ZA889711B - A process for the preparation of antibodies by genetic engineering - Google Patents

A process for the preparation of antibodies by genetic engineering

Info

Publication number
ZA889711B
ZA889711B ZA889711A ZA889711A ZA889711B ZA 889711 B ZA889711 B ZA 889711B ZA 889711 A ZA889711 A ZA 889711A ZA 889711 A ZA889711 A ZA 889711A ZA 889711 B ZA889711 B ZA 889711B
Authority
ZA
South Africa
Prior art keywords
antibodies
preparation
genetic engineering
hapten
antigen
Prior art date
Application number
ZA889711A
Other languages
English (en)
Inventor
Andreas Plueckthun
Plueckthun Andreas
Arne Skerra
Skerra Arne
Original Assignee
Plueckthun Andreas
Skerra Arne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6343878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA889711(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plueckthun Andreas, Skerra Arne filed Critical Plueckthun Andreas
Publication of ZA889711B publication Critical patent/ZA889711B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
ZA889711A 1987-12-31 1988-12-29 A process for the preparation of antibodies by genetic engineering ZA889711B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873744595 DE3744595A1 (de) 1987-12-31 1987-12-31 Verfahren zur gentechnischen herstellung von antikoerpern

Publications (1)

Publication Number Publication Date
ZA889711B true ZA889711B (en) 1989-09-27

Family

ID=6343878

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA889711A ZA889711B (en) 1987-12-31 1988-12-29 A process for the preparation of antibodies by genetic engineering

Country Status (12)

Country Link
EP (1) EP0324162B1 (da)
JP (1) JP2771204B2 (da)
KR (1) KR970007861B1 (da)
AT (1) ATE102651T1 (da)
AU (1) AU628310B2 (da)
DE (2) DE3744595A1 (da)
DK (1) DK732988A (da)
ES (1) ES2063022T3 (da)
HU (1) HU212592B (da)
IE (1) IE62257B1 (da)
PT (1) PT89362B (da)
ZA (1) ZA889711B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5576195A (en) * 1985-11-01 1996-11-19 Xoma Corporation Vectors with pectate lyase signal sequence
GB9206318D0 (en) * 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
US7063943B1 (en) 1990-07-10 2006-06-20 Cambridge Antibody Technology Methods for producing members of specific binding pairs
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
SE9101433D0 (sv) * 1991-05-13 1991-05-13 Marianne Hansson Recombinant dna sequence and its use
US5858657A (en) * 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US5962255A (en) * 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US6492160B1 (en) 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5871907A (en) 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
EP0604580A1 (en) * 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JP2000505641A (ja) * 1991-12-18 2000-05-16 ザ ユニバーシティー オブ カルガリー 生物学的に活性なｆｖフラグメント生産用発現分泌ベクター
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US7368111B2 (en) 1995-10-06 2008-05-06 Cambridge Antibody Technology Limited Human antibodies specific for TGFβ2
GB9705376D0 (en) * 1997-03-14 1997-04-30 Harris William J Antibody fragment formulations and assay formats for detecting the presence an d concentration of analytes
US6492497B1 (en) 1999-04-30 2002-12-10 Cambridge Antibody Technology Limited Specific binding members for TGFbeta1
EP1908769A1 (en) * 2001-08-27 2008-04-09 Genentech, Inc. A system for antibody expression and assembly
EP1427744B1 (en) 2001-08-27 2007-12-26 Genentech, Inc. A system for antibody expression and assembly
JP5226697B2 (ja) * 2007-01-12 2013-07-03 ダウ グローバル テクノロジーズ エルエルシー 浸透圧によって細胞にショックを与えるための装置および方法
RU2677925C1 (ru) 2013-12-12 2019-01-22 Конинклейке Филипс Н.В. Способ обеспечения функционирования стандартных адаптеров электропитания, преобразующих переменный ток в постоянный ток, в сильных магнитных полях

