ZA909512B - Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals - Google Patents

Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals

Info

Publication number
ZA909512B
ZA909512B ZA909512A ZA909512A ZA909512B ZA 909512 B ZA909512 B ZA 909512B ZA 909512 A ZA909512 A ZA 909512A ZA 909512 A ZA909512 A ZA 909512A ZA 909512 B ZA909512 B ZA 909512B
Authority
ZA
South Africa
Prior art keywords
iontophoresis
combination
topical administration
pharmaceuticals
transdermal flux
Prior art date
Application number
ZA909512A
Other languages
English (en)
Inventor
Michael Lee Francoeur
Lee Francoeur Michael
Russell Owen Potts
Owen Potts Russell
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA909512B publication Critical patent/ZA909512B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA909512A 1989-11-29 1990-11-27 Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals ZA909512B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/443,699 US5023085A (en) 1989-11-29 1989-11-29 Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals

Publications (1)

Publication Number Publication Date
ZA909512B true ZA909512B (en) 1992-06-24

Family

ID=23761854

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA909512A ZA909512B (en) 1989-11-29 1990-11-27 Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals

Country Status (17)

Country Link
US (1) US5023085A (de)
EP (1) EP0435436B1 (de)
JP (1) JPH0688912B2 (de)
KR (1) KR930007248B1 (de)
AT (1) ATE99961T1 (de)
AU (1) AU613281B1 (de)
CA (1) CA2030943A1 (de)
DE (1) DE69006000T2 (de)
DK (1) DK0435436T3 (de)
HU (1) HUT55629A (de)
IE (1) IE63597B1 (de)
IL (1) IL96449A (de)
MY (1) MY109727A (de)
NZ (1) NZ236253A (de)
PH (1) PH27105A (de)
PT (1) PT96021B (de)
ZA (1) ZA909512B (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
WO1988006041A1 (fr) * 1987-02-23 1988-08-25 Shiseido Company Ltd. Stimulateur d'absorption percutanee et preparation dermatologique pour usage externe
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
US5334138A (en) * 1990-03-15 1994-08-02 North Carolina State University Method and composition for increased skin concentration of active agents by iontophoresis
US5383848A (en) * 1990-04-12 1995-01-24 Gensia, Inc. Iontophoretic administration of drugs
US6575957B1 (en) * 1990-11-01 2003-06-10 Robert Tapper Iontophoretic treatment system
US6238381B1 (en) 1990-11-01 2001-05-29 Robert Tapper Iontophoretic treatment system
US6235013B1 (en) 1990-11-01 2001-05-22 Robert Tapper Iontophoretic treatment system
US6582416B2 (en) 1990-11-01 2003-06-24 Robert Tapper Iontophoretic treatment system
US6223076B1 (en) 1990-11-01 2001-04-24 Robert Tapper Sweat control system
US6600950B1 (en) * 1990-11-01 2003-07-29 Robert Tapper Iontophoretic treatment system
US6139537A (en) * 1990-11-01 2000-10-31 Tapper; Robert Iontophoretic treatment system
US5224927A (en) * 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US5131403A (en) * 1991-06-05 1992-07-21 Becton Dickinson And Company Method for obtaining blood using iontophoresis
US5356632A (en) * 1991-09-12 1994-10-18 S.I. Scientific Innovations Ltd. Transdermal drug delivery device
ES2120477T3 (es) * 1992-01-21 1998-11-01 Macrochem Corp Administracion iontoforetica de medicamentos perfeccionada.
EP0751801B1 (de) * 1992-06-02 1997-11-26 Alza Corporation Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
US5580574A (en) * 1994-04-28 1996-12-03 Hoffmann-La Roche Inc. Pharmaceutical composition for transdermal delivery
