ZA892448B - Antibody heteroconjugates for use in regulation of lymphocyte activity - Google Patents

Antibody heteroconjugates for use in regulation of lymphocyte activity

Info

Publication number: ZA892448B
Authority: ZA; South Africa
Prior art keywords: heteroconjugates; lymphocytes; regulation; antibody; heteroconjugate
Prior art date: 1988-04-04

Application number

ZA892448A

Other languages

English (en)

Inventor

Jeffrey A Ledbetter

A Ledbetter Jeffrey

Original Assignee

Oncogen

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-04

Filing date

1989-04-03

Publication date

1989-12-27

1989-04-03 Application filed by Oncogen filed Critical Oncogen

1989-12-27 Publication of ZA892448B publication Critical patent/ZA892448B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2806—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/289—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Microbiology (AREA)
Mycology (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Coating With Molten Metal (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Spinning Or Twisting Of Yarns (AREA)

ZA892448A 1988-04-04 1989-04-03 Antibody heteroconjugates for use in regulation of lymphocyte activity ZA892448B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17682588A	1988-04-04	1988-04-04
US27193488A	1988-11-14	1988-11-14

Publications (1)

Publication Number	Publication Date
ZA892448B true ZA892448B (en)	1989-12-27

Family

ID=26872636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA892448A ZA892448B (en)	1988-04-04	1989-04-03	Antibody heteroconjugates for use in regulation of lymphocyte activity

Country Status (20)

Country	Link
EP (1)	EP0336379B1 (de)
JP (1)	JP2613106B2 (de)
KR (1)	KR100205833B1 (de)
CN (1)	CN1058296C (de)
AT (1)	ATE133866T1 (de)
AU (1)	AU629204B2 (de)
DE (1)	DE68925593T2 (de)
DK (1)	DK173382B1 (de)
ES (1)	ES2083960T3 (de)
FI (1)	FI105320B (de)
GR (1)	GR3019224T3 (de)
HU (1)	HU213576B (de)
IE (1)	IE72187B1 (de)
IL (1)	IL89823A (de)
MY (1)	MY106592A (de)
NO (1)	NO178699C (de)
NZ (1)	NZ228560A (de)
PT (1)	PT90195B (de)
YU (1)	YU68589A (de)
ZA (1)	ZA892448B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5460961A (en) *	1988-06-14	1995-10-24	La Region Wallonne	Human myeloperoxidase and its therapeutic application
US5846799A (en) *	1988-06-14	1998-12-08	La Region Wallone	Human myeloperoxidase and its therapeutic application
US5681566A (en) *	1988-10-24	1997-10-28	3I Research Exploitation Limited	Antibody conjugates with two or more covalently linked FC regions
US6685941B1 (en)	1988-11-23	2004-02-03	The Regents Of The University Of Michigan	Methods of treating autoimmune disease via CTLA-4Ig
AU6290090A (en) *	1989-08-29	1991-04-08	University Of Southampton	Bi-or trispecific (fab)3 or (fab)4 conjugates
US5378815A (en) *	1989-10-20	1995-01-03	National Research Council Canada	Process for indirect targeted immunocytolysis
DE69032484D1 (de) *	1989-10-27	1998-08-20	Arch Dev Corp	Zusammensetzungen und deren verwendung zur förderung der immunopotentiation
US6406696B1 (en)	1989-10-27	2002-06-18	Tolerance Therapeutics, Inc.	Methods of stimulating the immune system with anti-CD3 antibodies
US5273743A (en) *	1990-03-09	1993-12-28	Hybritech Incorporated	Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
IL97459A0 (en) *	1990-03-09	1992-06-21	Hybritech Inc	Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
JPH05268986A (ja) *	1990-03-19	1993-10-19	Bristol Myers Squibb Co	モノクローナル抗体及びリンパ球の活性法
GB9021679D0 (en) *	1990-10-05	1990-11-21	Gorman Scott David	Antibody preparation
CA2065658A1 (en) *	1991-04-19	1992-10-20	Tse-Wen Chang	Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators
US6197298B1 (en)	1991-04-19	2001-03-06	Tanox, Inc.	Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals
US5872222A (en) *	1991-04-19	1999-02-16	Tanox Biosystems, Inc.	Conjugates of polymers and antibodies specific for T lymphocytes, and their use as adjuvants
US6129916A (en) *	1991-04-19	2000-10-10	Tanox, Inc.	Method of Increasing activation on proliferation of T cells using antibody-microbead conjugates
US6106835A (en) *	1991-04-19	2000-08-22	Tanox, Inc.	Modified binding molecules specific for T or B lymphocytes and their use as in vivo immune modulators
IE922233A1 (en) *	1991-07-10	1993-01-13	Augusto C Ochoa	Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity
GB9206422D0 (en) *	1992-03-24	1992-05-06	Bolt Sarah L	Antibody preparation
ES2125248T3 (es) *	1992-04-10	1999-03-01	Thomas Totterman	Metodo de deteccion de una infeccion cmv.
US5635602A (en) *	1993-08-13	1997-06-03	The Regents Of The University Of California	Design and synthesis of bispecific DNA-antibody conjugates
KR100373813B1 (ko)	1994-05-02	2003-10-08	베른트 그로너	이관능성단백질,그의제조및용도
DE4421391C1 (de)	1994-06-18	1995-11-30	Gsf Forschungszentrum Umwelt	Verwendung von Antikörpern gegen T-Zellen zur verlängerten Immunsuppression
EP0945139A1 (de) *	1998-03-23	1999-09-29	Katholieke Universiteit Nijmegen	Verfahren un Mitteln zur Herstellung von Immunkrankheiten wie Graft-Versus-Host-Krankheit
WO2000078348A1 (en) *	1999-06-17	2000-12-28	University Of Vermont And State Agricultural College	Autologous adoptive immunotherapy with primed antigen-specific t cells or b cells
US7572631B2 (en)	2000-02-24	2009-08-11	Invitrogen Corporation	Activation and expansion of T cells
US7541184B2 (en)	2000-02-24	2009-06-02	Invitrogen Corporation	Activation and expansion of cells
DE10034607A1 (de) *	2000-07-20	2002-02-07	Gundram Jung	Multispezifisches Reagenz zur selektiven Stimulierung von Zelloberflächenrezeptoren
ATE423571T1 (de) *	2001-10-12	2009-03-15	Schering Corp	Verwendung von bispezifischen antikörpern gegen einen aktivierenden rezeptor fcepsilonri und gegen einen inhibierenden rezeptor ox2ra (cd200ra) zur regulierung der immunantworten
GB0305702D0 (en) *	2003-03-12	2003-04-16	Univ Birmingham	Bispecific antibodies
CN118994397A (zh)	2019-05-21	2024-11-22	诺华股份有限公司	针对bcma的三特异性结合分子及其用途
UY38701A (es)	2019-05-21	2020-12-31	Novartis Ag	Moléculas de unión a cd19, conjugados, composiciones que las comprenden y usos de las mismas
EP4103609A1 (de) *	2020-02-13	2022-12-21	UCB Biopharma SRL	Bispezifische antikörper gegen cd9 und cd7
EP4378529A1 (de) *	2022-12-03	2024-06-05	Universitätsklinikum Hamburg-Eppendorf	Antikörper zur verwendung in einer therapie mit effektorzell-engagement

