ZA888127B - Targeted forms of methyltrithio antitumor agents - Google Patents

Targeted forms of methyltrithio antitumor agents

Info

Publication number: ZA888127B
Authority: ZA; South Africa
Prior art keywords: antitumor agents; targeted forms; methyltrithio antitumor; methyltrithio; targeted
Prior art date: 1987-10-30

Application number

ZA888127A

Other languages

English (en)

Inventor

William James Mcgahren

James Mcgahren William

Martin Leon Sassiver

Leon Sassiver Martin

George A Ellestad

A Ellestad George

Philip R Hamann

R Hamann Philip

Lois M Hinman

M Hinman Lois

Janis Upeslacis

Upeslacis Janis

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-30

Filing date

1988-10-28

Publication date

1989-07-26

1988-10-28 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1989-07-26 Publication of ZA888127B publication Critical patent/ZA888127B/xx

Links

239000002246 antineoplastic agent Substances 0.000 title 1
-1 methyltrithio Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA888127A 1987-10-30 1988-10-28 Targeted forms of methyltrithio antitumor agents ZA888127B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11494087A	1987-10-30	1987-10-30

Publications (1)

Publication Number	Publication Date
ZA888127B true ZA888127B (en)	1989-07-26

Family

ID=22358378

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA888127A ZA888127B (en)	1987-10-30	1988-10-28	Targeted forms of methyltrithio antitumor agents
ZA888123A ZA888123B (en)	1987-10-30	1988-10-28	Disulfur analogs of ll-e33288 antitumor agents

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA888123A ZA888123B (en)	1987-10-30	1988-10-28	Disulfur analogs of ll-e33288 antitumor agents

Country Status (20)

Country	Link
EP (2)	EP0313873B1 (de)
JP (2)	JP2720933B2 (de)
KR (2)	KR970011385B1 (de)
AR (1)	AR246083A1 (de)
AT (2)	ATE112172T1 (de)
AU (2)	AU612714B2 (de)
BR (1)	BR1100939A (de)
CA (1)	CA1321582C (de)
DE (2)	DE3851682T2 (de)
DK (2)	DK174739B1 (de)
ES (2)	ES2061586T3 (de)
FI (2)	FI95204C (de)
HK (2)	HK131897A (de)
IE (2)	IE65053B1 (de)
IL (2)	IL87946A (de)
NO (2)	NO173506C (de)
NZ (2)	NZ226727A (de)
PT (2)	PT88882B (de)
PY (1)	PY0101654A (de)
ZA (2)	ZA888127B (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000032773A1 (en)	1998-11-27	2000-06-08	Darwin Discovery Ltd.	Compositions and methods for increasing bone mineralization
WO2005003158A2 (en)	2003-06-16	2005-01-13	Celltech R & D, Inc.	Compositions and methods for increasing bone mineralization
WO2005014650A2 (en)	2003-06-16	2005-02-17	Celltech R & D, Inc.	Antibodies specific for sclerostin and methods for increasing bone mineralization

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5079233A (en) *	1987-01-30	1992-01-07	American Cyanamid Company	N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) *	1987-10-30	1997-02-25	American Cyanamid Company	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL93733A (en) *	1989-04-14	1996-01-19	American Cyanamid Co	Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group and targeted forms thereof
GB9007384D0 (en) *	1990-04-02	1990-05-30	Duncan Ruth	Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5714586A (en) *	1995-06-07	1998-02-03	American Cyanamid Company	Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) *	1995-06-07	1998-01-27	American Cyanamid Company	Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
NZ511705A (en) *	2001-05-14	2004-03-26	Horticulture & Food Res Inst	Methods and rapid immunoassay device for detecting progesterone and other steroids
WO2008028050A2 (en) *	2006-08-30	2008-03-06	Wisconsin Alumni Research Foundation	Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) *	2008-07-16	2010-09-03	한주학	수직축형 부력풍차
CN108047287B (zh) *	2013-11-04	2021-04-27	辉瑞大药厂	用于合成加利车霉素衍生物的中间体和方法
WO2018138591A1 (en) *	2017-01-24	2018-08-02	Pfizer Inc.	Calicheamicin derivatives and antibody drug conjugates thereof
CA3129501A1 (en) *	2019-02-15	2020-08-20	University Of Southern California	Lym-1 and lym-2 antibody compositions and improved car constructs
JP7750853B2 (ja) *	2020-10-22	2025-10-07	富士フイルム株式会社	皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2430943A1 (fr) *	1978-07-13	1980-02-08	Toyo Jozo Kk	Nouveaux derives disulfures
EP0040506B1 (de) *	1980-05-21	1986-08-20	Teijin Limited	Reaktives Polymer und Verfahren zu seiner Herstellung
US4530835A (en) *	1983-07-08	1985-07-23	Warner-Lambert Company	CL-1577 Antibiotic compounds and their production
CA1314245C (en) *	1984-05-23	1993-03-09	Franz Jansen	Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
IL76878A (en) *	1984-11-16	1991-12-15	American Cyanamid Co	Antitumor antibiotic ll-33288alpha-br complex and process for its preparation
EP0330874A3 (de) *	1988-02-29	1989-10-18	American Cyanamid Company	Antibakterielle und Antitumor-Mittel LL-E33288 epsilon-I und LL-E33288-epsilon-Br, deren Herstellungen und Zwischenprodukte
EP0342341A3 (de) *	1988-05-17	1991-07-24	American Cyanamid Company	Verfahren zur Herstellung von Antitumor-Antibiotika LL-E33288 Gamma 2

