ZA899672B - Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-1-reductase - Google Patents

Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-1-reductase

Info

Publication number: ZA899672B
Authority: ZA; South Africa
Prior art keywords: reductase; inhibitors; steroid; phosphonic acid; substituted aromatic
Prior art date: 1988-12-23

Application number

ZA899672A

Other languages

English (en)

Inventor

Dennis Alan Holt

Alan Holt Dennis

Mark Alan Levy

Alan Levy Mark

Brian Walter Metcalf

Walter Metcalf Brian

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-23

Filing date

1989-12-18

Publication date

1990-11-28

1989-12-18 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1990-11-28 Publication of ZA899672B publication Critical patent/ZA899672B/xx

Links

239000003112 inhibitor Substances 0.000 title abstract 2
-1 aromatic steroids Chemical class 0.000 title 1
ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
150000003431 steroids Chemical class 0.000 title 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA899672A 1988-12-23 1989-12-18 Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-1-reductase ZA899672B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/290,056 US4882319A (en)	1988-12-23	1988-12-23	Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase

Publications (1)

Publication Number	Publication Date
ZA899672B true ZA899672B (en)	1990-11-28

Family

ID=23114357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA899672A ZA899672B (en)	1988-12-23	1989-12-18	Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-1-reductase

Country Status (13)

Country	Link
US (1)	US4882319A (de)
EP (1)	EP0375345B1 (de)
JP (1)	JPH02212499A (de)
AT (1)	ATE114666T1 (de)
AU (1)	AU631587B2 (de)
CA (1)	CA2004946A1 (de)
DE (1)	DE68919660T2 (de)
DK (1)	DK654689A (de)
ES (1)	ES2065400T3 (de)
GR (1)	GR3015039T3 (de)
IE (1)	IE69337B1 (de)
PT (1)	PT92720A (de)
ZA (1)	ZA899672B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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US5571817A (en) *	1984-02-27	1996-11-05	Merck & Co., Inc.	Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5138063A (en) *	1984-02-27	1992-08-11	Merck & Co., Inc.	17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5026882A (en) *	1988-12-23	1991-06-25	Smithkline Beecham Corporation	Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
US5162332A (en) *	1990-06-20	1992-11-10	Merck & Co., Inc.	Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5151430A (en) *	1990-06-20	1992-09-29	Merck & Co., Inc.	Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5061802A (en) *	1990-06-20	1991-10-29	Merck & Co. Inc.	17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5098908A (en) *	1990-06-20	1992-03-24	Merck & Co., Inc.	17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5300294A (en) *	1990-06-27	1994-04-05	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
US5075450A (en) *	1990-06-28	1991-12-24	Merck & Co., Inc.	Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes
US5091380A (en) *	1990-06-28	1992-02-25	Merck & Co., Inc.	N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
IL101243A (en) *	1991-03-20	1999-12-22	Merck & Co Inc	Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
ATE165368T1 (de) *	1991-12-20	1998-05-15	Glaxo Wellcome Inc	Inhibitoren von testosteron-5-alpha reductase.
AU674145B2 (en) *	1992-05-20	1996-12-12	Merck & Co., Inc.	New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
CZ283894A3 (en) *	1992-05-20	1995-09-13	Merck & Co Inc	7beta-substituted 4-aza-5alpha-cholestanones, their use for the preparation of pharmaceutical preparations and pharmaceutical compositions containing thereof
AU676478B2 (en) *	1992-05-20	1997-03-13	Merck & Co., Inc.	New delta-17 and delta-20 olefinic and saturated 17beta- substituted-4-aza-5alpha-androstan-3-ones as 5alpha- reductase inhibitors
WO1993023039A1 (en) *	1992-05-20	1993-11-25	Merck & Co., Inc.	Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors
CA2135173A1 (en) *	1992-05-20	1993-11-25	Bruce E. Witzel	Ester derivatives of 4-aza-steroids
US5237064A (en) *	1992-05-20	1993-08-17	Merck & Co., Inc.	Process for producing 7β-substituted-aza-5αandrostan-3-ones
DE69326008T2 (de) *	1992-05-20	2000-03-02	Merck & Co., Inc.	17-amino-substituierte 4-azasteroide als 5-alpha-reductase inhibitoren
EP0641204B1 (de) *	1992-05-20	2000-08-16	Merck & Co. Inc.	17-ether und thioether von 4-aza-steroiden
ATE195129T1 (de) *	1992-05-20	2000-08-15	Merck & Co Inc	4-azasteroide als 5-alpha-reduktase
GB9210880D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Corp	Compounds
GB9213901D0 (en) *	1992-06-30	1992-08-12	Smithkline Beecham Corp	Compounds
JPH0641038A (ja)	1992-07-17	1994-02-15	Mitsubishi Kasei Corp	カルボン酸誘導体
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
US5324734A (en) *	1992-09-15	1994-06-28	Merck & Co., Inc.	Oxidization metabolites of 5-α-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5278159A (en) *	1992-10-06	1994-01-11	Merck & Co., Inc.	Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5359071A (en) *	1993-03-12	1994-10-25	Merck & Co., Inc.	15-substituted 4-azasteroids
US5621104A (en) *	1993-03-24	1997-04-15	Merck & Co., Inc.	Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
DE69405760T2 (de) *	1993-06-28	1998-04-09	Merck & Co Inc	4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5430157A (en) *	1993-12-13	1995-07-04	Eli Lilly And Company	Reduced phenanthrenes
US5637310A (en) *	1993-12-20	1997-06-10	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
US5525608A (en) *	1994-04-20	1996-06-11	Merck & Co., Inc.	17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
JP3816550B2 (ja) *	1994-11-07	2006-08-30	キヤノンファインテック株式会社	プリント媒体搬送装置およびラベルプリンタ
US6054446A (en) *	1997-12-24	2000-04-25	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
US6548491B2 (en) *	1997-12-24	2003-04-15	Sri International	Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
ES2347027T3 (es)	1998-05-22	2010-10-22	The Board Of Trustees Of The Leland Stanford Junior University	Moleculas bifuncionales y terapias basadas en las mismas.
EP2671507A3 (de)	2005-04-28	2014-02-19	Proteus Digital Health, Inc.	Pharma-Informatiksystem
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
CA2752373C (en)	2009-02-20	2017-10-10	To-Bbb Holding B.V.	Glutathione-based drug delivery system
IL255113B (en)	2009-05-06	2022-09-01	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1049498A (en) *	1973-11-29	1979-02-27	Gunther Kruger	Steroid compounds and processes therefor
AU534679B2 (en) *	1979-03-15	1984-02-09	Commonwealth Scientific And Industrial Research Organisation	Steroid immunogens
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
US4937237A (en) *	1988-12-23	1990-06-26	Smithkline Beckman Corporation	Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
US5026882A (en) *	1988-12-23	1991-06-25	Smithkline Beecham Corporation	Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase

1988
- 1988-12-23 US US07/290,056 patent/US4882319A/en not_active Expired - Fee Related
1989
- 1989-12-08 CA CA002004946A patent/CA2004946A1/en not_active Abandoned
- 1989-12-18 ZA ZA899672A patent/ZA899672B/xx unknown
- 1989-12-19 AT AT89313258T patent/ATE114666T1/de not_active IP Right Cessation
- 1989-12-19 ES ES89313258T patent/ES2065400T3/es not_active Expired - Lifetime
- 1989-12-19 DE DE68919660T patent/DE68919660T2/de not_active Expired - Fee Related
- 1989-12-19 EP EP89313258A patent/EP0375345B1/de not_active Expired - Lifetime
- 1989-12-20 JP JP1330926A patent/JPH02212499A/ja active Pending
- 1989-12-20 AU AU46995/89A patent/AU631587B2/en not_active Ceased
- 1989-12-20 IE IE410789A patent/IE69337B1/en not_active IP Right Cessation
- 1989-12-21 DK DK654689A patent/DK654689A/da not_active Application Discontinuation
- 1989-12-22 PT PT92720A patent/PT92720A/pt not_active Application Discontinuation
1995
- 1995-02-09 GR GR950400271T patent/GR3015039T3/el unknown

Also Published As

Publication number	Publication date
PT92720A (pt)	1990-06-29
DK654689A (da)	1990-06-24
EP0375345B1 (de)	1994-11-30
AU631587B2 (en)	1992-12-03
EP0375345A1 (de)	1990-06-27
DK654689D0 (da)	1989-12-21
DE68919660D1 (de)	1995-01-12
ES2065400T3 (es)	1995-02-16
ATE114666T1 (de)	1994-12-15
DE68919660T2 (de)	1995-05-24
CA2004946A1 (en)	1990-06-23
GR3015039T3 (en)	1995-05-31
IE894107L (en)	1990-06-23
JPH02212499A (ja)	1990-08-23
AU4699589A (en)	1990-06-28
IE69337B1 (en)	1996-09-04
US4882319A (en)	1989-11-21

Publication	Publication Date	Title
ZA899672B (en)	1990-11-28	Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-1-reductase
IE894109L (en)	1990-06-23	Phosphinic acid substituted aromatic steroids as inhibitors¹of steroid 5ó-reductase
GR3015476T3 (en)	1995-06-30	Sulphonic acid substituted aromatic steroids as inhibitors of steroid 5-alpha-reductase.
ZA899671B (en)	1990-11-28	Phosphinic acid substituted steroids as inhibitors of steroid 5-alpha-reductase
DK196691A (da)	1991-12-05	Steroid-5-alfa-reduktaseinhibitorer
ZA893971B (en)	1990-05-30	Aromatic steroid 5-alpha-reductase inhibitors
ZA899670B (en)	1990-11-28	Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors