ZA913092B - Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines - Google Patents

Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines

Info

Publication number: ZA913092B
Authority: ZA; South Africa
Prior art keywords: imidazol; substituted; phenyl; dihydrohalide; pyridinyl
Prior art date: 1990-04-25

Application number

ZA913092A

Other languages

English (en)

Inventor

William Dennis Dean

Dennis Dean William

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-25

Filing date

1991-04-24

Publication date

1992-02-26

1991-04-24 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1992-02-26 Publication of ZA913092B publication Critical patent/ZA913092B/xx

Links

238000000034 method Methods 0.000 title abstract 4
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
-1 2-pyridinyl Chemical group 0.000 abstract 4
JPPRNSQAQOGYPJ-UHFFFAOYSA-N 2-(3-imidazol-1-ylphenyl)guanidine Chemical compound NC(=N)NC1=CC=CC(N2C=NC=C2)=C1 JPPRNSQAQOGYPJ-UHFFFAOYSA-N 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Photoreceptors In Electrophotography (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA913092A 1990-04-25 1991-04-24 Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines ZA913092B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/514,455 US5064963A (en)	1990-04-25	1990-04-25	Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines

Publications (1)

Publication Number	Publication Date
ZA913092B true ZA913092B (en)	1992-02-26

Family

ID=24047219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA913092A ZA913092B (en)	1990-04-25	1991-04-24	Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines

Country Status (19)

Country	Link
US (1)	US5064963A (fr)
EP (1)	EP0453731B1 (fr)
JP (1)	JPH04225975A (fr)
KR (1)	KR0168679B1 (fr)
AT (1)	ATE170184T1 (fr)
AU (1)	AU630849B2 (fr)
CA (1)	CA2041031A1 (fr)
DE (1)	DE69130029T2 (fr)
DK (1)	DK0453731T3 (fr)
ES (1)	ES2121757T3 (fr)
FI (1)	FI100533B (fr)
GR (1)	GR3027762T3 (fr)
HU (1)	HU211774B (fr)
IE (1)	IE911366A1 (fr)
NO (1)	NO177567C (fr)
NZ (1)	NZ237870A (fr)
SG (1)	SG47565A1 (fr)
TW (1)	TW215087B (fr)
ZA (1)	ZA913092B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5521184A (en) *	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en) *	1992-08-31	1996-05-14	Ciba-Geigy Corporation	Further use of pyrimidine derivatives
KR100643419B1 (ko) *	1998-03-27	2006-11-10	얀센 파마슈티카 엔.브이.	Ｈｉｖ를 억제하는 피리미딘 유도체
TR200200763T2 (tr)	1999-09-24	2003-09-22	Janssen Pharmaceutica N.V.	Antiviral bileşimler
US7803806B2 (en)	2005-11-03	2010-09-28	Sgx Pharmaceuticals, Inc.	Pyrimidinyl-thiophene kinase modulators
KR20090130345A (ko) *	2007-05-04	2009-12-22	아이알엠 엘엘씨	Ｃ-ｋｉｔ 및 ｐｄｇｆｒ 키나제 억제제로서의 화합물 및 조성물
EP2863913B1 (fr)	2012-06-20	2018-09-12	Merck Sharp & Dohme Corp.	Analogues d'imidazolyle en tant qu'inhibiteurs de syk
EP2863914B1 (fr) *	2012-06-20	2018-10-03	Merck Sharp & Dohme Corp.	Dérivés de pyrazolyle en tant qu'inhibiteurs de syk
CN110330447B (zh) *	2019-07-16	2022-04-15	北京赛升药业股份有限公司	一种甲磺酸萘莫司他中间体的制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5319479A (en) *	1978-12-22	1980-06-26	Ici Australia Limited	Pyrimidinyl amino phenoxy carboxylate derivatives
EP0164204A1 (fr) *	1984-05-12	1985-12-11	FISONS plc	Pyrimidines utiles dans des préparations pharmaceutiques
US4788195A (en) *	1986-01-13	1988-11-29	American Cyanamid Company	4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines