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4381292A (en) *	1980-11-14	1983-04-26	The Board Of Trustees Of The Leland Stanford Jr. University	Anti-human T-lymphocyte monoclonal antibody
EP0153871A3 (de) *	1984-03-01	1987-07-01	Centocor, Inc.	Steigerung der Antigenimmunogenität mittels Antikörper
ATE64622T1 (de) *	1984-04-23	1991-07-15	Boston Biomed Res Inst	Doppelspezifische antikoerper-determinanten.
GB8605316D0 (en) *	1986-03-04	1986-04-09	Royal Free Hosp School Med	Immunosuppression
EP0241907A3 (de) *	1986-04-14	1989-09-13	The General Hospital Corporation	Heterobifunktionelle Antikörper und Verfahren zur Verwendung derselben
GB8626412D0 (en) *	1986-11-05	1986-12-03	Clark M R	Antibodies
DE3850542T2 (de) *	1987-09-23	1994-11-24	Bristol Myers Squibb Co	Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.

1989
- 1989-03-30 FI FI891528A patent/FI105320B/fi not_active IP Right Cessation
- 1989-03-31 HU HU891607A patent/HU213576B/hu unknown
- 1989-03-31 NO NO891375A patent/NO178699C/no not_active IP Right Cessation
- 1989-03-31 NZ NZ228560A patent/NZ228560A/xx unknown
- 1989-04-03 CN CN89101965A patent/CN1058296C/zh not_active Expired - Lifetime
- 1989-04-03 ZA ZA892448A patent/ZA892448B/xx unknown
- 1989-04-03 MY MYPI89000419A patent/MY106592A/en unknown
- 1989-04-03 IL IL8982389A patent/IL89823A/en not_active IP Right Cessation
- 1989-04-03 IE IE105489A patent/IE72187B1/en not_active IP Right Cessation
- 1989-04-03 DK DK198901594A patent/DK173382B1/da not_active IP Right Cessation
- 1989-04-04 YU YU00685/89A patent/YU68589A/xx unknown
- 1989-04-04 AT AT89105907T patent/ATE133866T1/de not_active IP Right Cessation
- 1989-04-04 PT PT90195A patent/PT90195B/pt not_active IP Right Cessation
- 1989-04-04 ES ES89105907T patent/ES2083960T3/es not_active Expired - Lifetime
- 1989-04-04 DE DE68925593T patent/DE68925593T2/de not_active Expired - Lifetime
- 1989-04-04 AU AU32423/89A patent/AU629204B2/en not_active Expired
- 1989-04-04 JP JP1084148A patent/JP2613106B2/ja not_active Expired - Fee Related
- 1989-04-04 EP EP89105907A patent/EP0336379B1/de not_active Expired - Lifetime
- 1989-04-04 KR KR1019890004473A patent/KR100205833B1/ko not_active Expired - Fee Related
1996
- 1996-03-06 GR GR960400631T patent/GR3019224T3/el unknown

Also Published As

Publication number	Publication date
CN1058296C (zh)	2000-11-08
JPH01304356A (ja)	1989-12-07
NO178699B (no)	1996-02-05
DK173382B1 (da)	2000-09-11
HU213576B (en)	1997-08-28
ATE133866T1 (de)	1996-02-15
IE72187B1 (en)	1997-03-26
CN1036988A (zh)	1989-11-08
JP2613106B2 (ja)	1997-05-21
AU629204B2 (en)	1992-10-01
MY106592A (en)	1995-06-30
EP0336379A3 (en)	1990-01-31
IL89823A (en)	1994-07-31
DK159489A (da)	1989-10-05
NZ228560A (en)	1991-10-25
FI105320B (fi)	2000-07-31
KR890015751A (ko)	1989-11-25
ES2083960T3 (es)	1996-05-01
NO178699C (no)	1996-05-15
IL89823A0 (en)	1989-12-15
NO891375D0 (no)	1989-03-31
DK159489D0 (da)	1989-04-03
EP0336379B1 (de)	1996-02-07
DE68925593T2 (de)	1996-06-13
KR100205833B1 (ko)	1999-07-01
AU3242389A (en)	1989-10-05
HUT51338A (en)	1990-04-28
IE891054L (en)	1989-10-04
PT90195B (pt)	1994-06-30
DE68925593D1 (de)	1996-03-21
NO891375L (no)	1989-10-05
FI891528L (fi)	1989-10-05
GR3019224T3 (en)	1996-06-30
FI891528A0 (fi)	1989-03-30
YU68589A (en)	1991-10-31
PT90195A (pt)	1989-11-10
EP0336379A2 (de)	1989-10-11

Publication	Publication Date	Title
EP0336379A3 (en)	1990-01-31	Antibody heteroconjugates for use in regulation of lymphocyte activity
ATE47155T1 (de)	1989-10-15	Monoklonaler antikoerper.
ES2106195T3 (es)	1997-11-01	Anticuerpo igg aglicosilado anti cd3.
GR3020108T3 (en)	1996-08-31	Monoclonal antibody reactive with a novel HLA determinant on MHC class I molecules and method for activating lymphocytes
IL88248A (en)	1993-03-15	Solid phase immunoassay for detecting hiv antigens using kc-57 monoclonal antibody, and kit for the performance thereof
EP0597829A4 (de)	1992-02-27	Monoklonaler antikörper gegen einen neuen mit menschlichen tumoren assoziierten antigen.
ES2124533T3 (es)	1999-02-01	Anticuerpos monoclonales inmunoestimulantes.
DE69021953D1 (de)	1995-10-05	Enzymimmuntest für Antigene und dafür verwendbare feste Phase.
IE883062L (en)	1989-05-02	Monoclonal antibodies
ATE132267T1 (de)	1996-01-15	Immuntest unter verwendung von antigenen, produziert in heterologen organismen
GB2233091B (en)	1992-05-27	Immunoassays using monoclonal antibodies directed against natural binding proteins
ES546594A0 (es)	1987-04-01	Un procedimiento para preparar un anticuerpo monocional anti-urocinasa.
DE69111429D1 (de)	1995-08-24	Monoklonale antikörper, die einen unterschied zwischen nativproteinen und proteinen mit einer modifizierten sequenz machen.
DK673789A (da)	1990-02-19	Monoklonalt antistof, som specifikt binder til kc-48-antigenet i neutrophiler og eosinophiler, samt hybridomocellelinie, som producerer antistoffet
AU4938790A (en)	1990-08-16	Monoclonal antibodies in immune serum globulin
ZA89257B (en)	1989-10-25	Antigen antibody conjugate