US5594015A (en) * 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
JP4090072B2 (ja) * 1994-07-13 2008-05-28 アルザ・コーポレーション 経皮電気的移送式作用剤投与を促進するための組成物と方法
US5540654A (en) * 1994-09-02 1996-07-30 North Carolina State University Iontophoretic electrode
US5736580A (en) * 1994-11-14 1998-04-07 Alza Croporation Composition, device, and method for electrotransport agent delivery
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
US5985316A (en) * 1995-04-28 1999-11-16 Alza Corporation Composition and method of enhancing electrotransport agent delivery
US5990179A (en) * 1995-04-28 1999-11-23 Alza Corporation Composition and method of enhancing electrotransport agent delivery
US6355025B1 (en) 1995-06-07 2002-03-12 Alza Corporation Adjustable electrotransport drug delivery using a fixed output controller
AU7286996A (en) * 1995-10-18 1997-05-07 Ciba-Geigy Ag Thermopile powered transdermal drug delivery device
US7094422B2 (en) 1996-02-19 2006-08-22 Acrux Dds Pty Ltd. Topical delivery of antifungal agents
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
EP0849265A1 (de) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Neue polymorphe Form von Doxazosin-Mesylat (Form II)
AUPO907697A0 (en) * 1997-09-09 1997-10-02 Day, Robert Edward Chemical supplementation of bone
GB9723669D0 (en) * 1997-11-07 1998-01-07 Univ Aberdeen Skin penetration enhancing components
AU766913B2 (en) 1998-11-02 2003-10-23 Alza Corporation Electrotransport device including a compatible antimicrobial agent
JP2001072592A (ja) 1999-07-01 2001-03-21 Kyowa Hakko Kogyo Co Ltd テロメラーゼ阻害剤
CA2400325A1 (en) 2000-02-18 2001-08-23 University Of Utah Research Foundation Methods for delivering agents using alternating current
JP2003522613A (ja) 2000-02-18 2003-07-29 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション 交流を用いて物質を抽出する方法
US6452014B1 (en) 2000-12-22 2002-09-17 Geron Corporation Telomerase inhibitors and methods of their use
US7137975B2 (en) * 2001-02-13 2006-11-21 Aciont, Inc. Method for increasing the battery life of an alternating current iontophoresis device using a barrier-modifying agent
WO2002081024A1 (en) * 2001-04-04 2002-10-17 Alza Corporation Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US20050220439A1 (en) * 2004-03-19 2005-10-06 Carton Owen A Interactive multimedia system and method
US20060222692A1 (en) * 2005-03-31 2006-10-05 Fairfield Clinical Trials Llc Method and compositions for transdermal administration of antimicrobial medications
AU2006264407B2 (en) * 2005-07-04 2012-08-30 Ramu Krishnan Improved drug or pharmaceutical compounds and a preparation thereof
WO2007147043A2 (en) * 2006-06-16 2007-12-21 Transport Pharmaceutical, Inc. Pharmaceutical formulations for iontophoretic tetracycline antibiotic delivery
EP2363116A1 (de) 2008-06-25 2011-09-07 US Worldmeds LLC Lofexidin enthaltende Formulierungen mit verzögerter Freisetzung zur oralen Verabreichung
EP2365812A4 (de) * 2008-11-10 2012-05-16 Nitric Biotherapeutics Inc Pharmazeutische formulierungen zur iontophoretischen abgabe eines kortikosteroids
US20100331812A1 (en) * 2009-06-29 2010-12-30 Nitric Biotherapeutics, Inc. Pharmaceutical Formulations for Iontophoretic Delivery of an Immunomodulator
KR20150036825A (ko) 2010-04-13 2015-04-07 나지브 바불 1-메틸-2''-6''-피페콜옥실리디드의 피부 약제학적 조성물 및 사용 방법
AU2014369916A1 (en) 2013-12-24 2016-06-16 Durect Corporation Uses of oxygenated cholesterol sulfates (OCS)
US11564970B2 (en) 2017-10-09 2023-01-31 The Broad Institute, Inc. Compositions and methods for combinatorial drug discovery in nanoliter droplets

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US3989816A (en) * 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4405616A (en) * 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US4954487A (en) * 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
JPS6036299B2 (ja) * 1981-07-02 1985-08-20 タカラベルモント株式会社 イオン導入器
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4919648A (en) * 1983-08-18 1990-04-24 Drug Delivery Systems Inc. High tack drug patch
JPS6222662A (ja) * 1985-07-19 1987-01-30 林原　健 イオン導入電子治療器
MY102980A (en) * 1986-10-31 1993-03-31 Pfizer Transdermal flux enhancing compositions
US5108363A (en) * 1988-02-19 1992-04-28 Gensia Pharmaceuticals, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
PT89837B (pt) * 1988-02-29 1994-01-31 Pfizer Processo para a preparacao de composicoes para aumentar o fluxo transdermico contendo uma 1-alquilazaciclo-heptan-2-ona ou uma cis-olefina

Also Published As

Publication number Publication date
IE904281A1 (en) 1991-06-05
US5023085A (en) 1991-06-11
IL96449A (en) 1996-07-23
PT96021B (pt) 1998-02-27
KR930007248B1 (ko) 1993-08-04
JPH03176426A (ja) 1991-07-31
KR910009250A (ko) 1991-06-28
EP0435436A2 (de) 1991-07-03
MY109727A (en) 1997-05-31
JPH0688912B2 (ja) 1994-11-09
DK0435436T3 (da) 1994-02-28
PT96021A (pt) 1991-09-13
NZ236253A (en) 1993-05-26
ATE99961T1 (de) 1994-01-15
HUT55629A (en) 1991-06-28
EP0435436B1 (de) 1994-01-12
CA2030943A1 (en) 1991-05-30
PH27105A (en) 1993-03-16
DE69006000D1 (de) 1994-02-24
DE69006000T2 (de) 1994-05-05
EP0435436A3 (en) 1992-01-08
IE63597B1 (en) 1995-05-17
AU613281B1 (en) 1991-07-25

Similar Documents

Publication Publication Date Title
EP0435436A3 (en) Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
KR880700675A (ko) 경피투여 시스템
FI862882A7 (fi) 1-substituoituja oksindoli-3 -karboksiamideja tulehdusta ja kipua estävinä aineina.
AU576724B2 (en) Transdermally delivering nitroglycerine
DE3751761D1 (de) Penetrationsverbesserer für die transdermale Verabreichung von systemisch wirksamen Arzneimitteln
ATE72991T1 (de) Nasale verabreichung von arzneimitteln.
ZA875397B (en) Pharmaceutical composition with analgesic activity
NO941593D0 (de)
DK304485D0 (da) Faste laegemiddelpraeparater med dihydropyridiner samt fremstilling deraf
ATE140703T1 (de) Diaminsalze von clavulansäure
EP0227531A3 (de) Pyroglutaminsäureester zur Verwendung als dermaler Penetrationsbeschleuniger für Arzneistoffe
DK131586A (da) Transdermalt, antiallergisk, farmaceutisk praeparat
DE3863200D1 (de) In der krebstherapie verwendbare zusammensetzung auf der basis von aminosaeure und vitaminen.
FR2566662B1 (fr) Association medicamenteuse utilisee en photochimiotherapie
ZA851991B (en) 3-substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
AU6658686A (en) N-(5-tetrazolyl) pyrazine-2-carboxamides and their use as anti-allergic agents
EP0190860A3 (de) 6-Chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepin-N-oxyd und dieses enthaltende Arzneimittel
PH23435A (en) Benzamide and application thereof in the therapeutic field
DK222988D0 (da) Farmaceutiske praeparater indeholdende ornithin-decarboxylase-inhibitorer
ATE65396T1 (de) Verwendung von carbonsaeure in fuer topische anwendung vorgesehenen pharmazeutischen zubereitungen.
PT83721B (pt) Processo de preparacao de composicoes farmaceuticas a base de activadores de plasminogenio com actividade trombolitica
DE3777411D1 (de) Mittel zur verbesserung der perkutanen verabreichung von arzneimitteln.
EP0325616A4 (de) Durchdringungserhöhende mittel für transdermale verabreichung systemischer mittel.
AP8500009A0 (en) New phenoxypropanolamine salts and pharmaceutical preparations thereof.
FI875294A7 (fi) Oleiinihappoesterit ja farmaseuttiset valmisteet.