1988
- 1988-10-03 AT AT88116338T patent/ATE112172T1/de not_active IP Right Cessation
- 1988-10-03 DE DE3851682T patent/DE3851682T2/de not_active Expired - Lifetime
- 1988-10-03 EP EP88116338A patent/EP0313873B1/de not_active Expired - Lifetime
- 1988-10-03 DE DE3889063T patent/DE3889063T2/de not_active Expired - Lifetime
- 1988-10-03 ES ES88116339T patent/ES2061586T3/es not_active Expired - Lifetime
- 1988-10-03 ES ES88116338T patent/ES2059464T3/es not_active Expired - Lifetime
- 1988-10-03 AT AT88116339T patent/ATE104309T1/de not_active IP Right Cessation
- 1988-10-03 EP EP88116339A patent/EP0313874B1/de not_active Expired - Lifetime
- 1988-10-06 IL IL8794688A patent/IL87946A/en active Protection Beyond IP Right Term
- 1988-10-06 IL IL8794788A patent/IL87947A/en active Protection Beyond IP Right Term
- 1988-10-26 NZ NZ226727A patent/NZ226727A/en unknown
- 1988-10-26 NZ NZ226726A patent/NZ226726A/xx unknown
- 1988-10-27 AR AR88312321A patent/AR246083A1/es active
- 1988-10-28 FI FI884984A patent/FI95204C/fi not_active IP Right Cessation
- 1988-10-28 AU AU24494/88A patent/AU612714B2/en not_active Expired
- 1988-10-28 ZA ZA888127A patent/ZA888127B/xx unknown
- 1988-10-28 ZA ZA888123A patent/ZA888123B/xx unknown
- 1988-10-28 NO NO884834A patent/NO173506C/no not_active IP Right Cessation
- 1988-10-28 DK DK198806025A patent/DK174739B1/da not_active IP Right Cessation
- 1988-10-28 IE IE326188A patent/IE65053B1/en not_active IP Right Cessation
- 1988-10-28 PT PT88882A patent/PT88882B/pt not_active IP Right Cessation
- 1988-10-28 FI FI884983A patent/FI91262C/fi not_active IP Right Cessation
- 1988-10-28 CA CA000581590A patent/CA1321582C/en not_active Expired - Lifetime
- 1988-10-28 DK DK602488A patent/DK602488A/da not_active Application Discontinuation
- 1988-10-28 NO NO884833A patent/NO176480C/no not_active IP Right Cessation
- 1988-10-28 IE IE326288A patent/IE65989B1/en not_active IP Right Cessation
- 1988-10-28 AU AU24489/88A patent/AU618763B2/en not_active Expired
- 1988-10-28 PT PT88881A patent/PT88881B/pt not_active IP Right Cessation
- 1988-10-29 JP JP63272006A patent/JP2720933B2/ja not_active Expired - Lifetime
- 1988-10-29 JP JP63272007A patent/JP2820256B2/ja not_active Expired - Lifetime
- 1988-10-30 KR KR1019880014245A patent/KR970011385B1/ko not_active Expired - Fee Related
- 1988-10-30 KR KR1019880014246A patent/KR0133130B1/ko not_active Expired - Fee Related
1997
- 1997-05-14 BR BR1100939-0A patent/BR1100939A/pt active IP Right Grant
- 1997-06-26 HK HK131897A patent/HK131897A/en not_active IP Right Cessation
- 1997-06-26 HK HK131997A patent/HK131997A/en not_active IP Right Cessation
2001
- 2001-01-26 PY PY200100101654A patent/PY0101654A/es unknown

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000032773A1 (en)	1998-11-27	2000-06-08	Darwin Discovery Ltd.	Compositions and methods for increasing bone mineralization
EP2261335A1 (de)	1998-11-27	2010-12-15	UCB Pharma S.A.	Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
WO2005003158A2 (en)	2003-06-16	2005-01-13	Celltech R & D, Inc.	Compositions and methods for increasing bone mineralization
WO2005014650A2 (en)	2003-06-16	2005-02-17	Celltech R & D, Inc.	Antibodies specific for sclerostin and methods for increasing bone mineralization
EP2338906A1 (de)	2003-06-16	2011-06-29	UCB Manufacturing, Inc.	Zusammensetzungen und Methoden zur Verstärkung der Knochenmineralisierung
EP2341071A1 (de)	2003-06-16	2011-07-06	UCB Manufacturing, Inc.	Zusammensetzungen und Methoden zur Verstärkung der Knochenmineralisierung

Also Published As

Publication number	Publication date
NO884833D0 (no)	1988-10-28
DK602488A (da)	1989-05-01
PT88881B (pt)	1993-01-29
DK602488D0 (da)	1988-10-28
ATE104309T1 (de)	1994-04-15
FI95204B (fi)	1995-09-29
JPH0296599A (ja)	1990-04-09
AU618763B2 (en)	1992-01-09
FI884984A7 (fi)	1989-05-01
EP0313874A2 (de)	1989-05-03
NZ226726A (en)	1991-08-27
NO884834D0 (no)	1988-10-28
DE3889063T2 (de)	1994-12-01
FI884984A0 (fi)	1988-10-28
DE3851682D1 (de)	1994-11-03
JPH01193282A (ja)	1989-08-03
PT88882B (pt)	1993-01-29
ZA888123B (en)	1989-07-26
HK131997A (en)	1997-10-03
FI91262C (fi)	1994-06-10
IE883261L (en)	1989-04-30
NO176480C (no)	1995-04-12
KR0133130B1 (ko)	1998-04-17
JP2820256B2 (ja)	1998-11-05
IE883262L (en)	1989-04-30
IE65989B1 (en)	1995-11-29
DE3889063D1 (de)	1994-05-19
FI95204C (fi)	1996-01-10
NZ226727A (en)	1991-12-23
NO176480B (no)	1995-01-02
IL87947A (en)	1995-05-26
FI884983A0 (fi)	1988-10-28
NO884833L (no)	1989-05-02
ATE112172T1 (de)	1994-10-15
NO173506C (no)	1993-12-22
FI884983L (fi)	1989-05-01
FI91262B (fi)	1994-02-28
EP0313874A3 (en)	1990-05-09
NO173506B (no)	1993-09-13
DK602588D0 (da)	1988-10-28
EP0313874B1 (de)	1994-04-13
IL87946A0 (en)	1989-03-31
DK602588A (da)	1989-05-01
EP0313873A1 (de)	1989-05-03
IL87946A (en)	1995-06-29
AU2448988A (en)	1989-05-04
AU2449488A (en)	1989-05-04
HK131897A (en)	1997-10-03
EP0313873B1 (de)	1994-09-28
KR970011385B1 (ko)	1997-07-10
NO884834L (no)	1989-05-02
DK174739B1 (da)	2003-10-13
IE65053B1 (en)	1995-10-04
ES2061586T3 (es)	1994-12-16
KR890006245A (ko)	1989-06-12
AR246083A1 (es)	1994-03-30
IL87947A0 (en)	1989-03-31
PY0101654A (es)	2002-08-01
KR890006244A (ko)	1989-06-12
CA1321582C (en)	1993-08-24
BR1100939A (pt)	1999-08-31
DE3851682T2 (de)	1995-05-04
AU612714B2 (en)	1991-07-18
JP2720933B2 (ja)	1998-03-04
ES2059464T3 (es)	1994-11-16

Publication	Publication Date	Title
JPS6471896A (en)	1989-03-16	Manufacture of alkyloligoglycoside
JPS6471895A (en)	1989-03-16	Manufacture of alkyloligoglycoside
ZA888127B (en)	1989-07-26	Targeted forms of methyltrithio antitumor agents
JPS6471897A (en)	1989-03-16	Manufacture of alkyloligoglycoside
GB8801560D0 (en)	1988-02-24	Antioxygen agents
GB8727737D0 (en)	1987-12-31	Antitumour agents
ZA886285B (en)	1989-04-26	Flame treatment
EP0310386A3 (en)	1989-11-15	Therapeutic agents
ZA894441B (en)	1990-02-28	Novel antiarrhymtic agents ii
GB8821380D0 (en)	1988-11-02	Antiviral agents
GB8704532D0 (en)	1987-04-01	Treatment of froth
JPS6450830A (en)	1989-02-27	Manufacture of polyfluorobutene
GB8801274D0 (en)	1988-02-17	Therapeutic agents
JPS6450842A (en)	1989-02-27	Manufacture of alkylpentenoate
GB8727792D0 (en)	1987-12-31	Therapeutic agents
YU146288A (en)	1990-10-31	Derivatives of benzimidazole-2-il-pyridinium
GB2217729B (en)	1991-10-23	Obtenation of scualane
DE3665260D1 (en)	1989-10-05	Antitumor agent
JPS6429333A (en)	1989-01-31	Manufacture of alpha-fluoroketones
JPS6468338A (en)	1989-03-14	Manufacture of bisphenol-bisacrylate
ZA902840B (en)	1991-12-24	Targeted forms of methyltrithio antitumor agents
PH27270A (en)	1993-05-04	Targeted forms of methyltrithio antitumor agents
IE901332L (en)	1990-10-14	Targeted forms of methylthio antitumor agents
GB8721343D0 (en)	1987-10-14	Therapeutic agents
GB8721342D0 (en)	1987-10-14	Therapeutic agents