ZA911471B - The use of guanidine derivatives for the preparation of a pharmaceutical product having pny antagonistic activity - Google Patents

The use of guanidine derivatives for the preparation of a pharmaceutical product having pny antagonistic activity

Info

Publication number
ZA911471B
ZA911471B ZA911471A ZA911471A ZA911471B ZA 911471 B ZA911471 B ZA 911471B ZA 911471 A ZA911471 A ZA 911471A ZA 911471 A ZA911471 A ZA 911471A ZA 911471 B ZA911471 B ZA 911471B
Authority
ZA
South Africa
Prior art keywords
pny
preparation
antagonistic activity
guanidine derivatives
pharmaceutical product
Prior art date
Application number
ZA911471A
Other languages
English (en)
Inventor
Martin C Dr Michel
C Michel Dr Martin
Johan Peter Dr Moersdorf
Peter Moersdorf Dr Johan
Heidrun Dr Engler
Engler Dr Heidrun
Helmut Dr Schickaneder
Schickaneder Dr Helmut
Kurt-Henning Dr Ahrens
Ahrens Dr Kurt-Henning
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Publication of ZA911471B publication Critical patent/ZA911471B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA911471A 1990-03-30 1991-02-28 The use of guanidine derivatives for the preparation of a pharmaceutical product having pny antagonistic activity ZA911471B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90106200A EP0448765B1 (fr) 1990-03-30 1990-03-30 Uitlisation de dérivés de la guanidine pour la fabrication d'un médicament à activité antagoniste du neuropeptide Y

Publications (1)

Publication Number Publication Date
ZA911471B true ZA911471B (en) 1991-11-27

Family

ID=8203843

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA911471A ZA911471B (en) 1990-03-30 1991-02-28 The use of guanidine derivatives for the preparation of a pharmaceutical product having pny antagonistic activity

Country Status (14)

Country Link
EP (1) EP0448765B1 (fr)
JP (1) JPH0789939A (fr)
KR (1) KR910016329A (fr)
AT (1) ATE109979T1 (fr)
AU (1) AU637882B2 (fr)
CA (1) CA2037433A1 (fr)
DE (1) DE59006842D1 (fr)
DK (1) DK0448765T3 (fr)
ES (1) ES2058651T3 (fr)
HU (1) HU207945B (fr)
IE (1) IE65252B1 (fr)
IL (1) IL97424A (fr)
PT (1) PT97138A (fr)
ZA (1) ZA911471B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993012139A1 (fr) * 1991-12-19 1993-06-24 Garvan Institute Of Medical Research Nouvelle molecule inhibant la fonction biologique du neuropeptide tyrosine
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) * 1994-02-03 1996-08-13 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5989920A (en) * 1994-12-02 1999-11-23 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en) 1994-12-02 1997-02-11 Synaptic Pharmaceutical Corporation DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
AU7692996A (en) * 1995-12-01 1997-06-27 Ciba-Geigy Ag Receptor antagonists
WO1997020822A1 (fr) * 1995-12-01 1997-06-12 Novartis Ag Quinazolin-2,4-diazirines en tant qu'antagoniste du recepteur du neuropeptide y
AU2764797A (en) * 1996-05-14 1997-12-05 Novo Nordisk A/S Somatostatin agonists and antagonists
WO1998007420A1 (fr) * 1996-08-23 1998-02-26 Agouron Acquisition Corp. Ligands du neuropeptide y
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2001502712A (ja) * 1996-10-31 2001-02-27 ノボ ノルディスク アクティーゼルスカブ 束縛されたソマトスタチン・アゴニスト及びアンタゴニスト
US6048900A (en) 1998-02-13 2000-04-11 Bayer Corporation Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists
US6245817B1 (en) 1997-02-14 2001-06-12 Bayer Corporation NPY5 receptor antagonists and methods for using same
AU6267198A (en) * 1997-02-14 1998-09-08 Bayer Corporation Amides as npy5 receptor antagonists
WO1998035957A1 (fr) * 1997-02-14 1998-08-20 Bayer Corporation Derives amides actifs comme antagonistes selectifs du recepteur du neuropeptide y
US6713265B1 (en) 1997-06-04 2004-03-30 Synaptic Pharmaceutical Corporation Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
US6121260A (en) 1997-07-03 2000-09-19 Neurogen Corporation Method of treating conditions susceptible to modulation of NPY receptors with diarylimidazole derivatives
ES2161594B1 (es) * 1998-12-17 2003-04-01 Servier Lab Nuevos derivados de la hidrazida, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AU2935200A (en) 1999-04-30 2000-11-17 Pfizer Products Inc. Compounds for the treatment of obesity
WO2002024657A2 (fr) 2000-09-20 2002-03-28 Schering Corporation Imidazoles substitues en tant qu'agonistes ou antagonistes doubles des recepteurs h1 and h3 de l'histamine
WO2002044141A2 (fr) 2000-09-20 2002-06-06 Schering Corporation Imidazoles substituees utilisees comme agonistes ou antagonistes doubles d'histamine h1 et h3
MXPA03002448A (es) 2000-09-20 2003-06-19 Schering Corp Eimidazoles sustituidos como agonistas o antagonistas duales h1 y h3 de histamina.
MY129677A (en) 2000-09-20 2007-04-30 Schering Corp Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0199845B1 (fr) * 1985-04-02 1990-08-01 HEUMANN PHARMA GMBH & CO Dérivés d'imidazolylalkylguanidine, leur procédé de préparation et compositions les contenant
DE3631334A1 (de) * 1986-09-15 1988-03-17 Heumann Pharma Gmbh & Co Neue imidazolylguanidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
IE65252B1 (en) 1995-10-18
ES2058651T3 (es) 1994-11-01
JPH0789939A (ja) 1995-04-04
CA2037433A1 (fr) 1991-10-01
IE910995A1 (en) 1991-10-09
AU7206891A (en) 1991-10-03
KR910016329A (ko) 1991-11-05
ATE109979T1 (de) 1994-09-15
HUT57044A (en) 1991-11-28
IL97424A0 (en) 1992-06-21
IL97424A (en) 1995-05-26
DK0448765T3 (da) 1994-09-19
DE59006842D1 (de) 1994-09-22
PT97138A (pt) 1991-11-29
AU637882B2 (en) 1993-06-10
HU207945B (en) 1993-07-28
HU910979D0 (en) 1991-10-28
EP0448765B1 (fr) 1994-08-17
EP0448765A1 (fr) 1991-10-02

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