PL2104535T3 - Związki i kompozycje jako inhibitory proteazy aktywujące kanały - Google Patents

Związki i kompozycje jako inhibitory proteazy aktywujące kanały

Info

Publication number: PL2104535T3
Authority: PL; Poland
Prior art keywords: compositions; compounds; protease inhibitors; activating protease; channel activating
Prior art date: 2007-01-10

Application number

PL07854747T

Other languages

English (en)

Inventor

David C Tully

Arnab K Chatterjee

Agnes Vidal

Badry Bursulaya

Glen Spraggon

Original Assignee

Irm Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-10

Filing date

2007-11-21

Publication date

2011-05-31

2007-11-21 Application filed by Irm Llc filed Critical Irm Llc

2011-05-31 Publication of PL2104535T3 publication Critical patent/PL2104535T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrrole Compounds (AREA)

PL07854747T 2007-01-10 2007-11-21 Związki i kompozycje jako inhibitory proteazy aktywujące kanały PL2104535T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US88433407P	2007-01-10	2007-01-10
US89147407P	2007-02-23	2007-02-23
PCT/US2007/085366 WO2008085608A1 (en)	2007-01-10	2007-11-21	Compounds and compositions as channel activating protease inhibitors
EP07854747A EP2104535B9 (en)	2007-01-10	2007-11-21	Compounds and compositions as channel activating protease inhibitors

Publications (1)

Publication Number	Publication Date
PL2104535T3 true PL2104535T3 (pl)	2011-05-31

Family

ID=39148650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07854747T PL2104535T3 (pl)	2007-01-10	2007-11-21	Związki i kompozycje jako inhibitory proteazy aktywujące kanały

Country Status (32)

Country	Link
US (1)	US20080176901A1 (pl)
EP (2)	EP2279777A2 (pl)
JP (1)	JP2010515729A (pl)
KR (1)	KR101084787B1 (pl)
AR (1)	AR064841A1 (pl)
AT (1)	ATE493174T1 (pl)
AU (1)	AU2007342223B2 (pl)
BR (1)	BRPI0720799A2 (pl)
CA (1)	CA2673803A1 (pl)
CL (1)	CL2008000060A1 (pl)
CO (1)	CO6190626A2 (pl)
CU (1)	CU23762B7 (pl)
CY (1)	CY1111340T1 (pl)
DE (1)	DE602007011670D1 (pl)
DK (1)	DK2104535T3 (pl)
EA (1)	EA016199B1 (pl)
EC (1)	ECSP099517A (pl)
GT (1)	GT200900196A (pl)
HN (1)	HN2009001282A (pl)
HR (1)	HRP20110201T1 (pl)
MA (1)	MA31037B1 (pl)
MX (1)	MX2009007476A (pl)
NO (1)	NO20092817L (pl)
NZ (1)	NZ577939A (pl)
PE (1)	PE20081566A1 (pl)
PL (1)	PL2104535T3 (pl)
PT (1)	PT2104535E (pl)
RS (1)	RS51644B (pl)
SV (1)	SV2009003330A (pl)
TN (1)	TN2009000294A1 (pl)
TW (1)	TW200845981A (pl)
WO (1)	WO2008085608A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2651762A1 (en)	2006-05-23	2007-11-29	Irm Llc	Compounds and compositions as channel activating protease inhibitors
BRPI0806542A2 (pt)	2007-01-10	2014-04-22	Hoffmann La Roche	Derivados de sulfonamida como inibidores de quimase
AU2008214217B2 (en)	2007-02-09	2011-10-13	Irm Llc	Compounds and compositions as channel activating protease inhibitors
NZ595705A (en)	2009-05-18	2013-01-25	Orion Corp	Protease inhibitors
US10399940B2 (en) *	2016-10-07	2019-09-03	Abbvie S.Á.R.L.	Substituted pyrrolidines and methods of use
GB201805174D0 (en)	2018-03-29	2018-05-16	Univ Leeds Innovations Ltd	Compounds
IL311042B1 (en)	2018-05-29	2026-04-01	Omeros Corp	MASP-2 inhibitors and methods of use
US11584714B2 (en)	2018-05-29	2023-02-21	Omeros Corporation	MASP-2 inhibitors and methods of use
BR112021018456A2 (pt) *	2019-03-22	2021-11-23	Achillion Pharmaceuticals Inc	Compostos farmacêuticos para o tratamento de distúrbios mediados por complemento
JP7672641B2 (ja)	2019-09-17	2025-05-08	メレオバイオファーマ４リミテッド	移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
IL293588B1 (en)	2019-12-04	2026-04-01	Omeros Corp	3-Amino-1-methylpyrazin-2(H1)-one derivatives as MASP-2 inhibitors, compositions containing them and uses thereof
EP4069678A1 (en)	2019-12-04	2022-10-12	Omeros Corporation	Masp-2 inhibitors and methods of use
EP4069676A1 (en) *	2019-12-04	2022-10-12	Omeros Corporation	Masp-2 inhibitors and methods of use
BR112022010895A2 (pt)	2019-12-04	2022-09-06	Omeros Corp	Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan
IL297211B2 (en)	2020-04-16	2025-12-01	Mereo Biopharma 4 Ltd	Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
KR20240090272A (ko)	2021-10-20	2024-06-21	메레오 바이오파마 4 리미티드	섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제
WO2023183405A2 (en) *	2022-03-22	2023-09-28	Alexion Pharmaceuticals, Inc.	Pharmaceutical compounds for the treatment of complement mediated disorders