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
EP0196864A3 (en) * 1985-03-25 1988-03-23 Cetus Corporation Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences
JPS62201581A (ja) * 1986-02-28 1987-09-05 Rikagaku Kenkyusho 新規プラスミド、微生物細胞及びヒト免疫グロブリンＧ　Ｆｃ領域蛋白質の製造方法
EP0234592A1 (en) * 1986-02-28 1987-09-02 Teijin Limited Plasmid containing DNA fragment coding for human immunoglobulin G Fc region protein and use thereof for production of said protein
EP0368926A4 (en) * 1987-07-16 1991-11-27 Codon Transfected cells containing plasmids having genes oriented in opposing directions and methods of obtaining the same
CA1341235C (en) * 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use

Also Published As

Publication number Publication date
AU628310B2 (en) 1992-09-17
HUT49169A (en) 1989-08-28
EP0324162B1 (de) 1994-03-09
IE62257B1 (en) 1995-01-11
EP0324162A1 (de) 1989-07-19
DK732988D0 (da) 1988-12-30
HU212592B (en) 1996-08-29
ES2063022T3 (es) 1995-01-01
JP2771204B2 (ja) 1998-07-02
KR970007861B1 (ko) 1997-05-17
DE3744595A1 (de) 1989-07-13
JPH02799A (ja) 1990-01-05
KR890010203A (ko) 1989-08-07
DK732988A (da) 1989-07-01
ATE102651T1 (de) 1994-03-15
PT89362A (pt) 1989-12-29
PT89362B (pt) 1993-08-31
DE3888337D1 (de) 1994-04-14
IE883893L (en) 1989-06-30
AU2761788A (en) 1989-07-06

Similar Documents

Publication Publication Date Title
AU2761788A (en) A process for the preparation of antibodies by genetic engineering
US4948874A (en) Purified protein G from streptococcal bacteria
EP0807683A3 (en) Endothelial cell-leukocyte adhesion molecules (elams) and molecules involved in leukocyte adhesion (milas)
IL87255A (en) Dna constructs containing a kluyveromycesalpha- factorleader sequence for directingsecretion of heterologouspolypeptides
WO1998027114A3 (en) Mammalian cell surface antigens; related reagents
AU4055697A (en) Mammalian cell surface antigens; related reagents
NO913186L (no) Fremgangsmaate for anvendelse og syntese av peptider.
ATE44768T1 (de) Verfahren zur mikrobiologischen herstellung von menschlichem serum-albumin.
Dübel et al. Regulated secretion and purification of recombinant antibodies in E. coli
GR3017915T3 (en) Antigens composed of "major histocompatibility complex" class I antigens and specific carrier molecules, their production and use.
HUP9900768A2 (hu) Photorhabdusból származó inszekticid protein toxinok
WO1997021812A3 (en) Mammalian chemokine ccf8 and chemokine receptor cckr3
EP1114864A3 (en) Mammalian cell surface antigens, related reagents
WO1992007939A3 (en) Polypeptide with 46kd hmfg differentiation antigen binding specificity
EP0997476A3 (en) Antibodies to a mammalian Langerhans cell antigen and their uses
EP0276984A3 (en) Measuring anti-dna antibodies
SE8802939D0 (sv) A method for the production and isolation of a fusion protein in eukaryotic cells
Wu et al. Artificial antibodies for affinity chromatography of homologous proteins: application to blood clotting proteins
WO1994024283A3 (en) A mammalian guanine nucleotide binding protein with an adp-rybosylation factor domain
EP0335567A3 (en) Controlled release of periplasmic proteins into the medium
Joyce et al. Affinity chromatography of aminoacyl-tRNA synthetases on specific tRNA columns without prior purification of tRNA
Goud et al. Specific glycosidase activity isolated from a random phage display antibody library
Lee et al. Studies on inhibition of rabbit ribonuclease activity by its homologous antibodies
Shimizu et al. Techniques for assaying C 1, C 2 and D botulinal antitoxins.
SKERRA et al. Sy (IGS) ARE A FAM