ZA917531B - Isoprenoid phospholipase a2 inhibitors and preparations comprising same - Google Patents

Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Info

Publication number
ZA917531B
ZA917531B ZA917531A ZA917531A ZA917531B ZA 917531 B ZA917531 B ZA 917531B ZA 917531 A ZA917531 A ZA 917531A ZA 917531 A ZA917531 A ZA 917531A ZA 917531 B ZA917531 B ZA 917531B
Authority
ZA
South Africa
Prior art keywords
phospholipase
isoprenoid
preparations
inhibitors
same
Prior art date
Application number
ZA917531A
Other languages
English (en)
Inventor
F Ivy Carroll
Ivy Carroll F
Anita Lewin
Lewin Anita
Kenneth Tramposch
Tramposch Kenneth
Stephen A Steiner
A Steiner Stephen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA917531B publication Critical patent/ZA917531B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
ZA917531A 1990-09-21 1991-09-20 Isoprenoid phospholipase a2 inhibitors and preparations comprising same ZA917531B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,159 US5141959A (en) 1990-09-21 1990-09-21 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Publications (1)

Publication Number Publication Date
ZA917531B true ZA917531B (en) 1992-07-29

Family

ID=24344545

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA917531A ZA917531B (en) 1990-09-21 1991-09-20 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Country Status (18)

Country Link
US (1) US5141959A (de)
EP (1) EP0476682B1 (de)
JP (1) JP2943089B2 (de)
AT (1) ATE117979T1 (de)
AU (1) AU637756B2 (de)
CA (1) CA2051766A1 (de)
DE (1) DE69107153T2 (de)
DK (1) DK0476682T3 (de)
ES (1) ES2067822T3 (de)
FI (1) FI104168B (de)
GR (1) GR3014944T3 (de)
IE (1) IE66745B1 (de)
IL (1) IL99536A (de)
MX (1) MX9101163A (de)
NZ (1) NZ239844A (de)
OA (1) OA09514A (de)
PT (1) PT99014B (de)
ZA (1) ZA917531B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5436369A (en) * 1993-06-16 1995-07-25 Bristol-Myers Squibb Company Alicyclic phospholipase A2 inhibitors
US5688781A (en) * 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6267945B1 (en) * 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers
US6538010B1 (en) 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
WO2003099272A1 (en) * 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
US20040018533A1 (en) * 2002-06-04 2004-01-29 Adam Gail Isabel Reid Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
WO2004002295A2 (en) * 2002-06-27 2004-01-08 Sequenom, Inc. Diagnosing predisposition to fat deposition and associated condition
AU2003248794B2 (en) * 2002-06-27 2007-10-04 Harkness Pharmaceuticals, Inc. Therapeutic methods for reducing fat deposition and treating associated conditions
JP2006508986A (ja) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
EP1817020A4 (de) * 2004-11-08 2012-11-21 Errant Gene Therapeutics Inc Inhibitoren der histondeacetylase
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
WO2008131368A2 (en) * 2007-04-20 2008-10-30 Acucela Inc. Styrenyl derivative compounds for treating ophthalmic diseases and disorders
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
EP2539706B1 (de) 2010-02-24 2015-03-04 Research Triangle Institute Arylpiperazin-opioid-rezeptor-antagonisten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194007A (en) * 1978-01-13 1980-03-18 Scott Eugene J Van α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions
US4456618A (en) * 1982-10-15 1984-06-26 Sri International Naphthenic and heterocyclic retinoic acid analogues
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
DE69107153T2 (de) 1995-05-24
EP0476682A1 (de) 1992-03-25
FI914405A0 (fi) 1991-09-19
PT99014B (pt) 1999-02-26
ES2067822T3 (es) 1995-04-01
IL99536A0 (en) 1992-08-18
DK0476682T3 (da) 1995-04-03
DE69107153D1 (de) 1995-03-16
FI104168B1 (fi) 1999-11-30
IE913318A1 (en) 1992-02-25
IE66745B1 (en) 1996-02-07
IL99536A (en) 1995-10-31
JP2943089B2 (ja) 1999-08-30
GR3014944T3 (en) 1995-05-31
CA2051766A1 (en) 1992-03-22
JPH04270261A (ja) 1992-09-25
NZ239844A (en) 1993-04-28
AU637756B2 (en) 1993-06-03
AU8462691A (en) 1992-03-26
PT99014A (pt) 1992-08-31
FI914405L (fi) 1992-03-22
ATE117979T1 (de) 1995-02-15
MX9101163A (es) 1992-05-04
US5141959A (en) 1992-08-25
FI104168B (fi) 1999-11-30
OA09514A (en) 1992-11-15
EP0476682B1 (de) 1995-02-01

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