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1219606A (en)	1968-07-15	1971-01-20	Rech S Et D Applic Scient Soge	Quinuclidinol derivatives and preparation thereof
JPS6235216A (ja)	1985-08-09	1987-02-16	Noritoshi Nakabachi	不均質物質層の層厚非破壊測定方法および装置
GB8923590D0 (en)	1989-10-19	1989-12-06	Pfizer Ltd	Antimuscarinic bronchodilators
PT100441A (pt)	1991-05-02	1993-09-30	Smithkline Beecham Corp	Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
WO1993018007A1 (fr)	1992-03-13	1993-09-16	Tokyo Tanabe Company Limited	Nouveau derive de carbostyrile
US5552438A (en)	1992-04-02	1996-09-03	Smithkline Beecham Corporation	Compounds useful for treating allergic and inflammatory diseases
JP3192424B2 (ja)	1992-04-02	2001-07-30	スミスクライン・ビーチャム・コーポレイション	アレルギーまたは炎症疾患の治療用化合物
JP3251587B2 (ja)	1992-04-02	2002-01-28	スミスクライン・ビーチャム・コーポレイション	炎症疾患の治療および腫瘍壊死因子の産生阻害に有用な化合物
US5705487A (en) *	1994-03-04	1998-01-06	Eli Lilly And Company	Antithrombotic agents
IL112795A (en) *	1994-03-04	2001-01-28	Astrazeneca Ab	Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
US5726159A (en) *	1994-03-04	1998-03-10	Eli Lilly And Company	Antithrombotic agents
US5707966A (en) *	1994-03-04	1998-01-13	Eli Lilly And Company	Antithrombotic agents
US5914319A (en) *	1995-02-27	1999-06-22	Eli Lilly And Company	Antithrombotic agents
GB2299455B (en) *	1995-03-31	1999-12-22	Motorola Inc	Self phased antenna element with dielectric and associated method
JP2000514788A (ja) *	1996-06-25	2000-11-07	イーライ・リリー・アンド・カンパニー	抗凝固剤
GB9622386D0 (en)	1996-10-28	1997-01-08	Sandoz Ltd	Organic compounds
US6166037A (en)	1997-08-28	2000-12-26	Merck & Co., Inc.	Pyrrolidine and piperidine modulators of chemokine receptor activity
WO1999016766A1 (en)	1997-10-01	1999-04-08	Kyowa Hakko Kogyo Co., Ltd.	Benzodioxole derivatives
US6541669B1 (en)	1998-06-08	2003-04-01	Theravance, Inc.	β2-adrenergic receptor agonists
BR9815931A (pt)	1998-06-30	2001-02-20	Dow Chemical Co	Polióis poliméricos, um processo para sua produção, e espuma de poliuretanoobtida
GB9913083D0 (en)	1999-06-04	1999-08-04	Novartis Ag	Organic compounds
SK287418B6 (sk)	1999-05-04	2010-09-07	Schering Corporation	Farmaceutický prípravok s obsahom CCR5 antagonistov a súprava s obsahom tohto prípravku
KR100439357B1 (ko)	1999-05-04	2004-07-07	쉐링 코포레이션	Ｃｃｒ５ 길항제로서 유용한 피페리딘 유도체
US6683115B2 (en)	1999-06-02	2004-01-27	Theravance, Inc.	β2-adrenergic receptor agonists
ES2165768B1 (es)	1999-07-14	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CA2715683A1 (en)	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
OA11558A (en)	1999-12-08	2004-06-03	Advanced Medicine Inc	Beta 2-adrenergic receptor agonists.
SK15382002A3 (sk)	2000-04-27	2003-03-04	Boehringer Ingelheim Pharma Kg	Betamimetiká, farmaceutický prostriedok s ich obsahom a ich použitie
