ZA888250B - Human tissue-type plasminogen activator variant - Google Patents

Human tissue-type plasminogen activator variant

Info

Publication number
ZA888250B
ZA888250B ZA888250A ZA888250A ZA888250B ZA 888250 B ZA888250 B ZA 888250B ZA 888250 A ZA888250 A ZA 888250A ZA 888250 A ZA888250 A ZA 888250A ZA 888250 B ZA888250 B ZA 888250B
Authority
ZA
South Africa
Prior art keywords
plasminogen activator
human tissue
type plasminogen
activator variant
variant
Prior art date
Application number
ZA888250A
Other languages
English (en)
Inventor
Adair J Hotchkiss
J Hotchkiss Adair
John V O'connor
V O'connor John
Michael W Spellman
W Spellman Michael
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ZA888250B publication Critical patent/ZA888250B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA888250A 1987-11-06 1988-11-03 Human tissue-type plasminogen activator variant ZA888250B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11809887A 1987-11-06 1987-11-06

Publications (1)

Publication Number Publication Date
ZA888250B true ZA888250B (en) 1990-07-25

Family

ID=22376492

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA888250A ZA888250B (en) 1987-11-06 1988-11-03 Human tissue-type plasminogen activator variant

Country Status (18)

Country Link
EP (2) EP0754753A1 (da)
JP (1) JPH03500843A (da)
KR (1) KR920009521B1 (da)
AT (1) ATE151812T1 (da)
AU (2) AU2804989A (da)
CA (1) CA1341609C (da)
DD (1) DD286613A5 (da)
DE (1) DE3855874T2 (da)
DK (1) DK175482B1 (da)
FI (1) FI102970B (da)
HU (1) HU215230B (da)
IL (1) IL88247A0 (da)
NO (1) NO307612B1 (da)
NZ (1) NZ226829A (da)
PH (1) PH30064A (da)
PT (1) PT88938B (da)
WO (1) WO1989004368A1 (da)
ZA (1) ZA888250B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
DE69113049T2 (de) * 1990-07-31 1996-04-04 Genentech, Inc., South San Francisco, Calif. Varianten des gewebeplasminogenaktivators mit vermindertem abbau.
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
JP3559559B2 (ja) 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
DE69719265T2 (de) * 1996-09-06 2003-12-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
WO2025262265A1 (en) 2024-06-21 2025-12-26 Etablissement Francais Du Sang Chimeric molecules comprising an anti-fibrin antibody and an antithrombotic molecule

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
WO1987004722A1 (en) * 1986-01-31 1987-08-13 Genetics Institute, Inc. Novel thrombolytic proteins
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
EP0311589B1 (en) * 1987-10-09 1994-03-23 Monsanto Company Modified tissue plasminogen activator

Also Published As

Publication number Publication date
EP0387290B1 (en) 1997-04-16
IL88247A0 (en) 1989-06-30
DE3855874T2 (de) 1997-09-11
FI102970B1 (fi) 1999-03-31
PT88938A (pt) 1989-11-30
CA1341609C (en) 2011-02-01
DK112290D0 (da) 1990-05-04
AU2131792A (en) 1992-11-19
DD286613A5 (de) 1991-01-31
ATE151812T1 (de) 1997-05-15
EP0754753A1 (en) 1997-01-22
KR920009521B1 (ko) 1992-10-17
AU2804989A (en) 1989-06-01
DE3855874D1 (de) 1997-05-22
HUT54209A (en) 1991-01-28
AU658909B2 (en) 1995-05-04
DK175482B1 (da) 2004-11-08
EP0387290A1 (en) 1990-09-19
HU215230B (hu) 2000-03-28
JPH03500843A (ja) 1991-02-28
PT88938B (pt) 1993-05-31
FI902239A0 (fi) 1990-05-04
FI102970B (fi) 1999-03-31
KR890701733A (ko) 1989-12-21
NO901995L (no) 1990-07-05
DK112290A (da) 1990-07-06
HU890157D0 (en) 1990-12-28
PH30064A (en) 1996-11-08
NO901995D0 (no) 1990-05-04
WO1989004368A1 (en) 1989-05-18
NO307612B1 (no) 2000-05-02
NZ226829A (en) 1991-06-25

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