1990
- 1990-04-25 US US07/514,455 patent/US5064963A/en not_active Expired - Fee Related
1991
- 1991-02-27 DK DK91102859T patent/DK0453731T3/da active
- 1991-02-27 SG SG1996002850A patent/SG47565A1/en unknown
- 1991-02-27 AT AT91102859T patent/ATE170184T1/de active
- 1991-02-27 ES ES91102859T patent/ES2121757T3/es not_active Expired - Lifetime
- 1991-02-27 EP EP91102859A patent/EP0453731B1/fr not_active Expired - Lifetime
- 1991-02-27 DE DE69130029T patent/DE69130029T2/de not_active Expired - Fee Related
- 1991-03-22 TW TW080102248A patent/TW215087B/zh active
- 1991-04-18 NZ NZ237870A patent/NZ237870A/xx unknown
- 1991-04-23 CA CA002041031A patent/CA2041031A1/fr not_active Abandoned
- 1991-04-23 JP JP3117918A patent/JPH04225975A/ja active Pending
- 1991-04-24 AU AU75905/91A patent/AU630849B2/en not_active Ceased
- 1991-04-24 NO NO911632A patent/NO177567C/no unknown
- 1991-04-24 HU HU911373A patent/HU211774B/hu not_active IP Right Cessation
- 1991-04-24 IE IE136691A patent/IE911366A1/en unknown
- 1991-04-24 FI FI911983A patent/FI100533B/fi active
- 1991-04-24 KR KR1019910006612A patent/KR0168679B1/ko not_active Expired - Fee Related
- 1991-04-24 ZA ZA913092A patent/ZA913092B/xx unknown
1998
- 1998-08-27 GR GR980401941T patent/GR3027762T3/el unknown

Also Published As

Publication number	Publication date
FI911983L (fi)	1991-10-26
DE69130029D1 (de)	1998-10-01
US5064963A (en)	1991-11-12
NZ237870A (en)	1993-05-26
AU7590591A (en)	1991-11-07
GR3027762T3 (en)	1998-11-30
EP0453731A3 (en)	1992-09-02
SG47565A1 (en)	1998-04-17
NO911632D0 (no)	1991-04-24
AU630849B2 (en)	1992-11-05
EP0453731A2 (fr)	1991-10-30
ATE170184T1 (de)	1998-09-15
FI911983A0 (fi)	1991-04-24
NO911632L (no)	1991-10-28
DE69130029T2 (de)	1999-02-18
NO177567B (no)	1995-07-03
HU911373D0 (en)	1991-10-28
IE911366A1 (en)	1991-11-06
HUT57719A (en)	1991-12-30
CA2041031A1 (fr)	1991-10-26
JPH04225975A (ja)	1992-08-14
NO177567C (no)	1995-10-11
HU211774B (en)	1995-12-28
KR910018375A (ko)	1991-11-30
TW215087B (fr)	1993-10-21
EP0453731B1 (fr)	1998-08-26
KR0168679B1 (ko)	1999-01-15
DK0453731T3 (da)	1999-02-15
ES2121757T3 (es)	1998-12-16
FI100533B (fi)	1997-12-31

Publication	Publication Date	Title
US5675006A (en)	1997-10-07	Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor
ZA913092B (en)	1992-02-26	Process for the synthesis of n-(3-(1h-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidinamines
US6018049A (en)	2000-01-25	Process for the preparation of carbamoylated imidazole derivatives
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US5789597A (en)	1998-08-04	Process for the preparation of compounds having ACE inhibitory action and intermediates in said process
US4855439A (en)	1989-08-08	Process for the preparation of cimetidine
GB2085871A (en)	1982-05-06	New 3-substituted-2-propenimidamides and method of manufacturing the same
US3429911A (en)	1969-02-25	1-bis(cyanomethyl)-3-phenylureas
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US7067671B2 (en)	2006-06-27	Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof
JPS636063B2 (fr)	1988-02-08
CA1305718C (fr)	1992-07-28	Derives alpha-acyloxycetone
JP2668168B2 (ja)	1997-10-27	フェノキシ誘導体
Zawistoski	1990	Synthesis of 4‐[3‐(1H)‐indolyl]‐2‐[N‐guanidinomethyl] thiazole dihydrochloride
JPH07309843A (ja)	1995-11-28	２−シアノイミダゾール系化合物の製造方法
JPH0359905B2 (fr)	1991-09-12
HU213116B (en)	1997-02-28	A new process for producing n``-cyano-n`-(4-pyridyl)-n-(1,2,2-trimethyl-propyl)-guanidine
JPH0561264B2 (fr)	1993-09-06