KR100751981B1 (ko)	2000-06-27	2007-08-28	라보라토리오스 살바트, 에스.에이.	아릴알킬아민으로부터 유도된 카바메이트
GB0015876D0 (en)	2000-06-28	2000-08-23	Novartis Ag	Organic compounds
DE10038639A1 (de)	2000-07-28	2002-02-21	Schering Ag	Nichtsteroidale Entzündungshemmer
SI1775305T1 (sl)	2000-08-05	2015-01-30	Glaxo Group Limited	S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
GB0028383D0 (en)	2000-11-21	2001-01-03	Novartis Ag	Organic compounds
NZ526580A (en)	2000-12-22	2005-04-29	Almirall Prodesfarma Ag	Quinuclidine carbamate derivatives and their use as M3 antagonists
DE60121813T2 (de)	2000-12-28	2007-09-20	Almirall Ag	Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten
GB0103630D0 (en)	2001-02-14	2001-03-28	Glaxo Group Ltd	Chemical compounds
US7144908B2 (en)	2001-03-08	2006-12-05	Glaxo Group Limited	Agonists of beta-adrenoceptors
ES2296923T3 (es)	2001-03-22	2008-05-01	Glaxo Group Limited	Derivados formanilidas como agonistas del adrenorreceptor beta2.
KR100831534B1 (ko)	2001-04-30	2008-05-22	글락소 그룹 리미티드	17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
ES2307751T3 (es)	2001-06-12	2008-12-01	Glaxo Group Limited	Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
DK2327765T3 (en)	2001-06-21	2015-07-13	Basf Enzymes Llc	nitrilases
AU2002331064B2 (en) *	2001-08-10	2007-08-23	Palatin Technologies, Inc.	Peptidomimetics of biologically active metallopeptides
KR20090057477A (ko)	2001-09-14	2009-06-05	글락소 그룹 리미티드	호흡기 질환 치료용 펜에탄올아민 유도체
CN1571787A (zh)	2001-10-17	2005-01-26	Ucb公司	奎宁环衍生物、制备它们的方法和它们作为m2和/或m3毒蕈碱受体抑制剂的用途
GB0125259D0 (en)	2001-10-20	2001-12-12	Glaxo Group Ltd	Novel compounds
AR037517A1 (es)	2001-11-05	2004-11-17	Novartis Ag	Derivados de naftiridinas, un proceso para su preparacion, composicion farmaceutica y el uso de los mismos para la preparacion de un medicamento para el tratamiento de una enfermedad inflamatoria
TWI249515B (en)	2001-11-13	2006-02-21	Theravance Inc	Aryl aniline beta2 adrenergic receptor agonists
US6653323B2 (en)	2001-11-13	2003-11-25	Theravance, Inc.	Aryl aniline β2 adrenergic receptor agonists
AU2002356759A1 (en)	2001-12-01	2003-06-17	Glaxo Group Limited	17.alpha. -cyclic esters of 16-methylpregnan-3,20-dione as anti-inflammatory agents
JP4505227B2 (ja)	2001-12-20	2010-07-21	キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ	１−アルキル−１−アゾニアビシクロ［２．２．２］オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用
AU2003202044A1 (en)	2002-01-15	2003-09-09	Glaxo Group Limited	17.alpha-cycloalkyl/cycloylkenyl esters of alkyl-or haloalkyl-androst-4-en-3-on-11.beta.,17.alpha.-diol 17.beta.-carboxylates as anti-inflammatory agents
AU2003201693A1 (en)	2002-01-21	2003-09-02	Glaxo Group Limited	Non-aromatic 17.alpha.-esters of androstane-17.beta.-carboxylate esters as anti-inflammatory agents
GB0202216D0 (en)	2002-01-31	2002-03-20	Glaxo Group Ltd	Novel compounds
