ZA917008B - An enzymatic process for the conversion of preproinsulins into insulins - Google Patents

An enzymatic process for the conversion of preproinsulins into insulins

Info

Publication number
ZA917008B
ZA917008B ZA917008A ZA917008A ZA917008B ZA 917008 B ZA917008 B ZA 917008B ZA 917008 A ZA917008 A ZA 917008A ZA 917008 A ZA917008 A ZA 917008A ZA 917008 B ZA917008 B ZA 917008B
Authority
ZA
South Africa
Prior art keywords
preproinsulins
insulins
conversion
enzymatic process
intermediates
Prior art date
Application number
ZA917008A
Other languages
English (en)
Inventor
Michael Doerschug
Doerschug Michael
Klaus-Peter Koller
Koller Klaus-Peter
Ruediger Marquardt
Marquardt Ruediger
Johannes Meiwes
Meiwes Johannes
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA917008B publication Critical patent/ZA917008B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA917008A 1990-09-05 1991-09-04 An enzymatic process for the conversion of preproinsulins into insulins ZA917008B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4028118 1990-09-05

Publications (1)

Publication Number Publication Date
ZA917008B true ZA917008B (en) 1992-04-29

Family

ID=6413629

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA917008A ZA917008B (en) 1990-09-05 1991-09-04 An enzymatic process for the conversion of preproinsulins into insulins

Country Status (26)

Country Link
US (1) US5728543A (fr)
EP (1) EP0474212B1 (fr)
JP (1) JP3005335B2 (fr)
KR (1) KR100188800B1 (fr)
AT (1) ATE145922T1 (fr)
AU (1) AU637254B2 (fr)
CA (1) CA2050606C (fr)
CZ (1) CZ283234B6 (fr)
DE (1) DE59108392D1 (fr)
DK (1) DK0474212T3 (fr)
ES (1) ES2095891T3 (fr)
FI (1) FI103805B (fr)
GR (1) GR3021909T3 (fr)
HR (1) HRP940766A2 (fr)
HU (1) HU214676B (fr)
IE (1) IE75723B1 (fr)
IL (1) IL99383A (fr)
LT (1) LT3328B (fr)
LV (1) LV10508B (fr)
NO (1) NO300980B1 (fr)
NZ (1) NZ239652A (fr)
PL (1) PL167810B1 (fr)
RU (1) RU2062301C1 (fr)
SK (1) SK279686B6 (fr)
YU (1) YU147491A (fr)
ZA (1) ZA917008B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2122549C1 (ru) * 1997-12-29 1998-11-27 Закрытое акционерное общество "Фосфосорб" Способ хроматографического выделения и очистки белков, пептидов и их комплексов
RU2238951C2 (ru) * 1998-03-31 2004-10-27 Тонгхуа Гэнтеч Биотекнолоджи Лтд. Химерный белок, обеспечивающий образование биоактивной конформации, способ получения белка с инсулиновой активностью, способ идентификации пептидильного фрагмента
US6461834B1 (en) * 1998-11-06 2002-10-08 Bionebraska, Inc. Clostripain catalyzed amidation of peptides
DE19915938A1 (de) * 1999-04-09 2000-10-19 Aventis Pharma Gmbh Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
EP1513945A4 (fr) * 2002-05-24 2008-12-24 Restoragen Inc Methode de production enzymatique universelle de peptides bioactifs
WO2003099854A2 (fr) * 2002-05-24 2003-12-04 Nps Allelix Corp. Procede de production enzymatique de peptides glp-2 (1-34) et glp-2 (1-33)
EP1551435A4 (fr) * 2002-05-24 2007-08-08 Restoragen Inc Methode de production enzymatique de peptides amides glp-1 (7-36)
HRP20120315T1 (hr) * 2003-11-21 2012-05-31 Nps Pharmaceuticals Proizvodnja peptida 2 nalik glukagonu i analoga
WO2013015697A1 (fr) * 2011-07-28 2013-01-31 Mabion S.A. Protéine recombinante, polynucléotide codant pour celle-ci ainsi que procédé d'obtention d'insuline ou de son analogue
KR102646845B1 (ko) 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU81606A1 (de) 1979-08-14 1981-03-24 Arbed Verfahren und einrichtung zur wiederverwertung von kohlenstoffreichen abfallprodukten
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
EP0109420A1 (fr) 1982-05-27 1984-05-30 Neiman S.A. Serrure cylindrique, notamment verrou de direction pour vehicule automobile
JPS60217894A (ja) * 1984-04-14 1985-10-31 Suntory Ltd 新規プロテア−ゼ及びその製造方法
DE3440988A1 (de) 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
IL84110A (en) 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
DE4012818A1 (de) * 1990-04-21 1991-10-24 Hoechst Ag Verfahren zur herstellung von fremdproteinen in streptomyceten
DE58906966D1 (de) 1988-06-23 1994-03-24 Hoechst Ag Mini-Proinsulin, seine Herstellung und Verwendung.
DE3919852A1 (de) * 1988-06-23 1989-12-28 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung
EP0367163B1 (fr) 1988-11-03 1996-01-03 Hoechst Aktiengesellschaft Procédé de préparation d'un précurseur d'insuline chez les streptomyces
US5617606A (en) 1996-02-29 1997-04-08 Baracuda International Corp. Fluted swimming pool cleaner discs

Also Published As

Publication number Publication date
DE59108392D1 (de) 1997-01-16
FI103805B1 (fi) 1999-09-30
LV10508A (lv) 1995-02-20
HUT58823A (en) 1992-03-30
KR920006504A (ko) 1992-04-27
EP0474212A2 (fr) 1992-03-11
IE913117A1 (en) 1992-03-11
AU637254B2 (en) 1993-05-20
PL167810B1 (pl) 1995-11-30
PL291617A1 (en) 1992-03-09
JPH04258296A (ja) 1992-09-14
HU214676B (hu) 1998-04-28
DK0474212T3 (da) 1997-05-12
NO913474L (no) 1992-03-06
LTIP712A (en) 1995-01-31
NO300980B1 (no) 1997-08-25
LV10508B (en) 1996-02-20
AU8356791A (en) 1992-03-12
YU147491A (sh) 1995-10-24
US5728543A (en) 1998-03-17
RU2062301C1 (ru) 1996-06-20
EP0474212B1 (fr) 1996-12-04
IL99383A0 (en) 1992-08-18
FI914151L (fi) 1992-03-06
HRP940766A2 (en) 1997-08-31
CA2050606C (fr) 2002-08-13
FI914151A0 (fi) 1991-09-03
HU912875D0 (en) 1992-01-28
SK279686B6 (sk) 1999-02-11
NZ239652A (en) 1992-09-25
NO913474D0 (no) 1991-09-04
GR3021909T3 (en) 1997-03-31
EP0474212A3 (fr) 1992-04-08
FI103805B (fi) 1999-09-30
CZ283234B6 (cs) 1998-02-18
JP3005335B2 (ja) 2000-01-31
KR100188800B1 (ko) 1999-06-01
ES2095891T3 (es) 1997-03-01
IL99383A (en) 1996-01-31
CS271191A3 (en) 1992-03-18
LT3328B (en) 1995-07-25
IE75723B1 (en) 1997-09-24
CA2050606A1 (fr) 1992-03-06
ATE145922T1 (de) 1996-12-15

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