ZA89861B - Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number: ZA89861B
Authority: ZA; South Africa
Prior art keywords: atoms; group; radical; denote; hydrogen
Prior art date: 1988-02-06

Application number

ZA89861A

Other languages

English (en)

Inventor

Juergen Kleinschroth

Kleinschroth Juergen

Johannes Hartenstein

Hartenstein Johannes

Hubert Barth

Barth Hubert

Christoph Schaechtele

Schaechtele Christoph

Claus Rudolph

Rudolph Claus

Guenter Weinheimer

Weinheimer Guenter

Original Assignee

Goedecke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-02-06

Filing date

1989-02-03

Publication date

1989-11-29

1989-02-03 Application filed by Goedecke Ag filed Critical Goedecke Ag

1989-11-29 Publication of ZA89861B publication Critical patent/ZA89861B/xx

Links

VVVPGLRKXQSQSZ-UHFFFAOYSA-N indolo[3,2-c]carbazole Chemical class C1=CC=CC2=NC3=C4C5=CC=CC=C5N=C4C=CC3=C21 VVVPGLRKXQSQSZ-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 9
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
150000002431 hydrogen Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

ZA89861A 1988-02-06 1989-02-03 Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them ZA89861B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3803620A DE3803620A1 (de)	1988-02-06	1988-02-06	Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number	Publication Date
ZA89861B true ZA89861B (en)	1989-11-29

Family

ID=6346797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA89861A ZA89861B (en)	1988-02-06	1989-02-03	Indolocarbazole derivatives,processes for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country	Link
EP (1)	EP0328000B1 (fr)
JP (1)	JP2866096B2 (fr)
KR (1)	KR890013035A (fr)
CN (1)	CN1035667A (fr)
AT (1)	ATE117304T1 (fr)
AU (1)	AU616468B2 (fr)
CA (1)	CA1337767C (fr)
DD (1)	DD283394A5 (fr)
DE (2)	DE3803620A1 (fr)
DK (1)	DK51489A (fr)
ES (1)	ES2066798T3 (fr)
GR (1)	GR3015194T3 (fr)
HU (1)	HU203758B (fr)
IE (1)	IE65256B1 (fr)
PT (1)	PT89623B (fr)
ZA (1)	ZA89861B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3010675B2 (ja) *	1989-03-23	2000-02-21	萬有製薬株式会社	抗腫瘍性物質ｂｅ―１３７９３ｃ
US5618809A (en) *	1989-12-14	1997-04-08	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
AU7035991A (en) *	1989-12-14	1991-07-18	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) *	1989-12-21	1991-06-27	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US5668271A (en) *	1991-11-29	1997-09-16	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US5547976A (en) *	1992-03-20	1996-08-20	Burroughs Wellcome Co.	Further indole derivatives with antiviral activity
DE4243321A1 (de) *	1992-12-21	1994-06-23	Goedecke Ag	Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
AU678435B2 (en) *	1993-05-10	1997-05-29	F. Hoffmann-La Roche Ag	Substituted pyrroles
US5721230A (en) *	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
AU679752B2 (en) *	1993-05-28	1997-07-10	Cephalon, Inc.	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US5468872A (en) *	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
PT657458E (pt) *	1993-12-07	2002-02-28	Lilly Co Eli	Inibidores de proteina cinase c
EP0657411B1 (fr) *	1993-12-07	1999-06-09	Eli Lilly And Company	Synthese de Bisindolylmaleimides
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
CA2179650C (fr) *	1993-12-23	2007-10-30	William Francis Heath, Jr.	Bis-indolemaleimides et utilisation connexe comme inhibiteurs de la proteine kinase c
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5616724A (en) *	1996-02-21	1997-04-01	Cephalon, Inc.	Fused pyrrolo[2,3-c]carbazole-6-ones
CA2245029A1 (fr)	1998-03-13	1999-09-13	University Of British Columbia	Composes granulatimide en tant qu'inhibiteurs de controle g2
ATE251624T1 (de) *	1998-03-13	2003-10-15	Univ British Columbia	Granulatimide-derivate zur behandlung von krebs
US6653290B2 (en)	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
RU2003131269A (ru)	2001-03-22	2005-05-10	Бристол-Маерс Сквибб Компани (Us)	Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
CA2393720C (fr)	2002-07-12	2010-09-14	Eli Lilly And Company	Monochlorhydrate de 3-(1-methyl-1h-indol-3-yl)-4-[[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole-2,5-dione cristallin
CN117486782A (zh) *	2023-12-29	2024-02-02	中国医学科学院药用植物研究所	一种n-取代咔唑衍生物及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4737496A (en) *	1986-10-01	1988-04-12	Ciba-Geigy Corporation	1,3,4,16b-tetrahydro-2H,10H-indolo[2,1-c]pyrazino-[1,2-a][1,4]benzodiazepines useful as serotonin-2 receptor antagonists

1988
- 1988-02-06 DE DE3803620A patent/DE3803620A1/de not_active Withdrawn
1989
- 1989-02-03 ZA ZA89861A patent/ZA89861B/xx unknown
- 1989-02-03 DK DK051489A patent/DK51489A/da not_active Application Discontinuation
- 1989-02-03 PT PT89623A patent/PT89623B/pt not_active IP Right Cessation
- 1989-02-03 HU HU89548A patent/HU203758B/hu not_active IP Right Cessation
- 1989-02-03 ES ES89101940T patent/ES2066798T3/es not_active Expired - Lifetime
- 1989-02-03 DE DE58908892T patent/DE58908892D1/de not_active Expired - Fee Related
- 1989-02-03 DD DD89325511A patent/DD283394A5/de not_active IP Right Cessation
- 1989-02-03 AT AT89101940T patent/ATE117304T1/de not_active IP Right Cessation
- 1989-02-03 EP EP89101940A patent/EP0328000B1/fr not_active Expired - Lifetime
- 1989-02-03 CA CA000590001A patent/CA1337767C/fr not_active Expired - Fee Related
- 1989-02-03 AU AU29607/89A patent/AU616468B2/en not_active Ceased
- 1989-02-03 IE IE35989A patent/IE65256B1/en not_active IP Right Cessation
- 1989-02-04 KR KR1019890001349A patent/KR890013035A/ko not_active Withdrawn
- 1989-02-04 CN CN89100641A patent/CN1035667A/zh active Pending
- 1989-02-06 JP JP1027350A patent/JP2866096B2/ja not_active Expired - Fee Related
1995
- 1995-02-27 GR GR950400404T patent/GR3015194T3/el unknown

Also Published As

Publication number	Publication date
CN1035667A (zh)	1989-09-20
IE890359L (en)	1989-08-06
AU2960789A (en)	1989-08-10
PT89623A (pt)	1989-10-04
GR3015194T3 (en)	1995-05-31
AU616468B2 (en)	1991-10-31
PT89623B (pt)	1994-02-28
EP0328000A2 (fr)	1989-08-16
EP0328000A3 (fr)	1991-04-03
JP2866096B2 (ja)	1999-03-08
HU203758B (en)	1991-09-30
DK51489D0 (da)	1989-02-03
KR890013035A (ko)	1989-09-21
ES2066798T3 (es)	1995-03-16
CA1337767C (fr)	1995-12-19
ATE117304T1 (de)	1995-02-15
DE58908892D1 (de)	1995-03-02
DK51489A (da)	1989-08-07
EP0328000B1 (fr)	1995-01-18
IE65256B1 (en)	1995-10-18
DE3803620A1 (de)	1989-08-17
JPH02149520A (ja)	1990-06-08
DD283394A5 (de)	1990-10-10

Publication	Publication Date	Title
IE890359L (en)	1989-08-06	Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL102354A (en)	1997-01-10	Pharmaceutically active hydrazine derivatives and process for the preparation thereof
GB8919417D0 (en)	1989-10-11	Novel compounds
GB8919434D0 (en)	1989-10-11	Novel compounds
AR033996A1 (es)	2004-01-21	Una 7-oxo-piridopirimidina, su uso, un proceso para prepararla, una composicion farmaceutica que la comprende, un proceso para producir una pirimidina, un proceso para producir una piridopirimidina, y compuestos preparados mediante dichos procesos
IL77452A (en)	1991-08-16	Derivatives of arylcyclobutylalkyl-amines,their preparation and pharmaceutical compositions containing them
DE3661913D1 (en)	1989-03-02	Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them
DK96783A (da)	1983-09-02	Fremgangsmaade til fremstilling af 4''-epierythromycin a eller derivater deraf
DE3065435D1 (en)	1983-12-01	Thiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
HUT50142A (en)	1989-12-28	Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them
IL106356A (en)	1997-06-10	4-amino-n-(4-methyl- 4-piperidinyl)- 2-methoxybenzamides, their preparation and pharmaceutical compositions containing them
ATE134376T1 (de)	1996-03-15	Mono- und bis-alkylaminoanthracycline
IE901314L (en)	1990-10-15	2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
DE69029781D1 (de)	1997-03-06	Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
ZA918991B (en)	1992-08-26	Imidazole compounds,process for the preparation thereof and pharmaceutical compositions containing them
DE3161553D1 (en)	1984-01-05	Thiazolo(3,2-a)pyrimidine derivatives, their preparation and pharmaceutical compositions containing them
FR2630111B1 (fr)	1990-07-27	Nouveaux derives trieniques de structure chromenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SE9203824L (sv)	1993-06-28	Bensofuranylimidazol-derivat, foerfarande foer framstaellning daerav och terapeutiska kompositioner innehaallande desamma
ZA934110B (en)	1994-01-07	Diacylglycerol nicotinates, process fot their preparation and the pharmaceutical compositions which contain them
HUT45059A (en)	1988-05-30	Process for producing abeoergoline derivatives
ATE36154T1 (de)	1988-08-15	4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
ES2006336A6 (es)	1989-04-16	Procedimiento de preparacion de nuevas acetamidas derivadas de la 2,3-dihidro-3-fenil-2-benzofuranona.