GB0204719D0 (en)	2002-02-28	2002-04-17	Glaxo Group Ltd	Medicinal compounds
WO2003082787A1 (en)	2002-03-26	2003-10-09	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2478156C (en)	2002-03-26	2011-02-15	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP1496892B1 (en)	2002-04-11	2011-01-26	Merck Sharp & Dohme Corp.	1h-benzo(f)indazol-5-yl derivatives as selective glucocorticoid receptor modulators
ES2206021B1 (es)	2002-04-16	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de pirrolidinio.
JP2005523920A (ja)	2002-04-25	2005-08-11	グラクソ　グループ　リミテッド	フェネタノールアミン誘導体
WO2003099764A1 (en)	2002-05-28	2003-12-04	Theravance, Inc.	ALKOXY ARYL β2 ADRENERGIC RECEPTOR AGONISTS
ES2201907B1 (es)	2002-05-29	2005-06-01	Almirall Prodesfarma, S.A.	Nuevos derivados de indolilpiperidina como potentes agentes antihistaminicos y antialergicos.
US7186864B2 (en)	2002-05-29	2007-03-06	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE10224888A1 (de)	2002-06-05	2003-12-24	Merck Patent Gmbh	Pyridazinderivate
US7074806B2 (en)	2002-06-06	2006-07-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE10225574A1 (de)	2002-06-10	2003-12-18	Merck Patent Gmbh	Aryloxime
DE10227269A1 (de)	2002-06-19	2004-01-08	Merck Patent Gmbh	Thiazolderivate
ATE356808T1 (de)	2002-06-25	2007-04-15	Merck Frosst Canada Ltd	8-(biaryl)chinolin-pde4-inhibitoren
AU2003281219A1 (en)	2002-07-02	2004-01-23	Bernard Cote	Di-aryl-substituted-ethane pyridone pde4 inhibitors
ES2204295B1 (es)	2002-07-02	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de quinuclidina-amida.
JP4503436B2 (ja)	2002-07-08	2010-07-14	ファイザー・プロダクツ・インク	糖質コルチコイド受容体のモジュレーター
GB0217225D0 (en)	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicinal compounds
PE20050130A1 (es)	2002-08-09	2005-03-29	Novartis Ag	Compuestos organicos
EP1556369A1 (en)	2002-08-10	2005-07-27	ALTANA Pharma AG	Pyridazinone-derivatives as pde4 inhibitors
BR0313330A (pt)	2002-08-10	2005-06-14	Altana Pharma Ag	Piperidina-ftalazonas substituìdas com pirrolidinadiona como inibidores de pde4
WO2004018449A1 (en)	2002-08-10	2004-03-04	Altana Pharma Ag	Piperidine-derivatives as pde4 inhibitors
US20060166995A1 (en)	2002-08-10	2006-07-27	Altana Pharma Ag	Piperidine-n-oxide-derivatives
RS20050117A (sr)	2002-08-17	2007-06-04	Altana Pharma Ag.,	Novi benzonaftiridini
CA2495597A1 (en)	2002-08-17	2004-03-04	Altana Pharma Ag	Novel phenanthridines
JP2006504678A (ja)	2002-08-21	2006-02-09	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
SE0202483D0 (sv)	2002-08-21	2002-08-21	Astrazeneca Ab	Chemical compounds
EP1534675B1 (en)	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
JP4587294B2 (ja)	2002-08-29	2010-11-24	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
ATE353217T1 (de)	2002-08-29	2007-02-15	Altana Pharma Ag	3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
