ZA885535B - Dna constructs containing a kluyveromyces alpha-factor leader sequence for directing secretion of heterologous polypeptides - Google Patents

Dna constructs containing a kluyveromyces alpha-factor leader sequence for directing secretion of heterologous polypeptides

Info

Publication number
ZA885535B
ZA885535B ZA885535A ZA885535A ZA885535B ZA 885535 B ZA885535 B ZA 885535B ZA 885535 A ZA885535 A ZA 885535A ZA 885535 A ZA885535 A ZA 885535A ZA 885535 B ZA885535 B ZA 885535B
Authority
ZA
South Africa
Prior art keywords
factor leader
leader sequence
heterologous polypeptides
dna constructs
constructs containing
Prior art date
Application number
ZA885535A
Other languages
English (en)
Inventor
Anthony J Brake
J Brake Anthony
Johannes A Van Den Berg
A Van Den Berg Johannes
Original Assignee
Gist Brocades Nv
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv, Chiron Corp filed Critical Gist Brocades Nv
Publication of ZA885535B publication Critical patent/ZA885535B/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA885535A 1987-07-28 1988-07-28 Dna constructs containing a kluyveromyces alpha-factor leader sequence for directing secretion of heterologous polypeptides ZA885535B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/078,551 US5010182A (en) 1987-07-28 1987-07-28 DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides

Publications (1)

Publication Number Publication Date
ZA885535B true ZA885535B (en) 1989-04-26

Family

ID=22144759

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA885535A ZA885535B (en) 1987-07-28 1988-07-28 Dna constructs containing a kluyveromyces alpha-factor leader sequence for directing secretion of heterologous polypeptides

Country Status (19)

Country Link
US (1) US5010182A (de)
EP (1) EP0301669B1 (de)
JP (1) JP2680054B2 (de)
KR (1) KR970004940B1 (de)
CN (1) CN1045620C (de)
AT (1) ATE90727T1 (de)
AU (1) AU623860B2 (de)
CA (1) CA1327762C (de)
DE (1) DE3881776T2 (de)
DK (1) DK175365B1 (de)
ES (1) ES2058238T3 (de)
FI (1) FI101232B1 (de)
HU (1) HU213015B (de)
IE (1) IE62261B1 (de)
IL (1) IL87255A (de)
NO (1) NO180381C (de)
NZ (1) NZ225596A (de)
PT (1) PT88115B (de)
ZA (1) ZA885535B (de)

Families Citing this family (163)

* Cited by examiner, † Cited by third party
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EP0301669B1 (de) 1993-06-16
IL87255A0 (en) 1988-12-30
CN1045620C (zh) 1999-10-13
ES2058238T3 (es) 1994-11-01
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HUT47638A (en) 1989-03-28
CN1032367A (zh) 1989-04-12
DE3881776D1 (de) 1993-07-22
CA1327762C (en) 1994-03-15
IE882313L (en) 1989-01-28
FI883541L (fi) 1989-01-29
DK175365B1 (da) 2004-09-13
JPH01124390A (ja) 1989-05-17
JP2680054B2 (ja) 1997-11-19
DK422288A (da) 1989-01-29
PT88115B (pt) 1995-03-01
HU213015B (en) 1997-01-28
ATE90727T1 (de) 1993-07-15
PT88115A (pt) 1989-06-30
FI101232B (fi) 1998-05-15
NO883346D0 (no) 1988-07-28
US5010182A (en) 1991-04-23
IL87255A (en) 1993-04-04
AU2013688A (en) 1989-02-02
DK422288D0 (da) 1988-07-28
NZ225596A (en) 1991-04-26
NO883346L (no) 1989-01-30
KR970004940B1 (ko) 1997-04-10
AU623860B2 (en) 1992-05-28
NO180381C (no) 1997-04-09
FI101232B1 (fi) 1998-05-15
NO180381B (no) 1996-12-30
EP0301669A1 (de) 1989-02-01
IE62261B1 (en) 1995-01-11
KR890002406A (ko) 1989-04-10
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