ZA879166B - Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
ZA879166B
ZA879166B ZA879166A ZA879166A ZA879166B ZA 879166 B ZA879166 B ZA 879166B ZA 879166 A ZA879166 A ZA 879166A ZA 879166 A ZA879166 A ZA 879166A ZA 879166 B ZA879166 B ZA 879166B
Authority
ZA
South Africa
Prior art keywords
pyrrolobenzimidazoles
processes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
ZA879166A
Other languages
English (en)
Inventor
Friebe Walter-Gunar
Mertens Alfred
Strein Klaus
Boehm Erwin
Original Assignee
Boehringer Mannheim Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh. filed Critical Boehringer Mannheim Gmbh.
Publication of ZA879166B publication Critical patent/ZA879166B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA879166A 1986-12-11 1987-12-07 Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them ZA879166B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863642315 DE3642315A1 (de) 1986-12-11 1986-12-11 Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel

Publications (1)

Publication Number Publication Date
ZA879166B true ZA879166B (en) 1988-06-14

Family

ID=6315954

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879166A ZA879166B (en) 1986-12-11 1987-12-07 Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (13)

Country Link
US (1) US4863945A (fr)
EP (1) EP0271040A3 (fr)
JP (1) JPS63162692A (fr)
KR (1) KR880007536A (fr)
AU (1) AU8245087A (fr)
DD (1) DD267047A5 (fr)
DE (1) DE3642315A1 (fr)
DK (1) DK650187A (fr)
FI (1) FI875438A7 (fr)
HU (1) HU200339B (fr)
IL (1) IL84589A0 (fr)
PT (1) PT86331B (fr)
ZA (1) ZA879166B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5434163A (en) * 1993-05-14 1995-07-18 The Medical College Of Pennsylvania Treatment of Cryptococcus neoformans infection
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
EP1598353A1 (fr) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones et leur utilisation en tant qu'agents antiproliferatifs
US7285569B2 (en) 2004-09-24 2007-10-23 Hoff Hoffmann-La Roche Inc. Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) * 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
DE602006002887D1 (de) * 2005-04-14 2008-11-06 Hoffmann La Roche Tricyclische azolderivate, ihre herstellung und ihre verwendung als pharmazeutische mittel
KR20070113286A (ko) * 2005-04-14 2007-11-28 에프. 호프만-라 로슈 아게 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도
BRPI0619955A2 (pt) * 2005-12-15 2011-10-25 Hoffmann La Roche derivados tricìclicos da lactama, sua produção e seus usos como agentes farmacêuticos
JP2009530337A (ja) * 2006-03-23 2009-08-27 エフ．ホフマン−ラ ロシュ アーゲー 置換インダゾール誘導体、その製造方法、及びその薬剤としての利用法
WO2008063888A2 (fr) 2006-11-22 2008-05-29 Plexxikon, Inc. Composés modulant l'activité de c-fms et/ou de c-kit et utilisations associées
WO2009012283A1 (fr) 2007-07-17 2009-01-22 Plexxikon Inc. Composés et procédés pour la modulation des kinases et leurs indications
MY172424A (en) 2009-04-03 2019-11-25 Hoffmann La Roche Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CN106220623A (zh) 2009-11-06 2016-12-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR851085B (fr) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
DE3445669A1 (de) * 1984-12-14 1986-06-19 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
PT86331B (pt) 1990-11-07
JPS63162692A (ja) 1988-07-06
DK650187D0 (da) 1987-12-10
EP0271040A3 (fr) 1989-11-02
IL84589A0 (en) 1988-04-29
PT86331A (de) 1988-01-01
HU200339B (en) 1990-05-28
US4863945A (en) 1989-09-05
HUT47278A (en) 1989-02-28
DE3642315A1 (de) 1988-06-23
DD267047A5 (de) 1989-04-19
EP0271040A2 (fr) 1988-06-15
FI875438A0 (fi) 1987-12-10
FI875438A7 (fi) 1988-06-12
DK650187A (da) 1988-06-12
AU8245087A (en) 1988-06-16
KR880007536A (ko) 1988-08-27

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