WO2004019935A1 (en)	2002-08-29	2004-03-11	Boehringer Ingelheim Pharmaceuticals, Inc.	-3 (sulfonamidoethyl) -indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
GB0220730D0 (en)	2002-09-06	2002-10-16	Glaxo Group Ltd	Medicinal compounds
JP2006096662A (ja)	2002-09-18	2006-04-13	Sumitomo Pharmaceut Co Ltd	新規６−置換ウラシル誘導体及びアレルギー性疾患の治療剤
CA2497903A1 (en)	2002-09-18	2004-04-01	Ono Pharmaceutical Co., Ltd.	Triazaspiro[5.5]undecane derivatives and drugs comprising the same as the active ingredient
JP2004107299A (ja)	2002-09-20	2004-04-08	Japan Energy Corp	新規１−置換ウラシル誘導体及びアレルギー性疾患の治療剤
AU2003270783C1 (en)	2002-09-20	2010-05-20	Merck Sharp & Dohme Corp.	Octahydro-2-H-naphtho[1,2-F] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
DE10246374A1 (de)	2002-10-04	2004-04-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Betamimetika mit verlängerter Wirkungsdauer, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2302938T3 (es)	2002-10-11	2008-08-01	Pfizer Inc.	Derivados de indol como agonistas beta-2.
EP1440966A1 (en)	2003-01-10	2004-07-28	Pfizer Limited	Indole derivatives useful for the treatment of diseases
EP1554264B1 (en)	2002-10-22	2007-08-08	Glaxo Group Limited	Medicinal arylethanolamine compounds
EA010408B1 (ru)	2002-10-23	2008-08-29	Гленмарк Фармасьютикалс Лтд.	Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы
EP1556342B1 (en)	2002-10-28	2008-03-26	Glaxo Group Limited	Phenethanolamine derivative for the treatment of respiratory diseases
GB0225030D0 (en)	2002-10-28	2002-12-04	Glaxo Group Ltd	Medicinal compounds
GB0225287D0 (en)	2002-10-30	2002-12-11	Glaxo Group Ltd	Novel compounds
GB0225535D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Medicinal compounds
GB0225540D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Medicinal compounds
DE10253282A1 (de)	2002-11-15	2004-05-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE10253426B4 (de)	2002-11-15	2005-09-22	Elbion Ag	Neue Hydroxyindole, deren Verwendung als Inhibitoren der Phosphodiesterase 4 und Verfahren zu deren Herstellung
DE10253220A1 (de)	2002-11-15	2004-05-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Dihydroxy-Methyl-Phenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE10261874A1 (de)	2002-12-20	2004-07-08	Schering Ag	Nichtsteroidale Entzündungshemmer
US7019019B2 (en) *	2002-12-23	2006-03-28	Dendreon Corporation	Matriptase inhibitors and methods of use
CA2512987C (en)	2003-01-21	2011-06-14	Merck & Co., Inc.	17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators
PE20040950A1 (es)	2003-02-14	2005-01-01	Theravance Inc	DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1460064A1 (en)	2003-03-14	2004-09-22	Pfizer Limited	Indole-2-carboxamide derivatives useful as beta-2 agonists
GB0507577D0 (en) *	2005-04-14	2005-05-18	Novartis Ag	Organic compounds

