ZA919410B - Guanidine compounds,process for preparing these and pharmaceutical compositions containing them - Google Patents

Guanidine compounds,process for preparing these and pharmaceutical compositions containing them

Info

Publication number: ZA919410B
Authority: ZA; South Africa
Prior art keywords: group; denotes; preparing; pharmaceutical compositions; compositions containing
Prior art date: 1990-11-29

Application number

ZA919410A

Other languages

English (en)

Inventor

Charles Malen

Malen Charles

Jean-Michel Lacoste

Lacoste Jean-Michel

Guillaume De Nanteuil

De Nanteuil Guillaume

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-29

Filing date

1991-11-28

Publication date

1993-04-28

1991-11-28 Application filed by Adir filed Critical Adir

1993-04-28 Publication of ZA919410B publication Critical patent/ZA919410B/xx

Links

150000002357 guanidines Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Neurology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compositions Of Macromolecular Compounds (AREA)

ZA919410A 1990-11-29 1991-11-28 Guanidine compounds,process for preparing these and pharmaceutical compositions containing them ZA919410B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9014898A FR2669927B1 (fr)	1990-11-29	1990-11-29	Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number	Publication Date
ZA919410B true ZA919410B (en)	1993-04-28

Family

ID=9402693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA919410A ZA919410B (en)	1990-11-29	1991-11-28	Guanidine compounds,process for preparing these and pharmaceutical compositions containing them

Country Status (14)

Country	Link
US (2)	US5494934A (de)
EP (1)	EP0488897B1 (de)
JP (1)	JPH0669999B2 (de)
AT (1)	ATE101128T1 (de)
AU (1)	AU638879B2 (de)
CA (1)	CA2056560A1 (de)
DE (1)	DE69101141T2 (de)
DK (1)	DK0488897T3 (de)
ES (1)	ES2063471T3 (de)
FR (1)	FR2669927B1 (de)
IE (1)	IE65632B1 (de)
NZ (1)	NZ240789A (de)
PT (1)	PT99644B (de)
ZA (1)	ZA919410B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5612332A (en) *	1984-03-19	1997-03-18	Alteon Inc.	Di- and triaminoguanidines, and methods of use
US5852009A (en) *	1984-03-19	1998-12-22	The Rockefeller University	Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
JPH0778038B2 (ja) *	1989-01-18	1995-08-23	日東紡績株式会社	Ｌ―アルギニナールジ低級アルキルアセタールの製造法
US5478946A (en) *	1989-06-21	1995-12-26	Abbott Laboratories	Guanidino compounds as regulators of nitric oxide synthase
US5380945A (en) *	1989-06-21	1995-01-10	Abbott Laboratories	Guanidino compounds as regulators of nitric oxide synthase
HUT64023A (en) *	1991-03-22	1993-11-29	Sandoz Ag	Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
US5441984A (en) *	1994-01-06	1995-08-15	Eli Lilly And Company	Urea, thiourea and guanidine derivatives
WO1995028377A1 (en) *	1994-04-18	1995-10-26	Abbott Laboratories	Guanidine compounds as regulators of nitric oxide synthase
US5972948A (en) *	1994-07-01	1999-10-26	Solvay Pharmaceuticals Gmbh	Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) *	1994-07-01	1996-01-04	Kali Chemie Pharma Gmbh	Antihyperglykämisch wirksame Arzneimittel
IT1279386B1 (it) *	1994-11-07	1997-12-10	Sigma Tau Ind Farmaceuti	1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5850840A (en) *	1995-11-15	1998-12-22	Alteon Inc.	Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) *	1995-12-26	1999-03-02	Alteon Inc.	N-acylaminoalkyl-hydrazinecarboximidamides
US6110968A (en) *	1995-12-26	2000-08-29	The Picower Institute For Medical Research	Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
CA2250426C (en) *	1996-03-29	2006-05-02	3-Dimensional Pharmaceuticals, Inc.	Amidinohydrazones as protease inhibitors
JP2000136250A (ja) *	1998-10-29	2000-05-16	Rhein Chem Rheinau Gmbh	加硫促進剤としてのキサントゲン酸アリ―ルグアニジニウムの使用およびそれの製造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1205521B (de) *	1960-06-20	1965-11-25	Ciba Geigy	Verfahren zur Herstellung von Guanylhydrazonen
US3658993A (en) *	1967-10-12	1972-04-25	Shell Oil Co	Methods of inducing a cardiovascular hypotensive response
GB1223491A (en) *	1967-10-13	1971-02-24	American Home Prod	Guanidines
US3816531A (en) *	1970-07-01	1974-06-11	American Home Prod	(2,6-disubstituted benzylidene)amino guanidines and related compounds
US4102890A (en) *	1972-12-28	1978-07-25	Science-Union Et Cie, Societe Francaise De Recherche Medicale	2-Amino oxazolines and process for making the same
GB1453703A (en) *	1972-12-28	1976-10-27	Science Union & Cie	Substituted cyclopropylmethylamines processes for their preparation and pharmaceutical compositions containing them
US3916531A (en) *	1974-01-02	1975-11-04	Paul S Morton	Leveling method and device for motor home
US4136188A (en) *	1976-06-25	1979-01-23	Daiichi Seiyaku Co., Ltd.	Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds
JPS54115330A (en) *	1978-02-27	1979-09-07	Tamio Nishimura	Nnsubstituted amidinohydrazones and their manufacture
FR2444673A1 (fr) *	1978-12-20	1980-07-18	Science Union & Cie	Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
JPS55151570A (en) *	1979-05-15	1980-11-26	Takeda Chem Ind Ltd	Pyrimidine derivatives, their preparation and antimicrobial for agriculture
ES511134A0 (es) *	1981-04-06	1983-02-16	Hexachimie	"procedimiento de preparacion de nuevos derivados de la hidrazina, utiles como fungicidas y bactericidas".
EP0101411B1 (de) *	1982-08-11	1989-01-25	Ciba-Geigy Ag	Verfahren zur chemischen Bindung von Stabilisatoren an Polymere
FR2549049B1 (fr) *	1983-07-13	1986-06-20	Chauvin Blache Lab	Nouvelles amidines, leur procede de preparation et leur application therapeutique
HU190639B (en) *	1983-12-12	1986-09-29	Gyogyszerkutato Intezet Kv,Hu	Process for production of new aminoguanidin derivatives
DE3416695A1 (de) *	1984-05-05	1985-11-07	Bayer Ag, 5090 Leverkusen	Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
EP0362135A3 (de) *	1988-09-28	1990-10-17	Ciba-Geigy Ag	Schädlingsbekämpfungsmittel

