (en)	1986-05-01	Novel peptides which are active on the central nervous system and have an action on the cholinergic system
EP0219082A3 (en)	1988-03-16	Process for preparing halogen-magnesium alanate, and its use
IT8567535A1 (it)	1986-12-07	Procedimento per la preparazione di amminoidrossicefamcarbossilati.
EP0179412A3 (de)	1988-08-24	Antigen-Peptidverbindungen
FI855017A7 (fi)	1986-06-20	Menetelmä 26,26,26-trifluor-1 ,25 -dihydroksikolekalsiferolin valmistamiseksi.
ES8401320A1 (es)	1983-12-16	"un procedimiento para preparar composiciones farmaceuticas a base de sales de teofilina y aminoacidos basicos".
IL80300A0 (en)	1987-01-30	Mitogenic peptides
EP0202523A3 (en)	1987-10-07	Process for the preparation of 1,3-di(alkoxycarbonylamino) propane
HUT58415A (en)	1992-02-28	Apparatus for creating permanent deformation on the surface of leathers preferably upper leathers, amid dynamic circumstances
FI863109A7 (fi)	1988-01-31	Menetelmä monoterpeenien erottamiseksi.
SU1111454A1 (ru)	1996-03-27	Способ получения (4,6-дизамещенный пиримидинил-2)тиофанийбромидов
UA7130A1 (uk)	1995-06-30	Імуностимулюючий засіб "тімоген"
SU1216944A1 (ru)	1996-02-27	Способ получения 2,6-ди-трет-бутилфенола
BG41624A1 (en)	1987-07-15	System for regulating productivity of coal vapour generator
BG40657A3 (en)	1987-01-15	Method for preparing derivatives of a- 21978c cyclic peptides
PL265911A1 (en)	1988-12-08	System for series stabilizing of d.c. voltage
GB8610703D0 (en)	1986-06-04	Composition for immune system enhancement