2007
- 2007-11-21 RS RS20110129A patent/RS51644B/sr unknown
- 2007-11-21 AT AT07854747T patent/ATE493174T1/de active
- 2007-11-21 CA CA002673803A patent/CA2673803A1/en not_active Abandoned
- 2007-11-21 DE DE602007011670T patent/DE602007011670D1/de active Active
- 2007-11-21 KR KR1020097014455A patent/KR101084787B1/ko not_active Expired - Fee Related
- 2007-11-21 PL PL07854747T patent/PL2104535T3/pl unknown
- 2007-11-21 PT PT07854747T patent/PT2104535E/pt unknown
- 2007-11-21 AU AU2007342223A patent/AU2007342223B2/en not_active Ceased
- 2007-11-21 JP JP2009545545A patent/JP2010515729A/ja not_active Ceased
- 2007-11-21 HR HR20110201T patent/HRP20110201T1/hr unknown
- 2007-11-21 NZ NZ577939A patent/NZ577939A/en not_active IP Right Cessation
- 2007-11-21 WO PCT/US2007/085366 patent/WO2008085608A1/en not_active Ceased
- 2007-11-21 MX MX2009007476A patent/MX2009007476A/es active IP Right Grant
- 2007-11-21 US US11/943,845 patent/US20080176901A1/en not_active Abandoned
- 2007-11-21 DK DK07854747.8T patent/DK2104535T3/da active
- 2007-11-21 BR BRPI0720799-9A patent/BRPI0720799A2/pt not_active IP Right Cessation
- 2007-11-21 EP EP10013675A patent/EP2279777A2/en not_active Withdrawn
- 2007-11-21 EA EA200900920A patent/EA016199B1/ru not_active IP Right Cessation
- 2007-11-21 EP EP07854747A patent/EP2104535B9/en active Active
2008
- 2008-01-10 PE PE2008000105A patent/PE20081566A1/es not_active Application Discontinuation
- 2008-01-10 CL CL200800060A patent/CL2008000060A1/es unknown
- 2008-01-10 AR ARP080100104A patent/AR064841A1/es not_active Application Discontinuation
- 2008-01-10 TW TW097101044A patent/TW200845981A/zh unknown
2009
- 2009-06-30 MA MA32060A patent/MA31037B1/fr unknown
- 2009-07-08 GT GT200900196A patent/GT200900196A/es unknown
- 2009-07-08 HN HN2009001282A patent/HN2009001282A/es unknown
- 2009-07-08 TN TNP2009000294A patent/TN2009000294A1/fr unknown
- 2009-07-10 CU CU20090122A patent/CU23762B7/es not_active IP Right Cessation
- 2009-07-10 SV SV2009003330A patent/SV2009003330A/es not_active Application Discontinuation
- 2009-07-13 CO CO09072488A patent/CO6190626A2/es not_active Application Discontinuation
- 2009-07-15 EC EC2009009517A patent/ECSP099517A/es unknown
- 2009-08-10 NO NO20092817A patent/NO20092817L/no not_active Application Discontinuation
2011
- 2011-03-14 CY CY20111100283T patent/CY1111340T1/el unknown

