ZA908343B - Antimuscarinic bronchodilators - Google Patents

Antimuscarinic bronchodilators

Info

Publication number
ZA908343B
ZA908343B ZA908343A ZA908343A ZA908343B ZA 908343 B ZA908343 B ZA 908343B ZA 908343 A ZA908343 A ZA 908343A ZA 908343 A ZA908343 A ZA 908343A ZA 908343 B ZA908343 B ZA 908343B
Authority
ZA
South Africa
Prior art keywords
halo
substituents
alkoxy
hydroxy
optionally substituted
Prior art date
Application number
ZA908343A
Other languages
English (en)
Inventor
Peter Edward Cross
Edward Cross Peter
Alan Stobie
Stobie Alan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA908343B publication Critical patent/ZA908343B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Feeding And Guiding Record Carriers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA908343A 1989-10-19 1990-10-18 Antimuscarinic bronchodilators ZA908343B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898923590A GB8923590D0 (en) 1989-10-19 1989-10-19 Antimuscarinic bronchodilators

Publications (1)

Publication Number Publication Date
ZA908343B true ZA908343B (en) 1992-06-24

Family

ID=10664848

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908343A ZA908343B (en) 1989-10-19 1990-10-18 Antimuscarinic bronchodilators

Country Status (19)

Country Link
US (1) US5171744A (de)
EP (1) EP0424021B1 (de)
JP (1) JPH06780B2 (de)
KR (1) KR930004845B1 (de)
CN (1) CN1022488C (de)
AT (1) ATE102198T1 (de)
AU (1) AU616362B2 (de)
CA (1) CA2027896A1 (de)
DE (1) DE69007009T2 (de)
FI (1) FI905147A7 (de)
GB (1) GB8923590D0 (de)
HU (1) HU206345B (de)
NO (1) NO174256C (de)
NZ (1) NZ235750A (de)
PL (1) PL287365A1 (de)
PT (1) PT95610A (de)
RU (1) RU2005721C1 (de)
YU (1) YU197290A (de)
ZA (1) ZA908343B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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CA2073005C (en) * 1990-09-06 1998-11-10 Alan Stobie Antimuscarinic bronchodilators
GB9119705D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic compounds
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
FR2754261B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de quinuclidine, leur preparation et leur application en therapeutique
US5981549A (en) * 1997-02-14 1999-11-09 Synapse Pharmaceutical International Method for controlling or alleviating the symptoms of respiratory disease and allergies
WO2000017175A1 (en) * 1998-09-18 2000-03-30 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
JP2003089688A (ja) * 1998-12-25 2003-03-28 Mitsubishi-Tokyo Pharmaceuticals Inc イミダゾリン化合物
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GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
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RU2421464C2 (ru) 2005-10-21 2011-06-20 Новартис Аг Человеческие антитела к il-13 и их терапевтическое применение
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP2322525B1 (de) 2006-04-21 2013-09-18 Novartis AG Purinderivate als Adenosin A2A Rezeptoragonisten
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
WO2008037477A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as p13k lipid kinase inhibitors
AU2007336054A1 (en) * 2006-12-19 2008-06-26 Astrazeneca Ab Quinuclidinol derivatives as muscarinic receptor antagonists
PL2104535T3 (pl) 2007-01-10 2011-05-31 Irm Llc Związki i kompozycje jako inhibitory proteazy aktywujące kanały
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JP2011522860A (ja) 2008-06-10 2011-08-04 ノバルティス アーゲー 上皮性ナトリウムチャネルブロッカーとしてのピラジン誘導体
EP2206712A1 (de) * 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. Alkaloidaminoester-Derivate und medizinische Zusammensetzung davon
PT2391366E (pt) 2009-01-29 2013-02-05 Novartis Ag Benzimidazoles substituídos para o tratamento de astrocitomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
JP5781510B2 (ja) 2009-08-12 2015-09-24 ノバルティス アーゲー ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
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JP5775871B2 (ja) 2009-08-20 2015-09-09 ノバルティス アーゲー ヘテロ環式オキシム化合物
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US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
KR20130111968A (ko) * 2010-06-22 2013-10-11 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
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US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
WO2012107500A1 (en) 2011-02-10 2012-08-16 Novartis Ag [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
WO2012116237A2 (en) 2011-02-23 2012-08-30 Intellikine, Llc Heterocyclic compounds and uses thereof
WO2012116217A1 (en) 2011-02-25 2012-08-30 Irm Llc Compounds and compositions as trk inhibitors
EP2510928A1 (de) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
EA026655B1 (ru) 2011-09-15 2017-05-31 Новартис Аг 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
CN103946221B (zh) 2011-09-16 2016-08-03 诺华股份有限公司 用于治疗囊性纤维化的杂环化合物
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
US9056867B2 (en) 2011-09-16 2015-06-16 Novartis Ag N-substituted heterocyclyl carboxamides
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JP2015512425A (ja) 2012-04-03 2015-04-27 ノバルティス アーゲー チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
EP2968340A4 (de) 2013-03-15 2016-08-10 Intellikine Llc Kombination von kinaseinhibitoren und verwendungen davon
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KR20160141856A (ko) 2014-04-24 2016-12-09 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체
EP3134397A1 (de) 2014-04-24 2017-03-01 Novartis AG Aminopyrazinderivate als phosphatidylinositol-3-kinasehemmer
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ES2831416T3 (es) 2014-07-31 2021-06-08 Novartis Ag Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR
WO2020250116A1 (en) 2019-06-10 2020-12-17 Novartis Ag Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis
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TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

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US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
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IT1228288B (it) * 1989-01-09 1991-06-07 Zambon Spa Composti ad attivita' antiserotoninica

Also Published As

Publication number Publication date
CN1051041A (zh) 1991-05-01
CN1022488C (zh) 1993-10-20
PL287365A1 (en) 1991-06-03
PT95610A (pt) 1991-09-13
KR910007924A (ko) 1991-05-30
AU616362B2 (en) 1991-10-24
HU906495D0 (en) 1991-04-29
NO174256B (no) 1993-12-27
DE69007009T2 (de) 1994-06-09
EP0424021B1 (de) 1994-03-02
NO904523L (no) 1991-04-22
DE69007009D1 (de) 1994-04-07
JPH06780B2 (ja) 1994-01-05
ATE102198T1 (de) 1994-03-15
US5171744A (en) 1992-12-15
EP0424021A1 (de) 1991-04-24
AU6472690A (en) 1991-07-25
HU206345B (en) 1992-10-28
KR930004845B1 (ko) 1993-06-09
YU197290A (sh) 1993-10-20
NO904523D0 (no) 1990-10-18
NO174256C (no) 1994-04-06
FI905147A7 (fi) 1991-04-20
RU2005721C1 (ru) 1994-01-15
HUT56365A (en) 1991-08-28
NZ235750A (en) 1992-03-26
JPH03133980A (ja) 1991-06-07
GB8923590D0 (en) 1989-12-06
FI905147A0 (fi) 1990-10-18
CA2027896A1 (en) 1991-04-20

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