1990
- 1990-11-29 FR FR9014898A patent/FR2669927B1/fr not_active Expired - Fee Related
1991
- 1991-11-04 US US07/787,374 patent/US5494934A/en not_active Expired - Fee Related
- 1991-11-28 PT PT99644A patent/PT99644B/pt not_active IP Right Cessation
- 1991-11-28 AU AU88243/91A patent/AU638879B2/en not_active Ceased
- 1991-11-28 CA CA002056560A patent/CA2056560A1/fr not_active Abandoned
- 1991-11-28 NZ NZ240789A patent/NZ240789A/en unknown
- 1991-11-28 ZA ZA919410A patent/ZA919410B/xx unknown
- 1991-11-28 IE IE413991A patent/IE65632B1/en not_active IP Right Cessation
- 1991-11-29 DE DE69101141T patent/DE69101141T2/de not_active Expired - Fee Related
- 1991-11-29 JP JP3316651A patent/JPH0669999B2/ja not_active Expired - Lifetime
- 1991-11-29 ES ES91403230T patent/ES2063471T3/es not_active Expired - Lifetime
- 1991-11-29 DK DK91403230.5T patent/DK0488897T3/da active
- 1991-11-29 AT AT91403230T patent/ATE101128T1/de not_active IP Right Cessation
- 1991-11-29 EP EP91403230A patent/EP0488897B1/de not_active Expired - Lifetime
1993
- 1993-01-19 US US08/005,653 patent/US5296498A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JPH04308561A (ja)	1992-10-30
ES2063471T3 (es)	1995-01-01
PT99644A (pt)	1992-10-30
DE69101141T2 (de)	1994-08-04
DK0488897T3 (da)	1994-05-02
IE65632B1 (en)	1995-11-01
JPH0669999B2 (ja)	1994-09-07
CA2056560A1 (fr)	1992-05-30
PT99644B (pt)	1999-05-31
AU8824391A (en)	1992-06-04
EP0488897A1 (de)	1992-06-03
AU638879B2 (en)	1993-07-08
NZ240789A (en)	1993-02-25
EP0488897B1 (de)	1994-02-02
DE69101141D1 (de)	1994-03-17
FR2669927A1 (fr)	1992-06-05
ATE101128T1 (de)	1994-02-15
IE914139A1 (en)	1992-06-03
FR2669927B1 (fr)	1994-04-08
US5494934A (en)	1996-02-27
US5296498A (en)	1994-03-22

Publication	Publication Date	Title
AU8824391A (en)	1992-06-04	New guanidine compounds, process for preparing these and pharmaceutical compositions containing them
ATE33838T1 (de)	1988-05-15	Thiazolidinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
ES482134A1 (es)	1980-04-01	Un procedimiento para preparar derivados de 1-(3-mercapto- 2-metilpropanoil)-prolil-aminoacido.
DE3873612D1 (de)	1992-09-17	Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IL103944A0 (en)	1993-05-13	Piperazine derivatives,their preparation and pharmaceutical compositions containing them
ES8302002A1 (es)	1982-12-16	Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
IE810392L (en)	1981-09-01	Hydropyridine derivatives.
ZA911403B (en)	1991-11-27	Derivatives having a naphthalene structure,process for preparing these and pharmaceutical compositions containing them
IL85725A (en)	1991-12-12	Imidazole derivatives,their manufacture and pharmaceutical compositions containing them
BG101501A (en)	1998-01-30	Nitro-benzamides useful as anti-arrhytmic agents
AU639154B2 (en)	1993-07-15	New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
ZA946659B (en)	1995-04-20	2(1h)-quinolone compounds process for preparing them and pharmaceutical compositions containing them
ATE27455T1 (de)	1987-06-15	Heterocyclische guanidino-phenylamidine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
AU4583489A (en)	1990-06-14	New indole derivatives, process for preparing them and pharmaceutical compositions containing them
CA2053705A1 (en)	1992-04-20	Piperazine derivatives
IE46226L (en)	1978-06-24	O-propyloximes
IL106564A (en)	1997-07-13	Tetrahydronaphthalene derivatives their preparation and pharmaceutical compositions containing them
ZA905407B (en)	1991-04-24	Pyrrolo(2,1-b)thiozle derivatives
ZA909557B (en)	1991-09-25	Substituted benzothiazolinones,process for preparing these and pharmaceutical compositions containing them