Also Published As

Publication number	Publication date
PE20081566A1 (es)	2008-12-14
NZ577939A (en)	2011-03-31
TW200845981A (en)	2008-12-01
CU23762B7 (es)	2012-01-31
JP2010515729A (ja)	2010-05-13
AU2007342223B2 (en)	2011-02-24
EA016199B1 (ru)	2012-03-30
HN2009001282A (es)	2012-04-16
EP2104535A1 (en)	2009-09-30
KR101084787B1 (ko)	2011-11-21
ATE493174T1 (de)	2011-01-15
TN2009000294A1 (en)	2010-12-31
AR064841A1 (es)	2009-04-29
AU2007342223A1 (en)	2008-07-17
CO6190626A2 (es)	2010-08-19
DE602007011670D1 (de)	2011-02-10
ECSP099517A (es)	2009-08-28
CU20090122A7 (es)	2011-07-11
WO2008085608A1 (en)	2008-07-17
BRPI0720799A2 (pt)	2014-03-11
US20080176901A1 (en)	2008-07-24
RS51644B (sr)	2011-10-31
SV2009003330A (es)	2011-07-28
CY1111340T1 (el)	2015-08-05
EP2104535B1 (en)	2010-12-29
MA31037B1 (fr)	2009-12-01
EP2279777A2 (en)	2011-02-02
GT200900196A (es)	2010-03-15
HK1129860A1 (en)	2009-12-11
DK2104535T3 (da)	2011-04-04
KR20090087511A (ko)	2009-08-17
MX2009007476A (es)	2009-07-22
EA200900920A1 (ru)	2010-02-26
HRP20110201T1 (hr)	2011-08-31
CA2673803A1 (en)	2008-07-17
CL2008000060A1 (es)	2008-07-18
NO20092817L (no)	2009-10-08
PT2104535E (pt)	2011-03-31
EP2104535B9 (en)	2011-06-15

Publication	Publication Date	Title
PL2104535T3 (pl)	2011-05-31	Związki i kompozycje jako inhibitory proteazy aktywujące kanały
PL2019837T3 (pl)	2011-09-30	Związki i kompozycje jako inhibitory proteazy aktywującej kanały
HUS1900009I1 (hu)	2019-03-28	Új vegyületek és készítmények, továbbá alkalmazási eljárásaik
IL184303A0 (en)	2007-10-31	Amino-pyridines as inhibitors of ??-secretase
ZA201008169B (en)	2012-02-29	Compositions and methods comprising variant microbial proteases
IL195619A0 (en)	2009-09-01	Compositions and methods for joininig non-conjoined iumens
IL213694A0 (en)	2011-07-31	Melanin production inhibitor compounds and compositions comprising the same
BRPI0806970A2 (pt)	2014-04-08	Compostos e composições como inibidores de protease de ativação de canal
BRPI0807483A2 (pt)	2014-05-13	Compostos e composições como inibidores de protease de ativação de canal
IL202306A0 (en)	2010-06-30	Stabilized thrombin compositions
EP2064177A4 (en)	2014-08-20	PROTEASE INHIBITORS
EP2313426A4 (en)	2012-01-18	NEW PROTEASE INHIBITORS
ZA200908771B (en)	2011-04-28	Cysteine protease inhibitors
ZA200904414B (en)	2010-04-28	Compounds and compositions as channel activating protease inhibitors
HU0600482D0 (en)	2006-09-28	Composition of additives
TWI339580B (en)	2011-04-01	Compound and its composition
GB0712176D0 (en)	2007-08-01	Protease inhibitors
GB0712544D0 (en)	2007-08-08	Protease inhibitors
GB0712543D0 (en)	2007-08-08	Protease inhibitors
GB0700369D0 (en)	2007-02-14	Protease inhibitors
GB0700378D0 (en)	2007-02-14	Protease inhibitors
GB0705212D0 (en)	2007-04-25	Protease inhibitors
GB0705213D0 (en)	2007-04-25	Protease inhibitors
HU0600759D0 (en)	2006-11-28	Composition of additives
ZA201008202B (en)	2012-03-28	Compositions and methods comprising variant microbial proteases