ZA915932B - (2r)-2-(di(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane,its preparation and use - Google Patents

(2r)-2-(di(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane,its preparation and use

Info

Publication number: ZA915932B
Authority: ZA; South Africa
Prior art keywords: trimethylacetoxypropane; phosphonylmethoxy; toluenesulfonyloxy; propyl; preparation
Prior art date: 1990-08-06

Application number

ZA915932A

Other languages

English (en)

Inventor

Petr Alexander

Alexander Petr

Antonin Holy

Holy Antonin

Hanna Dvorakova

Dvorakova Hanna

Original Assignee

Ceskoslovenska Akademie Ved

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-06

Filing date

1991-07-29

Publication date

1992-04-29

1991-07-29 Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved

1992-04-29 Publication of ZA915932B publication Critical patent/ZA915932B/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA915932A 1990-08-06 1991-07-29 (2r)-2-(di(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane,its preparation and use ZA915932B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS903871A CS276072B6 (en)	1990-08-06	1990-08-06	(2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF

Publications (1)

Publication Number	Publication Date
ZA915932B true ZA915932B (en)	1992-04-29

Family

ID=5380072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA915932A ZA915932B (en)	1990-08-06	1991-07-29	(2r)-2-(di(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane,its preparation and use

Country Status (13)

Country	Link
US (2)	US5130427A (cs)
EP (1)	EP0470809A1 (cs)
JP (1)	JP2955402B2 (cs)
AU (1)	AU8149291A (cs)
CA (1)	CA2046755C (cs)
CS (1)	CS276072B6 (cs)
FI (1)	FI913702A7 (cs)
IE (1)	IE71217B1 (cs)
IL (1)	IL98849A0 (cs)
NO (1)	NO913035L (cs)
NZ (1)	NZ239131A (cs)
PT (1)	PT98590B (cs)
ZA (1)	ZA915932B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ284678B6 (cs) *	1991-05-20	1999-01-13	Ústav Organické Chemie A Biochemie Avčr	Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
US6057305A (en) *	1992-08-05	2000-05-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiretroviral enantiomeric nucleotide analogs
JP2532818B2 (ja)	1993-02-01	1996-09-11	松下電器産業株式会社	対物レンズおよび光ヘッド装置
US5502177A (en) *	1993-09-17	1996-03-26	Gilead Sciences, Inc.	Pyrimidine derivatives for labeled binding partners
JP4555536B2 (ja) *	2000-02-18	2010-10-06	サザン・リサーチ・インスティテュート	２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
CN1291994C (zh)	2000-07-21	2006-12-27	吉里德科学公司	核苷酸膦酸酯类似物前药及其筛选和制备方法
AU2003235501A1 (en) *	2002-05-13	2003-11-11	Metabasis Therapeutics, Inc.	PMEA and PMPA cyclic producing synthesis
NZ536328A (en) *	2002-05-13	2007-11-30	Metabasis Therapeutics Inc	Novel phosphonic acid based prodrugs of PMEA and its analogues
MXPA06014013A (es) *	2004-06-08	2007-03-15	Metabasis Therapeutics Inc	Sintesis mediada por acidos de lewis de esteres ciclicos.
RU2606845C2 (ru)	2010-12-10	2017-01-10	СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи	Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
EP2794624B1 (en)	2011-12-22	2019-05-15	Geron Corporation	Guanine analogs as telomerase substrates and telomere length affectors
US10449210B2 (en)	2014-02-13	2019-10-22	Ligand Pharmaceuticals Inc.	Prodrug compounds and their uses
CN106687118A (zh)	2014-07-02	2017-05-17	配体药物公司	前药化合物及其用途
CN111788196A (zh)	2018-01-09	2020-10-16	配体药物公司	缩醛化合物及其治疗用途
JP7151348B2 (ja) *	2018-10-03	2022-10-12	日本製鉄株式会社	金属板用塗料およびこれを用いた塗装金属板の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4868187A (en) *	1980-09-16	1989-09-19	Syntex (U.S.A.) Inc.	Anti-viral N-substituted pyrimidines
US4816447A (en) *	1981-08-26	1989-03-28	Merck & Co., Inc.	Anti-viral guanine compounds
CS233665B1 (en) *	1983-01-06	1985-03-14	Antonin Holy	Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US5047533A (en) *	1983-05-24	1991-09-10	Sri International	Acyclic purine phosphonate nucleotide analogs
CS263951B1 (en) *	1985-04-25	1989-05-12	Antonin Holy	9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) *	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU8092587A (en) *	1986-11-18	1988-05-19	Bristol-Myers Squibb Company	Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids
US4927830A (en) *	1988-04-08	1990-05-22	The Regents Of The University Of Michigan	Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
US4968686A (en) *	1988-04-08	1990-11-06	The Regents Of The University Of Michigan	Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
JP3116079B2 (ja) *	1990-08-10	2000-12-11	インスティチュートオブオーガニックケミストリアンドバイオケミストリアカデミーオブサイエンスオブザチェコリパブリック	ヌクレオチドの新規な製法

1990
- 1990-08-06 CS CS903871A patent/CS276072B6/cs not_active IP Right Cessation
1991
- 1991-07-11 CA CA002046755A patent/CA2046755C/en not_active Expired - Lifetime
- 1991-07-12 US US07/729,422 patent/US5130427A/en not_active Ceased
- 1991-07-15 IL IL98849A patent/IL98849A0/xx unknown
- 1991-07-25 NZ NZ239131A patent/NZ239131A/xx not_active IP Right Cessation
- 1991-07-29 ZA ZA915932A patent/ZA915932B/xx unknown
- 1991-07-30 AU AU81492/91A patent/AU8149291A/en not_active Abandoned
- 1991-08-02 FI FI913702A patent/FI913702A7/fi unknown
- 1991-08-02 IE IE275891A patent/IE71217B1/en not_active IP Right Cessation
- 1991-08-05 JP JP3195454A patent/JP2955402B2/ja not_active Expired - Lifetime
- 1991-08-05 NO NO91913035A patent/NO913035L/no unknown
- 1991-08-06 PT PT98590A patent/PT98590B/pt not_active IP Right Cessation
- 1991-08-06 EP EP91307208A patent/EP0470809A1/en not_active Withdrawn
1994
- 1994-07-14 US US08/275,186 patent/USRE35558E/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH05230087A (ja)	1993-09-07
NO913035D0 (no)	1991-08-05
US5130427A (en)	1992-07-14
NO913035L (no)	1992-02-07
IL98849A0 (en)	1992-07-15
CS387190A3 (en)	1992-03-18
FI913702L (fi)	1992-02-07
FI913702A0 (fi)	1991-08-02
PT98590B (pt)	1999-04-30
NZ239131A (en)	1994-04-27
FI913702A7 (fi)	1992-02-07
CA2046755A1 (en)	1992-02-07
EP0470809A1 (en)	1992-02-12
IE912758A1 (en)	1992-02-12
CA2046755C (en)	2002-02-12
CS276072B6 (en)	1992-03-18
JP2955402B2 (ja)	1999-10-04
USRE35558E (en)	1997-07-08
PT98590A (pt)	1992-06-30
AU8149291A (en)	1992-02-13
IE71217B1 (en)	1997-02-12

Publication	Publication Date	Title
PH30928A (en)	1997-12-23	Pharmaceutical agents.
HUP9801570A3 (en)	1999-03-01	Polysiloxane-comprising perfluoroalkyl ethers, and the preparation and use thereof
IE900184L (en)	1990-07-23	Grisle wire for medical use.
EP0685202A3 (en)	1996-03-20	Fabric measures.
IL98849A0 (en)	1992-07-15	(2r)-2-(di-(2-propyl)phosphonylmethoxy)-3-p-toluenesulfonyloxy-1-trimethylacetoxypropane,its preparation and use
ZA951374B (en)	1996-01-10	Ranitidine solid dosage form
EP0472078A3 (en)	1993-03-31	Phosphonopyrrolidin- and piperidin-containing statin-type pseudopeptides, their preparation and use against retroviruses
OA09308A (en)	1992-09-15	Anti-HIV agent.
ZA91525B (en)	1992-02-26	Pharmaceutical formulation
PL286620A1 (en)	1992-05-18	Microbiocidal agent
EP0536311A4 (en)	1993-05-19	Compositions comprising vitamin d precursors, analogs thereof and their use
GB9000241D0 (en)	1990-03-07	Pharmaceutical use
IL109993A0 (en)	1994-10-07	Ipsapirone medicament formulation
GB9418550D0 (en)	1994-11-02	Drug formulation
ZA917789B (en)	1993-03-30	Pharmaceutical preparation.
ZA957349B (en)	1997-03-03	Pharmaceutical formulations.
CA63211S (en)	1989-05-09	Medicament applicator
GB8900228D0 (en)	1989-03-08	Pharmaceutical use
GB9021241D0 (en)	1990-11-14	New pharmaceutical use
GB9004360D0 (en)	1990-04-25	New pharmaceutical use
GB9014230D0 (en)	1990-08-15	New pharmaceutical use
GB9014231D0 (en)	1990-08-15	New pharmaceutical use
GB9014229D0 (en)	1990-08-15	New pharmaceutical use
GB9004372D0 (en)	1990-04-25	New pharmaceutical use
GB9023646D0 (en)	1990-12-12	New pharmaceutical use